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The claustrum and synchronized brain states. 磁鼓与大脑同步状态
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-11-02 DOI: 10.1016/j.tins.2024.10.003
Alison D Do, Coline Portet, Romain Goutagny, Jesse Jackson
{"title":"The claustrum and synchronized brain states.","authors":"Alison D Do, Coline Portet, Romain Goutagny, Jesse Jackson","doi":"10.1016/j.tins.2024.10.003","DOIUrl":"10.1016/j.tins.2024.10.003","url":null,"abstract":"<p><p>Cortical activity is constantly fluctuating between distinct spatiotemporal activity patterns denoted by changes in brain state. States of cortical desynchronization arise during motor generation, increased attention, and high cognitive load. Synchronized brain states comprise spatially widespread, coordinated low-frequency neural activity during rest and sleep when disengaged from the external environment or 'offline'. The claustrum is a small subcortical structure with dense reciprocal connections with the cortex suggesting modulation by, or participation in, brain state regulation. Here, we highlight recent work suggesting that neural activity in the claustrum supports cognitive processes associated with synchronized brain states characterized by increased low-frequency network activity. As an example, we outline how claustrum activity could support episodic memory consolidation during sleep.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"1028-1040"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defining and characterizing neuronal senescence, 'neurescence', as GX arrested cells. 将神经元衰老（"神经衰老"）定义为 GX 停止细胞，并确定其特征。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-10-09 DOI: 10.1016/j.tins.2024.09.006
Hannah R Hudson, Markus Riessland, Miranda E Orr
{"title":"Defining and characterizing neuronal senescence, 'neurescence', as G<sub>X</sub> arrested cells.","authors":"Hannah R Hudson, Markus Riessland, Miranda E Orr","doi":"10.1016/j.tins.2024.09.006","DOIUrl":"10.1016/j.tins.2024.09.006","url":null,"abstract":"<p><p>Cellular senescence is a cell state characterized by resistance to apoptosis and stable cell cycle arrest. Senescence was first observed in mitotic cells in vitro. Recent evidence from in vivo studies and human tissue indicates that postmitotic cells, including neurons, may also become senescent. The quiescent cell state of neurons and inconsistent descriptions of neuronal senescence across studies, however, have caused confusion in this burgeoning field. We summarize evidence demonstrating that exit from G<sub>0</sub> quiescence may protect neurons against apoptosis and predispose them toward senescence. Additionally, we propose the term 'neurescent' for senescent neurons and introduce the cell state, G<sub>X</sub>, to describe cell cycle arrest achieved by passing through G<sub>0</sub> quiescence. Criteria are provided to identify neurescent cells, distinguish them from G<sub>0</sub> quiescent neurons, and compare neurescent phenotypes with classic replicative senescence.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"971-984"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nature versus laboratory: how to optimize housing conditions for zebrafish neuroscience research. 自然与实验室：如何优化斑马鱼神经科学研究的饲养条件。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-09-21 DOI: 10.1016/j.tins.2024.08.013
Benjamin Tsang, Robert Gerlai
{"title":"Nature versus laboratory: how to optimize housing conditions for zebrafish neuroscience research.","authors":"Benjamin Tsang, Robert Gerlai","doi":"10.1016/j.tins.2024.08.013","DOIUrl":"10.1016/j.tins.2024.08.013","url":null,"abstract":"<p><p>Although zebrafish (Danio rerio) neuroscience research is rapidly expanding, the fundamental question of how these fish should be maintained in research laboratories remains largely unstudied. This may explain the diverse practices and broad range of environmental parameters used in zebrafish facilities. Here, we provide examples of these parameters and practices, including housing density, tank size, and water chemistry. We discuss the principles of stochastic resonance versus homeostasis and provide hypothetical examples to explain why keeping zebrafish outside of their tolerated range of environmental parameters may increase phenotypical variance and reduce replicability. We call for systematic studies to establish the optimal maintenance conditions for zebrafish. Furthermore, we discuss why knowing more about the natural behavior and ecology of this species could be a guiding principle for these studies.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"985-993"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Splenic nociceptive neural connection promotes humoral immunity. 脾脏痛觉神经连接可促进体液免疫。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-10-02 DOI: 10.1016/j.tins.2024.09.008
Cheng Qian, Jiaming Wang, Xuetao Cao
{"title":"Splenic nociceptive neural connection promotes humoral immunity.","authors":"Cheng Qian, Jiaming Wang, Xuetao Cao","doi":"10.1016/j.tins.2024.09.008","DOIUrl":"10.1016/j.tins.2024.09.008","url":null,"abstract":"<p><p>Recent work by Wu and colleagues unveiled a previously enigmatic population of spleen-innervating nociceptors from left T8-T13 dorsal root ganglia (DRGs) in mice. They found a specific DRG-spleen sensorineural connection that promotes humoral immunity via a CGRP-CALCRL/RAMP1 axis, providing a valuable target for immune regulation in local microenvironments.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"968-970"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An expanding repertoire of circuit mechanisms for visual prediction errors. 视觉预测错误的电路机制不断扩大。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-11-08 DOI: 10.1016/j.tins.2024.10.007
Jordan M Ross, Jordan P Hamm
{"title":"An expanding repertoire of circuit mechanisms for visual prediction errors.","authors":"Jordan M Ross, Jordan P Hamm","doi":"10.1016/j.tins.2024.10.007","DOIUrl":"10.1016/j.tins.2024.10.007","url":null,"abstract":"<p><p>Cortical responses to stimuli vary dependingon context and expectation. Adding insight into this process, Furutachi et al. recently demonstrated that higher-order thalamic input to visual cortex cooperates with interneurons to augment responses to unexpected stimuli, consistent with a body of literature implicating top-down modulation and local inhibition in predictive processing.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"963-964"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dopaminergic circuits controlling threat and safety learning. 控制威胁和安全学习的多巴胺能回路
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1016/j.tins.2024.10.001
Sevil Duvarci
{"title":"Dopaminergic circuits controlling threat and safety learning.","authors":"Sevil Duvarci","doi":"10.1016/j.tins.2024.10.001","DOIUrl":"10.1016/j.tins.2024.10.001","url":null,"abstract":"<p><p>The ability to learn from experience that certain cues and situations are associated with threats or safety is crucial for survival and adaptive behavior. Understanding the neural substrates of threat and safety learning has high clinical significance because deficits in these forms of learning characterize anxiety disorders. Traditionally, dopamine neurons were thought to uniformly support reward learning by signaling reward prediction errors. However, the dopamine system is functionally more diverse than was initially appreciated and is also critical for processing threat and safety. In this review, I highlight recent studies demonstrating that dopamine neurons generate prediction errors for threat and safety, and describe how dopamine projections to the amygdala, medial prefrontal cortex (mPFC), and striatum regulate associative threat and safety learning.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"1014-1027"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retinal ganglion cell circuits and glial interactions in humans and mice. 人类和小鼠的视网膜神经节细胞回路和神经胶质相互作用。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-10-24 DOI: 10.1016/j.tins.2024.09.010
Kang-Chieh Huang, Mohamed Tawfik, Melanie A Samuel
{"title":"Retinal ganglion cell circuits and glial interactions in humans and mice.","authors":"Kang-Chieh Huang, Mohamed Tawfik, Melanie A Samuel","doi":"10.1016/j.tins.2024.09.010","DOIUrl":"10.1016/j.tins.2024.09.010","url":null,"abstract":"<p><p>Retinal ganglion cells (RGCs) are the brain's gateway for vision, and their degeneration underlies several blinding diseases. RGCs interact with other neuronal cell types, microglia, and astrocytes in the retina and in the brain. Much knowledge has been gained about RGCs and glia from mice and other model organisms, often with the assumption that certain aspects of their biology may be conserved in humans. However, RGCs vary considerably between species, which could affect how they interact with their neuronal and glial partners. This review details which RGC and glial features are conserved between mice, humans, and primates, and which differ. We also discuss experimental approaches for studying human and primate RGCs. These strategies will help to bridge the gap between rodent and human RGC studies and increase study translatability to guide future therapeutic strategies.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"994-1013"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CAMs in command: aging brain macrophages fine-tune stroke immune responses. CAMs指挥：衰老的脑巨噬细胞可微调中风免疫反应。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-12-01 Epub Date: 2024-10-22 DOI: 10.1016/j.tins.2024.10.002
Rodney M Ritzel, Danye Jiang, Louise D McCullough
{"title":"CAMs in command: aging brain macrophages fine-tune stroke immune responses.","authors":"Rodney M Ritzel, Danye Jiang, Louise D McCullough","doi":"10.1016/j.tins.2024.10.002","DOIUrl":"10.1016/j.tins.2024.10.002","url":null,"abstract":"<p><p>Central nervous system-associated macrophages (CAMs) are a unique subset of immune cells located at the interface between the blood and the brain parenchyma. In a recent study in mice, Levard and colleagues found that CAMs regulate immune cell trafficking, endothelial activation, and antigen presentation following stroke exclusively in aged animals, underscoring the importance of using translationally relevant models for studying age-related diseases.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"965-967"},"PeriodicalIF":14.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The injured axon: intrinsic mechanisms driving axonal regeneration. 受伤的轴突：驱动轴突再生的内在机制。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-11-01 Epub Date: 2024-10-21 DOI: 10.1016/j.tins.2024.09.009
Diogo Tomé, Ramiro D Almeida
{"title":"The injured axon: intrinsic mechanisms driving axonal regeneration.","authors":"Diogo Tomé, Ramiro D Almeida","doi":"10.1016/j.tins.2024.09.009","DOIUrl":"10.1016/j.tins.2024.09.009","url":null,"abstract":"<p><p>Injury to the central nervous system (CNS) often results in permanent neurological impairments because axons fail to regenerate and re-establish lost synaptic contacts. By contrast, peripheral neurons can activate a pro-regenerative program and regenerate following a nerve lesion. This relies on an intricate intracellular communication system between the severed axon and the cell body. Locally activated signaling molecules are retrogradely transported to the soma to promote the epigenetic and transcriptional changes required for the injured neuron to regain growth competence. These signaling events rely heavily on intra-axonal translation and mitochondrial trafficking into the severed axon. Here, we discuss the interplay between these mechanisms and the main intrinsic barriers to axonal regeneration. We also examine the potential of manipulating these processes for driving CNS repair.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"875-891"},"PeriodicalIF":14.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The multiple roles of chronic stress and glucocorticoids in Alzheimer's disease pathogenesis. 慢性压力和糖皮质激素在阿尔茨海默病发病机制中的多重作用。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-11-01 Epub Date: 2024-09-21 DOI: 10.1016/j.tins.2024.08.015
Mia R Burke, Ioannis Sotiropoulos, Clarissa L Waites
{"title":"The multiple roles of chronic stress and glucocorticoids in Alzheimer's disease pathogenesis.","authors":"Mia R Burke, Ioannis Sotiropoulos, Clarissa L Waites","doi":"10.1016/j.tins.2024.08.015","DOIUrl":"10.1016/j.tins.2024.08.015","url":null,"abstract":"<p><p>Chronic stress and the accompanying long-term elevation of glucocorticoids (GCs), the stress hormones of the body, increase the risk and accelerate the progression of Alzheimer's disease (AD). Signatures of AD include intracellular tau (MAPT) tangles, extracellular amyloid β (Aβ) plaques, and neuroinflammation. A growing body of work indicates that stress and GCs initiate cellular processes underlying these pathologies through dysregulation of protein homeostasis and trafficking, mitochondrial bioenergetics, and response to damage-associated stimuli. In this review, we integrate findings from mechanistic studies in rodent and cellular models, wherein defined chronic stress protocols or GC administration have been shown to elicit AD-related pathology. We specifically discuss the effects of chronic stress and GCs on tau pathogenesis, including hyperphosphorylation, aggregation, and spreading, amyloid precursor protein (APP) processing and trafficking culminating in Aβ production, immune priming by proinflammatory cytokines and disease-associated molecular patterns, and alterations to glial cell and blood-brain barrier (BBB) function.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"933-948"},"PeriodicalIF":14.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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