Trends in biotechnology最新文献_第3页

Welfare impacts of China's regulatory change toward genome-edited crops. 中国对基因组编辑作物监管变化对福利的影响。

IF 14.3 1区工程技术

Trends in biotechnology Pub Date : 2025-05-01 DOI: 10.1016/j.tibtech.2025.04.010

Yan Jin, Zuzana Smeets Kristkova, Justus Wesseler

引用次数: 0

Photocatalytic material-microorganism hybrid systems in water decontamination. 光催化材料-微生物复合系统在水净化中的应用。

IF 14.3 1区工程技术

Trends in biotechnology Pub Date : 2025-05-01 Epub Date: 2024-12-07 DOI: 10.1016/j.tibtech.2024.11.012

Jie Ming, Shou-Qing Ni, Ziyu Guo, Zhi-Bin Wang, Liangke Xie

引用次数: 0

Dynamic anaerobic digestion-based biorefineries for on-demand renewable energy and bioproducts in a circular bioeconomy. 循环生物经济中按需可再生能源和生物产品的动态厌氧消化生物精炼厂。

IF 14.3 1区工程技术

Trends in biotechnology Pub Date : 2025-05-01 Epub Date: 2025-02-15 DOI: 10.1016/j.tibtech.2025.01.005

Rajas Shinde, Anga Hackula, Milena Marycz, Archishman Bose, Richard O'Shea, Susanne Barth, Jerry D Murphy, David M Wall

{"title":"Dynamic anaerobic digestion-based biorefineries for on-demand renewable energy and bioproducts in a circular bioeconomy.","authors":"Rajas Shinde, Anga Hackula, Milena Marycz, Archishman Bose, Richard O'Shea, Susanne Barth, Jerry D Murphy, David M Wall","doi":"10.1016/j.tibtech.2025.01.005","DOIUrl":"10.1016/j.tibtech.2025.01.005","url":null,"abstract":"Anaerobic digestion (AD) is an important biotechnology for treating biodegradable residues and producing bioenergy, yet its full potential remains untapped. We investigate a two-phase AD system for biorefinery applications, producing valuable bioproducts, such as volatile fatty acids (VFAs) and biogas, from grass feedstock. We introduce a demand-driven operational approach to match market conditions, while minimising water use by reusing the process effluent. The proposed biorefinery model yields ~23 kg of VFAs and 75 kWh of biogas, with a potential gross revenue of €84 per tonne of grass. However, a preliminary economic analysis indicates that this biorefinery model is currently unprofitable. A sensitivity analysis suggests that reducing operating costs through technology advancements and policy support are vital to ensure economic viability. Such biorefineries offer opportunities for the diversification of farmers' incomes and the transition away from fossil resources. Our work exemplifies the role of AD as a key biotechnology in the circular bioeconomy.","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":" ","pages":"1140-1165"},"PeriodicalIF":14.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene editing technology: shaping international standards for health and food safety assurance. 基因编辑技术：制定保证健康和食品安全的国际标准。

IF 14.3 1区工程技术

Trends in biotechnology Pub Date : 2025-05-01 Epub Date: 2024-10-17 DOI: 10.1016/j.tibtech.2024.09.019

Jacob T Liberty, Bikram Poudel, Olivia Ihedioha, Haijiao Lin, Ernest Habanabakize, Zihan Gao, Ayodele T Adesoji, Shilni J Liberty

引用次数: 0

CRISPR/Cas9 editing of p-COUMAROYL-CoA:MONOLIGNOL TRANSFERASE 1 in maize alters phenolic metabolism, lignin structure, and lignin-first biomass processing. CRISPR/Cas9编辑玉米对coumaroyl - coa:MONOLIGNOL TRANSFERASE 1改变了酚代谢、木质素结构和木质素优先生物质加工。

IF 14.3 1区工程技术

Trends in biotechnology Pub Date : 2025-05-01 Epub Date: 2025-02-15 DOI: 10.1016/j.tibtech.2025.01.006

Dyoni M Oliveira, Marina de L S Saleme, Rebecca A Smith, Thijs Vangeel, Marcelo de F Lima, Alexandra A Chanoca, Thatiane R Mota, Yasmine Vanhevel, Griet Coussens, Korneel Van Aelst, Jordi Geerts, Iris Cornet, Dries Vaneechoutte, Klaas Vandepoele, Laurens Pauwels, Geert Goeminne, Kris Morreel, Bert F Sels, John Ralph, Ruben Vanholme, Wout Boerjan

{"title":"CRISPR/Cas9 editing of p-COUMAROYL-CoA:MONOLIGNOL TRANSFERASE 1 in maize alters phenolic metabolism, lignin structure, and lignin-first biomass processing.","authors":"Dyoni M Oliveira, Marina de L S Saleme, Rebecca A Smith, Thijs Vangeel, Marcelo de F Lima, Alexandra A Chanoca, Thatiane R Mota, Yasmine Vanhevel, Griet Coussens, Korneel Van Aelst, Jordi Geerts, Iris Cornet, Dries Vaneechoutte, Klaas Vandepoele, Laurens Pauwels, Geert Goeminne, Kris Morreel, Bert F Sels, John Ralph, Ruben Vanholme, Wout Boerjan","doi":"10.1016/j.tibtech.2025.01.006","DOIUrl":"10.1016/j.tibtech.2025.01.006","url":null,"abstract":"Valorization of lignocellulosic biomass for sustainable production of high-value chemicals is challenged by the complexity of lignin, a phenolic biopolymer. Beyond the classical lignin monomers derived from p-coumaryl, coniferyl, and sinapyl alcohol, grass lignins incorporate substantial amounts of monolignol p-coumarates that are produced by p-COUMAROYL-CoA:MONOLIGNOL TRANSFERASE (PMT). Here, the CRISPR/Cas9-mediated mutation of ZmPMT1 in maize enabled the design of biomass depleted in p-coumaroylated lignin and enriched in guaiacyl lignin. Lignin-first biorefining of stem biomass from zmpmt1 mutants by reductive catalytic fractionation (RCF) generated a lignin oil depleted in carboxylates and enriched in guaiacyl-derived alcohols, which are desirable substrates for bio-based polyurethane synthesis. The reported lignin engineering in maize is a promising strategy for designing a dual-purpose crop, providing both food and feed, along with a renewable feedstock for the production of plant-based chemicals.","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":" ","pages":"1166-1195"},"PeriodicalIF":14.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automated adjustment of metabolic niches enables the control of natural and engineered microbial co-cultures. 代谢生态位的自动调节使控制自然和工程微生物共培养成为可能。

IF 14.3 1区工程技术

Trends in biotechnology Pub Date : 2025-05-01 Epub Date: 2025-01-23 DOI: 10.1016/j.tibtech.2024.12.005

Juan Andres Martinez, Romain Bouchat, Tiphaine Gallet de Saint Aurin, Luz María Martínez, Luis Caspeta, Samuel Telek, Andrew Zicler, Guillermo Gosset, Frank Delvigne

{"title":"Automated adjustment of metabolic niches enables the control of natural and engineered microbial co-cultures.","authors":"Juan Andres Martinez, Romain Bouchat, Tiphaine Gallet de Saint Aurin, Luz María Martínez, Luis Caspeta, Samuel Telek, Andrew Zicler, Guillermo Gosset, Frank Delvigne","doi":"10.1016/j.tibtech.2024.12.005","DOIUrl":"10.1016/j.tibtech.2024.12.005","url":null,"abstract":"Much attention has focused on understanding microbial interactions leading to stable co-cultures. In this work, substrate pulsing was performed to promote better control of the metabolic niches (MNs) corresponding to each species, leading to the continuous co-cultivation of diverse microbial organisms. We used a cell-machine interface, which allows adjustment of the temporal profile of two MNs according to a rhythm, ensuring the successive growth of two species, in our case, a yeast and a bacterium. The resulting approach, called 'automated adjustment of metabolic niches' (AAMN), was effective for stabilizing both cooperative and competitive co-cultures. AAMN can be considered an enabling technology for the deployment of co-cultures in bioprocesses, demonstrated here based on the continuous bioproduction of p-coumaric acid. The data accumulated suggest that AAMN could be used not only for a wider range of biological systems, but also to gain fundamental insights into microbial interaction mechanisms.","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":" ","pages":"1116-1139"},"PeriodicalIF":14.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An epigenetic regulator synergizes with alphavirus-mediated gene therapy via biomimetic delivery for enhanced cancer therapy. 一种表观遗传调节剂通过仿生递送与甲病毒介导的基因治疗协同作用，以增强癌症治疗。

IF 14.3 1区工程技术

Trends in biotechnology Pub Date : 2025-05-01 Epub Date: 2025-02-15 DOI: 10.1016/j.tibtech.2025.01.007

Yuqiong Xia, Maozhi Su, Zixuan Ye, Fuyu Du, Xinruo Wang, Dashan Guan, Xianghan Zhang, Zhiping Rao, Pengbo Ning

{"title":"An epigenetic regulator synergizes with alphavirus-mediated gene therapy via biomimetic delivery for enhanced cancer therapy.","authors":"Yuqiong Xia, Maozhi Su, Zixuan Ye, Fuyu Du, Xinruo Wang, Dashan Guan, Xianghan Zhang, Zhiping Rao, Pengbo Ning","doi":"10.1016/j.tibtech.2025.01.007","DOIUrl":"10.1016/j.tibtech.2025.01.007","url":null,"abstract":"Gene therapy is promising for treating genetic disorders, but faces challenges in treating cancer due to the intricate genetic and immunosuppressive landscape of this disease. Here, we describe a technology combining alphavirus-based gene therapy with an epigenetic regulator via pyroptosis and immune checkpoints to address these challenges. A filamentous actin-mimicking liposomal delivery system, with high fusion efficiency, was developed that encapsulates the Semliki Forest virus (pSFV) DNA vector to deliver p53 and PDL1 scFv DNA, bypassing traditional endocytic barriers to deliver genes with high efficiency via membrane fusion. To enhance this combined therapy, the DNA methyltransferase inhibitor decitabine (DAC) was used to increase Gasdermin E (GSDME) expression, converting apoptosis to pyroptosis. This approach kills apoptosis-resistant tumor cells, and also promotes T cell infiltration and activation, facilitating an anti-PDL1 therapy and the systemic antitumor immune response. This multifaceted therapeutic strategy combines gene therapy with epigenetic regulation to significantly improve immune checkpoint therapy (ICT) effectiveness, offering a robust potential as a transformative cancer treatment.","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":" ","pages":"1196-1214"},"PeriodicalIF":14.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stimulus-assisted in situ bioprinting: advancing direct bench-to-bedside delivery. 刺激辅助的原位生物打印：推进直接从实验室到床边的输送。

IF 14.3 1区工程技术

Trends in biotechnology Pub Date : 2025-05-01 Epub Date: 2024-12-05 DOI: 10.1016/j.tibtech.2024.11.001

Hanjun Hwangbo, YoungWon Koo, Francis Nacionales, JuYeon Kim, SooJung Chae, Geun Hyung Kim

引用次数: 0

CarveAdornCurate: a versatile cloud-based platform for constructing multiscale metabolic models. CarveAdornCurate：一个基于云的多功能平台，用于构建多尺度代谢模型。

IF 14.3 1区工程技术

Trends in biotechnology Pub Date : 2025-05-01 Epub Date: 2025-03-04 DOI: 10.1016/j.tibtech.2025.01.011

Yang Cheng, Wenwen Yu, Xinyu Bi, Yanfeng Liu, Jianghua Li, Guocheng Du, Jian Chen, Xueqin Lv, Long Liu

{"title":"CarveAdornCurate: a versatile cloud-based platform for constructing multiscale metabolic models.","authors":"Yang Cheng, Wenwen Yu, Xinyu Bi, Yanfeng Liu, Jianghua Li, Guocheng Du, Jian Chen, Xueqin Lv, Long Liu","doi":"10.1016/j.tibtech.2025.01.011","DOIUrl":"10.1016/j.tibtech.2025.01.011","url":null,"abstract":"Multiscale modeling is a promising approach for understanding cellular behaviors. However, existing multiscale modeling tools require meticulously curated genome-scale metabolic models (GEMs) as inputs, limiting the broad applications of multiscale models due to complex and time-consuming construction processes. To this end, we developed a novel workflow named CarveAdornCurate (CAC) for de novo multiscale modeling. The Carve module generates an ensemble of GEMs with strong genetic evidence, which is then upgraded to multiscale models using Adorn module. The Curate module was designed to find features important to the generated models. These three modules are integrated into a cloud-based platform to promote broad accessibility. As proof of concept, we constructed CAC-based multiscale models for Corynebacterium glutamicum and Yarrowia lipolytica, demonstrating their potential in guiding metabolic engineering. Overall, CAC is demonstrated to be an efficient and user-friendly tool for constructing multiscale models. It is available online at www.carveadorncurate.com/.","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":" ","pages":"1234-1259"},"PeriodicalIF":14.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Molecular farming for the food sector. 食品行业的分子农业。

IF 14.3 1区工程技术

Trends in biotechnology Pub Date : 2025-05-01 Epub Date: 2024-10-16 DOI: 10.1016/j.tibtech.2024.09.015

Francesca Turetta, Matteo Leonardi, Roberto Reniero, Amedeo Alpi, Enrico Costanzo

引用次数: 0