Trends in biotechnology最新文献

Frog 'N' Roll: novel synthetic peptides selective against Gram-negative pathogens. 青蛙‘N’ Roll：新的合成肽选择性抗革兰氏阴性病原体。

IF 14.3 1区工程技术

Trends in biotechnology Pub Date : 2025-06-14 DOI: 10.1016/j.tibtech.2025.06.004

Santiago Ramón-García

引用次数: 0

Inflammation-targeting and self-limited neutrophilic membrane-encapsulated teicoplanin for the treatment of infectious pneumonia. 炎症靶向和自限性中性粒细胞膜包膜替柯普兰治疗感染性肺炎。

IF 14.3 1区工程技术

Trends in biotechnology Pub Date : 2025-06-14 DOI: 10.1016/j.tibtech.2025.05.009

Huidan Lu, Kaixin Zhang, Wanying Zhang, Wenting Zhang, Jicheng Wu, Xinliang Ming, Yuqiao Huang, Feng Xu, Ben Wang

{"title":"Inflammation-targeting and self-limited neutrophilic membrane-encapsulated teicoplanin for the treatment of infectious pneumonia.","authors":"Huidan Lu, Kaixin Zhang, Wanying Zhang, Wenting Zhang, Jicheng Wu, Xinliang Ming, Yuqiao Huang, Feng Xu, Ben Wang","doi":"10.1016/j.tibtech.2025.05.009","DOIUrl":"https://doi.org/10.1016/j.tibtech.2025.05.009","url":null,"abstract":"Methicillin-resistant Staphylococcus aureus (MRSA) pneumonia has a high clinical incidence and is associated with a significant mortality risk. The existence of intracellular pathogens and the infection-induced swarming of neutrophils exacerbate the challenges in treating pneumonia. Here, we addressed these issues by developing a platform based on neutrophilic membrane-camouflaged teicoplanin (Teic@NEV) to kill bacteria in tissue and prevent inflammatory lung injury associated with MRSA pneumonia. Teic@NEV improved the efficiency of drug entry into cells, meaningfully increasing the intracellular drug concentration in infected cells and eliminating intracellular MRSA. Moreover, Teic@NEV enhanced the penetration of teicoplanin into the biofilm and improved antimicrobial and antibiofilm activities in vitro. Surprisingly, Teic@NEV delivered teicoplanin specifically to sites of inflammation and reduced lung injury by hindering neutrophil swarming in vivo. Thus, this platform represents an effective strategy to limit neutrophil swarming and kill intracellular pathogens in patients with MRSA pneumonia, demonstrating its significant potential for use in clinical practice.","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":" ","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging gene editing to combat methane emissions in ruminant agriculture. 利用基因编辑技术对抗反刍动物农业中的甲烷排放。

IF 14.3 1区工程技术

Trends in biotechnology Pub Date : 2025-06-14 DOI: 10.1016/j.tibtech.2025.05.020

Yuchao Zhao, Jian Tan, Luoyun Fang, Linshu Jiang

引用次数: 0

Innervating 3D in vitro models: bioengineering and design blueprints. 支配3D体外模型：生物工程和设计蓝图。

IF 14.3 1区工程技术

Trends in biotechnology Pub Date : 2025-06-13 DOI: 10.1016/j.tibtech.2025.05.012

Mariana-Tomás de Carvalho, Margarida Henriques-Pereira, Maria V Monteiro, Meriem Lamghari, João F Mano, Vítor M Gaspar

引用次数: 0

UFSC Biotech Network: a transdisciplinary platform for biotechnology innovation in Brazil. UFSC生物技术网络：巴西生物技术创新的跨学科平台。

IF 14.3 1区工程技术

Trends in biotechnology Pub Date : 2025-06-10 DOI: 10.1016/j.tibtech.2025.05.011

Carlos Yure B Oliveira, Acácio Antonio Ferreira Zielinski, Afonso Celso Dias Bainy, Aguinaldo Roberto Pinto, Alcilene Rodrigues Monteiro Fritz, Ana Paula Serafini Immich Boemo, Ariádne Cristiane Cabral da Cruz, Camila Michels, Carlos Ivan Aguilar Vildoso, Claudia Sayer, Claudio Roberto Fonseca Sousa Soares, Cristiano José de Andrade, Daiane Martins Ramos, Diogo Robl, Edmundo Carlos Grisard, Elise Sommer Watzko, Gislaine Fongaro, Glauber Wagner, Gloria Regina Botelho, Hugo Moreira Soares, Jaciane Lutz Ienczak, Jose Wilmo da Cruz Junior, Juliano de Dea Lindner, Katia Rezzadori, Leonardo Rubi Rorig, Marco Di Luccio, Maria Manuela Camino Feltes, Mario Steindel, Martina Blank, Nelson Libardi Junior, Patricia Flavia Quaresma, Patricia Hermes Stoco, Patrícia Poletto, Pedro Henrique Hermes de Araujo, Pedro Luiz Manique Barreto, Rita de Cassia Siqueira Curto Valle, Rosete Pescador, Rubens Tadeu Delgado Duarte, Silvani Verruck, Valdir Marcos Stefenon, Vanessa Almeida de Oliveira, Willian Rodrigues Macedo, Débora de Oliveira

{"title":"UFSC Biotech Network: a transdisciplinary platform for biotechnology innovation in Brazil.","authors":"Carlos Yure B Oliveira, Acácio Antonio Ferreira Zielinski, Afonso Celso Dias Bainy, Aguinaldo Roberto Pinto, Alcilene Rodrigues Monteiro Fritz, Ana Paula Serafini Immich Boemo, Ariádne Cristiane Cabral da Cruz, Camila Michels, Carlos Ivan Aguilar Vildoso, Claudia Sayer, Claudio Roberto Fonseca Sousa Soares, Cristiano José de Andrade, Daiane Martins Ramos, Diogo Robl, Edmundo Carlos Grisard, Elise Sommer Watzko, Gislaine Fongaro, Glauber Wagner, Gloria Regina Botelho, Hugo Moreira Soares, Jaciane Lutz Ienczak, Jose Wilmo da Cruz Junior, Juliano de Dea Lindner, Katia Rezzadori, Leonardo Rubi Rorig, Marco Di Luccio, Maria Manuela Camino Feltes, Mario Steindel, Martina Blank, Nelson Libardi Junior, Patricia Flavia Quaresma, Patricia Hermes Stoco, Patrícia Poletto, Pedro Henrique Hermes de Araujo, Pedro Luiz Manique Barreto, Rita de Cassia Siqueira Curto Valle, Rosete Pescador, Rubens Tadeu Delgado Duarte, Silvani Verruck, Valdir Marcos Stefenon, Vanessa Almeida de Oliveira, Willian Rodrigues Macedo, Débora de Oliveira","doi":"10.1016/j.tibtech.2025.05.011","DOIUrl":"https://doi.org/10.1016/j.tibtech.2025.05.011","url":null,"abstract":"Biotech Network (Rede Biotech in Portuguese) is a crossdisciplinary initiative launched at the Federal University of Santa Catarina (UFSC) to foster innovative biotechnological solutions aligned with Brazil's scientific, environmental, and societal challenges. Here, we highlight the structure, mission, and pioneering research efforts of the network, offering a model for integrated and sustainable biotechnology development in emerging economies.","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":" ","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered transcription factor-binding arrays for DNA-based gene expression control in mammalian cells. 用于哺乳动物细胞dna基因表达控制的工程转录因子结合阵列。

IF 14.3 1区工程技术

Trends in biotechnology Pub Date : 2025-06-09 DOI: 10.1016/j.tibtech.2025.05.006

Annalise Zouein, Brittany Lende-Dorn, Kate E Galloway, Tom Ellis, Francesca Ceroni

引用次数: 0

Extracellular polyol esters of fatty acids by Rhodotorula yeast for streamlined biorefineries. 流线型生物精炼厂用红酵母制备的脂肪酸胞外多元醇酯。

IF 14.3 1区工程技术

Trends in biotechnology Pub Date : 2025-06-09 DOI: 10.1016/j.tibtech.2025.05.003

Sujit S Jagtap, Christopher V Rao

引用次数: 0

The Spirit of Asilomar: lessons for the next era of biotechnology governance. 阿西洛玛精神：下一个生物技术治理时代的教训。

IF 14.3 1区工程技术

Trends in biotechnology Pub Date : 2025-06-09 DOI: 10.1016/j.tibtech.2025.05.013

Kutubuddin A Molla, Felix Moronta-Barrios, Margaret Karembu, Leyma P De Haro, Roudlotul Jannah

引用次数: 0

Accelerating promoter identification and design by deep learning. 通过深度学习加速启动子识别和设计。

IF 14.3 1区工程技术

Trends in biotechnology Pub Date : 2025-06-04 DOI: 10.1016/j.tibtech.2025.05.008

Xinglong Wang, Kangjie Xu, Zhongshi Huang, Yanna Lin, Jingwen Zhou, Lianqun Zhou, Fuqiang Ma

引用次数: 0

Meta-adaptive biomaterials: multiscale, spatiotemporal organization and actuation in engineered tissues. 元适应生物材料：工程组织中的多尺度、时空组织和驱动。

IF 14.3 1区工程技术

Trends in biotechnology Pub Date : 2025-06-04 DOI: 10.1016/j.tibtech.2025.05.004

Gerardo Cedillo-Servin, Essa A A Al-Jehani, Tamara Rossy, Simão P B Teixeira, Fanny Sage, Rui M A Domingues, Ritu Raman, Miguel Castilho

{"title":"Meta-adaptive biomaterials: multiscale, spatiotemporal organization and actuation in engineered tissues.","authors":"Gerardo Cedillo-Servin, Essa A A Al-Jehani, Tamara Rossy, Simão P B Teixeira, Fanny Sage, Rui M A Domingues, Ritu Raman, Miguel Castilho","doi":"10.1016/j.tibtech.2025.05.004","DOIUrl":"https://doi.org/10.1016/j.tibtech.2025.05.004","url":null,"abstract":"Organized cell architecture and dynamic forces are key for (re)creating native-like tissue function (e.g., contractile soft tissues). However, few studies have explored the combined effects of material-guided 3D cell organization with mechanical stimulation. Herein we underscore the importance of converging material-driven guidance of cell organization with stimulus-responsive actuation for multiscale biomaterial design, outlining strategies to engineer such biomaterials. Given the state-of-the-art biomaterials for multiscale spatiotemporally controlled organization and actuation, we propose a synergistic approach ('meta-adaptive biomaterials') that unlocks complexity in engineered biomaterials, harnessing adaptive feedback pathways arising from cell-material interactions. These can be designed similarly to cell-extracellular matrix (ECM) interactions to reinforce user-specified behaviors and yield functionalities that resemble or surpass native tissues, expanding possibilities in tissue engineering, in vitro models, and biohybrid robotics.","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":" ","pages":""},"PeriodicalIF":14.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0