Interplay between physical activity, tau pathophysiology, and cognition.

IF 14.6 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2025-06-05 DOI:10.1016/j.tins.2025.05.006

Marcos Olvera-Rojas, Francisco B Ortega, Irene Esteban-Cornejo

引用次数: 0

Abstract

Physical activity (PA) has emerged as a modifiable protective lifestyle factor for Alzheimer's disease (AD). In a recent study by Kim and colleagues, higher levels of PA were associated with reduced phosphorylated tau (ptau) 217 concentrations even after accounting for β-amyloid (Aβ) brain uptake, suggesting a link with tau pathophysiology; this link also mediated better general cognition.

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体育活动、tau病理生理和认知之间的相互作用。

体育活动（PA）已成为阿尔茨海默病（AD）可改变的保护性生活方式因素。在Kim及其同事最近的一项研究中，即使考虑到β-淀粉样蛋白（a β）脑摄取，较高水平的PA与磷酸化tau (ptau) 217浓度降低有关，这表明与tau病理生理有关；这种联系也介导了更好的一般认知。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.