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Trends in Neurosciences最新文献

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Peripheral, central, and chemotherapy-induced neuropathic changes in pancreatic cancer. 胰腺癌外周、中枢和化疗诱导的神经性改变。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-26 DOI: 10.1016/j.tins.2024.11.008
Luju Jiang, Shuqi Cai, Zheqi Weng, Shan Zhang, Shu-Heng Jiang
{"title":"Peripheral, central, and chemotherapy-induced neuropathic changes in pancreatic cancer.","authors":"Luju Jiang, Shuqi Cai, Zheqi Weng, Shan Zhang, Shu-Heng Jiang","doi":"10.1016/j.tins.2024.11.008","DOIUrl":"https://doi.org/10.1016/j.tins.2024.11.008","url":null,"abstract":"<p><p>In pancreatic cancer, significant alterations occur in the local nervous system, including axonogenesis, neural remodeling, perineural invasion, and perineural neuritis. Pancreatic cancer can impact the central nervous system (CNS) through cancer cell-intrinsic factors or systemic factors, particularly in the context of cancer cachexia. These peripheral and central neuropathic changes exert substantial influence on cancer initiation and progression. Moreover, chemotherapy-induced neuropathy is common in pancreatic cancer, causing peripheral nerve damage and cognitive dysfunction. Targeting the crosstalk between pancreatic cancer and the nervous system, either peripherally or centrally, holds promise in cancer treatment, pain relief, and improved quality of life. Here, we summarize recent findings on the molecular mechanisms behind these neuropathic changes in pancreatic cancer and discuss potential intervention strategies.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing brain-wide outcomes of dopamine system activation in the living rodent brain. 评估活体啮齿动物大脑中多巴胺系统激活的全脑结果。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-24 DOI: 10.1016/j.tins.2024.12.003
Christian Limberger, Eduardo R Zimmer
{"title":"Assessing brain-wide outcomes of dopamine system activation in the living rodent brain.","authors":"Christian Limberger, Eduardo R Zimmer","doi":"10.1016/j.tins.2024.12.003","DOIUrl":"https://doi.org/10.1016/j.tins.2024.12.003","url":null,"abstract":"<p><p>In a recent study, Haas, Bravo, and colleagues integrated optogenetic stimulation with simultaneous functional in vivo positron emission tomography (PET)/magnetic resonance imaging (MRI) measurements in rats. By activating the nigrostriatal pathway in the substantia nigra pars compacta (SNc), they observed concurrent metabolic and hemodynamic fluctuations associated with the dopaminergic pathway in living animals at the whole-brain level.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interconnected neural circuits mediating social reward. 介导社会奖赏的神经回路相互连接。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-11-11 DOI: 10.1016/j.tins.2024.10.004
Jennifer Isaac, Malavika Murugan
{"title":"Interconnected neural circuits mediating social reward.","authors":"Jennifer Isaac, Malavika Murugan","doi":"10.1016/j.tins.2024.10.004","DOIUrl":"10.1016/j.tins.2024.10.004","url":null,"abstract":"<p><p>Across species, social behaviors are shaped and maintained through positive reinforcement of affiliative social interactions. As with nonsocial rewards, the reinforcing properties of social interactions have been shown to involve interplay between various brain regions and the mesolimbic reward system. In this review, we summarize findings from rodent research on the neural circuits that encode and mediate different components of social reward-seeking behavior. We explore methods to parse and study social reward-related behaviors using available behavioral paradigms. We also compare the neural mechanisms that support social versus nonsocial reward-seeking. Finally, we discuss how internal state and neuromodulatory systems affect reward-seeking behavior and the neural circuits that underlie social reward.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"1041-1054"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Representational spaces in orbitofrontal and ventromedial prefrontal cortex: task states, values, and beyond. 眶额叶和腹内侧前额叶皮层的表征空间：任务状态、价值及其他。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-11-14 DOI: 10.1016/j.tins.2024.10.005
Nir Moneta, Shany Grossman, Nicolas W Schuck
{"title":"Representational spaces in orbitofrontal and ventromedial prefrontal cortex: task states, values, and beyond.","authors":"Nir Moneta, Shany Grossman, Nicolas W Schuck","doi":"10.1016/j.tins.2024.10.005","DOIUrl":"10.1016/j.tins.2024.10.005","url":null,"abstract":"<p><p>The orbitofrontal cortex (OFC) and ventromedial-prefrontal cortex (vmPFC) play a key role in decision-making and encode task states in addition to expected value. We review evidence suggesting a connection between value and state representations and argue that OFC / vmPFC integrate stimulus, context, and outcome information. Comparable encoding principles emerge in late layers of deep reinforcement learning (RL) models, where single nodes exhibit similar forms of mixed-selectivity, which enables flexible readout of relevant variables by downstream neurons. Based on these lines of evidence, we suggest that outcome-maximization leads to complex representational spaces that are insufficiently characterized by linear value signals that have been the focus of most prior research on the topic. Major outstanding questions concern the role of OFC/ vmPFC in learning across tasks, in encoding of task-irrelevant aspects, and the role of hippocampus-PFC interactions.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"1055-1069"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The claustrum and synchronized brain states. 磁鼓与大脑同步状态
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-11-02 DOI: 10.1016/j.tins.2024.10.003
Alison D Do, Coline Portet, Romain Goutagny, Jesse Jackson
{"title":"The claustrum and synchronized brain states.","authors":"Alison D Do, Coline Portet, Romain Goutagny, Jesse Jackson","doi":"10.1016/j.tins.2024.10.003","DOIUrl":"10.1016/j.tins.2024.10.003","url":null,"abstract":"<p><p>Cortical activity is constantly fluctuating between distinct spatiotemporal activity patterns denoted by changes in brain state. States of cortical desynchronization arise during motor generation, increased attention, and high cognitive load. Synchronized brain states comprise spatially widespread, coordinated low-frequency neural activity during rest and sleep when disengaged from the external environment or 'offline'. The claustrum is a small subcortical structure with dense reciprocal connections with the cortex suggesting modulation by, or participation in, brain state regulation. Here, we highlight recent work suggesting that neural activity in the claustrum supports cognitive processes associated with synchronized brain states characterized by increased low-frequency network activity. As an example, we outline how claustrum activity could support episodic memory consolidation during sleep.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"1028-1040"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defining and characterizing neuronal senescence, 'neurescence', as GX arrested cells. 将神经元衰老（"神经衰老"）定义为 GX 停止细胞，并确定其特征。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-10-09 DOI: 10.1016/j.tins.2024.09.006
Hannah R Hudson, Markus Riessland, Miranda E Orr
{"title":"Defining and characterizing neuronal senescence, 'neurescence', as G<sub>X</sub> arrested cells.","authors":"Hannah R Hudson, Markus Riessland, Miranda E Orr","doi":"10.1016/j.tins.2024.09.006","DOIUrl":"10.1016/j.tins.2024.09.006","url":null,"abstract":"<p><p>Cellular senescence is a cell state characterized by resistance to apoptosis and stable cell cycle arrest. Senescence was first observed in mitotic cells in vitro. Recent evidence from in vivo studies and human tissue indicates that postmitotic cells, including neurons, may also become senescent. The quiescent cell state of neurons and inconsistent descriptions of neuronal senescence across studies, however, have caused confusion in this burgeoning field. We summarize evidence demonstrating that exit from G<sub>0</sub> quiescence may protect neurons against apoptosis and predispose them toward senescence. Additionally, we propose the term 'neurescent' for senescent neurons and introduce the cell state, G<sub>X</sub>, to describe cell cycle arrest achieved by passing through G<sub>0</sub> quiescence. Criteria are provided to identify neurescent cells, distinguish them from G<sub>0</sub> quiescent neurons, and compare neurescent phenotypes with classic replicative senescence.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"971-984"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nature versus laboratory: how to optimize housing conditions for zebrafish neuroscience research. 自然与实验室：如何优化斑马鱼神经科学研究的饲养条件。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-09-21 DOI: 10.1016/j.tins.2024.08.013
Benjamin Tsang, Robert Gerlai
{"title":"Nature versus laboratory: how to optimize housing conditions for zebrafish neuroscience research.","authors":"Benjamin Tsang, Robert Gerlai","doi":"10.1016/j.tins.2024.08.013","DOIUrl":"10.1016/j.tins.2024.08.013","url":null,"abstract":"<p><p>Although zebrafish (Danio rerio) neuroscience research is rapidly expanding, the fundamental question of how these fish should be maintained in research laboratories remains largely unstudied. This may explain the diverse practices and broad range of environmental parameters used in zebrafish facilities. Here, we provide examples of these parameters and practices, including housing density, tank size, and water chemistry. We discuss the principles of stochastic resonance versus homeostasis and provide hypothetical examples to explain why keeping zebrafish outside of their tolerated range of environmental parameters may increase phenotypical variance and reduce replicability. We call for systematic studies to establish the optimal maintenance conditions for zebrafish. Furthermore, we discuss why knowing more about the natural behavior and ecology of this species could be a guiding principle for these studies.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"985-993"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Splenic nociceptive neural connection promotes humoral immunity. 脾脏痛觉神经连接可促进体液免疫。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-10-02 DOI: 10.1016/j.tins.2024.09.008
Cheng Qian, Jiaming Wang, Xuetao Cao
{"title":"Splenic nociceptive neural connection promotes humoral immunity.","authors":"Cheng Qian, Jiaming Wang, Xuetao Cao","doi":"10.1016/j.tins.2024.09.008","DOIUrl":"10.1016/j.tins.2024.09.008","url":null,"abstract":"<p><p>Recent work by Wu and colleagues unveiled a previously enigmatic population of spleen-innervating nociceptors from left T8-T13 dorsal root ganglia (DRGs) in mice. They found a specific DRG-spleen sensorineural connection that promotes humoral immunity via a CGRP-CALCRL/RAMP1 axis, providing a valuable target for immune regulation in local microenvironments.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"968-970"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An expanding repertoire of circuit mechanisms for visual prediction errors. 视觉预测错误的电路机制不断扩大。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-11-08 DOI: 10.1016/j.tins.2024.10.007
Jordan M Ross, Jordan P Hamm
{"title":"An expanding repertoire of circuit mechanisms for visual prediction errors.","authors":"Jordan M Ross, Jordan P Hamm","doi":"10.1016/j.tins.2024.10.007","DOIUrl":"10.1016/j.tins.2024.10.007","url":null,"abstract":"<p><p>Cortical responses to stimuli vary dependingon context and expectation. Adding insight into this process, Furutachi et al. recently demonstrated that higher-order thalamic input to visual cortex cooperates with interneurons to augment responses to unexpected stimuli, consistent with a body of literature implicating top-down modulation and local inhibition in predictive processing.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"963-964"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dopaminergic circuits controlling threat and safety learning. 控制威胁和安全学习的多巴胺能回路
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1016/j.tins.2024.10.001
Sevil Duvarci
{"title":"Dopaminergic circuits controlling threat and safety learning.","authors":"Sevil Duvarci","doi":"10.1016/j.tins.2024.10.001","DOIUrl":"10.1016/j.tins.2024.10.001","url":null,"abstract":"<p><p>The ability to learn from experience that certain cues and situations are associated with threats or safety is crucial for survival and adaptive behavior. Understanding the neural substrates of threat and safety learning has high clinical significance because deficits in these forms of learning characterize anxiety disorders. Traditionally, dopamine neurons were thought to uniformly support reward learning by signaling reward prediction errors. However, the dopamine system is functionally more diverse than was initially appreciated and is also critical for processing threat and safety. In this review, I highlight recent studies demonstrating that dopamine neurons generate prediction errors for threat and safety, and describe how dopamine projections to the amygdala, medial prefrontal cortex (mPFC), and striatum regulate associative threat and safety learning.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"1014-1027"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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