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IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-08-13 DOI: 10.1016/s0166-2236(24)00135-8
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引用次数: 0
Emerging modes of regulation of neuromodulatory G protein-coupled receptors. 神经调节 G 蛋白偶联受体的新调节模式。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-08-01 Epub Date: 2024-06-11 DOI: 10.1016/j.tins.2024.05.008
Alberto J Gonzalez-Hernandez, Hermany Munguba, Joshua Levitz
{"title":"Emerging modes of regulation of neuromodulatory G protein-coupled receptors.","authors":"Alberto J Gonzalez-Hernandez, Hermany Munguba, Joshua Levitz","doi":"10.1016/j.tins.2024.05.008","DOIUrl":"10.1016/j.tins.2024.05.008","url":null,"abstract":"<p><p>In the nervous system, G protein-coupled receptors (GPCRs) control neuronal excitability, synaptic transmission, synaptic plasticity, and, ultimately, behavior through spatiotemporally precise initiation of a variety of signaling pathways. However, despite their critical importance, there is incomplete understanding of how these receptors are regulated to tune their signaling to specific neurophysiological contexts. A deeper mechanistic picture of neuromodulatory GPCR function is needed to fully decipher their biological roles and effectively harness them for the treatment of neurological and psychiatric disorders. In this review, we highlight recent progress in identifying novel modes of regulation of neuromodulatory GPCRs, including G protein- and receptor-targeting mechanisms, receptor-receptor crosstalk, and unique features that emerge in the context of chemical synapses. These emerging principles of neuromodulatory GPCR tuning raise critical questions to be tackled at the molecular, cellular, synaptic, and neural circuit levels in the future.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"635-650"},"PeriodicalIF":14.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11324403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A survey of brain functional network extraction methods using fMRI data. 利用 fMRI 数据提取大脑功能网络方法的调查。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-08-01 Epub Date: 2024-06-20 DOI: 10.1016/j.tins.2024.05.011
Yuhui Du, Songke Fang, Xingyu He, Vince D Calhoun
{"title":"A survey of brain functional network extraction methods using fMRI data.","authors":"Yuhui Du, Songke Fang, Xingyu He, Vince D Calhoun","doi":"10.1016/j.tins.2024.05.011","DOIUrl":"10.1016/j.tins.2024.05.011","url":null,"abstract":"<p><p>Functional network (FN) analyses play a pivotal role in uncovering insights into brain function and understanding the pathophysiology of various brain disorders. This paper focuses on classical and advanced methods for deriving brain FNs from functional magnetic resonance imaging (fMRI) data. We systematically review their foundational principles, advantages, shortcomings, and interrelations, encompassing both static and dynamic FN extraction approaches. In the context of static FN extraction, we present hypothesis-driven methods such as region of interest (ROI)-based approaches as well as data-driven methods including matrix decomposition, clustering, and deep learning. For dynamic FN extraction, both window-based and windowless methods are surveyed with respect to the estimation of time-varying FN and the subsequent computation of FN states. We also discuss the scope of application of the various methods and avenues for future improvements.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"608-621"},"PeriodicalIF":14.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141437525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outdoor air pollution and brain development in childhood and adolescence. 室外空气污染与儿童和青少年的大脑发育。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-08-01 Epub Date: 2024-07-24 DOI: 10.1016/j.tins.2024.06.008
Megan M Herting, Katherine L Bottenhorn, Devyn L Cotter
{"title":"Outdoor air pollution and brain development in childhood and adolescence.","authors":"Megan M Herting, Katherine L Bottenhorn, Devyn L Cotter","doi":"10.1016/j.tins.2024.06.008","DOIUrl":"10.1016/j.tins.2024.06.008","url":null,"abstract":"<p><p>Exposure to outdoor air pollution has been linked to adverse health effects, including potential widespread impacts on the CNS. Ongoing brain development may render children and adolescents especially vulnerable to neurotoxic effects of air pollution. While mechanisms remain unclear, promising advances in human neuroimaging can help elucidate both sensitive periods and neurobiological consequences of exposure to air pollution. Herein we review the potential influences of air pollution exposure on neurodevelopment, drawing from animal toxicology and human neuroimaging studies. Due to ongoing cellular and system-level changes during childhood and adolescence, the developing brain may be more sensitive to pollutants' neurotoxic effects, as a function of both timing and duration, with relevance to cognition and mental health. Building on these foundations, the emerging field of environmental neuroscience is poised to further decipher which air toxicants are most harmful and to whom.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"593-607"},"PeriodicalIF":14.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11324378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do metabolic deficits contribute to sleep disruption in monogenic intellectual disability syndromes? 新陈代谢障碍是否会导致单基因智障综合征的睡眠障碍？
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-08-01 Epub Date: 2024-07-24 DOI: 10.1016/j.tins.2024.06.006
Mariela Lopez Valencia, Folasade A Sofela, Thomas A Jongens, Amita Sehgal
{"title":"Do metabolic deficits contribute to sleep disruption in monogenic intellectual disability syndromes?","authors":"Mariela Lopez Valencia, Folasade A Sofela, Thomas A Jongens, Amita Sehgal","doi":"10.1016/j.tins.2024.06.006","DOIUrl":"10.1016/j.tins.2024.06.006","url":null,"abstract":"<p><p>Intellectual disability is defined as limitations in cognitive and adaptive behavior that often arise during development. Disordered sleep is common in intellectual disability and, given the importance of sleep for cognitive function, it may contribute to other behavioral phenotypes. Animal models of intellectual disability, in particular of monogenic intellectual disability syndromes (MIDS), recapitulate many disease phenotypes and have been invaluable for linking some of these phenotypes to specific molecular pathways. An emerging feature of MIDS, in both animal models and humans, is the prevalence of metabolic abnormalities, which could be relevant for behavior. Focusing on specific MIDS that have been molecularly characterized, we review sleep, circadian, and metabolic phenotypes in animal models and humans and propose that altered metabolic state contributes to the abnormal sleep/circadian phenotypes in MIDS.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"583-592"},"PeriodicalIF":14.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiological and pathological roles of caveolins in the central nervous system. 洞穴素在中枢神经系统中的生理和病理作用。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-08-01 Epub Date: 2024-07-06 DOI: 10.1016/j.tins.2024.06.003
Jérôme Badaut, Camille Blochet, André Obenaus, Lorenz Hirt
{"title":"Physiological and pathological roles of caveolins in the central nervous system.","authors":"Jérôme Badaut, Camille Blochet, André Obenaus, Lorenz Hirt","doi":"10.1016/j.tins.2024.06.003","DOIUrl":"10.1016/j.tins.2024.06.003","url":null,"abstract":"<p><p>Caveolins are a family of transmembrane proteins located in caveolae, small lipid raft invaginations of the plasma membrane. The roles of caveolin-enriched lipid rafts are diverse, and include mechano-protection, lipid homeostasis, metabolism, transport, and cell signaling. Caveolin-1 (Cav-1) and other caveolins were described in endothelial cells and later in other cell types of the central nervous system (CNS), including neurons, astrocytes, oligodendrocytes, microglia, and pericytes. This pancellular presence of caveolins demands a better understanding of their functional roles in each cell type. In this review we describe the various functions of Cav-1 in the cells of normal and pathological brains. Several emerging preclinical findings suggest that Cav-1 could represent a potential therapeutic target in brain disorders.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"651-664"},"PeriodicalIF":14.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11324375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141555538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The forgotten wave of early pupillometry research. 被遗忘的早期瞳孔测量研究浪潮。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-08-01 Epub Date: 2024-06-27 DOI: 10.1016/j.tins.2024.06.002
Christoph Strauch
{"title":"The forgotten wave of early pupillometry research.","authors":"Christoph Strauch","doi":"10.1016/j.tins.2024.06.002","DOIUrl":"10.1016/j.tins.2024.06.002","url":null,"abstract":"<p><p>Changes in pupil size offer a rich, continuous, and integrated neurophysiological readout of attention and cognition. I here briefly reintroduce examples of a vast, forgotten literature, full of inspiring ideas, which described attentional modulations of pupil size decades earlier than often assumed. I outline parallels between these early studies and recent developments in pupillometry.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"571-572"},"PeriodicalIF":14.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do oligodendrocytes regulate axonal glucose uptake and consumption? 少突胶质细胞能调节轴突的葡萄糖摄取和消耗吗？
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-08-01 Epub Date: 2024-06-11 DOI: 10.1016/j.tins.2024.06.001
Jessica L Fletcher, Kaylene M Young
{"title":"Do oligodendrocytes regulate axonal glucose uptake and consumption?","authors":"Jessica L Fletcher, Kaylene M Young","doi":"10.1016/j.tins.2024.06.001","DOIUrl":"10.1016/j.tins.2024.06.001","url":null,"abstract":"<p><p>Neurons have high energy demands. In a recent study, Looser et al. identified oligodendrocyte Kir4.1 as the activity-dependent driver of oligodendrocyte glycolysis that ensures that lactate is supplied to active neurons. Given that oligodendrocyte Kir4.1 also influenced axonal glucose consumption and uptake, oligodendrocytes may play a broader role in neuronal metabolic regulation.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"569-570"},"PeriodicalIF":14.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The immune and metabolic milieu of the choroid plexus as a potential target in brain protection. 脉络丛的免疫和代谢环境是保护大脑的潜在目标。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-08-01 Epub Date: 2024-06-29 DOI: 10.1016/j.tins.2024.05.010
Afroditi Tsitsou-Kampeli, Stefano Suzzi, Michal Schwartz
{"title":"The immune and metabolic milieu of the choroid plexus as a potential target in brain protection.","authors":"Afroditi Tsitsou-Kampeli, Stefano Suzzi, Michal Schwartz","doi":"10.1016/j.tins.2024.05.010","DOIUrl":"10.1016/j.tins.2024.05.010","url":null,"abstract":"<p><p>The brain's choroid plexus (CP), which operates as an anatomical and functional 'checkpoint', regulates the communication between brain and periphery and contributes to the maintenance of healthy brain homeostasis throughout life. Evidence from mouse models and humans reveals a link between loss of CP checkpoint properties and dysregulation of the CP immune milieu as a conserved feature across diverse neurological conditions. In particular, we suggest that an imbalance between different immune signals at the CP, including CD4<sup>+</sup> T cell-derived cytokines, type-I interferon, and complement components, can perpetuate brain inflammation and cognitive deterioration in aging and neurodegeneration. Furthermore, we highlight the role of CP metabolism in controlling CP inflammation, and propose that targeting molecules that regulate CP metabolism could be effective in safeguarding brain function.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"573-582"},"PeriodicalIF":14.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-07-09 DOI: 10.1016/s0166-2236(24)00104-8
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0166-2236(24)00104-8","DOIUrl":"https://doi.org/10.1016/s0166-2236(24)00104-8","url":null,"abstract":"No Abstract","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"6 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141571240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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