Gi signaling controls microglial surveillance and neuronal synchronization.

IF 15.1 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2025-06-01 Epub Date: 2025-05-08 DOI:10.1016/j.tins.2025.04.006

Aletta M R van den Bosch, Jörg Hamann

引用次数: 0

Abstract

Microglia-neuron interactions are essential for maintaining brain homeostasis. In a recent study, Zhao and colleagues demonstrated that activation of Gi-G-protein-coupled receptors (Gi-GPCRs) on microglia suppresses microglial process dynamics, reduces neuronal activity, and disrupts network synchronization. These findings highlight the role of microglial Gi-GPCR signaling in neuromodulation and its role in network activity in the healthy brain.

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Gi信号控制小胶质细胞监视和神经元同步。

小胶质细胞与神经元之间的相互作用对于维持大脑稳态至关重要。在最近的一项研究中，Zhao和他的同事证明了小胶质细胞上gi - g蛋白偶联受体（gi - gpcr）的激活会抑制小胶质细胞过程动力学，降低神经元活性，并破坏网络同步。这些发现强调了小胶质细胞Gi-GPCR信号在神经调节中的作用及其在健康大脑网络活动中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.