Trends in Neurosciences最新文献

筛选
英文 中文
Human-derived monoclonal autoantibodies as interrogators of cellular proteotypes in the brain. 人源单克隆自身抗体作为脑细胞蛋白型的询问因子。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-01 Epub Date: 2024-09-05 DOI: 10.1016/j.tins.2024.08.004
Matthew L Baum, Christopher M Bartley
{"title":"Human-derived monoclonal autoantibodies as interrogators of cellular proteotypes in the brain.","authors":"Matthew L Baum, Christopher M Bartley","doi":"10.1016/j.tins.2024.08.004","DOIUrl":"10.1016/j.tins.2024.08.004","url":null,"abstract":"<p><p>A major aim of neuroscience is to identify and model the functional properties of neural cells whose dysfunction underlie neuropsychiatric illness. In this article, we propose that human-derived monoclonal autoantibodies (HD-mAbs) are well positioned to selectively target and manipulate neural subpopulations as defined by their protein expression; that is, cellular proteotypes. Recent technical advances allow for efficient cloning of autoantibodies from neuropsychiatric patients. These HD-mAbs can be introduced into animal models to gain biological and pathobiological insights about neural proteotypes of interest. Protein engineering can be used to modify, enhance, silence, or confer new functional properties to native HD-mAbs, thereby enhancing their versatility. Finally, we discuss the challenges and limitations confronting HD-mAbs as experimental research tools for neuroscience.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"753-765"},"PeriodicalIF":14.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Object-oriented olfaction: challenges for chemosensation and for chemosensory research. 面向对象的嗅觉:化学感觉和化学感觉研究面临的挑战。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-01 Epub Date: 2024-09-07 DOI: 10.1016/j.tins.2024.08.008
Dan Rokni, Yoram Ben-Shaul
{"title":"Object-oriented olfaction: challenges for chemosensation and for chemosensory research.","authors":"Dan Rokni, Yoram Ben-Shaul","doi":"10.1016/j.tins.2024.08.008","DOIUrl":"10.1016/j.tins.2024.08.008","url":null,"abstract":"<p><p>Many animal species use olfaction to extract information about objects in their environment. Yet, the specific molecular signature that any given object emits varies due to various factors. Here, we detail why such variability makes chemosensory-mediated object recognition such a hard problem, and we propose that a major function of the elaborate chemosensory network is to overcome it. We describe previous work addressing different elements of the problem and outline future research directions that we consider essential for a full understanding of object-oriented olfaction. In particular, we call for extensive representation of olfactory object variability in chemical, behavioral, and electrophysiological analyses. While written with an emphasis on macrosmatic mammalian species, our arguments apply to all organisms that employ chemosensation to navigate complex environments.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"834-848"},"PeriodicalIF":14.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142155053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural adaptation to changes in self-voice during puberty. 青春期自我声音变化的神经适应。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-10-01 Epub Date: 2024-08-29 DOI: 10.1016/j.tins.2024.08.001
Ana P Pinheiro, Jean-Julien Aucouturier, Sonja A Kotz
{"title":"Neural adaptation to changes in self-voice during puberty.","authors":"Ana P Pinheiro, Jean-Julien Aucouturier, Sonja A Kotz","doi":"10.1016/j.tins.2024.08.001","DOIUrl":"10.1016/j.tins.2024.08.001","url":null,"abstract":"<p><p>The human voice is a potent social signal and a distinctive marker of individual identity. As individuals go through puberty, their voices undergo acoustic changes, setting them apart from others. In this article, we propose that hormonal fluctuations in conjunction with morphological vocal tract changes during puberty establish a sensitive developmental phase that affects the monitoring of the adolescent voice and, specifically, self-other distinction. Furthermore, the protracted maturation of brain regions responsible for voice processing, coupled with the dynamically evolving social environment of adolescents, likely disrupts a clear differentiation of the self-voice from others' voices. This socioneuroendocrine framework offers a holistic understanding of voice monitoring during adolescence.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"777-787"},"PeriodicalIF":14.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rethinking the role of TRKB in the action of antidepressants and psychedelics 重新思考TRKB在抗抑郁药和迷幻药作用中的作用
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-09-19 DOI: 10.1016/j.tins.2024.08.011
Cecilia Anna Brunello, Cecilia Cannarozzo, Eero Castrén
{"title":"Rethinking the role of TRKB in the action of antidepressants and psychedelics","authors":"Cecilia Anna Brunello, Cecilia Cannarozzo, Eero Castrén","doi":"10.1016/j.tins.2024.08.011","DOIUrl":"https://doi.org/10.1016/j.tins.2024.08.011","url":null,"abstract":"<p>Antidepressant drugs promote neuronal plasticity, and activation of brain-derived neurotrophic factor (BDNF) signaling through its receptor neuronal receptor tyrosine kinase 2 (NTRK2 or TRKB) is among the critical steps in this process. These mechanisms are shared by typical slow-acting antidepressants, fast-acting ketamine, and psychedelic compounds, although the cellular targets of each drug differ. In this opinion, we propose that some of these antidepressants may directly bind to TRKB and allosterically potentiate BDNF signaling, among other possible effects. TRKB activation in parvalbumin-containing interneurons disinhibits cortical networks and reactivates a juvenile-like plasticity window. Subsequent rewiring of aberrant networks, coupled with environmental stimuli, may underlie its clinical antidepressant effects. The end-to-end hypothesis proposed may stimulate the search for new treatment strategies.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"33 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meningeal brain borders and migraine headache genesis 脑膜边界与偏头痛的成因
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-09-19 DOI: 10.1016/j.tins.2024.08.012
Sarah Louise Christensen, Dan Levy
{"title":"Meningeal brain borders and migraine headache genesis","authors":"Sarah Louise Christensen, Dan Levy","doi":"10.1016/j.tins.2024.08.012","DOIUrl":"https://doi.org/10.1016/j.tins.2024.08.012","url":null,"abstract":"<p>Migraine is a highly prevalent and disabling pain disorder that affects &gt;1 billion people worldwide. One central hypothesis points to the cranial meninges as a key site underlying migraine headache genesis through complex interplay between meningeal sensory nerves, blood vessels, and adjacent immune cells. How these interactions might generate migraine headaches remains incompletely understood and a subject of much debate. In this review we discuss clinical and preclinical evidence supporting the concept that meningeal sterile inflammation, involving neurovascular and neuroimmune interactions, underlies migraine headache genesis. We examine downstream signaling pathways implicated in the development of migraine pain in response to exogenous events such as infusing migraine-triggering chemical substances. We further discuss cortex-to-meninges signaling pathways that could underlie migraine pain in response to endogenous events, such as cortical spreading depolarization (CSD), and explore future directions for the field.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"3 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroimmune interactions in the development and chronification of migraine headache 偏头痛发展和慢性化过程中的神经免疫相互作用
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-09-12 DOI: 10.1016/j.tins.2024.08.009
Jintao Zhang, Roli Simoes, Tingting Guo, Yu-Qing Cao
{"title":"Neuroimmune interactions in the development and chronification of migraine headache","authors":"Jintao Zhang, Roli Simoes, Tingting Guo, Yu-Qing Cao","doi":"10.1016/j.tins.2024.08.009","DOIUrl":"https://doi.org/10.1016/j.tins.2024.08.009","url":null,"abstract":"<p>Migraine is highly prevalent and debilitating. The persistent headaches in this condition are thought to arise from the activation and sensitization of the trigeminovascular pathway. Both clinical and animal model studies have suggested that neuroimmune interactions contribute to the pathophysiology of migraine headache. In this review, we first summarize the findings from human studies implicating the dysregulation of the immune system in migraine, including genetic analyses, measurement of circulatory factors, and neuroimaging data. We next discuss recent advances from rodent studies aimed at elucidating the neuroimmune interactions that manifest at various levels of the trigeminovascular pathway and lead to the recruitment of innate and adaptive immune cells as well as immunocompetent glial cells. These cells reciprocally modulate neuronal activity via multiple pro- and anti-inflammatory mediators, thereby regulating peripheral and central sensitization. Throughout the discussions, we highlight the potential clinical and translational implications of the findings.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"1 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142196527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Getting stress-related disorders under control: the untapped potential of neurofeedback 控制与压力有关的失调:神经反馈尚未开发的潜力
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-09-10 DOI: 10.1016/j.tins.2024.08.007
Florian Krause, David E.J. Linden, Erno J. Hermans
{"title":"Getting stress-related disorders under control: the untapped potential of neurofeedback","authors":"Florian Krause, David E.J. Linden, Erno J. Hermans","doi":"10.1016/j.tins.2024.08.007","DOIUrl":"https://doi.org/10.1016/j.tins.2024.08.007","url":null,"abstract":"<p>Stress-related disorders are among the biggest global health challenges. Despite significant progress in understanding their neurocognitive basis, the promise of applying insights from fundamental research to prevention and treatment remains largely unfulfilled. We argue that neurofeedback – a method for training voluntary control over brain activity – has the potential to fill this translational gap. We provide a contemporary perspective on neurofeedback as endogenous neuromodulation that can target complex brain network dynamics, is transferable to real-world scenarios outside a laboratory or treatment facility, can be trained prospectively, and is individually adaptable. This makes neurofeedback a prime candidate for a personalized preventive neuroscience-based intervention strategy that focuses on the ecological momentary neuromodulation of stress-related brain networks in response to actual stressors in real life.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"25 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142196529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-09-10 DOI: 10.1016/s0166-2236(24)00159-0
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0166-2236(24)00159-0","DOIUrl":"https://doi.org/10.1016/s0166-2236(24)00159-0","url":null,"abstract":"No Abstract","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"69 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142196528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 15.9 1区 医学
Trends in Neurosciences Pub Date : 2024-09-10 DOI: 10.1016/s0166-2236(24)00162-0
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s0166-2236(24)00162-0","DOIUrl":"https://doi.org/10.1016/s0166-2236(24)00162-0","url":null,"abstract":"No Abstract","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":"26 1","pages":""},"PeriodicalIF":15.9,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142196473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Behavioral neuroscience's inevitable SABV growing pains. 行为神经科学不可避免的 SABV 阵痛。
IF 14.6 1区 医学
Trends in Neurosciences Pub Date : 2024-09-01 Epub Date: 2024-07-20 DOI: 10.1016/j.tins.2024.06.007
Rebecca M Shansky
{"title":"Behavioral neuroscience's inevitable SABV growing pains.","authors":"Rebecca M Shansky","doi":"10.1016/j.tins.2024.06.007","DOIUrl":"10.1016/j.tins.2024.06.007","url":null,"abstract":"<p><p>The field of rodent behavioral neuroscience is undergoing two major sea changes: an ever-growing technological revolution, and worldwide calls to consider sex as a biological variable (SABV) in experimental design. Both have enormous potential to improve the precision and rigor with which the brain can be studied, but the convergence of these shifts in scientific practice has exposed critical limitations in classic and widely used behavioral paradigms. While our tools have advanced, our behavioral metrics - mostly developed in males and often allowing for only binary outcomes - have not. This opinion article explores how this disconnect has presented challenges for the accurate depiction and interpretation of sex differences in brain function, arguing for the expansion of current behavioral constructs to better account for behavioral diversity.</p>","PeriodicalId":23325,"journal":{"name":"Trends in Neurosciences","volume":" ","pages":"669-676"},"PeriodicalIF":14.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信