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Neuromelanin and selective neuronal vulnerability to Parkinson's disease. 神经黑色素和选择性神经易感性对帕金森病。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1016/j.tins.2025.04.005
Anastasia Filimontseva, YuHong Fu, Miquel Vila, Glenda M Halliday
{"title":"Neuromelanin and selective neuronal vulnerability to Parkinson's disease.","authors":"Anastasia Filimontseva, YuHong Fu, Miquel Vila, Glenda M Halliday","doi":"10.1016/j.tins.2025.04.005","DOIUrl":"10.1016/j.tins.2025.04.005","url":null,"abstract":"<p><p>Neuromelanin is a unique pigment made by some human catecholamine neurons. These neurons survive with their neuromelanin content for a lifetime but can also be affected by age-related neurodegenerative conditions, as observed using new neuromelanin imaging techniques. The limited quantities of neuromelanin has made understanding its normal biology difficult, but recent rodent and primate models, as well as omics studies, have confirmed its importance for selective neuronal loss in Parkinson's disease (PD). We review the development of neuromelanin in dopamine versus noradrenaline neurons and focus on previously overlooked cellular organelles in neuromelanin formation and function. We discuss the role of neuromelanin in stimulating endogenous α-synuclein misfolding in PD which renders neuromelanin granules vulnerable, and can exacerbates other pathogenic processes.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"445-459"},"PeriodicalIF":15.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A place for place cells in post-stroke cognitive impairment. 位置细胞在中风后认知障碍中的位置。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-06-01 Epub Date: 2025-05-20 DOI: 10.1016/j.tins.2025.05.001
Abbie C Chapman
{"title":"A place for place cells in post-stroke cognitive impairment.","authors":"Abbie C Chapman","doi":"10.1016/j.tins.2025.05.001","DOIUrl":"10.1016/j.tins.2025.05.001","url":null,"abstract":"<p><p>In a recent study, Heiser et al. showed that hippocampal place cell stability and spatial encoding were disrupted in mice after brain-wide microstrokes. These findings suggest that hippocampal neurons are particularly vulnerable to dysfunction after stroke, even in the absence of local lesions. They also highlight the potential to improve place cell stability and rescue post-stroke memory function.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"391-392"},"PeriodicalIF":15.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanical stress connects cortical folding to fiber organization in the developing brain. 机械应力将皮质折叠与发育中的大脑纤维组织联系起来。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-06-01 Epub Date: 2025-04-29 DOI: 10.1016/j.tins.2025.04.001
Kara E Garcia, Christopher D Kroenke, Philip V Bayly
{"title":"Mechanical stress connects cortical folding to fiber organization in the developing brain.","authors":"Kara E Garcia, Christopher D Kroenke, Philip V Bayly","doi":"10.1016/j.tins.2025.04.001","DOIUrl":"10.1016/j.tins.2025.04.001","url":null,"abstract":"<p><p>During development of the gyrencephalic brain, both the formation of cortical folds and the establishment of axonal tracts require large, coordinated mechanical deformations. Cortical folding enables a high ratio of cortical surface area to brain volume, which is thought to enhance overall processing power. Meanwhile, a complex network of axonal connections facilitates communication between distant brain regions. The mechanisms underlying the formation of brain folds and axon tract organization remain widely debated. However, evidence emerging from measurements of mechanical stress, combined with physical and mathematical models, suggests that constrained cortical expansion generates folds via mechanical instability. In this opinion article, we highlight recent models and experimental data suggesting that mechanical stress induced by cortical folding also mediates axonal growth. We propose a key role for mechanics in establishing brain morphology and the organization of white matter fascicles of the mature brain.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"395-402"},"PeriodicalIF":15.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Probing the role of anterior cingulate cortex in sustained reward seeking. 探讨前扣带皮层在持续奖赏寻求中的作用。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-06-01 Epub Date: 2025-04-22 DOI: 10.1016/j.tins.2025.04.002
Qiyue Zhang, Jingfeng Zhou
{"title":"Probing the role of anterior cingulate cortex in sustained reward seeking.","authors":"Qiyue Zhang, Jingfeng Zhou","doi":"10.1016/j.tins.2025.04.002","DOIUrl":"10.1016/j.tins.2025.04.002","url":null,"abstract":"<p><p>A recent study by González et al. provides causal evidence that the anterior cingulate cortex (ACC) is crucial for rats to maintain persistence in reward-seeking behaviors across both information- and effort-based choice tasks, highlighting a fundamental and unified role of the ACC in goal-directed decision-making.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"389-390"},"PeriodicalIF":15.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The multifaceted roles of Akkermansia muciniphila in neurological disorders. 嗜粘液阿克曼氏菌在神经系统疾病中的多重作用。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1016/j.tins.2025.04.004
Xin Ma, Qiang Liu, Guan Yang
{"title":"The multifaceted roles of Akkermansia muciniphila in neurological disorders.","authors":"Xin Ma, Qiang Liu, Guan Yang","doi":"10.1016/j.tins.2025.04.004","DOIUrl":"10.1016/j.tins.2025.04.004","url":null,"abstract":"<p><p>Gut commensals regulate neurological disorders through dynamic bidirectional communication along the gut-brain axis. Recent evidence has highlighted the well-documented beneficial role of the commensal gut bacterium Akkermansia muciniphila and its components in promoting host health. However, numerous clinical studies have demonstrated a paradoxical role of A. muciniphila in individuals with various neurological conditions. In this opinion article, we review the correlation between the prevalence of this gut commensal and the development of several disorders, including stroke, multiple sclerosis (MS), Parkinson's disease (PD), and Alzheimer's disease (AD). We focus on the potential mechanisms by which A. muciniphila may contribute to these diseases. An in-depth understanding of these correlations and the underlying pathogenic mechanisms could shed new light on the mechanisms of disease pathogenesis and provide a logical rationale for developing new therapies for these neurological conditions.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"403-415"},"PeriodicalIF":15.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatiotemporal calcium dynamics orchestrate oligodendrocyte development and myelination. 时空钙动态调控少突胶质细胞发育和髓鞘形成。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-05-01 Epub Date: 2025-03-28 DOI: 10.1016/j.tins.2025.02.010
Jiaxing Li, Frederic Fiore, Kelly R Monk, Amit Agarwal
{"title":"Spatiotemporal calcium dynamics orchestrate oligodendrocyte development and myelination.","authors":"Jiaxing Li, Frederic Fiore, Kelly R Monk, Amit Agarwal","doi":"10.1016/j.tins.2025.02.010","DOIUrl":"10.1016/j.tins.2025.02.010","url":null,"abstract":"<p><p>Oligodendrocyte lineage cells (OLCs), comprising oligodendrocyte precursor cells (OPCs) and oligodendrocytes, are pivotal in sculpting central nervous system (CNS) architecture and function. OPCs mature into oligodendrocytes, which enwrap axons with myelin sheaths that are critical for enhancing neural transmission. Notably, OLCs actively respond to neuronal activity, modulating neural circuit functions. Understanding neuron-OLC interactions is key to unraveling how OLCs contribute to CNS health and pathology. This review highlights insights from zebrafish and mouse models, revealing how synaptic and extrasynaptic pathways converge to shape spatiotemporal calcium (Ca<sup>2+</sup>) dynamics within OLCs. We explore how Ca<sup>2+</sup> signal integration across spatial and temporal scales acts as a master regulator of OLC fate determination and myelin plasticity.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"377-388"},"PeriodicalIF":15.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BIN1 and Alzheimer's disease: the tau connection. BIN1和阿尔茨海默病：tau的联系。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-05-01 Epub Date: 2025-04-22 DOI: 10.1016/j.tins.2025.03.004
Pierre Dourlen, Devrim Kilinc, Isabelle Landrieu, Julien Chapuis, Jean-Charles Lambert
{"title":"BIN1 and Alzheimer's disease: the tau connection.","authors":"Pierre Dourlen, Devrim Kilinc, Isabelle Landrieu, Julien Chapuis, Jean-Charles Lambert","doi":"10.1016/j.tins.2025.03.004","DOIUrl":"10.1016/j.tins.2025.03.004","url":null,"abstract":"<p><p>Bridging integrator 1 (BIN1) is a ubiquitously expressed protein that plays a critical role in endocytosis, trafficking and cytoskeletal dynamics. In 2010, BIN1 gene was reported as a major genetic risk factor for Alzheimer's disease (AD), which shifted the focus on its physiological and pathophysiological roles in the brain (at a time when data available were scarce). In this review, we discuss the multiple cerebral roles of BIN1, especially in regulating synaptic function, and the strong link between BIN1 and tau pathology, supported by recent evidence ranging from genetic and clinical/postmortem observations to molecular interactions.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"349-361"},"PeriodicalIF":15.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Somatic mosaicism and interneuron involvement in mTORopathies. 肌病中的体细胞镶嵌和中间神经元的参与。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-05-01 Epub Date: 2025-03-22 DOI: 10.1016/j.tins.2025.02.009
Lilian G Jerow, Darcy A Krueger, Christina Gross, Steve C Danzer
{"title":"Somatic mosaicism and interneuron involvement in mTORopathies.","authors":"Lilian G Jerow, Darcy A Krueger, Christina Gross, Steve C Danzer","doi":"10.1016/j.tins.2025.02.009","DOIUrl":"10.1016/j.tins.2025.02.009","url":null,"abstract":"<p><p>Somatic mutations in genes regulating mechanistic target of rapamycin (mTOR) pathway signaling can cause epilepsy, autism, and cognitive dysfunction. Research has predominantly focused on mTOR regulation of excitatory neurons in these conditions; however, dysregulated mTOR signaling among interneurons may also be critical. In this review, we discuss clinical evidence for interneuron involvement, and potential mechanisms, known and hypothetical, by which interneurons might come to directly harbor pathogenic mutations. To understand how mTOR hyperactive interneurons might drive dysfunction, we review studies in which mTOR signaling has been selectively disrupted among interneurons and interneuron progenitors in mouse model systems. Complex cellular mosaicism and dual roles for mTOR (hyper)activation in mediating disease pathogenesis and homeostatic responses raise challenging questions for effective treatment of these disorders.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"362-376"},"PeriodicalIF":15.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The long and the short of TDP-43. TDP-43的长与短。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-05-01 Epub Date: 2025-03-24 DOI: 10.1016/j.tins.2025.03.003
Marc Shenouda, Paul M McKeever, Janice Robertson
{"title":"The long and the short of TDP-43.","authors":"Marc Shenouda, Paul M McKeever, Janice Robertson","doi":"10.1016/j.tins.2025.03.003","DOIUrl":"10.1016/j.tins.2025.03.003","url":null,"abstract":"<p><p>In a recent study, Dykstra and colleagues show that shortened TAR DNA Binding Protein 43 (sTDP-43) isoforms are generated as by-products of TDP-43 autoregulation. sTDP-43 levels are regulated through nonsense-mediated decay and proteasomal and autophagic degradation, and elicit toxicity through dominant negative effects on TDP-43 splicing activity. These results identify mechanisms contributing to sTDP-43 accumulation and toxicity in disease.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"313-314"},"PeriodicalIF":15.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defining brain fog across medical conditions. 在医疗条件下定义脑雾。
IF 15.1 1区 医学
Trends in Neurosciences Pub Date : 2025-05-01 Epub Date: 2025-02-25 DOI: 10.1016/j.tins.2025.01.003
Peter Denno, Sijia Zhao, Masud Husain, Adam Hampshire
{"title":"Defining brain fog across medical conditions.","authors":"Peter Denno, Sijia Zhao, Masud Husain, Adam Hampshire","doi":"10.1016/j.tins.2025.01.003","DOIUrl":"10.1016/j.tins.2025.01.003","url":null,"abstract":"<p><p>'Brain fog' is commonly reported in more than a dozen chronic diseases, but what is it? We review research across conditions which has characterised brain fog and evaluate its definitions and objective correlates. Brain fog has been used to refer to a variable set of overlapping symptoms implicating cognition, fatigue, and affect. It has been defined as a distinct symptom, a syndrome, or a nonspecific term. We consider the evidence that brain fog is a transdiagnostic entity with a common phenomenology and profile of objective cognitive deficits. We discuss where these commonalities arise and argue that linguistic ambiguity, shared cognitive impairments, and noncognitive factors are more likely than shared neurobiology. We suggest how future research might apply existing tools to disambiguate the phenomena that brain fog conflates.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"330-348"},"PeriodicalIF":15.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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