Copine-6调节TRPM3膜运输和有害热感。

IF 15.1 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2025-08-12 DOI:10.1016/j.tins.2025.08.001

Chen Zhang, Qingjian Han

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引用次数: 0

摘要

毒热感涉及多个分子受体在复杂的调控机制下运作。在最近的一项研究中，Gao、Yan和同事们发现Copine-6是一种钙敏感的磷脂结合蛋白，可以促进TRPM3运输到热感觉神经元的质膜，从而增强小鼠的有害热敏性。这些发现扩大了目前对调节热感觉机制的理解。

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Copine-6 as a regulator of TRPM3 membrane trafficking and noxious heat sensation.

Noxious heat sensation involves multiple molecular receptors that operate under complex regulatory mechanisms. In a recent study, Gao, Yan, and colleagues identified Copine-6 as a calcium-sensitive phospholipid-binding protein that promotes TRPM3 trafficking to the plasma membrane in thermal sensory neurons and thereby enhances noxious heat sensitivity in mice. These findings expand current understanding of the mechanisms regulating thermal sensation.

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.