Randy R Brutkiewicz, Wei Cao, David Morgan, Roberta Souza Dos Reis, Vidyani Suryadevara, Auriel A Willette, Sara A Willette, Season K Wyatt-Johnson, Michael R Duggan
{"title":"What would it take to prove that a chronic infection is a causal agent in Alzheimer's disease?","authors":"Randy R Brutkiewicz, Wei Cao, David Morgan, Roberta Souza Dos Reis, Vidyani Suryadevara, Auriel A Willette, Sara A Willette, Season K Wyatt-Johnson, Michael R Duggan","doi":"10.1016/j.tins.2025.05.009","DOIUrl":null,"url":null,"abstract":"<p><p>Accumulating evidence over several years suggests that microbial infections (e.g., bacteria, viruses, fungi) may play a role in the etiology of Alzheimer's disease (AD). In this review, we discuss the reported associations between a variety of microbes and the development of AD, as well as potential causal relationships between infections and AD risk. Having evaluated the current state of knowledge, we make specific recommendations for what it would take to present definitive evidence that chronic infections play a causal role in AD pathogenesis.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":""},"PeriodicalIF":15.1000,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Neurosciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.tins.2025.05.009","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Accumulating evidence over several years suggests that microbial infections (e.g., bacteria, viruses, fungi) may play a role in the etiology of Alzheimer's disease (AD). In this review, we discuss the reported associations between a variety of microbes and the development of AD, as well as potential causal relationships between infections and AD risk. Having evaluated the current state of knowledge, we make specific recommendations for what it would take to present definitive evidence that chronic infections play a causal role in AD pathogenesis.
期刊介绍:
For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.