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Retinal ganglion cell circuits and glial interactions in humans and mice. 人类和小鼠的视网膜神经节细胞回路和神经胶质相互作用。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-10-24 DOI: 10.1016/j.tins.2024.09.010
Kang-Chieh Huang, Mohamed Tawfik, Melanie A Samuel
{"title":"Retinal ganglion cell circuits and glial interactions in humans and mice.","authors":"Kang-Chieh Huang, Mohamed Tawfik, Melanie A Samuel","doi":"10.1016/j.tins.2024.09.010","DOIUrl":"10.1016/j.tins.2024.09.010","url":null,"abstract":"<p><p>Retinal ganglion cells (RGCs) are the brain's gateway for vision, and their degeneration underlies several blinding diseases. RGCs interact with other neuronal cell types, microglia, and astrocytes in the retina and in the brain. Much knowledge has been gained about RGCs and glia from mice and other model organisms, often with the assumption that certain aspects of their biology may be conserved in humans. However, RGCs vary considerably between species, which could affect how they interact with their neuronal and glial partners. This review details which RGC and glial features are conserved between mice, humans, and primates, and which differ. We also discuss experimental approaches for studying human and primate RGCs. These strategies will help to bridge the gap between rodent and human RGC studies and increase study translatability to guide future therapeutic strategies.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"994-1013"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CAMs in command: aging brain macrophages fine-tune stroke immune responses. CAMs指挥：衰老的脑巨噬细胞可微调中风免疫反应。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-10-22 DOI: 10.1016/j.tins.2024.10.002
Rodney M Ritzel, Danye Jiang, Louise D McCullough
{"title":"CAMs in command: aging brain macrophages fine-tune stroke immune responses.","authors":"Rodney M Ritzel, Danye Jiang, Louise D McCullough","doi":"10.1016/j.tins.2024.10.002","DOIUrl":"10.1016/j.tins.2024.10.002","url":null,"abstract":"<p><p>Central nervous system-associated macrophages (CAMs) are a unique subset of immune cells located at the interface between the blood and the brain parenchyma. In a recent study in mice, Levard and colleagues found that CAMs regulate immune cell trafficking, endothelial activation, and antigen presentation following stroke exclusively in aged animals, underscoring the importance of using translationally relevant models for studying age-related diseases.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"965-967"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The injured axon: intrinsic mechanisms driving axonal regeneration. 受伤的轴突：驱动轴突再生的内在机制。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-11-01 Epub Date: 2024-10-21 DOI: 10.1016/j.tins.2024.09.009
Diogo Tomé, Ramiro D Almeida
{"title":"The injured axon: intrinsic mechanisms driving axonal regeneration.","authors":"Diogo Tomé, Ramiro D Almeida","doi":"10.1016/j.tins.2024.09.009","DOIUrl":"10.1016/j.tins.2024.09.009","url":null,"abstract":"<p><p>Injury to the central nervous system (CNS) often results in permanent neurological impairments because axons fail to regenerate and re-establish lost synaptic contacts. By contrast, peripheral neurons can activate a pro-regenerative program and regenerate following a nerve lesion. This relies on an intricate intracellular communication system between the severed axon and the cell body. Locally activated signaling molecules are retrogradely transported to the soma to promote the epigenetic and transcriptional changes required for the injured neuron to regain growth competence. These signaling events rely heavily on intra-axonal translation and mitochondrial trafficking into the severed axon. Here, we discuss the interplay between these mechanisms and the main intrinsic barriers to axonal regeneration. We also examine the potential of manipulating these processes for driving CNS repair.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"875-891"},"PeriodicalIF":14.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The multiple roles of chronic stress and glucocorticoids in Alzheimer's disease pathogenesis. 慢性压力和糖皮质激素在阿尔茨海默病发病机制中的多重作用。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-11-01 Epub Date: 2024-09-21 DOI: 10.1016/j.tins.2024.08.015
Mia R Burke, Ioannis Sotiropoulos, Clarissa L Waites
{"title":"The multiple roles of chronic stress and glucocorticoids in Alzheimer's disease pathogenesis.","authors":"Mia R Burke, Ioannis Sotiropoulos, Clarissa L Waites","doi":"10.1016/j.tins.2024.08.015","DOIUrl":"10.1016/j.tins.2024.08.015","url":null,"abstract":"<p><p>Chronic stress and the accompanying long-term elevation of glucocorticoids (GCs), the stress hormones of the body, increase the risk and accelerate the progression of Alzheimer's disease (AD). Signatures of AD include intracellular tau (MAPT) tangles, extracellular amyloid β (Aβ) plaques, and neuroinflammation. A growing body of work indicates that stress and GCs initiate cellular processes underlying these pathologies through dysregulation of protein homeostasis and trafficking, mitochondrial bioenergetics, and response to damage-associated stimuli. In this review, we integrate findings from mechanistic studies in rodent and cellular models, wherein defined chronic stress protocols or GC administration have been shown to elicit AD-related pathology. We specifically discuss the effects of chronic stress and GCs on tau pathogenesis, including hyperphosphorylation, aggregation, and spreading, amyloid precursor protein (APP) processing and trafficking culminating in Aβ production, immune priming by proinflammatory cytokines and disease-associated molecular patterns, and alterations to glial cell and blood-brain barrier (BBB) function.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"933-948"},"PeriodicalIF":14.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defining slow wave sleep without slow waves. 定义无慢波睡眠
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-11-01 Epub Date: 2024-09-25 DOI: 10.1016/j.tins.2024.09.002
Janna D Lendner, Randolph F Helfrich
{"title":"Defining slow wave sleep without slow waves.","authors":"Janna D Lendner, Randolph F Helfrich","doi":"10.1016/j.tins.2024.09.002","DOIUrl":"10.1016/j.tins.2024.09.002","url":null,"abstract":"<p><p>Recent research by Parks, Schneider, and colleagues demonstrates that brain states during rodent sleep can be predicted from neural activity on millisecond and micrometer scales. These findings contradict the traditional view that defines sleep by brain-wide oscillations. Instead, this work posits that nonoscillatory activity governs different brain states.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"853-855"},"PeriodicalIF":14.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging roles of antimicrobial peptides in innate immunity, neuronal function, and neurodegeneration. 抗菌肽在先天性免疫、神经元功能和神经退化中的新作用。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-11-01 Epub Date: 2024-10-09 DOI: 10.1016/j.tins.2024.09.001
Soojin Lee, Neal Silverman, Fen-Biao Gao
{"title":"Emerging roles of antimicrobial peptides in innate immunity, neuronal function, and neurodegeneration.","authors":"Soojin Lee, Neal Silverman, Fen-Biao Gao","doi":"10.1016/j.tins.2024.09.001","DOIUrl":"10.1016/j.tins.2024.09.001","url":null,"abstract":"<p><p>Antimicrobial peptides (AMPs), a collection of small proteins with important roles in classical innate immunity, have been extensively studied in multiple organisms, particularly in Drosophila melanogaster. Advances in CRISPR/Cas9 genome editing have allowed individual AMP functions to be dissected, revealing specific and selective roles in host defense. Recent findings have also revealed many unexpected contributions of endogenous AMPs to neuronal functions and neurodegenerative diseases, and have shed light on the intersections between innate immunity and neurobiology. We explore the intricate relationships between AMPs and sleep regulation, memory formation, as well as traumatic brain injury and several neurodegenerative diseases such as Alzheimer's disease (AD), frontotemporal dementia (FTD), and Parkinson's disease (PD). Understanding the diverse functions of AMPs opens new avenues for neuroinflammation and neurodegenerative disease research and potential therapeutic development.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"949-961"},"PeriodicalIF":14.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural circuits for goal-directed navigation across species. 不同物种目标导航的神经回路
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-11-01 Epub Date: 2024-10-10 DOI: 10.1016/j.tins.2024.09.005
Jayeeta Basu, Katherine Nagel
{"title":"Neural circuits for goal-directed navigation across species.","authors":"Jayeeta Basu, Katherine Nagel","doi":"10.1016/j.tins.2024.09.005","DOIUrl":"10.1016/j.tins.2024.09.005","url":null,"abstract":"<p><p>Across species, navigation is crucial for finding both resources and shelter. In vertebrates, the hippocampus supports memory-guided goal-directed navigation, whereas in arthropods the central complex supports similar functions. A growing literature is revealing similarities and differences in the organization and function of these brain regions. We review current knowledge about how each structure supports goal-directed navigation by building internal representations of the position or orientation of an animal in space, and of the location or direction of potential goals. We describe input pathways to each structure - medial and lateral entorhinal cortex in vertebrates, and columnar and tangential neurons in insects - that primarily encode spatial and non-spatial information, respectively. Finally, we highlight similarities and differences in spatial encoding across clades and suggest experimental approaches to compare coding principles and behavioral capabilities across species. Such a comparative approach can provide new insights into the neural basis of spatial navigation and neural computation.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"904-917"},"PeriodicalIF":14.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TDP-43 nuclear condensation and neurodegenerative proteinopathies. TDP-43 核凝聚与神经退行性蛋白病。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-11-01 Epub Date: 2024-09-25 DOI: 10.1016/j.tins.2024.09.003
Florencia Vassallu, Lionel M Igaz
{"title":"TDP-43 nuclear condensation and neurodegenerative proteinopathies.","authors":"Florencia Vassallu, Lionel M Igaz","doi":"10.1016/j.tins.2024.09.003","DOIUrl":"10.1016/j.tins.2024.09.003","url":null,"abstract":"<p><p>RNA-binding proteins (RBPs) can undergo phase separation and form condensates, processes that, in turn, can be critical for their functionality. In a recent study, Huang, Ellis, and colleagues show that cellular stress can trigger transient alterations in nuclear TAR DNA-binding protein 43 (TDP-43), leading to changes crucial for proper neuronal function. These findings have implications for understanding neurological TDP-43 proteinopathies.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"849-850"},"PeriodicalIF":14.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Principles of intensive human neuroimaging. 强化人类神经成像原理
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-11-01 Epub Date: 2024-10-24 DOI: 10.1016/j.tins.2024.09.011
Eline R Kupers, Tomas Knapen, Elisha P Merriam, Kendrick N Kay
{"title":"Principles of intensive human neuroimaging.","authors":"Eline R Kupers, Tomas Knapen, Elisha P Merriam, Kendrick N Kay","doi":"10.1016/j.tins.2024.09.011","DOIUrl":"10.1016/j.tins.2024.09.011","url":null,"abstract":"<p><p>The rise of large, publicly shared functional magnetic resonance imaging (fMRI) data sets in human neuroscience has focused on acquiring either a few hours of data on many individuals ('wide' fMRI) or many hours of data on a few individuals ('deep' fMRI). In this opinion article, we highlight an emerging approach within deep fMRI, which we refer to as 'intensive' fMRI: one that strives for extensive sampling of cognitive phenomena to support computational modeling and detailed investigation of brain function at the single voxel level. We discuss the fundamental principles, trade-offs, and practical considerations of intensive fMRI. We also emphasize that intensive fMRI does not simply mean collecting more data: it requires careful design of experiments to enable a rich hypothesis space, optimizing data quality, and strategically curating public resources to maximize community impact.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"856-864"},"PeriodicalIF":14.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toward actionable neural markers of depression risk? 抑郁症风险的可操作神经标记？
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-11-01 Epub Date: 2024-09-27 DOI: 10.1016/j.tins.2024.09.007
Diego A Pizzagalli
{"title":"Toward actionable neural markers of depression risk?","authors":"Diego A Pizzagalli","doi":"10.1016/j.tins.2024.09.007","DOIUrl":"10.1016/j.tins.2024.09.007","url":null,"abstract":"<p><p>The search for neural markers of depression remains challenging. Despite progress, neuroimaging results have generally not yielded actionable findings that could transform how we understand and treat this disorder. However, in a recent study, Lynch and colleagues identified enlargement of the frontrostriatal salience network as a reproducible, trait-like marker of depression.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"851-852"},"PeriodicalIF":14.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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