Transactions of The Royal Society of Tropical Medicine and Hygiene最新文献_第3页

Chagas disease and mortality in a community-based cohort in Colombia: evidence for age-dependent effect modification. 哥伦比亚社区队列中的恰加斯病和死亡率：年龄依赖性效应修正的证据

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-10-05 DOI: 10.1093/trstmh/trag074

Martha Lucía Díaz, Lyda Z Rojas, Clara Isabel González-Rugeles, Luis Eduardo Echeverría, Sergio Alejandro Gómez-Ochoa

{"title":"Chagas disease and mortality in a community-based cohort in Colombia: evidence for age-dependent effect modification.","authors":"Martha Lucía Díaz, Lyda Z Rojas, Clara Isabel González-Rugeles, Luis Eduardo Echeverría, Sergio Alejandro Gómez-Ochoa","doi":"10.1093/trstmh/trag074","DOIUrl":"10.1093/trstmh/trag074","url":null,"abstract":"Background: Chagas disease (CD), caused by Trypanosoma cruzi, is a leading cause of cardiomyopathy in Latin America. Community-based prospective data on the CD-mortality association remain scarce.Methods: We analysed the ANTORCHA prospective cohort, enrolling individuals from T. cruzi-endemic communities in Santander, Colombia (2015-2025). The primary exposure was serologically confirmed CD; the primary outcome was all-cause mortality. Cox proportional hazards models with hierarchical adjustment and restricted mean survival time (RMST) were used.Results: Among 1509 participants (314 Chagas positive), 81 deaths occurred over a median follow-up of 5.6 y. After full multivariate adjustment, CD was not associated with overall mortality (hazard ratio [HR] 1.02 [95% confidence interval {CI} 0.61 to 1.72]). A significant age-dependent interaction was identified (p=0.007): CD was independently associated with increased mortality among participants <60 y of age (HR 4.96 [95% CI 1.80 to 13.71]) but not among those ≥60 y of age (HR 0.73 [95% CI 0.43 to 1.22]). RMST analysis confirmed an absolute survival loss of 121 d at approximately 10 y of follow-up in the younger subgroup (p=0.02).Conclusions: In this community-based cohort, CD was independently associated with markedly elevated mortality among adults <60 y of age. Younger T. cruzi-positive individuals warrant intensified cardiovascular surveillance.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1058-1067"},"PeriodicalIF":1.6,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of serum and cerebrospinal fluid cytokines in diagnosis and management of pure neuritic leprosy. 血清和脑脊液细胞因子在纯神经性麻风诊断和治疗中的作用。

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-10-05 DOI: 10.1093/trstmh/trag060

Sanjeev K Bhoi, Menka Jha, Yuvraj Lahre, Suvendu Purkait, Gautom K Saharia, Suprava Naik, Priyanka Samal, Pritimayee Behera

{"title":"The role of serum and cerebrospinal fluid cytokines in diagnosis and management of pure neuritic leprosy.","authors":"Sanjeev K Bhoi, Menka Jha, Yuvraj Lahre, Suvendu Purkait, Gautom K Saharia, Suprava Naik, Priyanka Samal, Pritimayee Behera","doi":"10.1093/trstmh/trag060","DOIUrl":"10.1093/trstmh/trag060","url":null,"abstract":"Background: Pure neuritic leprosy (PNL) lacks skin lesions, making diagnosis difficult. This study evaluated nerve histopathology, immunohistochemistry, serum and cerebrospinal fluid (CSF) cytokines in PNL diagnosis and management.Methods: In this prospective single-centre observational study conducted over 3 years, patients with mononeuropathy or mononeuropathy multiplex were screened. Diagnosis of PNL was based on clinical, electrophysiological, and nerve biopsy findings. Histopathology, immunohistochemistry, and immunofluorescence were performed. Serum and CSF levels of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-6, interleukin-10 (IL-10), and interleukin-1β were measured at baseline and after 3 months of therapy.Results: Among 83 screened patients, 45 were diagnosed with PNL. Most patients were male (84.44%) with a mean age of 44.98±15.03 years. Mononeuritis multiplex was observed in 44.44%. Post-treatment at 3 months reductions in serum and CSF IFN-γ and IL-10 were observed. CSF IFN-γ (p = .008) and IL-10 (p = .04) correlated significantly with clinical improvement. TNF-α negatively correlated with bacillary index (r = -0.448, p = .048), whereas IFN-γ showed a positive correlation (r = 0.673, p = .001).Conclusion: Elevated serum and CSF cytokine levels in pure neuritic leprosy decline after therapy, highlighting their potential role in diagnosis and treatment monitoring. Cytokine profiling with immunohistochemistry may support early diagnosis and treatment monitoring in pure neuritic leprosy.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1021-1026"},"PeriodicalIF":1.6,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac arrest revealing an occult interventricular septal hydatid cyst in a child. 心脏骤停显示儿童隐匿室间隔包虫囊肿。

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-10-05 DOI: 10.1093/trstmh/trag065

Emine Pinar Kulluoglu, Fatih Durak

引用次数: 0

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-10-01 DOI: 10.1093/trstmh/trag114

Santiago Pemberty, Stefani Piedrahita, Paola Muñoz-Laiton, Nelson Naranjo-Díaz, Ana María Vásquez, Margarita M Correa

{"title":"Malaria-related sociodemographic and socio-economic characteristics in two peri-urban Colombian Pacific neighbourhoods.","authors":"Santiago Pemberty, Stefani Piedrahita, Paola Muñoz-Laiton, Nelson Naranjo-Díaz, Ana María Vásquez, Margarita M Correa","doi":"10.1093/trstmh/trag114","DOIUrl":"https://doi.org/10.1093/trstmh/trag114","url":null,"abstract":"Background: Malaria constitutes an important public health problem in peri-urban neighbourhoods of Quibdó, Chocó Department, one of the most deprived areas of Colombia. This study evaluated sociodemographic and socio-economic characteristics and Plasmodium infection in two peri-urban neighbourhoods of Quibdó.Methods: A survey was provided to 136 individuals selected by non-probabilistic convenience sampling to evaluate sociodemographic, socio-economic and clinical aspects as well as Plasmodium infection and malaria prevention practices. Relationships between variables and Plasmodium infection were evaluated by an exploratory analysis.Results: Among participants, the malaria positivity rate was 8.8%. Northern participants mainly stayed/worked indoors, had better infrastructure and services, had access to bed nets and presented lower infection frequencies. Among the southern, more deprived population, outdoor work predominated; they experienced structural and protection resource gaps. Half of Plasmodium-infected participants had subclinical infection and nearly half carried gametocytes. Higher Plasmodium infection frequency was related with male sex, southern residence, lacking a bed net and deficient infrastructure.Conclusions: The results helped to identify the main sociodemographic and socio-economic characteristics relevant to transmission in peri-urban areas of Quibdó; they provide a preliminary perspective to strengthen control and prevention interventions through public health approaches and community participation.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malaria vaccines are here-can surveillance keep pace? 疟疾疫苗已经有了——监测能否跟上？

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-09-30 DOI: 10.1093/trstmh/trag118

Shrikant Nema, Praveen Kumar Bharti, Asif Mohmmed, Pawan Malhotra

引用次数: 0

Estimating age-stratified measles susceptibility using the screening method: an example from 2018-21 measles resurgence in Brazil. 使用筛查方法估计年龄分层麻疹易感性：以巴西2018-21年麻疹复发为例

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-09-29 DOI: 10.1093/trstmh/trag116

Denise Cammarota, Renato Mendes Coutinho, Roberto André Kraenkel

{"title":"Estimating age-stratified measles susceptibility using the screening method: an example from 2018-21 measles resurgence in Brazil.","authors":"Denise Cammarota, Renato Mendes Coutinho, Roberto André Kraenkel","doi":"10.1093/trstmh/trag116","DOIUrl":"https://doi.org/10.1093/trstmh/trag116","url":null,"abstract":"Objectives: Characterizing susceptibility profiles across age groups and administrative units is essential for targeted vaccination and control of resurgent vaccine-preventable diseases like measles, but is often limited by the lack of historical vaccination records.Methods: We proposed a methodology based on the screening method that uses routine surveillance data, such as case age and vaccination status, along with an estimate of vaccine effectiveness, to estimate age-stratified susceptibility to a vaccine-preventable disease.Results: Applying this method to the 10 most affected Brazilian municipalities by measles resurgence in 2018-21, we signal municipalities that have a population immunity below the herd immunity threshold, along with the age groups with the largest susceptible cohorts. Some municipalities show an overall large susceptibility, while others concentrate susceptible individuals in the age cohorts >20 years, as a result of past low vaccine coverage.Conclusion: The proposed methodology is a low-cost tool to estimate susceptibility using readily available surveillance data, allowing for identification of susceptible age cohorts, even in the absence of historical vaccination data. The results obtained offer actionable insights for designing vaccination strategies in Brazil as well as similar epidemiological contexts, as the methodology can be easily applied on similar datasets.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent shifts in infectious-disease mortality across BRICS, 1990-2023: a GBD 2023 analysis. 1990-2023年金砖国家传染病死亡率的近期变化：GBD 2023分析

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-09-26 DOI: 10.1093/trstmh/trag115

Minhong Yin, Guodong Sun, Ronghua Huang, Huijuan Cheng

{"title":"Recent shifts in infectious-disease mortality across BRICS, 1990-2023: a GBD 2023 analysis.","authors":"Minhong Yin, Guodong Sun, Ronghua Huang, Huijuan Cheng","doi":"10.1093/trstmh/trag115","DOIUrl":"https://doi.org/10.1093/trstmh/trag115","url":null,"abstract":"Objectives: BRICS countries carry a substantial infectious-disease burden, but evidence spanning the pandemic and early post-pandemic period remains limited.Methods: Data were obtained from the Global Burden of Disease 2023 Results Tool. Infectious diseases were classified into five categories: HIV/AIDS and sexually transmitted infections (HIV/STIs); respiratory infections and tuberculosis (RITB); enteric infections; neglected tropical diseases and malaria (NTDs/malaria); and other infectious diseases. Deaths, age-standardized mortality rates, and age-specific mortality rates were analysed for BRICS countries from 1990 to 2023. Temporal trends were quantified using the estimated annual percentage change.Results: Infectious-disease deaths in BRICS declined from 5.014 million in 1990 to 2.574 million in 2023, and the BRICS share of global infectious-disease deaths decreased from 40% to 31%. Patterns differed by disease and country. HIV/AIDS and sexually transmitted infection deaths increased by 564.65%, with adverse age-standardized trends in South Africa, Russia, China, and India. Respiratory infections and tuberculosis increased in Brazil, Russia, and South Africa, whereas China and India maintained long-term declines. Enteric infections decreased in all five countries. Except for HIV/AIDS and sexually transmitted infections, mortality became increasingly concentrated at older ages by 2023.Conclusion: BRICS achieved major reductions in infectious-disease mortality, but progress was uneven. Post-pandemic control should prioritize HIV-related mortality, respiratory infection and tuberculosis recovery, and age-sensitive prevention.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suboptimal management of Staphylococcus aureus bacteremia: a retrospective case series from a Nigerian tertiary hospital. 金黄色葡萄球菌菌血症的次优管理：尼日利亚一家三级医院的回顾性病例系列。

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-09-18 DOI: 10.1093/trstmh/trag111

Abdulmalik Murtala Garba, Garba Iliyasu, Aminu Bashir Mohammad, Abdulrazaq Garba Habib

引用次数: 0

Detection of monkeypox virus in persons presenting skin lesions; benefits of One Health in passive surveillance. 出现皮损者猴痘病毒检测；“同一个健康”在被动监测中的好处

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-09-17 DOI: 10.1093/trstmh/trag112

Clement A Meseko, Sadiq Yahaya, Bulus Mwanvwot, Nicodemus Mkpuma, Banenat B Dogonyaro, Dorcas Gado, Nanven Maurice, Mark Samson, Dennis Kabantiyok, Maren Damala, Adeyinka Adedeji

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Transactions of the Royal Society of Tropical Medicine and Hygiene: The study that proved the causative agent of Sri Lankan cutaneous leishmaniasis is Leishmania donovani. 《皇家热带医学与卫生学会学报》：研究证明斯里兰卡皮肤利什曼病的病原体是多诺瓦利什曼原虫。

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-09-15 DOI: 10.1093/trstmh/trag113

Chamarika Jayanetti Weerasekera

引用次数: 0