{"title":"The production and functions of caudal ganglionic eminence-derived inhibitory neurons.","authors":"Emma Horton, Mercedes F Paredes","doi":"10.1016/j.tins.2025.06.007","DOIUrl":null,"url":null,"abstract":"<p><p>In the brain, maintaining the appropriate levels of excitation and inhibition is required for proper cognitive function. Inhibitory neurons, essential for maintaining this balance and implicated in various neurodevelopmental diseases, are generated during embryonic development from the ganglionic eminences (GEs). This review discusses the importance of inhibitory neuronal subtypes generated from the most posterior GE subregion, the caudal ganglionic eminence (CGE), highlighting what is known about their developmental origins, diversity, and functions in mice, humans, and non-human primates. By reviewing the molecular composition and patterning of the CGE, we discuss how technological advances have provided insights into the spatial heterogeneity of progenitor populations and the distinctive molecular characteristics and functions of CGE-derived neurons.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"570-581"},"PeriodicalIF":15.1000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Neurosciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.tins.2025.06.007","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/31 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
In the brain, maintaining the appropriate levels of excitation and inhibition is required for proper cognitive function. Inhibitory neurons, essential for maintaining this balance and implicated in various neurodevelopmental diseases, are generated during embryonic development from the ganglionic eminences (GEs). This review discusses the importance of inhibitory neuronal subtypes generated from the most posterior GE subregion, the caudal ganglionic eminence (CGE), highlighting what is known about their developmental origins, diversity, and functions in mice, humans, and non-human primates. By reviewing the molecular composition and patterning of the CGE, we discuss how technological advances have provided insights into the spatial heterogeneity of progenitor populations and the distinctive molecular characteristics and functions of CGE-derived neurons.
期刊介绍：
For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.
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