Do oligodendrocytes regulate axonal glucose uptake and consumption?

IF 14.6 1区 医学 Q1 NEUROSCIENCES
Trends in Neurosciences Pub Date : 2024-08-01 Epub Date: 2024-06-11 DOI:10.1016/j.tins.2024.06.001
Jessica L Fletcher, Kaylene M Young
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引用次数: 0

Abstract

Neurons have high energy demands. In a recent study, Looser et al. identified oligodendrocyte Kir4.1 as the activity-dependent driver of oligodendrocyte glycolysis that ensures that lactate is supplied to active neurons. Given that oligodendrocyte Kir4.1 also influenced axonal glucose consumption and uptake, oligodendrocytes may play a broader role in neuronal metabolic regulation.

少突胶质细胞能调节轴突的葡萄糖摄取和消耗吗?
神经元对能量的需求很高。在最近的一项研究中,Looser 等人发现少突胶质细胞 Kir4.1 是少突胶质细胞糖酵解的活动依赖性驱动因子,可确保向活跃的神经元提供乳酸。鉴于少突胶质细胞 Kir4.1 也影响轴突的葡萄糖消耗和摄取,少突胶质细胞可能在神经元代谢调节中发挥更广泛的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Trends in Neurosciences
Trends in Neurosciences 医学-神经科学
CiteScore
26.50
自引率
1.30%
发文量
123
审稿时长
6-12 weeks
期刊介绍: For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.
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