The activity of combinations of currently used antigiardial drugs against Giardia duodenalis.

IF 1.5 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-18 DOI:10.1093/trstmh/traf101

Keely Fayd'Herbe, Chun Kit Lam, Christopher J S Hart, Tina S Skinner-Adams

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引用次数: 0

Abstract

Background: Drug-combination therapies are needed to combat treatment refractory giardiasis. However, data describing the activity of combinations of currently used drugs against Giardia duodenalis are unavailable.

Methods: The in vitro activity of combinations of currently used antigiardial drugs were investigated against G. duodenalis.

Results: Combinations of metronidazole with albendazole or quinacrine, and quinacrine with nitazoxanide, behaved additively, whereas combinations of metronidazole with nitazoxanide, albendazole or quinacrine behaved synergistically. Combinations of albendazole with nitazoxanide behaved antagonistically.

Conclusions: While combinations of metronidazole with nitazoxanide, or albendazole with quinacrine, may be effective treatments of giardiasis, combinations of albendazole with nitazoxanide are likely to result in negative pharmacodynamic interactions.

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目前使用的抗贾第虫药物联合治疗十二指肠贾第虫的活性。

背景：需要药物联合治疗来对抗难治性贾第虫病。然而，描述目前使用的药物联合治疗十二指肠贾第鞭毛虫活性的数据是不可获得的。方法：观察常用抗心绞痛药物联合用药对十二指肠巨噬菌的体外活性。结果：甲硝唑与阿苯达唑或阿苯达唑合用、阿苯达唑与硝唑昔宁合用表现为相加性，甲硝唑与硝唑昔宁、阿苯达唑昔宁合用表现为协同性。阿苯达唑与硝唑昔尼特联用具有拮抗作用。结论：甲硝唑与硝唑尼特合用或阿苯达唑与奎阿克里合用可能是治疗贾第虫病的有效方法，但阿苯达唑与硝唑尼特合用可能产生负的药效学相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transactions of The Royal Society of Tropical Medicine and Hygiene 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.00

自引率

9.10%

发文量

115

审稿时长

4-8 weeks

期刊介绍： Transactions of the Royal Society of Tropical Medicine and Hygiene publishes authoritative and impactful original, peer-reviewed articles and reviews on all aspects of tropical medicine.