CD8 T cells as drivers of blood-brain barrier disruption.

IF 15.1 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2025-07-01 Epub Date: 2025-06-12 DOI:10.1016/j.tins.2025.05.008

Marina Seady, Aaron J Johnson

引用次数: 0

Abstract

Blood-brain barrier (BBB) disruption is a hallmark of many neurological diseases. It is known that proinflammatory cytokines can disrupt tight junctions between endothelial cells of the BBB, allowing larger molecules to penetrate the brain. Along with BBB disruption, these diseases also feature increased numbers of CD8 T cells as components of the immune cell population in the brain. In this review, we discuss the mechanisms of CD8 T cell-mediated BBB disruption, including the roles of antigen presentation through MHC class I molecules, which emerge as an important determining feature of BBB disruption and immune cell infiltration into the brain.

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CD8 T细胞作为血脑屏障破坏的驱动因素。

血脑屏障（BBB）破坏是许多神经系统疾病的标志。众所周知，促炎细胞因子可以破坏血脑屏障内皮细胞之间的紧密连接，使更大的分子能够穿透大脑。随着血脑屏障的破坏，这些疾病还以CD8 T细胞数量增加为特征，CD8 T细胞是大脑中免疫细胞群的组成部分。在这篇综述中，我们讨论了CD8 T细胞介导的血脑屏障破坏的机制，包括通过MHC I类分子的抗原呈递的作用，MHC I类分子是血脑屏障破坏和免疫细胞渗入大脑的重要决定特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.