褐色脂肪组织工程：进展、挑战和未来方向。

IF 14.9 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Trends in biotechnology Pub Date : 2025-09-25 DOI:10.1016/j.tibtech.2025.08.010

Aslı Sena Karanfil, Fiona Louis, Michiya Matsusaki

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引用次数: 0

摘要

肥胖是一个主要的健康问题，因为它会增加患慢性疾病的风险，包括心血管疾病、糖尿病和某些类型的癌症。棕色脂肪组织（BAT）由于其燃烧脂肪和通过非寒颤产热产生热量的能力而成为肥胖治疗的一个有希望的目标。通过组织工程的最新进展，包括基于干细胞的方法、3D生物打印和类器官系统，用于治疗用途的BAT模型的开发已经成为可能。然而，在保持BAT生理相关性的同时优化分化方案仍然具有挑战性。这篇综述探讨了BAT工程的当前进展，并强调了在代谢健康干预中实现临床应用的未来研究重点。

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Brown adipose tissue engineering: advances, challenges, and future directions.

Obesity is a major health issue as it increases the risk of developing chronic diseases, including cardiovascular disorders, diabetes, and certain types of cancer. Brown adipose tissue (BAT) is a promising target for obesity treatment due to its ability to burn fat and create heat via non-shivering thermogenesis. The development of BAT models for therapeutic use has become possible through recent advances in tissue engineering, including stem cell-based methods, 3D bioprinting, and organoid systems. However, optimizing differentiation protocols while maintaining the physiological relevance of BAT remains challenging. This review explores current advances in BAT engineering and highlights future research priorities for achieving clinical applications in metabolic health interventions.

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来源期刊

Trends in biotechnology 工程技术-生物工程与应用微生物

CiteScore

28.60

自引率

1.20%

发文量

198

审稿时长

1 months

期刊介绍： Trends in Biotechnology publishes reviews and perspectives on the applied biological sciences, focusing on useful science applied to, derived from, or inspired by living systems. The major themes that TIBTECH is interested in include: Bioprocessing (biochemical engineering, applied enzymology, industrial biotechnology, biofuels, metabolic engineering) Omics (genome editing, single-cell technologies, bioinformatics, synthetic biology) Materials and devices (bionanotechnology, biomaterials, diagnostics/imaging/detection, soft robotics, biosensors/bioelectronics) Therapeutics (biofabrication, stem cells, tissue engineering and regenerative medicine, antibodies and other protein drugs, drug delivery) Agroenvironment (environmental engineering, bioremediation, genetically modified crops, sustainable development).