Aslı Sena Karanfil, Fiona Louis, Michiya Matsusaki
{"title":"Brown adipose tissue engineering: advances, challenges, and future directions.","authors":"Aslı Sena Karanfil, Fiona Louis, Michiya Matsusaki","doi":"10.1016/j.tibtech.2025.08.010","DOIUrl":null,"url":null,"abstract":"<p><p>Obesity is a major health issue as it increases the risk of developing chronic diseases, including cardiovascular disorders, diabetes, and certain types of cancer. Brown adipose tissue (BAT) is a promising target for obesity treatment due to its ability to burn fat and create heat via non-shivering thermogenesis. The development of BAT models for therapeutic use has become possible through recent advances in tissue engineering, including stem cell-based methods, 3D bioprinting, and organoid systems. However, optimizing differentiation protocols while maintaining the physiological relevance of BAT remains challenging. This review explores current advances in BAT engineering and highlights future research priorities for achieving clinical applications in metabolic health interventions.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":" ","pages":""},"PeriodicalIF":14.9000,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1016/j.tibtech.2025.08.010","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Obesity is a major health issue as it increases the risk of developing chronic diseases, including cardiovascular disorders, diabetes, and certain types of cancer. Brown adipose tissue (BAT) is a promising target for obesity treatment due to its ability to burn fat and create heat via non-shivering thermogenesis. The development of BAT models for therapeutic use has become possible through recent advances in tissue engineering, including stem cell-based methods, 3D bioprinting, and organoid systems. However, optimizing differentiation protocols while maintaining the physiological relevance of BAT remains challenging. This review explores current advances in BAT engineering and highlights future research priorities for achieving clinical applications in metabolic health interventions.
期刊介绍：
Trends in Biotechnology publishes reviews and perspectives on the applied biological sciences, focusing on useful science applied to, derived from, or inspired by living systems.
The major themes that TIBTECH is interested in include:
Bioprocessing (biochemical engineering, applied enzymology, industrial biotechnology, biofuels, metabolic engineering)
Omics (genome editing, single-cell technologies, bioinformatics, synthetic biology)
Materials and devices (bionanotechnology, biomaterials, diagnostics/imaging/detection, soft robotics, biosensors/bioelectronics)
Therapeutics (biofabrication, stem cells, tissue engineering and regenerative medicine, antibodies and other protein drugs, drug delivery)
Agroenvironment (environmental engineering, bioremediation, genetically modified crops, sustainable development).
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