Transactions of The Royal Society of Tropical Medicine and Hygiene最新文献_第3页

The utility of artificial intelligence in the management of dengue fever: a perspective on future directions. 人工智能在登革热管理中的应用：对未来方向的展望。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-10-01 DOI: 10.1093/trstmh/traf103

Mohammed Hussein, Elshimaa Ali, Yassin Kamal, Ali Elhouni, E L Mardi Ems, Yousif Eltayeb, Ali Awadallah Saeed, Ahmed Hassan Fahal

{"title":"The utility of artificial intelligence in the management of dengue fever: a perspective on future directions.","authors":"Mohammed Hussein, Elshimaa Ali, Yassin Kamal, Ali Elhouni, E L Mardi Ems, Yousif Eltayeb, Ali Awadallah Saeed, Ahmed Hassan Fahal","doi":"10.1093/trstmh/traf103","DOIUrl":"10.1093/trstmh/traf103","url":null,"abstract":"Dengue fever remains a significant public health challenge, particularly in tropical and subtropical regions. With millions affected each year and the increasing prevalence of the disease due to urbanisation and climate change, effective management strategies are crucial. The incorporation of artificial intelligence (AI) in healthcare presents transformative possibilities for the management of dengue fever. AI-driven systems can improve disease surveillance by analyzing extensive volumes of epidemiological, environmental, and socio-behavioral data to identify early warning indicators and forecast outbreak trends. Enhanced diagnostic instruments driven by AI algorithms can expedite and refine case identification, especially in resource-constrained environments. Moreover, AI can enhance targeted vector control tactics by pinpointing high-risk areas and optimizing the implementation of preventive measures. AI can optimize resource allocation in healthcare institutions. These applications have the potential to substantially alleviate the burden of dengue fever, enhance patient outcomes, and fortify health system resilience. As AI technologies progress, their influence in public health is expected to grow, facilitating creative, data-driven strategies that correspond with the United Nations Sustainable Development Goals (SDGs) to enhance global health equity and disease prevention. Continued research, collaboration, and community engagement will be crucial to realising the full potential of AI in addressing this pressing public health challenge.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1215-1221"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis of Plasmodium falciparum malaria at very low parasitaemias using a commercially available LAMP assay and RDT. 利用市售LAMP检测和RDT诊断恶性疟原虫疟疾的极低寄生虫血症。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-10-01 DOI: 10.1093/trstmh/traf050

Ruth O Payne, Nick J Edwards, Yrene Themistocleous, Sarah E Silk, Jordan R Barrett, Thomas A Rawlinson, Ian W Lim, Simon J Draper, Angela M Minassian

{"title":"Diagnosis of Plasmodium falciparum malaria at very low parasitaemias using a commercially available LAMP assay and RDT.","authors":"Ruth O Payne, Nick J Edwards, Yrene Themistocleous, Sarah E Silk, Jordan R Barrett, Thomas A Rawlinson, Ian W Lim, Simon J Draper, Angela M Minassian","doi":"10.1093/trstmh/traf050","DOIUrl":"10.1093/trstmh/traf050","url":null,"abstract":"Background: Malaria is the most common tropical infection in the UK. Current guidelines suggest that testing on 3 consecutive days is required following an initial negative result. This study aimed to see whether newer diagnostics (loop-mediated amplification assay [LAMP]) had sufficient sensitivity to support a change in diagnostic practice.Methods: Blood samples from 11 participants who had undergone controlled human malaria infection (CHMI) with Plasmodium falciparum malaria were assessed from day 6 (C+6) for malaria positivity using the Carestart Malaria rapid diagnostic test (RDT) and from C+4 using the Alethia Malaria LAMP assay. Quantitative polymerase chain reaction had been performed twice daily during CHMI follow-up. A retrospective analysis of samples submitted to the Sheffield Teaching Hospitals for malaria testing over a 5-y period was conducted, evaluating the combination of the Carestart RDT alongside blood film analysis, as per UK guidelines.Results: In CHMI samples, LAMP was positive for all parasitaemias >1000 parasites/ml, whereas RDTs were less reliable (59% positive for parasitaemias >1000 parasites/ml). The combination of RDT and blood films for clinical samples diagnosed most infections, but only a minority of negative samples had subsequent tests.Conclusions: LAMP has higher sensitivity than current UK recommended methods, with a potential to review the requirement for additional days of testing in the majority of patients.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1149-1156"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of anakinra in Crimean Congo haemorrhagic fever with haemophagocyctic lymphohistiocytosis: a case report. 阿那白在克里米亚刚果出血热伴噬血细胞淋巴组织细胞增多症中的应用：1例报告。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-10-01 DOI: 10.1093/trstmh/traf056

Ümit Çelik, Ayşe Hitay Telefon, Tuğba Kandemir Gülmez, Elif Afat Turgut, Rabia Miray Kisla Ekinci, Merve Kılıç Çil, Mehmet Deniz Erhan

引用次数: 0

Epidemiological insights into the co-circulation of Zika and dengue viruses in Yangon, Myanmar (2017-2019). 2017-2019年缅甸仰光寨卡病毒和登革热病毒共传播的流行病学见解

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-24 DOI: 10.1093/trstmh/traf102

Maurine Mumo Mutua, Mya Myat Ngwe Tun, Khine Mya Nwe, Htin Lin, Merveille Kapandji, Shingo Inoue, Kyaw Zin Thant, Yuki Takamatsu, Wah Wah Aung, Aye Aye Khin, Hlaing Myat Thu, Takeshi Urano, Kouichi Morita

{"title":"Epidemiological insights into the co-circulation of Zika and dengue viruses in Yangon, Myanmar (2017-2019).","authors":"Maurine Mumo Mutua, Mya Myat Ngwe Tun, Khine Mya Nwe, Htin Lin, Merveille Kapandji, Shingo Inoue, Kyaw Zin Thant, Yuki Takamatsu, Wah Wah Aung, Aye Aye Khin, Hlaing Myat Thu, Takeshi Urano, Kouichi Morita","doi":"10.1093/trstmh/traf102","DOIUrl":"https://doi.org/10.1093/trstmh/traf102","url":null,"abstract":"Background: Zika virus (ZIKV) is a mosquito-borne flavivirus mainly transmitted by Aedes aegypti and Aedes albopictus. While well-studied in the Americas, data from Southeast Asia, especially Myanmar, remain limited. This study assessed ZIKV infection among dengue-suspected patients in Yangon, Myanmar, from 2017 to 2019.Methods: This was a cross-sectional retrospective study that collected serum samples from 1162 clinically dengue-suspected patients. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) was used to detect ZIKV RNA and serological assays were used to identify ZIKV-specific immunoglobulin M (IgM), IgG and neutralizing antibodies. The age, gender, clinical manifestations and coinfections with dengue virus (DENV) were determined.Results: Of the 1162 samples, 23 (2.0%) were positive for ZIKV by RT-qPCR. Among these, nine samples showed coinfection with DENV: four with DENV-1, two with DENV-3 and three with DENV-4. Of the 111 (9.6%) samples that tested positive for ZIKV IgM, 11 (9.9%) had neutralizing antibodies against ZIKV, with 9 (8.1%) confirmed as ZIKV positive and 2 (1.8%) classified as probable cases.Conclusions: Our study reported that 32 cases (2.8%) were confirmed as ZIKV infections by molecular and serological detection. The findings underscore the need for improved surveillance, diagnostic accuracy and public health interventions to mitigate the impact of ZIKV.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of introducing ethambutol and integrating drugs into fixed-dose tablets on mortality in tuberculosis patients. 引入乙胺丁醇并将药物整合到固定剂量片中对结核病患者死亡率的影响。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-22 DOI: 10.1093/trstmh/traf100

Fredi Alexander Diaz-Quijano, Patricia Bartholomay, Kleydson Bonfim Andrade, Daniele Maria Pelissari, Denise Arakaki-Sanchez, Fernanda Dockhorn Costa, Rejane Sobrino Pinheiro

{"title":"Effect of introducing ethambutol and integrating drugs into fixed-dose tablets on mortality in tuberculosis patients.","authors":"Fredi Alexander Diaz-Quijano, Patricia Bartholomay, Kleydson Bonfim Andrade, Daniele Maria Pelissari, Denise Arakaki-Sanchez, Fernanda Dockhorn Costa, Rejane Sobrino Pinheiro","doi":"10.1093/trstmh/traf100","DOIUrl":"https://doi.org/10.1093/trstmh/traf100","url":null,"abstract":"Background: In response to increasing primary resistance to isoniazid, the Brazilian Ministry of Health modified the tuberculosis (TB) treatment regimen at the end of 2009. The changes included adding ethambutol to the intensive phase, using fixed-dose combination tablets and adjusting isoniazid and pyrazinamide dosages. This study aimed to estimate the effect of the regimen change on all-cause mortality and, secondarily, on TB-specific mortality, treatment success and loss to follow-up.Methods: We analysed cohorts of individuals ≥10 y of age who initiated TB treatment before (n = 145 528) and after (n = 161 264) the regimen change. Data were obtained from the national notifiable disease and mortality information systems. Missing data were imputed and effects were estimated using multilevel logistic regression models with states as the clustering level. Covariates were selected using a directed acyclic graph.Results: The regimen change was not associated with all-cause mortality (relative risk [RR] 1.01 [95% confidence interval {CI} 0.98 to 1.04]) or TB-specific mortality (RR 0.98 [95% CI 0.95 to 1.02]). The treatment success rate was lower, and loss to follow-up was higher during the modified regimen period compared with the previous one. However, sensitivity analyses suggest that changes in the handling of transfers and missing outcome data may partly explain these findings.Conclusion: We concluded that the modified regimen did not adversely affect survival among TB patients.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local attitudes towards malarial disease in a high-burden area of rural Ghana: a cross-sectional household survey. 加纳农村高负担地区当地人对疟疾的态度：一项横断面家庭调查。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-22 DOI: 10.1093/trstmh/traf099

Oliver B Gregory, Mohammed Malle Abdulai, Julia E Taylor, Victor Mogre, Michael G Head

引用次数: 0

Unusual sequential type I and II reactions in lepromatous leprosy: a case report. 麻风性麻风异常顺序I型和II型反应：1例报告。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-22 DOI: 10.1093/trstmh/traf097

Xinyu Qi, Shuqiong Huang

引用次数: 0

Butterflies in the stomach: a critical analysis on human scoleciasis. 胃里的蝴蝶：对人类脊柱侧弯病的批判性分析。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-19 DOI: 10.1093/trstmh/traf095

Michele Calatri

引用次数: 0

The activity of combinations of currently used antigiardial drugs against Giardia duodenalis. 目前使用的抗贾第虫药物联合治疗十二指肠贾第虫的活性。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-18 DOI: 10.1093/trstmh/traf101

Keely Fayd'Herbe, Chun Kit Lam, Christopher J S Hart, Tina S Skinner-Adams

引用次数: 0

Advances in population-based interventions to control falciparum malaria. 以人群为基础的控制恶性疟疾干预措施的进展。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-18 DOI: 10.1093/trstmh/traf088

Samuel E Glossop, Thomas J Peto, Bipin Adhikari

{"title":"Advances in population-based interventions to control falciparum malaria.","authors":"Samuel E Glossop, Thomas J Peto, Bipin Adhikari","doi":"10.1093/trstmh/traf088","DOIUrl":"https://doi.org/10.1093/trstmh/traf088","url":null,"abstract":"Malaria is a complex disease and transmission can be prevented in multiple ways. A range of interventions to achieve this became widely available from the year 2000, and cases continually declined, but progress has plateaued since 2015. This review aims to cover the population-level prevention strategies responsible for this and those that could continue this progress, focussing on how they can be successfully integrated. Insecticide-treated nets (ITNs) made the most substantial contribution to reducing malaria mortality, but their distribution, access and use remains suboptimal while development of insecticide resistance requires continuous adaptation. Chemoprevention provides protections to tens of millions of people, primarily children in sub-Saharan Africa, but is also threatened by the emergence and spread of drug resistance. These strategies may have reached a point of saturation for reducing morbidity and mortality, thus calling for innovative developments to build upon more basic approaches such as accurate early diagnosis, appropriate treatment and improved housing. The R21/Matrix-M vaccine is a significant improvement over the RTS,S/AS01 vaccine, with greater efficacy, lower cost and scalable mass production. Field trials of current monoclonal antibodies (mAbs) suggest that next-generation mAbs could be a promising tool for seasonal chemoprophylaxis. Furthermore, gene drives may have the potential to eradicate entire populations of malaria-transmitting mosquitoes. A multifaceted approach combining these new strategies with traditional approaches (ITNs and chemoprevention) offers a framework to reinvigorate progress towards malaria elimination.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0