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Trends in Neurosciences最新文献

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Unweaving type I interferons in age-related neuroinflammation. 解开 I 型干扰素在与年龄相关的神经炎症中的作用。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-01 Epub Date: 2024-09-04 DOI: 10.1016/j.tins.2024.08.014
David P J Hunt, Markus J Hofer
{"title":"Unweaving type I interferons in age-related neuroinflammation.","authors":"David P J Hunt, Markus J Hofer","doi":"10.1016/j.tins.2024.08.014","DOIUrl":"10.1016/j.tins.2024.08.014","url":null,"abstract":"<p><p>Neuroinflammation is a feature of both neurodegenerative disease and normal brain aging. The roles of type I interferon (IFN-I) in the aged brain are incompletely understood. A recent article by Roy et al. reveals pervasive IFN-I activity in normal mouse brain aging, and highlights the importance of microglial IFN-I signaling in neuroinflammation.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"751-752"},"PeriodicalIF":14.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When sensory input meets spontaneous brain activity. 当感官输入与大脑自发活动相遇时。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-01 Epub Date: 2024-08-31 DOI: 10.1016/j.tins.2024.08.010
Natalia Zaretskaya
{"title":"When sensory input meets spontaneous brain activity.","authors":"Natalia Zaretskaya","doi":"10.1016/j.tins.2024.08.010","DOIUrl":"10.1016/j.tins.2024.08.010","url":null,"abstract":"<p><p>A recent study by Wu, Podvalny, and colleagues investigated how ongoing spontaneous brain activity interacts with sensory input and shapes conscious perception. It reports diverse effects of prestimulus activity in several key networks, revealing new roles of the prefrontal cortex and the default mode network in perception and consciousness.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"749-750"},"PeriodicalIF":14.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transformers and cortical waves: encoders for pulling in context across time. 变压器和皮质波：跨时空语境牵引的编码器。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-01 Epub Date: 2024-09-27 DOI: 10.1016/j.tins.2024.08.006
Lyle Muller, Patricia S Churchland, Terrence J Sejnowski
{"title":"Transformers and cortical waves: encoders for pulling in context across time.","authors":"Lyle Muller, Patricia S Churchland, Terrence J Sejnowski","doi":"10.1016/j.tins.2024.08.006","DOIUrl":"10.1016/j.tins.2024.08.006","url":null,"abstract":"<p><p>The capabilities of transformer networks such as ChatGPT and other large language models (LLMs) have captured the world's attention. The crucial computational mechanism underlying their performance relies on transforming a complete input sequence - for example, all the words in a sentence - into a long 'encoding vector' that allows transformers to learn long-range temporal dependencies in naturalistic sequences. Specifically, 'self-attention' applied to this encoding vector enhances temporal context in transformers by computing associations between pairs of words in the input sequence. We suggest that waves of neural activity traveling across single cortical areas, or multiple regions on the whole-brain scale, could implement a similar encoding principle. By encapsulating recent input history into a single spatial pattern at each moment in time, cortical waves may enable a temporal context to be extracted from sequences of sensory inputs, the same computational principle as that used in transformers.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"788-802"},"PeriodicalIF":14.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human-derived monoclonal autoantibodies as interrogators of cellular proteotypes in the brain. 人源单克隆自身抗体作为脑细胞蛋白型的询问因子。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-01 Epub Date: 2024-09-05 DOI: 10.1016/j.tins.2024.08.004
Matthew L Baum, Christopher M Bartley
{"title":"Human-derived monoclonal autoantibodies as interrogators of cellular proteotypes in the brain.","authors":"Matthew L Baum, Christopher M Bartley","doi":"10.1016/j.tins.2024.08.004","DOIUrl":"10.1016/j.tins.2024.08.004","url":null,"abstract":"<p><p>A major aim of neuroscience is to identify and model the functional properties of neural cells whose dysfunction underlie neuropsychiatric illness. In this article, we propose that human-derived monoclonal autoantibodies (HD-mAbs) are well positioned to selectively target and manipulate neural subpopulations as defined by their protein expression; that is, cellular proteotypes. Recent technical advances allow for efficient cloning of autoantibodies from neuropsychiatric patients. These HD-mAbs can be introduced into animal models to gain biological and pathobiological insights about neural proteotypes of interest. Protein engineering can be used to modify, enhance, silence, or confer new functional properties to native HD-mAbs, thereby enhancing their versatility. Finally, we discuss the challenges and limitations confronting HD-mAbs as experimental research tools for neuroscience.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"753-765"},"PeriodicalIF":14.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain bilateral asymmetry - insights from nematodes, zebrafish, and Drosophila. 大脑双侧不对称--线虫、斑马鱼和果蝇的启示。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-01 Epub Date: 2024-09-24 DOI: 10.1016/j.tins.2024.08.003
François Lapraz, Cloé Fixary-Schuster, Stéphane Noselli
{"title":"Brain bilateral asymmetry - insights from nematodes, zebrafish, and Drosophila.","authors":"François Lapraz, Cloé Fixary-Schuster, Stéphane Noselli","doi":"10.1016/j.tins.2024.08.003","DOIUrl":"10.1016/j.tins.2024.08.003","url":null,"abstract":"<p><p>Chirality is a fundamental trait of living organisms, encompassing the homochirality of biological molecules and the left-right (LR) asymmetry of visceral organs and the brain. The nervous system in bilaterian organisms displays a lateralized organization characterized by the presence of asymmetrical neuronal circuits and brain functions that are predominantly localized within one hemisphere. Although body asymmetry is relatively well understood, and exhibits robust phenotypic expression and regulation via conserved molecular mechanisms across phyla, current findings indicate that the asymmetry of the nervous system displays greater phenotypic, genetic, and evolutionary variability. In this review we explore the use of nematode, zebrafish, and Drosophila genetic models to investigate neuronal circuit asymmetry. We discuss recent discoveries in the context of body-brain concordance and highlight the distinct characteristics of nervous system asymmetry and its cognitive correlates.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"803-818"},"PeriodicalIF":14.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Splenic nociceptive neural connection promotes humoral immunity. 脾脏痛觉神经连接可促进体液免疫。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-01 DOI: 10.1016/j.tins.2024.09.008
Cheng Qian, Jiaming Wang, Xuetao Cao
{"title":"Splenic nociceptive neural connection promotes humoral immunity.","authors":"Cheng Qian, Jiaming Wang, Xuetao Cao","doi":"10.1016/j.tins.2024.09.008","DOIUrl":"https://doi.org/10.1016/j.tins.2024.09.008","url":null,"abstract":"<p><p>Recent work by Wu and colleagues unveiled a previously enigmatic population of spleen-innervating nociceptors from left T8-T13 dorsal root ganglia (DRGs) in mice. They found a specific DRG-spleen sensorineural connection that promotes humoral immunity via a CGRP-CALCRL/RAMP1 axis, providing a valuable target for immune regulation in local microenvironments.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Object-oriented olfaction: challenges for chemosensation and for chemosensory research. 面向对象的嗅觉：化学感觉和化学感觉研究面临的挑战。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-01 Epub Date: 2024-09-07 DOI: 10.1016/j.tins.2024.08.008
Dan Rokni, Yoram Ben-Shaul
{"title":"Object-oriented olfaction: challenges for chemosensation and for chemosensory research.","authors":"Dan Rokni, Yoram Ben-Shaul","doi":"10.1016/j.tins.2024.08.008","DOIUrl":"10.1016/j.tins.2024.08.008","url":null,"abstract":"<p><p>Many animal species use olfaction to extract information about objects in their environment. Yet, the specific molecular signature that any given object emits varies due to various factors. Here, we detail why such variability makes chemosensory-mediated object recognition such a hard problem, and we propose that a major function of the elaborate chemosensory network is to overcome it. We describe previous work addressing different elements of the problem and outline future research directions that we consider essential for a full understanding of object-oriented olfaction. In particular, we call for extensive representation of olfactory object variability in chemical, behavioral, and electrophysiological analyses. While written with an emphasis on macrosmatic mammalian species, our arguments apply to all organisms that employ chemosensation to navigate complex environments.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"834-848"},"PeriodicalIF":14.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142155053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural adaptation to changes in self-voice during puberty. 青春期自我声音变化的神经适应。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-01 Epub Date: 2024-08-29 DOI: 10.1016/j.tins.2024.08.001
Ana P Pinheiro, Jean-Julien Aucouturier, Sonja A Kotz
{"title":"Neural adaptation to changes in self-voice during puberty.","authors":"Ana P Pinheiro, Jean-Julien Aucouturier, Sonja A Kotz","doi":"10.1016/j.tins.2024.08.001","DOIUrl":"10.1016/j.tins.2024.08.001","url":null,"abstract":"<p><p>The human voice is a potent social signal and a distinctive marker of individual identity. As individuals go through puberty, their voices undergo acoustic changes, setting them apart from others. In this article, we propose that hormonal fluctuations in conjunction with morphological vocal tract changes during puberty establish a sensitive developmental phase that affects the monitoring of the adolescent voice and, specifically, self-other distinction. Furthermore, the protracted maturation of brain regions responsible for voice processing, coupled with the dynamically evolving social environment of adolescents, likely disrupts a clear differentiation of the self-voice from others' voices. This socioneuroendocrine framework offers a holistic understanding of voice monitoring during adolescence.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"777-787"},"PeriodicalIF":14.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nature versus laboratory: how to optimize housing conditions for zebrafish neuroscience research. 自然与实验室：如何优化斑马鱼神经科学研究的饲养条件。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-09-21 DOI: 10.1016/j.tins.2024.08.013
Benjamin Tsang, Robert Gerlai
{"title":"Nature versus laboratory: how to optimize housing conditions for zebrafish neuroscience research.","authors":"Benjamin Tsang, Robert Gerlai","doi":"10.1016/j.tins.2024.08.013","DOIUrl":"https://doi.org/10.1016/j.tins.2024.08.013","url":null,"abstract":"<p><p>Although zebrafish (Danio rerio) neuroscience research is rapidly expanding, the fundamental question of how these fish should be maintained in research laboratories remains largely unstudied. This may explain the diverse practices and broad range of environmental parameters used in zebrafish facilities. Here, we provide examples of these parameters and practices, including housing density, tank size, and water chemistry. We discuss the principles of stochastic resonance versus homeostasis and provide hypothetical examples to explain why keeping zebrafish outside of their tolerated range of environmental parameters may increase phenotypical variance and reduce replicability. We call for systematic studies to establish the optimal maintenance conditions for zebrafish. Furthermore, we discuss why knowing more about the natural behavior and ecology of this species could be a guiding principle for these studies.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rethinking the role of TRKB in the action of antidepressants and psychedelics 重新思考TRKB在抗抑郁药和迷幻药作用中的作用
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-09-19 DOI: 10.1016/j.tins.2024.08.011
Cecilia Anna Brunello, Cecilia Cannarozzo, Eero Castrén
{"title":"Rethinking the role of TRKB in the action of antidepressants and psychedelics","authors":"Cecilia Anna Brunello, Cecilia Cannarozzo, Eero Castrén","doi":"10.1016/j.tins.2024.08.011","DOIUrl":"https://doi.org/10.1016/j.tins.2024.08.011","url":null,"abstract":"<p>Antidepressant drugs promote neuronal plasticity, and activation of brain-derived neurotrophic factor (BDNF) signaling through its receptor neuronal receptor tyrosine kinase 2 (NTRK2 or TRKB) is among the critical steps in this process. These mechanisms are shared by typical slow-acting antidepressants, fast-acting ketamine, and psychedelic compounds, although the cellular targets of each drug differ. In this opinion, we propose that some of these antidepressants may directly bind to TRKB and allosterically potentiate BDNF signaling, among other possible effects. TRKB activation in parvalbumin-containing interneurons disinhibits cortical networks and reactivates a juvenile-like plasticity window. Subsequent rewiring of aberrant networks, coupled with environmental stimuli, may underlie its clinical antidepressant effects. The end-to-end hypothesis proposed may stimulate the search for new treatment strategies.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"33 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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