Transactions of The Royal Society of Tropical Medicine and Hygiene最新文献

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Impact of geo-climatic factors on the prevalence and diversity of tick fauna in Achai cattle of the northern Hindukush Mountains, Khyber pakhtunkhwa, Pakistan. 地理气候因素对巴基斯坦开伯尔-普赫图赫瓦省兴都库什山脉北部阿柴牛蜱虫动物群的流行和多样性的影响。
IF 1.9 4区 医学
Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-06-05 DOI: 10.1093/trstmh/traf020
Israr Khan, Zia Ur Rehman Khalil, Muhammad Shuaib, Sami Ullah, Irfan Ullah, Obaid Ullah, Shahrood Ahmed Siddiqui, Anthony Pokoo-Aikins, Majid S Jabir, Ayman A Swelum
{"title":"Impact of geo-climatic factors on the prevalence and diversity of tick fauna in Achai cattle of the northern Hindukush Mountains, Khyber pakhtunkhwa, Pakistan.","authors":"Israr Khan, Zia Ur Rehman Khalil, Muhammad Shuaib, Sami Ullah, Irfan Ullah, Obaid Ullah, Shahrood Ahmed Siddiqui, Anthony Pokoo-Aikins, Majid S Jabir, Ayman A Swelum","doi":"10.1093/trstmh/traf020","DOIUrl":"10.1093/trstmh/traf020","url":null,"abstract":"<p><strong>Background: </strong>Ticks are blood-feeding ectoparasites that can transmit different diseases in livestock and humans. Globally, 994 tick species are recognized, belonging to three families, that is, Argasidae (220 species), Ixodidae (773 species) and Nuttalliellidae (one species). The current study investigated the impact of geo-climatic conditions on the prevalence and distribution of ticks in Achai cattle of the northern Hindukush Mountains of Khyber Pakhtunkhwa.</p><p><strong>Methods: </strong>A total of 707 households containing Achai cattle were investigated for the prevalence and distribution of ticks in Achai cattle.</p><p><strong>Results: </strong>The overall prevalence of positive households (388) was 53.46%. Different geo-climatic conditions, such as location, humidity, temperature and altitude, showed a significant impact on the prevalence and distribution of tick fauna. Higher tick prevalence was observed in Achai animals kept at altitudes of 1500-2000 m, 41-50% humidity and 10-20oC. The most prevalent tick species was Rhipicephalus microplus (67.26%), followed by Haemaphysalis montgomeryi (16.75%), under all studied geo-climatic conditions.</p><p><strong>Conclusions: </strong>Achai cattle are mostly susceptible to the tick species R. microplus, which might be due to its richness in the study area. Furthermore, the results regarding the impact of geo-climatic conditions on the diversity and richness of the tick species could be considered in preventive policies for tick control.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"613-622"},"PeriodicalIF":1.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Burden of mycetoma in Burkina Faso: case series and systematic review. 布基纳法索足菌肿负担:病例系列和系统评价。
IF 1.9 4区 医学
Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-06-05 DOI: 10.1093/trstmh/traf015
Abdourahmane Ouangré, Isidore W Yerbanga, Ibrahim Savadogo, Hamado Ouédraogo, Nebon Delphine Bado, André Nagalo, Fagnima Traoré, Abdoul Kader Dem, Sibiri Abdoul Karim Bouda, Djima Fahriane Dora Koulybari, Abdoulaye Sawadogo, Seydou Nakanabo Diallo, Jean-Pierre Gangneux, Ahmed Hassan Fahal, Sanata Bamba
{"title":"Burden of mycetoma in Burkina Faso: case series and systematic review.","authors":"Abdourahmane Ouangré, Isidore W Yerbanga, Ibrahim Savadogo, Hamado Ouédraogo, Nebon Delphine Bado, André Nagalo, Fagnima Traoré, Abdoul Kader Dem, Sibiri Abdoul Karim Bouda, Djima Fahriane Dora Koulybari, Abdoulaye Sawadogo, Seydou Nakanabo Diallo, Jean-Pierre Gangneux, Ahmed Hassan Fahal, Sanata Bamba","doi":"10.1093/trstmh/traf015","DOIUrl":"10.1093/trstmh/traf015","url":null,"abstract":"<p><p>Mycetoma is a chronic inflammatory disease characterized by progressive and devastating granulomatous subcutaneous tissue involvement. It primarily occurs in regions classified within the 'mycetoma belt', encompassing various countries. Notably, West African nations, including Burkina Faso (BF), are situated within this belt, yet there is a significant lack of data regarding mycetoma in these regions. With this background, this study set out to determine the mycetoma prevalence in BF. A comprehensive review was conducted to document the presence of mycetoma in BF. Searches were performed in PubMed, ScienceDirect, African Journals Online (AJOL) and Google Scholar databases. Data were reported following the Preferred Reporting Items for Systematic and Meta-analyses (PRISMA) guidelines. Additionally, the study encompassed a case series involving three patients. From 1960 to 2024, 25 mycetoma cases have been documented in BF. Overall, the clinical cases share similar sociodemographic, clinical, diagnostic, therapeutic and outcome characteristics. Specifically, these cases illustrate that mycetoma predominantly affects vulnerable groups in BF. The majority of mycetoma cases (96%) were reported in the Sahelian zone of BF. Predominantly, these cases (80%) had foot mycetoma. This study highlights the challenges of mycetoma management in BF, indicating significant obstacles in early diagnosis and effective treatment.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"570-577"},"PeriodicalIF":1.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding leprosy: immune response, clinical manifestations and emerging diagnostic approaches. 解码麻风病:免疫反应,临床表现和新兴诊断方法。
IF 1.9 4区 医学
Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-06-04 DOI: 10.1093/trstmh/traf058
Héctor Serrano-Coll, Lina Restrepo-Rivera, Yicenia Cuadros-Urrego, Nora Cardona-Castro
{"title":"Decoding leprosy: immune response, clinical manifestations and emerging diagnostic approaches.","authors":"Héctor Serrano-Coll, Lina Restrepo-Rivera, Yicenia Cuadros-Urrego, Nora Cardona-Castro","doi":"10.1093/trstmh/traf058","DOIUrl":"https://doi.org/10.1093/trstmh/traf058","url":null,"abstract":"<p><p>Leprosy is an infectious disease characterized by a broad immunological spectrum, which underlies its diverse clinical presentations and contributes to the physical and emotional disabilities experienced by patients with leprosy. Understanding the immunopathogenic mechanisms of this disease is essential for interpreting clinical manifestations and conventional diagnostic tests and developing diagnostic strategies for leprosy detection. This review aims to provide an overview of the immune response, clinical features and emerging diagnostic approaches in leprosy.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seroprevalence and risk factors of Anisakis simplex in Makoko schoolchildren: insights from a Lagos, Nigeria slum. 马科科学童单纯异尖线虫的血清患病率和危险因素:来自尼日利亚拉各斯贫民窟的见解。
IF 1.9 4区 医学
Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-05-29 DOI: 10.1093/trstmh/traf055
Chia-Kwung Fan, Ting-Wu Chuang, Hon-Ian Lei, Vincent P Gyang, Tyng-Shiuan Hsieh, Po-Ching Cheng, Chia-Mei Chou, Olaoluwa P Akinwale
{"title":"Seroprevalence and risk factors of Anisakis simplex in Makoko schoolchildren: insights from a Lagos, Nigeria slum.","authors":"Chia-Kwung Fan, Ting-Wu Chuang, Hon-Ian Lei, Vincent P Gyang, Tyng-Shiuan Hsieh, Po-Ching Cheng, Chia-Mei Chou, Olaoluwa P Akinwale","doi":"10.1093/trstmh/traf055","DOIUrl":"https://doi.org/10.1093/trstmh/traf055","url":null,"abstract":"<p><strong>Background: </strong>Anisakis simplex is a parasitic zoonosis associated with consuming raw or undercooked fish. Despite its global relevance, data from Africa are scarce. This study assessed the seroprevalence and risk factors of A. simplex infection among primary schoolchildren (PSC) in Makoko, an urban slum in Lagos, Nigeria.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from November 2013 to March 2014 involving 196 PSC from three government schools. Serodiagnosis was performed using enzyme-linked immunosorbent assay (ELISA) with recombinant Ani s 1 and Ani s 7 allergens. Stool samples were examined for soil-transmitted helminths (STHs) using the Kato-Katz method. Structured questionnaires gathered demographic and dietary information.</p><p><strong>Results: </strong>The overall seroprevalence of A. simplex infection was 12.25%. No significant association was found with gender or raw fish consumption. However, parental education and occupation influenced seropositivity. Interestingly, co-infection with STHs was inversely associated with A. simplex seropositivity. ELISA demonstrated high specificity with minimal cross-reactivity to STHs.</p><p><strong>Conclusions: </strong>This study provides the first seroepidemiological data on A. simplex in Nigerian children. Public health interventions, particularly fish-handling education, are warranted. Further research is needed to understand the clinical relevance of A. simplex sensitization in African settings.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An enigmatic case of lepromatous leprosy: unveiling the role of inoculation. 一个谜样的麻风病病例:揭示接种的作用。
IF 1.9 4区 医学
Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-05-24 DOI: 10.1093/trstmh/traf054
Kiranmayee Chandaluri, Sudhir Babu Karri, Vinod Hanumanthu
{"title":"An enigmatic case of lepromatous leprosy: unveiling the role of inoculation.","authors":"Kiranmayee Chandaluri, Sudhir Babu Karri, Vinod Hanumanthu","doi":"10.1093/trstmh/traf054","DOIUrl":"https://doi.org/10.1093/trstmh/traf054","url":null,"abstract":"","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hydroxynaphthol blue-based loop-mediated isothermal amplification for the rapid detection of Burkholderia pseudomallei. 基于羟基酚蓝的环介导等温扩增快速检测假马氏伯克氏菌。
IF 1.9 4区 医学
Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-05-23 DOI: 10.1093/trstmh/traf053
Wiphat Klayut, Panatda Aramrueang, Benjawan Phetsuksiri, Sopa Srisungngam, Watcharee Saisongkorh, Ballang Uppapong, Janisara Rudeeaneksin
{"title":"Hydroxynaphthol blue-based loop-mediated isothermal amplification for the rapid detection of Burkholderia pseudomallei.","authors":"Wiphat Klayut, Panatda Aramrueang, Benjawan Phetsuksiri, Sopa Srisungngam, Watcharee Saisongkorh, Ballang Uppapong, Janisara Rudeeaneksin","doi":"10.1093/trstmh/traf053","DOIUrl":"https://doi.org/10.1093/trstmh/traf053","url":null,"abstract":"<p><strong>Background: </strong>Melioidosis is a potentially life-threatening disease caused by Burkholderia pseudomallei. It is endemic in Southeast Asia and northern Australia and is increasingly distributed in other tropical and subtropical regions. Fast and accurate detection of B. pseudomallei is crucial for initiating prompt and effective treatment.</p><p><strong>Methods: </strong>Loop-mediated isothermal amplification (LAMP) using hydroxynaphthol blue (HNB) for visual detection has been developed and evaluated to detect B. pseudomallei.</p><p><strong>Results: </strong>The assay amplified B. pseudomallei TTSS1-orf2 at 63°C with a 60-min reaction and no cross-amplification was observed. The detection limit was 1.85×102 fg/µl of B. pseudomallei DNA or 2.08×102 CFU/ml of B. pseudomallei spiked in blood, sputum and urine samples. Clinical evaluation using 191 residual specimens revealed 100% negative agreement in detecting 48 of 49 culture-positive samples. Overall, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value were 97.96%, 100%, 99.48%, 100% and 99.30%, respectively, while the κ index showed substantial agreement with the culture method (κ=0.99).</p><p><strong>Conclusions: </strong>This LAMP assay demonstrated good performance, with easy operation and low cost for the rapid detection of B. pseudomallei. It has the potential to be an alternative molecular tool for the early diagnosis of melioidosis in clinical settings.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Projecting high-level dengue increases during low-incidence months in a large endemic urban area. 预测登革热在大城市流行地区的低发病率月份出现高水平上升。
IF 1.9 4区 医学
Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-05-22 DOI: 10.1093/trstmh/traf052
Alexandre Cunha Costa, José Micael Ferreira da Costa, Rafaella Pessoa Moreira, Tahissa Frota Cavalcante, Luiz Martins de Araújo Júnior, Thamara Kely de Sousa Fernandes, Glauciano de Oliveira Ferreira, Jéssica Silva, Cleiton da Silva Silveira, Luciano Pamplona de Góes Cavalcanti
{"title":"Projecting high-level dengue increases during low-incidence months in a large endemic urban area.","authors":"Alexandre Cunha Costa, José Micael Ferreira da Costa, Rafaella Pessoa Moreira, Tahissa Frota Cavalcante, Luiz Martins de Araújo Júnior, Thamara Kely de Sousa Fernandes, Glauciano de Oliveira Ferreira, Jéssica Silva, Cleiton da Silva Silveira, Luciano Pamplona de Góes Cavalcanti","doi":"10.1093/trstmh/traf052","DOIUrl":"https://doi.org/10.1093/trstmh/traf052","url":null,"abstract":"<p><strong>Background: </strong>Climate change projections impact dengue transmission in tropical regions, creating diverse and complex public health challenges. The aim of this study was to project future seasonal dengue incidence in a large tropical urban area of Brazil, where dengue is endemic, by systematically analyzing climatic and dengue case time series.</p><p><strong>Methods: </strong>An epidemiological dengue model was developed using time series analysis techniques and forced with statistical downscaling from various Coupled Model Intercomparison Project Phase 6 (CMIP6) climate models based on Shared Socioeconomic Pathway (SSP) scenarios for the late twenty-first century (2071-2100). The ecological time-series investigation analyzed 193 618 dengue cases from January 2008 to December 2018. Statistical downscaling transformed low-resolution Global Climate Models' outputs into high-resolution data, based on a 30-y climate baseline.</p><p><strong>Results: </strong>The results indicated significant climate changes in seasonal temperature and precipitation by the end of the century. Under both SSP2-4.5 and SSP5-8.5 scenarios, substantial increases in dengue cases are projected during current low-incidence months, resulting in a reduced seasonality of dengue.</p><p><strong>Conclusions: </strong>The findings represent considerable challenges for future public health systems, which may face sustained high levels of dengue incidence throughout the year.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vulnerability of French overseas territories: the 2018-2022 hepatitis A outbreak in New Caledonia. 法国海外领土的脆弱性:新喀里多尼亚2018-2022年甲型肝炎爆发。
IF 1.9 4区 医学
Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-05-20 DOI: 10.1093/trstmh/traf051
Ann-Claire Gourinat, Laura Dupont, Noémie Bargeolle, Anne Pfannstiel, Charlotte Duval, Vincent Portet-Sulla, Lina Mouna, Arnaud Cannet, Anne-Marie Roque-Afonso
{"title":"Vulnerability of French overseas territories: the 2018-2022 hepatitis A outbreak in New Caledonia.","authors":"Ann-Claire Gourinat, Laura Dupont, Noémie Bargeolle, Anne Pfannstiel, Charlotte Duval, Vincent Portet-Sulla, Lina Mouna, Arnaud Cannet, Anne-Marie Roque-Afonso","doi":"10.1093/trstmh/traf051","DOIUrl":"https://doi.org/10.1093/trstmh/traf051","url":null,"abstract":"<p><strong>Background: </strong>Hepatitis A virus (HAV) typically causes asymptomatic infection, especially in children <6 y of age. New Caledonia has low HAV endemicity, but a surge in cases between 2018 and 2022 prompted an analysis of epidemiological and virological features.</p><p><strong>Methods: </strong>A retrospective study analysed confirmed HAV cases (2018-2022), examining demographics, hospitalisations and alanine aminotransferase (ALT) levels. Phylogenetic analysis was conducted on isolated strains.</p><p><strong>Results: </strong>In mid-2018, imported cases from Vanuatu triggered the outbreak. Higher incidence rates were observed in the Loyalty Islands, particularly Maré Island, with subsequent spread to other areas. From 2018 to 2022, 672 cases were identified, with a median age of 13 y. Children <6 y of age accounted for 8.9% of cases, those ages 6-14 y for 54.2% and individuals ≥15 y for 36.9%. Hospitalisation occurred in 32.3% of cases. ALT levels were higher in hospitalised patients (p<0.001), but children <5 y of age had lower ALT levels overall. HAV genotyping from 16 available sera revealed subgenotype IA strains, with 14 of them linked to Vanuatu.</p><p><strong>Conclusions: </strong>The outbreak, triggered by imported strains from Vanuatu, was facilitated by environmental and infrastructural vulnerabilities. It highlights the need for improved vaccination, especially for travellers, and the critical role of water management in preventing future outbreaks. This also underscores the importance of tracking viral circulation in the Pacific region.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis of Plasmodium falciparum malaria at very low parasitaemias using a commercially available LAMP assay and RDT. 利用市售LAMP检测和RDT诊断恶性疟原虫疟疾的极低寄生虫血症。
IF 1.9 4区 医学
Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-05-20 DOI: 10.1093/trstmh/traf050
Ruth O Payne, Nick J Edwards, Yrene Themistocleous, Sarah E Silk, Jordan R Barrett, Thomas A Rawlinson, Ian W Lim, Simon J Draper, Angela M Minassian
{"title":"Diagnosis of Plasmodium falciparum malaria at very low parasitaemias using a commercially available LAMP assay and RDT.","authors":"Ruth O Payne, Nick J Edwards, Yrene Themistocleous, Sarah E Silk, Jordan R Barrett, Thomas A Rawlinson, Ian W Lim, Simon J Draper, Angela M Minassian","doi":"10.1093/trstmh/traf050","DOIUrl":"https://doi.org/10.1093/trstmh/traf050","url":null,"abstract":"<p><strong>Background: </strong>Malaria is the most common tropical infection in the UK. Current guidelines suggest that testing on 3 consecutive days is required following an initial negative result. This study aimed to see whether newer diagnostics (loop-mediated amplification assay [LAMP]) had sufficient sensitivity to support a change in diagnostic practice.</p><p><strong>Methods: </strong>Blood samples from 11 participants who had undergone controlled human malaria infection (CHMI) with Plasmodium falciparum malaria were assessed from day 6 (C+6) for malaria positivity using the Carestart Malaria rapid diagnostic test (RDT) and from C+4 using the Alethia Malaria LAMP assay. Quantitative polymerase chain reaction had been performed twice daily during CHMI follow-up. A retrospective analysis of samples submitted to the Sheffield Teaching Hospitals for malaria testing over a 5-y period was conducted, evaluating the combination of the Carestart RDT alongside blood film analysis, as per UK guidelines.</p><p><strong>Results: </strong>In CHMI samples, LAMP was positive for all parasitaemias >1000 parasites/ml, whereas RDTs were less reliable (59% positive for parasitaemias >1000 parasites/ml). The combination of RDT and blood films for clinical samples diagnosed most infections, but only a minority of negative samples had subsequent tests.</p><p><strong>Conclusions: </strong>LAMP has higher sensitivity than current UK recommended methods, with a potential to review the requirement for additional days of testing in the majority of patients.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ending nuclear weapons, before they end us†. 在核武器终结我们之前终结它们。
IF 1.9 4区 医学
Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-05-19 DOI: 10.1093/trstmh/traf047
Kamran Abbasi, Parveen Ali, Virginia Barbour, Marion Birch, Inga Blum, Peter Doherty, Andy Haines, Ira Helfand, Richard Horton, Kati Juva, Jose F Lapena, Robert Mash, Olga Mironova, Arun Mitra, Carlos Monteiro, Elena N Naumova, David Onazi, Tilman Ruff, Peush Sahni, James Tumwine, Carlos Umaña, Paul Yonga, Chris Zielinski
{"title":"Ending nuclear weapons, before they end us†.","authors":"Kamran Abbasi, Parveen Ali, Virginia Barbour, Marion Birch, Inga Blum, Peter Doherty, Andy Haines, Ira Helfand, Richard Horton, Kati Juva, Jose F Lapena, Robert Mash, Olga Mironova, Arun Mitra, Carlos Monteiro, Elena N Naumova, David Onazi, Tilman Ruff, Peush Sahni, James Tumwine, Carlos Umaña, Paul Yonga, Chris Zielinski","doi":"10.1093/trstmh/traf047","DOIUrl":"https://doi.org/10.1093/trstmh/traf047","url":null,"abstract":"","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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