利用UltraID-LIPA捕获α-突触核蛋白聚集相互作用。

IF 15.1 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2025-08-01 Epub Date: 2025-07-10 DOI:10.1016/j.tins.2025.07.002

Kreesan Reddy, Birger Victor Dieriks

引用次数: 0

摘要

Teixeira等人提出了超辅助光诱导蛋白聚集（UltraID-LIPA）技术，该技术将α-突触核蛋白聚集的光遗传诱导与基于接近度的蛋白质组学相结合。该系统能够高分辨率捕获活细胞中的早期聚集事件，并涉及已知和新的内溶酶体蛋白，为解剖突触核蛋白病的早期致病机制提供了一个强大的框架，并指导未来的创新。

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Capturing α-synuclein aggregation interactors using UltraID-LIPA.

Teixeira et al. present UltraID-light-inducible protein aggregation (UltraID-LIPA), a technique that combines optogenetic induction of α-synuclein aggregation with proximity-based proteomics. This system enables high-resolution capture of early aggregation events in live cells and implicates known and novel endolysosomal proteins, offering a robust framework for dissecting early pathogenic mechanisms in synucleinopathies and guiding future innovations.

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.