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CRISPR/Cas: a powerful tool for designing and improving oil crops. CRISPR/Cas：设计和改良油料作物的强大工具。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-10-03 DOI: 10.1016/j.tibtech.2024.09.007
Lijie Li, Dangquan Zhang, Zhiyong Zhang, Baohong Zhang
{"title":"CRISPR/Cas: a powerful tool for designing and improving oil crops.","authors":"Lijie Li, Dangquan Zhang, Zhiyong Zhang, Baohong Zhang","doi":"10.1016/j.tibtech.2024.09.007","DOIUrl":"https://doi.org/10.1016/j.tibtech.2024.09.007","url":null,"abstract":"<p><p>Improving oil yield and quality is a major goal for crop breeding, and CRISPR/Cas-mediated genome editing has opened a new era for designing oil crops with enhanced yield and quality. CRISPR/Cas technology can not only increase oil production but also enhance oil quality, including enhancing pharmaceutical and health components, improving oil nutrients, and removing allergic and toxic components. As new molecular targets for oil biosynthesis are discovered and the CRISPR/Cas system is further improved, CRISPR/Cas will become a better molecular tool for designing new oil crops with higher oil production, enhanced nutrients, and improved health components. 'CRISPRized' oil crops will have broad applications both in industry (e.g., as biofuels) and in daily human life.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precise engineering of the biomolecular corona to accelerate the clinical translation of lipid nanoparticles. 精确设计生物分子电晕，加速脂质纳米粒子的临床转化。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-10-01 Epub Date: 2024-03-13 DOI: 10.1016/j.tibtech.2024.02.012
Shahed Behzadi, Morteza Mahmoudi
{"title":"Precise engineering of the biomolecular corona to accelerate the clinical translation of lipid nanoparticles.","authors":"Shahed Behzadi, Morteza Mahmoudi","doi":"10.1016/j.tibtech.2024.02.012","DOIUrl":"10.1016/j.tibtech.2024.02.012","url":null,"abstract":"<p><p>Understanding and meticulously engineering the biomolecular corona on the surface of lipid nanoparticles can accelerate their successful clinical applications beyond mRNA vaccines. We outline the major hurdles of clinical development faced by lipid nanoparticles and discuss how considering and modifying the biomolecular corona could mitigate these challenges.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140132634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The biotechnology revolution in textile dyeing. 纺织品染色的生物技术革命。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-10-01 Epub Date: 2024-03-06 DOI: 10.1016/j.tibtech.2024.02.010
Mariana B N Alves, Alexandre M S Jorge, Jorge F B Pereira
{"title":"The biotechnology revolution in textile dyeing.","authors":"Mariana B N Alves, Alexandre M S Jorge, Jorge F B Pereira","doi":"10.1016/j.tibtech.2024.02.010","DOIUrl":"10.1016/j.tibtech.2024.02.010","url":null,"abstract":"<p><p>Biotechnology holds the potential to revolutionize textile dyeing by utilizing biopigments, biodegradable dyes, and fermentative dyeing methods as alternatives to synthetic options. While some challenges exist, these biotechnological approaches offer innovative solutions to minimize environmental impact and foster sustainable practices, leading toward a greener, circular and efficient textile bioindustry.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioengineered yeast for preventing age-related diseases. 用于预防老年疾病的生物工程酵母。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-10-01 DOI: 10.1016/j.tibtech.2024.08.011
Olga Sofianovich, Kate Willis-Urena, Yueming Dong, Codruta Ignea
{"title":"Bioengineered yeast for preventing age-related diseases.","authors":"Olga Sofianovich, Kate Willis-Urena, Yueming Dong, Codruta Ignea","doi":"10.1016/j.tibtech.2024.08.011","DOIUrl":"https://doi.org/10.1016/j.tibtech.2024.08.011","url":null,"abstract":"<p><p>The aging process entails a multifaceted decline in the capacity to restore homeostasis in response to stress. A prevalent characteristic of many age-related diseases is the presence of low-grade chronic inflammation, a risk factor contributing significantly to morbidity and mortality in the elderly population. Specific lifestyle interventions, such as regular physical activity, targeted diet, and supplementation, can delay the accumulation of chronic age-associated conditions by mitigating inflammation processes. Bioengineered yeast-producing compounds with distinctive bioactivities, including anti-inflammatory properties, have the potential to provide rich dietary alternatives for the prevention of age-related diseases. This review highlights recent achievements in engineering effective yeast platforms, namely Saccharomyces cerevisiae and Yarrowia lipolytica, that hold promise in retarding the onset of aging and age-related ailments.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microfluidic electrochemical biosensors: tools for advancing the sustainable development goals. 微流体电化学生物传感器：推进可持续发展目标的工具。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-10-01 Epub Date: 2024-05-06 DOI: 10.1016/j.tibtech.2024.04.005
Mkliwa Koumbia, Mpho Ngoepe, Joseph Benjamin Holman, Maluta Steven Mufamadi, Madoka Takai
{"title":"Microfluidic electrochemical biosensors: tools for advancing the sustainable development goals.","authors":"Mkliwa Koumbia, Mpho Ngoepe, Joseph Benjamin Holman, Maluta Steven Mufamadi, Madoka Takai","doi":"10.1016/j.tibtech.2024.04.005","DOIUrl":"10.1016/j.tibtech.2024.04.005","url":null,"abstract":"<p><p>New technologies can help to achieve the sustainable development goals (SDGs) of the United Nations. We discuss the contribution of microfluidic electrochemical biosensors to advancing the SDGs. These sensors can be applied in various fields given their low cost, self-powering ability, environmental compatibility, ease of use, and small sample volume requirements.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140877381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OneCarbonBio: industrial biotechnology 3.0. OneCarbonBio: 工业生物技术 3.0。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-10-01 Epub Date: 2024-07-30 DOI: 10.1016/j.tibtech.2024.07.003
Živa Švab, Bor Klančnik, Martin Kavšček, Gregor Kosec, David Virant
{"title":"OneCarbonBio: industrial biotechnology 3.0.","authors":"Živa Švab, Bor Klančnik, Martin Kavšček, Gregor Kosec, David Virant","doi":"10.1016/j.tibtech.2024.07.003","DOIUrl":"10.1016/j.tibtech.2024.07.003","url":null,"abstract":"","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Yeast-based screening platforms to understand and improve human health. 基于酵母的筛选平台，了解并改善人类健康。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-10-01 Epub Date: 2024-04-26 DOI: 10.1016/j.tibtech.2024.04.003
Marcus Deichmann, Frederik G Hansson, Emil D Jensen
{"title":"Yeast-based screening platforms to understand and improve human health.","authors":"Marcus Deichmann, Frederik G Hansson, Emil D Jensen","doi":"10.1016/j.tibtech.2024.04.003","DOIUrl":"10.1016/j.tibtech.2024.04.003","url":null,"abstract":"<p><p>Detailed molecular understanding of the human organism is essential to develop effective therapies. Saccharomyces cerevisiae has been used extensively for acquiring insights into important aspects of human health, such as studying genetics and cell-cell communication, elucidating protein-protein interaction (PPI) networks, and investigating human G protein-coupled receptor (hGPCR) signaling. We highlight recent advances and opportunities of yeast-based technologies for cost-efficient chemical library screening on hGPCRs, accelerated deciphering of PPI networks with mating-based screening and selection, and accurate cell-cell communication with human immune cells. Overall, yeast-based technologies constitute an important platform to support basic understanding and innovative applications towards improving human health.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering next-generation oxygen-generating scaffolds to enhance bone regeneration. 设计新一代氧气生成支架，促进骨再生。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-09-28 DOI: 10.1016/j.tibtech.2024.09.006
Jingtong Zhao, Naboneeta Sarkar, Yunke Ren, Arvind P Pathak, Warren L Grayson
{"title":"Engineering next-generation oxygen-generating scaffolds to enhance bone regeneration.","authors":"Jingtong Zhao, Naboneeta Sarkar, Yunke Ren, Arvind P Pathak, Warren L Grayson","doi":"10.1016/j.tibtech.2024.09.006","DOIUrl":"10.1016/j.tibtech.2024.09.006","url":null,"abstract":"<p><p>In bone, an adequate oxygen (O<sub>2</sub>) supply is crucial during development, homeostasis, and healing. Oxygen-generating scaffolds (OGS) have demonstrated significant potential to enhance bone regeneration. However, the complexity of O<sub>2</sub> delivery and signaling in vivo makes it challenging to tailor the design of OGS to precisely meet this biological requirement. We review recent advances in OGS and analyze persisting engineering and translational hurdles. We also discuss the potential of computational and machine learning (ML) models to facilitate the integration of novel imaging data with biological readouts and advanced biomanufacturing technologies. By elucidating how to tackle current challenges using cutting-edge technologies, we provide insights for transitioning from traditional to next-generation OGS to improve bone regeneration in patients.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phage-guided nanocarriers: a precision strategy against bacterial pathogens. 噬菌体引导的纳米载体：对抗细菌病原体的精准策略。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-09-27 DOI: 10.1016/j.tibtech.2024.09.002
Temoor Ahmed, Xinyan Xu, Muhammad Noman, Qi Wang, Bin Li
{"title":"Phage-guided nanocarriers: a precision strategy against bacterial pathogens.","authors":"Temoor Ahmed, Xinyan Xu, Muhammad Noman, Qi Wang, Bin Li","doi":"10.1016/j.tibtech.2024.09.002","DOIUrl":"https://doi.org/10.1016/j.tibtech.2024.09.002","url":null,"abstract":"<p><p>Bacterial infections pose a major threat to human health. Here, we describe the recent development of phage-guided therapeutic agent-loaded engineered nanomaterials for precise elimination of bacterial pathogens. This forum highlights the underexplored potential of bioinspired nano-enabled strategies for managing bacterial infections in a precise and safe manner.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sustainable production of porphyrins through synthetic biology. 通过合成生物学实现卟啉的可持续生产。
IF 14.3 1区 工程技术
Trends in biotechnology Pub Date : 2024-09-27 DOI: 10.1016/j.tibtech.2024.09.009
Fei Yu, Yongjin J Zhou
{"title":"Sustainable production of porphyrins through synthetic biology.","authors":"Fei Yu, Yongjin J Zhou","doi":"10.1016/j.tibtech.2024.09.009","DOIUrl":"https://doi.org/10.1016/j.tibtech.2024.09.009","url":null,"abstract":"<p><p>Porphyrin compounds are versatile heterocyclic molecules with diverse applications. However, their high-level production is limited by strict biosynthetic regulation and low catalytic efficiency of pathway enzymes. This forum article focuses on recent breakthroughs in porphyrin biosynthesis across various species, aiming to promote the sustainable production of porphyrins through synthetic biology.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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