Transactions of The Royal Society of Tropical Medicine and Hygiene最新文献_第10页

Phototherapy in lymphoproliferative and inflammatory diseases associated with human T-lymphotropic virus. 与人t淋巴细胞嗜性病毒相关的淋巴增生性和炎性疾病的光疗

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-10 DOI: 10.1093/trstmh/traf009

Brena Andrade de Lima Lobato, João Augusto Gomes de Souza Monteiro de Brito, José Maria de Castro Abreu Junior, Maísa Silva de Sousa, Carlos Augusto Moreira Silva, Thiago Xavier Carneiro, Rita Catarina Medeiros Sousa, Marília Brasil Xavier

{"title":"Phototherapy in lymphoproliferative and inflammatory diseases associated with human T-lymphotropic virus.","authors":"Brena Andrade de Lima Lobato, João Augusto Gomes de Souza Monteiro de Brito, José Maria de Castro Abreu Junior, Maísa Silva de Sousa, Carlos Augusto Moreira Silva, Thiago Xavier Carneiro, Rita Catarina Medeiros Sousa, Marília Brasil Xavier","doi":"10.1093/trstmh/traf009","DOIUrl":"https://doi.org/10.1093/trstmh/traf009","url":null,"abstract":"Background: Dermatological manifestations affect 5% of patients with human T-lymphotropic virus (HTLV).Methods: Thirteen patients with inflammatory or lymphoproliferative dermatological diseases, both HTLV-positive and HTLV-negative, were selected for treatment with ultraviolet B narrowband (UVB-NB) phototherapy. Clinical and histopathological evaluations were conducted before and after 120 d of phototherapy.Results: All seven HTLV-positive patients evaluated were type 1. Clinical evaluation showed improvement in all 13 patients. In the histopathological examination, all patients with lymphoproliferative diseases and five with inflammatory diseases showed regression in most of the assessed parameters.Conclusions: The present research suggests that UVB-NB phototherapy is a promising treatment for lymphoproliferative and inflammatory skin diseases in HTLV-1 patients.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From relief to resistance: implications of self-medication practice for malaria elimination in India. 从缓解到抵抗：印度自我药疗实践对消除疟疾的影响。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-10 DOI: 10.1093/trstmh/traf008

Kanika Verma, Nitika Nitika, Praveen Kumar Bharti

引用次数: 0

Unlocking the potential of blood-stage vaccines for malaria elimination. 释放血液阶段疫苗消除疟疾的潜力。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-08 DOI: 10.1093/trstmh/traf013

Shrikant Nema, Sumit Rathore, Asif Mohmmed, Pawan Malhotra

引用次数: 0

Diagnostic sensitivity of formalin-fixed faecal microscopy for the detection of soil-transmitted helminths. 福尔马林固定粪便显微镜检测土壤传播蠕虫的诊断敏感性。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-08 DOI: 10.1093/trstmh/traf011

Andrew Larkins, Boualay Keokhamphavanh, Breanna Knight, Kelly Taggart, Sarah Keatley, Bounnaloth Insisiengmay, Amanda Ash

{"title":"Diagnostic sensitivity of formalin-fixed faecal microscopy for the detection of soil-transmitted helminths.","authors":"Andrew Larkins, Boualay Keokhamphavanh, Breanna Knight, Kelly Taggart, Sarah Keatley, Bounnaloth Insisiengmay, Amanda Ash","doi":"10.1093/trstmh/traf011","DOIUrl":"https://doi.org/10.1093/trstmh/traf011","url":null,"abstract":"Background: Faecal microscopy is the mainstay of soil-transmitted helminth diagnosis and commonly completed on formalin-fixed samples when resources are insufficient to analyse fresh samples. This study assessed the diagnostic sensitivity of microscopic techniques using formalin-fixed samples.Methods: Formalin-fixed faecal samples from 574 individuals were tested by the formalin-ethyl acetate concentration technique (FECT), Malachite smear, McMaster and McMaster2 methods. Agreement between tests was assessed by Kappa. Bayesian latent class models and a composite reference standard estimated the diagnostic sensitivity of each test.Results: Moderate-to-good agreement between tests was observed for A. lumbricoides. Agreement was poorer for hookworm and Trichuris trichiura. The FECT (72.70%, credible interval [CrI]: 68.92-76.56%) and McMaster2 method (67.93%, 95% CrIs: 62.41-73.31%) had the highest sensitivities for A. lumbricoides. For hookworm, the McMaster2 method (70.56%, 95% CrIs: 64.10-76.96%) was more sensitive than all other tests. For T. trichiura, the McMaster (90.10%, 95% CrIs: 83.29-94.67%) and McMaster2 (89.3%, 95% CrIs: 82.28-94.52%) methods were the most sensitive.Conclusions: The McMaster2 method is a viable alternative to FECT and provides important information on the intensity of infection. The effect of formalin-fixation on test performance may not be as great as previously assumed. This study reports formalin-fixed sensitivities similar to previous estimates using fresh samples.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of repeat testing in tuberculosis patients with a trace call on Xpert MTB/RIF Ultra: a retrospective cohort study. Xpert MTB/RIF Ultra对肺结核患者重复检测的影响：一项回顾性队列研究

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-08 DOI: 10.1093/trstmh/traf002

Suyash Jha, Nitin Gupta, Tirlangi Praveen Kumar, Kiran Chawla, Vishnu P Shenoy, Muralidhar Varma, Mohan K Manu

引用次数: 0

Scrub typhus-leptospirosis co-infection in India: a systematic review and meta-analysis. 印度恙虫病-钩端螺旋体病合并感染：系统回顾和荟萃分析。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-04 DOI: 10.1093/trstmh/trae081

Siddhant Govekar, Oshin Puri, Mohit Bhatia

{"title":"Scrub typhus-leptospirosis co-infection in India: a systematic review and meta-analysis.","authors":"Siddhant Govekar, Oshin Puri, Mohit Bhatia","doi":"10.1093/trstmh/trae081","DOIUrl":"10.1093/trstmh/trae081","url":null,"abstract":"Scrub typhus and leptospirosis are re-emerging zoonotic infections with significant morbidity and mortality rates in India. Overlapping aetiological and epidemiological patterns indicate a high possibility of their co-infection in India, which can be a diagnostic challenge due to non-specific clinical features. A systematic search of the PubMed/MEDLINE, Scopus and Embase databases was conducted to identify relevant studies published through 31 August 2023. Studies reporting co-infection of scrub typhus and leptospirosis among the Indian population were included. Data extraction, quality assessment and statistical analysis were performed in accordance with established guidelines. Six studies met the inclusion criteria, comprising a total of 58 co-infection cases. Pooled prevalence of scrub typhus-leptospirosis co-infection among acute undifferentiated febrile illness patients was 3.7% (95% confidence interval [CI] 0.00 to 0.126). Among scrub typhus patients, the prevalence of co-infection with leptospirosis was 13.7% (95% CI 0.027 to 0.304). Significant heterogeneity was observed among the included studies, highlighting the need for cautious interpretation of prevalence estimates. This meta-analysis underscores the clinical importance of scrub typhus-leptospirosis co-infection in India and emphasizes the need for enhanced clinical awareness, improved diagnostic strategies and targeted research efforts to address this emerging infectious disease threat.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"97-106"},"PeriodicalIF":1.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determinants of antiretroviral therapy adherence among people living with HIV in a poor urban setting in Ghana: a hospital-based cross-sectional study. 加纳城市贫困地区艾滋病病毒感染者坚持抗逆转录病毒治疗的决定因素：一项基于医院的横断面研究。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-04 DOI: 10.1093/trstmh/trae091

Evelyn Adjei-Mensah, Yakubu Alhassan, Richmond Owusu, Irene A Kretchy

{"title":"Determinants of antiretroviral therapy adherence among people living with HIV in a poor urban setting in Ghana: a hospital-based cross-sectional study.","authors":"Evelyn Adjei-Mensah, Yakubu Alhassan, Richmond Owusu, Irene A Kretchy","doi":"10.1093/trstmh/trae091","DOIUrl":"10.1093/trstmh/trae091","url":null,"abstract":"Background: Without a cure, antiretroviral therapy (ART) continues to be the primary mode of managing HIV, transforming it from a formerly lethal disease to a less severe one. Adherence to ART can be impacted by several factors, including poor quality of care.Methods: A quantitative cross-sectional study design was used to assess the factors that influence adherence to ART among adults receiving care at two health facilities in Accra. A structured interviewer-administered questionnaire was used to collect data on factors associated with medication adherence using a modified four-item Medication Adherence Rating from 255 people living with HIV (PLHIV). Descriptive statistics were used to summarise the data, while multiple binary logistic regression was used to assess the factors influencing adherence to ART.Results: Adherence to HIV medication was 44.7% among PLHIV. Adherence was positively correlated with high client health service satisfaction (adjusted OR [AOR]: 26.59, 95% CI 7.46 to 94.82, p<0.001), increased privacy at the HIV clinics (AOR: 3.40, 95% CI 1.40 to 8.21, p<0.007) and among PLHIV who had been diagnosed with HIV for ≥5 y (AOR: 7.59, 95% CI 2.76 to 20.85, p<0.001).Conclusions: Adherence to ART was significantly low among study participants. The study highlights the importance of maintaining privacy and confidentiality at the facility while ensuring client satisfaction with HIV care to promote adherence to ART.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"135-144"},"PeriodicalIF":1.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Painful mycetoma: a study to understand the risk factors in patients visiting the Mycetoma Research Centre (MRC) in Khartoum, Sudan. 疼痛足菌肿：一项了解在苏丹喀土穆足菌肿研究中心（MRC）就诊的患者的危险因素的研究。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-04 DOI: 10.1093/trstmh/trae093

Saria O El-Amin, Rahba O El-Amin, Sarah M El-Sadig, Ahmed Hassan Fahal, Ahmed Musa

{"title":"Painful mycetoma: a study to understand the risk factors in patients visiting the Mycetoma Research Centre (MRC) in Khartoum, Sudan.","authors":"Saria O El-Amin, Rahba O El-Amin, Sarah M El-Sadig, Ahmed Hassan Fahal, Ahmed Musa","doi":"10.1093/trstmh/trae093","DOIUrl":"10.1093/trstmh/trae093","url":null,"abstract":"Background: Mycetoma, a neglected tropical disease endemic to Sudan, is traditionally characterized as a painless condition. However, recent studies reporting painful mycetoma lesions have challenged this assumption. With limited reports in the medical literature regarding pain in mycetoma, this study was conducted to investigate the risk factors for painful mycetoma lesions in patients visiting the Mycetoma Research Centre (MRC) in Khartoum, Sudan.Methods: This cross-sectional study aimed to identify the risk factors for painful mycetoma lesions. The study analyzed electronic records of 481 patients with confirmed mycetoma, seen between 1991 and 2020, using a systematic sampling approach.Results: The study found that pain was more likely to occur in cases with bone destruction, secondary bacterial infection and actinomycete infection (OR=1.762, 1.815 and 1.259, respectively). Additionally, pain was more frequently observed in patients aged 45 y and older. Smaller mycetoma lesions, measuring less than 5 cm, were less likely to cause pain, and this was identified as a significant risk factor for painful mycetoma lesions (β coefficient=-1.294).Conclusion: The findings suggested that pain in mycetoma is typically associated with the severity of the condition. Therefore, early initiation of appropriate treatment may help reduce pain. Furthermore, careful differentiation between actinomycetes and eumycetes is essential for the timely and accurate diagnosis of mycetoma.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"145-151"},"PeriodicalIF":1.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global health initiatives and mycetoma management: the unmet promise. 全球卫生倡议和足菌肿管理：未实现的承诺。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-04 DOI: 10.1093/trstmh/traf001

Ahmed Hassan Fahal, Dallas J Smith, Ali Awadalla Saeed, Borna Nyaoke, Fabiana Alves, Kingsley Asiedu, Rod Hay

引用次数: 0

Reported snakebite mortality and state compensation payments in Madhya Pradesh, India, from 2020 to 2022. 2020 年至 2022 年印度中央邦报告的蛇咬伤死亡率和邦政府支付的赔偿金。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-04 DOI: 10.1093/trstmh/trae045

Priyanka Kadam, Bhupeshwari Patel, Maya Gopalakrishnan, Freston M Sirur, Omesh K Bharti, Amit Agrawal, Md Yunus, Dayal B Majumdar, Stuart Ainsworth

{"title":"Reported snakebite mortality and state compensation payments in Madhya Pradesh, India, from 2020 to 2022.","authors":"Priyanka Kadam, Bhupeshwari Patel, Maya Gopalakrishnan, Freston M Sirur, Omesh K Bharti, Amit Agrawal, Md Yunus, Dayal B Majumdar, Stuart Ainsworth","doi":"10.1093/trstmh/trae045","DOIUrl":"10.1093/trstmh/trae045","url":null,"abstract":"Background: India experiences the highest snakebite burden globally, with 58 000 predicted deaths annually. The central Indian state of Madhya Pradesh is thought to have a substantial snakebite burden and provides compensation to families who can demonstrate by postmortem and hospital treatment reports that their relatives have died due to snakebite. This study represents the first report on the frequency of distribution of compensation for snakebite deaths in Madhya Pradesh.Methods: Statewide snakebite death compensation data from 2020-2021 and 2021-2022, provided by the Madhya Pradesh health authorities, were analysed alongside interviews with 15 families that described the events that ultimately led to their compensation claims.Results: Compensation was paid to a total of 5728 families, with a total value equating to 22 912 Lakhs (approximately US${$}$27.94 million). Families described commonly recognised snakebite risk factors and behaviours in the events that resulted in their relatives' deaths.Conclusions: The snakebite burden in Madhya Pradesh is significant, both in terms of mortality and economic expenditure of the state. Sustained investment in preventative interventions, as well as monitoring of the rate of compensation payouts due to snakebite death as a measure of intervention effectiveness, should be considered to substantially reduce snakebite incidence and mortality.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"158-165"},"PeriodicalIF":1.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11791426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0