Transactions of The Royal Society of Tropical Medicine and Hygiene最新文献_第3页

Assessment of uptake of sulphadoxine-pyrimethamine for intermittent preventive treatment among pregnant women in Osun State, Nigeria. 尼日利亚奥孙州孕妇间歇性预防治疗磺胺乙胺嘧啶使用情况评估。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-10-14 DOI: 10.1093/trstmh/trae076

Adebanjo J Adegbola, Ruth M Ogboye, Omotade A Ijarotimi, Akaninyene E Ubom, Bukola A Adesoji, Oluseye O Bolaji

{"title":"Assessment of uptake of sulphadoxine-pyrimethamine for intermittent preventive treatment among pregnant women in Osun State, Nigeria.","authors":"Adebanjo J Adegbola, Ruth M Ogboye, Omotade A Ijarotimi, Akaninyene E Ubom, Bukola A Adesoji, Oluseye O Bolaji","doi":"10.1093/trstmh/trae076","DOIUrl":"https://doi.org/10.1093/trstmh/trae076","url":null,"abstract":"Background: About 32 million pregnant women are at the risk of malaria infection yearly in malaria-endemic sub-Saharan Africa. To mitigate the risks associated with malaria in pregnancy, the WHO recommends ≥3 doses of intermittent preventive treatment in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP), covering from the second trimester of pregnancy until delivery.Methods: This cross-sectional study assessed the uptake and extent of adherence with IPTp-SP among pregnant women in Osun State, Nigeria, from October 2020 to March 2021. Assessment of the uptake was done by extracting information from the validated case report forms. Venous blood samples were obtained to assess the levels of sulphadoxine in plasma through HPLC-UV.Results: In total, 49.24%, 38.17% and 12.58% of the study participants obtained 1, 2 and ≥3 doses of IPTp-SP, respectively. In assessing the extent of adherence, 46.67% obtained their last dose within 28 d before sample collection. Uptake of IPTp-SP is not associated with gravidity (p=0.603), but is weakly associated with the age of the study participants (p=0.04). The median (IQR) plasma sulphadoxine concentration was 10.6248 (2.8124-27.1242) ug/mL.Conclusions: Utilisation of the intervention is still very low and adherence appears to be inadequate among the study population, suggesting that more advocacy on the IPTp-SP strategy and the implementation of directly observed therapy is necessary.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lagged effects of climate factors on bacillary dysentery in western China. 气候因素对中国西部细菌性痢疾的滞后效应。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-10-11 DOI: 10.1093/trstmh/trae064

Rui Li, Dongpeng Liu, Tingrong Wang, Donghua Li, Tianshan Shi, Xin Zhao, Hongmiao Zheng, Xiaowei Ren

{"title":"Lagged effects of climate factors on bacillary dysentery in western China.","authors":"Rui Li, Dongpeng Liu, Tingrong Wang, Donghua Li, Tianshan Shi, Xin Zhao, Hongmiao Zheng, Xiaowei Ren","doi":"10.1093/trstmh/trae064","DOIUrl":"https://doi.org/10.1093/trstmh/trae064","url":null,"abstract":"Background: Evidence has shown that the incidence of bacillary dysentery (BD) is associated with climatic factors. However, the lagged effects of climatic factors on BD are still unclear, especially lacking research evidence from arid and semi-arid regions. Therefore, this study aims to add new insights into this research field.Methods: Spatial autocorrelation, time series analysis and spatiotemporal scans were used to perform descriptive analyses of BD cases from 2009 to 2019. On the basis of monthly data from 2015 to 2019, multivariable distributed lag non-linear models were used to investigate the lagged effects of climatic factors on BD.Results: The hot spots for BD incidence are gradually decreasing and becoming increasingly concentrated in the southern part of Gansu Province. The maximum cumulative relative risks for monthly average temperature, sunshine duration, average relative humidity and precipitation were 3.21, 1.64, 1.55 and 1.41, respectively. The lagged effects peaked either in the current month or with a 1-month lag, and the shape of the exposure-response curve changed with the increase in maximum lag time. After stratification by per capita gross domestic product, there were differences in the effects.Conclusions: Climatic factors can influence the incidence of BD, with effects varying across different lag times. It is imperative to vigilantly track the disparities in the incidence of BD attributable to economic factors.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rectal artesunate: lives not saved. 直肠青蒿琥酯：没有挽救生命。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-10-01 DOI: 10.1093/trstmh/trae036

N J White, T Peto, J A Watson

引用次数: 0

Comparative functional characterization and in vitro immunological cross-reactivity studies on Daboia russelii and Craspedocephalus malabaricus venom. Daboia russelii 和 Craspedocephalus malabaricus 毒液的功能特性比较和体外免疫交叉反应研究。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-10-01 DOI: 10.1093/trstmh/trae038

Karthika Rajan, Aswathy Alangode, Jaideep C Menon, Dileepkumar Raveendran, Sudarslal Sadasivan Nair, Margaret Reick, Bipin Gopalakrishnan Nair, Martin Reick, Muralidharan Vanuopadath

{"title":"Comparative functional characterization and in vitro immunological cross-reactivity studies on Daboia russelii and Craspedocephalus malabaricus venom.","authors":"Karthika Rajan, Aswathy Alangode, Jaideep C Menon, Dileepkumar Raveendran, Sudarslal Sadasivan Nair, Margaret Reick, Bipin Gopalakrishnan Nair, Martin Reick, Muralidharan Vanuopadath","doi":"10.1093/trstmh/trae038","DOIUrl":"10.1093/trstmh/trae038","url":null,"abstract":"Background: Snake venom is a complex mixture of organic and inorganic constituents, including proteins and peptides. Several studies showed that antivenom efficacy differs due to intra- and inter-species venom variation.Methods: In the current study, comparative functional characterization of major enzymatic proteins present in Craspedocephalus malabaricus and Daboia russelii venom was investigated through various in vitro and immunological cross-reactivity assays.Results: The enzymatic assays revealed that hyaluronidase and phospholipase A2 activities were markedly higher in D. russelii. By contrast, fibrinogenolytic, fibrin clotting and L-amino acid oxidase activities were higher in C. malabaricus venom. ELISA results suggested that all the antivenoms had lower binding potential towards C. malabaricus venom. For D. russelii venom, the endpoint titration value was observed at 1:72 900 for all the antivenoms. In the case of C. malabaricus venom, the endpoint titration value was 1:2700, except for Biological E (1:8100). All these results, along with the avidity assays, indicate the strength of venom-antivenom interactions. Similarly, the western blot results suggest that all the antivenoms showed varied efficacies in binding and detecting the venom antigenic epitopes in both species.Conclusions: The results highlight the need for species-specific antivenom to better manage snakebite victims.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141301661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Community engagement around scrub typhus in northern Thailand: a pilot project. 泰国北部恙虫病社区参与：试点项目。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-10-01 DOI: 10.1093/trstmh/trae028

Carlo Perrone, Nipaphan Kanthawang, Phaik Yeong Cheah, Daranee Intralawan, Sue J Lee, Supalert Nedsuwan, Benjarat Fuwongsitt, Tri Wangrangsimakul, Rachel C Greer

{"title":"Community engagement around scrub typhus in northern Thailand: a pilot project.","authors":"Carlo Perrone, Nipaphan Kanthawang, Phaik Yeong Cheah, Daranee Intralawan, Sue J Lee, Supalert Nedsuwan, Benjarat Fuwongsitt, Tri Wangrangsimakul, Rachel C Greer","doi":"10.1093/trstmh/trae028","DOIUrl":"10.1093/trstmh/trae028","url":null,"abstract":"Background: Scrub typhus is highly endemic in northern Thailand yet awareness and knowledge are low. We developed a community engagement project to improve awareness in communities at risk of contracting scrub typhus.Methods: We conducted a series of engagement sessions with healthcare workers and community health volunteers so they would, in turn, engage with their communities. We evaluated our activities by assessing the increase in scrub typhus knowledge, using a series of Likert-scale items and open-ended questions. Three to 6 months after the sessions, participants were followed up to collect their experiences training community members.Results: Of 134 participants who took part in eight sessions, 87.3% were community health volunteers. Disease knowledge increased substantially after the sessions and was well maintained for up to 5 mo. Satisfaction was high and, through participant feedback, engagement materials were improved to be more useful to the communities. People with higher education had higher scores and retention.Conclusions: Community engagement was shown to be an effective tool to develop and carry out health-promoting activities in a culturally and context-appropriate manner.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140870226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Presence of Trypanosoma cruzi TcI and Trypanosoma dionisii in sylvatic bats from Yucatan, Mexico. 墨西哥尤卡坦半岛的蝙蝠体内存在克氏锥虫 TcI 和狄奥尼斯锥虫。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-10-01 DOI: 10.1093/trstmh/trae023

Joel Israel Moo-Millan, Weihong Tu, Teresa de Jesús Montalvo-Balam, Martha Pilar Ibarra-López, Silvia Hernández-Betancourt, Irving Jesús May-Concha, Carlos Napoleón Ibarra-Cerdeña, Christian Barnabé, Eric Dumonteil, Etienne Waleckx

{"title":"Presence of Trypanosoma cruzi TcI and Trypanosoma dionisii in sylvatic bats from Yucatan, Mexico.","authors":"Joel Israel Moo-Millan, Weihong Tu, Teresa de Jesús Montalvo-Balam, Martha Pilar Ibarra-López, Silvia Hernández-Betancourt, Irving Jesús May-Concha, Carlos Napoleón Ibarra-Cerdeña, Christian Barnabé, Eric Dumonteil, Etienne Waleckx","doi":"10.1093/trstmh/trae023","DOIUrl":"10.1093/trstmh/trae023","url":null,"abstract":"Background: Chagas disease is caused by Trypanosoma cruzi, whose genetic structure is divided into six discrete typing units (DTUs) known as TcI-TcVI. In the Yucatan Peninsula, Mexico, information regarding the DTUs circulating in wild mammals is scarce, while this is important knowledge for our understanding of T. cruzi transmission dynamics.Methods: In the current study, we sampled wild mammals in a sylvatic site of the Yucatan Peninsula and assessed their infection with T. cruzi by PCR. Then, for infected mammals, we amplified and sequenced nuclear and mitochondrial T. cruzi genetic markers for DTU identification.Results: In total, we captured 99 mammals belonging to the orders Chiroptera, Rodentia and Didelphimorphia. The prevalence of infection with T. cruzi was 9% (9/99; 95% CI [5, 16]), and we identified TcI in a Jamaican fruit bat, Artibeus jamaicensis. Moreover, we fortuitously identified Trypanosoma dionisii in another Jamaican fruit bat and detected an unidentified Trypanosoma species in a third specimen. While the latter discoveries were not expected because we used primers designed for T. cruzi, this study is the first to report the identification of T. dionisii in a bat from Yucatan, Mexico, adding to a recent first report of T. dionisii in bats from Veracruz, and first report of this Trypanosoma species in Mexico.Conclusion: Further research is needed to enhance our knowledge of T. cruzi DTUs and Trypanosoma diversity circulating in wildlife in Southeastern Mexico.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of community knowledge, attitudes and stigma towards leprosy in Nigeria: a mixed-methods study. 调查尼日利亚社区对麻风病的认识、态度和成见：一项混合方法研究。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-10-01 DOI: 10.1093/trstmh/trae050

Ngozi Murphy-Okpala, Tahir Dahiru, Chinwe Eze, Charles Nwafor, Ngozi Ekeke, Suleiman Abdullahi, Francis S Iyama, Anthony Meka, Martin Njoku, Okechukwu Ezeakile, Kingsley N Ukwaja, Chukwuma Anyaike, Omayeli Sesere, Joseph Chukwu

{"title":"Investigation of community knowledge, attitudes and stigma towards leprosy in Nigeria: a mixed-methods study.","authors":"Ngozi Murphy-Okpala, Tahir Dahiru, Chinwe Eze, Charles Nwafor, Ngozi Ekeke, Suleiman Abdullahi, Francis S Iyama, Anthony Meka, Martin Njoku, Okechukwu Ezeakile, Kingsley N Ukwaja, Chukwuma Anyaike, Omayeli Sesere, Joseph Chukwu","doi":"10.1093/trstmh/trae050","DOIUrl":"10.1093/trstmh/trae050","url":null,"abstract":"Background: Little is known about community knowledge and stigma towards leprosy in endemic settings. The aim of this study was to evaluate community knowledge, attitudes and stigma towards leprosy in Nigeria.Methods: This was a mixed-methods study consisting of a quantitative cross-sectional survey of community members and qualitative focus group discussions with community members and people affected by leprosy as well as key informant interviews with healthcare workers and community leaders.Results: Of the 811 survey participants, 401 (49.4%) had a poor knowledge of leprosy that was driven by cultural beliefs, fear of its contagiousness and poor knowledge of its means of transmission. The participants reported high stigma levels with a mean score of 18.96±7.73 on the Explanatory Model Interview Catalogue Community Stigma Scale and 9.39±7.03 on the Social Distance Scale. Stigma levels were influenced by age, residence, education and knowledge of leprosy. Qualitative data suggested that community members were scared of leprosy infectiousness, and local illness concepts and misconceptions informed attitudes and behaviour towards leprosy in the community.Conclusion: Community members have a poor knowledge of, and high stigma levels towards leprosy. Culture-specific health education and behavioural change interventions are needed to address the identified gaps.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards enhanced control of mycetoma: a roadmap to achieve the UN's sustainable development goals by 2030. 加强对霉菌瘤的控制：到 2030 年实现联合国可持续发展目标的路线图。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-10-01 DOI: 10.1093/trstmh/trae016

Ahmed Fahal, Dallas J Smith, Borna Nyaoke, Kingsley Asiedu, Fabiana Falves, Supriya Warusavithanas, Daniel Argaw, Roderick Hay

引用次数: 0

Assessing the knowledge, training and capacity of health workers in the diagnosis and management of soil-transmitted helminths and schistosomiasis in eastern Uganda. 评估乌干达东部卫生工作者在诊断和管理土壤传播蠕虫病和血吸虫病方面的知识、培训和能力。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-10-01 DOI: 10.1093/trstmh/trae029

Raymond Bernard Kihumuro, Timothy Mwanje Kintu, Lorna Atimango, Andrew Marvin Kanyike, Joel Bazira

{"title":"Assessing the knowledge, training and capacity of health workers in the diagnosis and management of soil-transmitted helminths and schistosomiasis in eastern Uganda.","authors":"Raymond Bernard Kihumuro, Timothy Mwanje Kintu, Lorna Atimango, Andrew Marvin Kanyike, Joel Bazira","doi":"10.1093/trstmh/trae029","DOIUrl":"10.1093/trstmh/trae029","url":null,"abstract":"Background: Neglected tropical diseases (NTDs) affect millions of people in Africa, with Uganda bearing a significant burden. The World Health Organization (WHO) set a goal to reduce NTDs and improve access to diagnosis and management by 2030. However, NTDs have not been well integrated into primary healthcare in many countries, including Uganda, due to limited knowledge and resources among health workers. The study aimed to assess the readiness and capacity of primary healthcare centres to diagnose and manage soil-transmitted helminths (STHs) and schistosomiasis.Methods: A cross-sectional quantitative study was conducted among 204 health workers in 20 health facilities in four districts bordering Lake Kyoga. In this study we evaluated health workers' knowledge of symptoms, diagnosis and management of STHs and schistosomiasis as well as the availability of resources and training.Results: Our findings indicate that health workers have strong knowledge about STHs (86.76%), with lower knowledge levels regarding Schistosoma haematobium (59.72%) and Schistosoma mansoni (71.43%). Regarding resources and training, 95% of health facilities had laboratory services, but the majority lacked diagnostic equipment. Furthermore, only 17% of health workers reported prior training on schistosomiasis and related topics and only 25% had training on surveillance and reporting.Conclusions: While health workers in eastern Uganda demonstrated a good knowledge base for some NTDs, there were knowledge gaps and challenges in training on surveillance and reporting mechanisms. Continuously building the capacity of health workers along with investing in diagnostic infrastructure is essential for improved NTD control and ultimately reducing associated morbidity and mortality in the region.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptation of lot quality assurance sampling to monitor seasonal malaria chemoprevention delivery performance. 调整批次质量保证抽样，以监测季节性疟疾化学预防的交付绩效。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-10-01 DOI: 10.1093/trstmh/trae051

Sol Richardson, Taiwo Ibinaiye, Olusola Oresanya, Chibuzo Oguoma, Chukwu Okoronkwo, Emanuel Shekarau, Daniel Sprague, Kevin Baker, Monica Anna de Cola, Arantxa Roca-Feltrer, Chuks Nnaji, Christian Rassi

引用次数: 0