Genetic architecture of FTLD-TDP pathological subtypes.

IF 15.1 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2025-08-01 Epub Date: 2025-07-02 DOI:10.1016/j.tins.2025.06.005

Oriol Dols-Icardo, Lianne M Reus, Alfredo Ramirez

引用次数: 0

Abstract

Until recently, few genetic risk factors had been identified for the distinct pathological subtypes of frontotemporal lobar degeneration (FTLD) with TDP-43 aggregation (FTLD-TDP). In a recent study, Pottier and colleagues addressed this gap by identifying common and rare genetic variants associated with FTLD-TDP subtypes, providing novel insights into the underlying mechanisms and heterogeneity of FTLD-TDP.

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FTLD-TDP病理亚型的遗传结构。

直到最近，很少有遗传风险因素被确定为具有TDP-43聚集（FTLD- tdp）的额颞叶变性（FTLD）的不同病理亚型。在最近的一项研究中，Pottier及其同事通过识别与FTLD-TDP亚型相关的常见和罕见遗传变异来解决这一差距，为FTLD-TDP的潜在机制和异质性提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.