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Trends in Neurosciences最新文献

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Making sense of vertebrate senses from a neural crest and cranial placode evo-devo perspective.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-03-01 Epub Date: 2025-01-23 DOI: 10.1016/j.tins.2024.12.008
Brittany M Edens, Marianne E Bronner
{"title":"Making sense of vertebrate senses from a neural crest and cranial placode evo-devo perspective.","authors":"Brittany M Edens, Marianne E Bronner","doi":"10.1016/j.tins.2024.12.008","DOIUrl":"10.1016/j.tins.2024.12.008","url":null,"abstract":"<p><p>The evolution of vertebrates from protochordate ancestors marked the beginning of the gradual transition to predatory lifestyles. Enabled by the acquisition of multipotent neural crest and cranial placode cell populations, vertebrates developed an elaborate peripheral nervous system, equipped with paired sense organs, which aided in adaptive behaviors and ultimately, successful colonization of diverse environmental niches. Underpinning the enduring success of vertebrates is the highly adaptable nature of the peripheral nervous system, which is enabled by the exceptional malleability of the neural crest and placode developmental programs. Here, we explore the embryonic origins of the vertebrate senses from the neural crest and cranial placodes and discuss the evolutionary trajectory of the senses in the context of adaptation to novel environments.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"213-226"},"PeriodicalIF":14.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defining brain fog across medical conditions.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-02-17 DOI: 10.1016/j.tins.2025.01.003
Peter Denno, Sijia Zhao, Masud Husain, Adam Hampshire
{"title":"Defining brain fog across medical conditions.","authors":"Peter Denno, Sijia Zhao, Masud Husain, Adam Hampshire","doi":"10.1016/j.tins.2025.01.003","DOIUrl":"https://doi.org/10.1016/j.tins.2025.01.003","url":null,"abstract":"<p><p>'Brain fog' is commonly reported in more than a dozen chronic diseases, but what is it? We review research across conditions which has characterised brain fog and evaluate its definitions and objective correlates. Brain fog has been used to refer to a variable set of overlapping symptoms implicating cognition, fatigue, and affect. It has been defined as a distinct symptom, a syndrome, or a nonspecific term. We consider the evidence that brain fog is a transdiagnostic entity with a common phenomenology and profile of objective cognitive deficits. We discuss where these commonalities arise and argue that linguistic ambiguity, shared cognitive impairments, and noncognitive factors are more likely than shared neurobiology. We suggest how future research might apply existing tools to disambiguate the phenomena that brain fog conflates.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coordinating the energetic strategy of glia and neurons for memory.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-02-01 Epub Date: 2025-01-22 DOI: 10.1016/j.tins.2025.01.001
Hannah Shoenhard, Amita Sehgal
{"title":"Coordinating the energetic strategy of glia and neurons for memory.","authors":"Hannah Shoenhard, Amita Sehgal","doi":"10.1016/j.tins.2025.01.001","DOIUrl":"10.1016/j.tins.2025.01.001","url":null,"abstract":"<p><p>Memory consolidation requires rapid energy supply to neurons. In a recent study, Francés et al. revealed the signal by which a neuron commands glia to limit fatty acid synthesis in favor of metabolite export during memory formation in Drosophila melanogaster. This mechanism coordinates just-in-time glial energy delivery in response to dynamic neuronal needs.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"93-95"},"PeriodicalIF":14.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing brain-wide outcomes of dopamine system activation in the living rodent brain. 评估活体啮齿动物大脑中多巴胺系统激活的全脑结果。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-02-01 Epub Date: 2024-12-24 DOI: 10.1016/j.tins.2024.12.003
Christian Limberger, Eduardo R Zimmer
{"title":"Assessing brain-wide outcomes of dopamine system activation in the living rodent brain.","authors":"Christian Limberger, Eduardo R Zimmer","doi":"10.1016/j.tins.2024.12.003","DOIUrl":"10.1016/j.tins.2024.12.003","url":null,"abstract":"<p><p>In a recent study, Haas, Bravo, and colleagues integrated optogenetic stimulation with simultaneous functional in vivo positron emission tomography (PET)/magnetic resonance imaging (MRI) measurements in rats. By activating the nigrostriatal pathway in the substantia nigra pars compacta (SNc), they observed concurrent metabolic and hemodynamic fluctuations associated with the dopaminergic pathway in living animals at the whole-brain level.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"96-97"},"PeriodicalIF":14.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CK2-dependent SK channel dysfunction as contributor to neuronal hyperexcitability in Alzheimer's disease. ck2依赖性SK通道功能障碍是阿尔茨海默病中神经元高兴奋性的贡献者。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-02-01 Epub Date: 2025-01-04 DOI: 10.1016/j.tins.2024.12.006
Xiaojie Wei, Binggui Sun
{"title":"CK2-dependent SK channel dysfunction as contributor to neuronal hyperexcitability in Alzheimer's disease.","authors":"Xiaojie Wei, Binggui Sun","doi":"10.1016/j.tins.2024.12.006","DOIUrl":"10.1016/j.tins.2024.12.006","url":null,"abstract":"<p><p>Neuronal hyperexcitability in the cortex and hippocampus represents an early event in Alzheimer's disease (AD). In a recent study, Blankenship and colleagues reported that in a mouse of AD, ventral tegmental area (VTA) dopamine neurons are also hyperexcitable, and this hyperexcitability is due to casein kinase 2 (CK2)-dependent SK channel dysfunction, adding new insights into the underlying mechanisms of aberrant neuronal properties in AD.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"98-99"},"PeriodicalIF":14.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neocortical somatostatin neuron diversity in cognition and learning. 新皮质生长抑素神经元在认知和学习中的多样性。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-02-01 Epub Date: 2025-01-16 DOI: 10.1016/j.tins.2024.12.004
Eunsol Park, Matthew B Mosso, Alison L Barth
{"title":"Neocortical somatostatin neuron diversity in cognition and learning.","authors":"Eunsol Park, Matthew B Mosso, Alison L Barth","doi":"10.1016/j.tins.2024.12.004","DOIUrl":"10.1016/j.tins.2024.12.004","url":null,"abstract":"<p><p>Somatostatin-expressing (SST) neurons are a major class of electrophysiologically and morphologically distinct inhibitory cells in the mammalian neocortex. Transcriptomic data suggest that this class can be divided into multiple subtypes that are correlated with morpho-electric properties. At the same time, availability of transgenic tools to identify and record from SST neurons in awake, behaving mice has stimulated insights about their response properties and computational function. Neocortical SST neurons are regulated by sleep and arousal, attention, and novelty detection, and show marked response plasticity during learning. Recent studies suggest that subtype-specific analysis of SST neurons may be critical for understanding their complex roles in cortical function. In this review, we discuss and synthesize recent advances in understanding the diversity, circuit integration, and functional properties of this important group of GABAergic neurons.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"140-155"},"PeriodicalIF":14.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishing functionally segregated dopaminergic circuits.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-02-01 Epub Date: 2025-01-24 DOI: 10.1016/j.tins.2024.12.002
Akiko Terauchi, Erin M Johnson-Venkatesh, Hisashi Umemori
{"title":"Establishing functionally segregated dopaminergic circuits.","authors":"Akiko Terauchi, Erin M Johnson-Venkatesh, Hisashi Umemori","doi":"10.1016/j.tins.2024.12.002","DOIUrl":"10.1016/j.tins.2024.12.002","url":null,"abstract":"<p><p>Despite accounting for only ~0.001% of all neurons in the human brain, midbrain dopaminergic neurons control numerous behaviors and are associated with many neuropsychiatric disorders that affect our physical and mental health. Dopaminergic neurons form various anatomically and functionally segregated pathways. Having such defined dopaminergic pathways is key to controlling varied sets of brain functions; therefore, segregated dopaminergic pathways must be properly and uniquely formed during development. How are these segregated pathways established? The three key developmental stages that dopaminergic neurons go through are cell migration, axon guidance, and synapse formation. In each stage, dopaminergic neurons and their processes receive unique molecular cues to guide the formation of specific dopaminergic pathways. Here, we outline the molecular mechanisms underlying the establishment of segregated dopaminergic pathways during each developmental stage in the mouse brain, focusing on the formation of the three major dopaminergic pathways: the nigrostriatal, mesolimbic, and mesocortical pathways. We propose that multiple stage-specific molecular gradients cooperate to establish functionally segregated dopaminergic circuits.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"156-170"},"PeriodicalIF":14.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peripheral, central, and chemotherapy-induced neuropathic changes in pancreatic cancer. 胰腺癌外周、中枢和化疗诱导的神经性改变。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-02-01 Epub Date: 2024-12-26 DOI: 10.1016/j.tins.2024.11.008
Luju Jiang, Shuqi Cai, Zheqi Weng, Shan Zhang, Shu-Heng Jiang
{"title":"Peripheral, central, and chemotherapy-induced neuropathic changes in pancreatic cancer.","authors":"Luju Jiang, Shuqi Cai, Zheqi Weng, Shan Zhang, Shu-Heng Jiang","doi":"10.1016/j.tins.2024.11.008","DOIUrl":"10.1016/j.tins.2024.11.008","url":null,"abstract":"<p><p>In pancreatic cancer, significant alterations occur in the local nervous system, including axonogenesis, neural remodeling, perineural invasion, and perineural neuritis. Pancreatic cancer can impact the central nervous system (CNS) through cancer cell-intrinsic factors or systemic factors, particularly in the context of cancer cachexia. These peripheral and central neuropathic changes exert substantial influence on cancer initiation and progression. Moreover, chemotherapy-induced neuropathy is common in pancreatic cancer, causing peripheral nerve damage and cognitive dysfunction. Targeting the crosstalk between pancreatic cancer and the nervous system, either peripherally or centrally, holds promise in cancer treatment, pain relief, and improved quality of life. Here, we summarize recent findings on the molecular mechanisms behind these neuropathic changes in pancreatic cancer and discuss potential intervention strategies.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"124-139"},"PeriodicalIF":14.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Origins of food selectivity in human visual cortex.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-02-01 DOI: 10.1016/j.tins.2024.12.001
Margaret M Henderson, Michael J Tarr, Leila Wehbe
{"title":"Origins of food selectivity in human visual cortex.","authors":"Margaret M Henderson, Michael J Tarr, Leila Wehbe","doi":"10.1016/j.tins.2024.12.001","DOIUrl":"10.1016/j.tins.2024.12.001","url":null,"abstract":"<p><p>Several recent studies, enabled by advances in neuroimaging methods and large-scale datasets, have identified areas in human ventral visual cortex that respond more strongly to food images than to images of many other categories, adding to our knowledge about the broad network of regions that are responsive to food. This finding raises important questions about the evolutionary and developmental origins of a possible food-selective neural population, as well as larger questions about the origins of category-selective neural populations more generally. Here, we propose a framework for how visual properties of food (particularly color) and nonvisual signals associated with multimodal reward processing, social cognition, and physical interactions with food may, in combination, contribute to the emergence of food selectivity. We discuss recent research that sheds light on each of these factors, alongside a broader account of category selectivity that incorporates both visual feature statistics and behavioral relevance.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"113-123"},"PeriodicalIF":14.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metacognition in the listening brain.
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2025-02-01 Epub Date: 2025-01-21 DOI: 10.1016/j.tins.2024.12.007
Jonas Obleser
{"title":"Metacognition in the listening brain.","authors":"Jonas Obleser","doi":"10.1016/j.tins.2024.12.007","DOIUrl":"10.1016/j.tins.2024.12.007","url":null,"abstract":"<p><p>How do you know you have heard right? Metacognition, the ability to assess and monitor one's own cognitive state, is key to understanding human communication in complex environments. However, the foundational role of metacognition in hearing and communication is only beginning to be explored, and the neuroscience behind it is an emerging field: how does confidence express in neural dynamics of the listening brain? What is known about auditory metaperceptual alterations as a hallmark phenomenon in psychosis, dementia, or hearing loss? Building on Bayesian ideas of auditory perception and auditory neuroscience, 'meta-listening' offers a framework for more comprehensive research into how metacognition in humans and non-humans shapes the listening brain.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"100-112"},"PeriodicalIF":14.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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