Transactions of The Royal Society of Tropical Medicine and Hygiene最新文献_第9页

Financial assistance for snakebite envenoming by OECD nations. 经济合作与发展组织国家对毒蛇咬伤事件的财政援助。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-05-01 DOI: 10.1093/trstmh/trae066

Richenda J Rae

引用次数: 0

False-positive dengue non-structural protein 1 in pregnancy. 妊娠期登革热非结构蛋白1假阳性。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-05-01 DOI: 10.1093/trstmh/trae134

Tonnii Sia, Tze-Cheng Wong, Yee-Chiing Ong

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Vector incrimination studies of lymphatic filariasis in rural areas of endemic Datia district of Madhya Pradesh, India. 印度中央邦流行的达蒂亚区农村地区淋巴丝虫病病媒的归罪研究。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-04-29 DOI: 10.1093/trstmh/traf045

Kumaramangalath Anjal, Vagisha Rawal, Satyendra Pandey, Manjini Harshavarthini, Anil K Verma, Braj Mohan, Shraddha Gurha, Gayatri Sondhiya, Afzal Ansari, Subbiah Kombiah, Suyesh Shrivastava, Pradip V Barde, Pushpendra Singh

{"title":"Vector incrimination studies of lymphatic filariasis in rural areas of endemic Datia district of Madhya Pradesh, India.","authors":"Kumaramangalath Anjal, Vagisha Rawal, Satyendra Pandey, Manjini Harshavarthini, Anil K Verma, Braj Mohan, Shraddha Gurha, Gayatri Sondhiya, Afzal Ansari, Subbiah Kombiah, Suyesh Shrivastava, Pradip V Barde, Pushpendra Singh","doi":"10.1093/trstmh/traf045","DOIUrl":"https://doi.org/10.1093/trstmh/traf045","url":null,"abstract":"Background: Lymphatic filariasis is a neglected tropical disease caused by infections from Wuchereria bancrofti, Brugia malayi or Brugia timori. These infections are spread by mosquito species such as Culex, Anopheles, Aedes and Mansonia. With >50 million cases in 44 countries, it is the most important parasitic disease next to malaria. India initiated a mass drug administration (MDA) program in 2004 and a gradual reduction was seen in the cases; however, few pockets continue to record new cases. We conducted this study in Datia district of Madhya Pradesh, known to be endemic for filariasis, to understand the ongoing transmission and vector incrimination.Methods: Mosquitoes were collected from rural and urban localities of Datia district. Mosquitoes were identified, segregated and pooled. The pools were tested for the presence of W. bancrofti using molecular tools. The polymerase chain reaction (PCR) products were sequenced for confirmation of results.Results: Of 974 tested female mosquitoes, 45.8% were Culex quinquefasciatus and 50.8% were Anopheles subpictus. The mosquitoes were segregated in 55 pools; 8 (14.54%) pools were found positive for W. bancrofti by real-time PCR. All the positive pools were of C. quinquefasciatus and the species-specific pool positivity rate was 24.24%. All the positive pools were from Sarsai village. The sequencing results confirmed the presence of W. bancrofti.Conclusions: This study confirms ongoing transmission of W. bancrofti and C. quinquefasciatus as the vector species in the rural parts of district. The intervention protocols such as MDA and vector control activities need to be strengthened in rural parts of endemic districts to halt the transmission.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Haemoconcentration in diagnosing dengue haemorrhagic fever: evidence from a rural Sri Lankan observational study. 血液浓缩诊断登革出血热：来自斯里兰卡农村观察性研究的证据。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-04-18 DOI: 10.1093/trstmh/traf044

Chamara Sarathchandra, Ruwanthi Bandara, Kosala Weerakoon, Anjana Silva, Hemal Senanayake, Prasanna Weerawansa, Sisira Siribaddana

{"title":"Haemoconcentration in diagnosing dengue haemorrhagic fever: evidence from a rural Sri Lankan observational study.","authors":"Chamara Sarathchandra, Ruwanthi Bandara, Kosala Weerakoon, Anjana Silva, Hemal Senanayake, Prasanna Weerawansa, Sisira Siribaddana","doi":"10.1093/trstmh/traf044","DOIUrl":"https://doi.org/10.1093/trstmh/traf044","url":null,"abstract":"Background: One of the World Health Organization criteria for dengue haemorrhagic fever (DHF) is a 20% increase in haematocrit. This study on dengue hospitalised patients compares haematocrit levels at baseline, at the onset of the critical phase and the maximum during the critical phase in rural Sri Lanka.Methods: This observational study included patients with dengue in the febrile phase who progressed to the critical phase. Haematocrit was recorded and ultrasound scans were performed thrice daily when the platelet count dropped to <100 000/μl. The onset of the critical phase was confirmed by ultrasound-detected plasma leakage.Results: Forty-three patients were included in the final analysis. The mean haematocrit at baseline and at the onset of the critical phase was 40.6% (standard deviation [SD] 4.7) and 41.3% (SD 5.1), respectively, with no difference (p=0.14, paired t-test). None of the participants showed a 20% increase in haematocrit at the onset of the critical phase, with the maximum observed increase being 17.0%.Conclusion: A 20% increase in haematocrit was not observed during the critical phase, suggesting that haemoconcentration is unreliable for diagnosing DHF in hospitalised patients. This study recommends revisiting the WHO criterion of a 20% haematocrit increase for diagnosing plasma leakage in dengue patients. It suggests that frequent ultrasound scans may be a more reliable method for early detection of plasma leakage.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Snakebite cases and treatment outcomes in the Afar region, Ethiopia: a retrospective and prospective study approach. 蛇咬伤病例和治疗结果在阿法尔地区，埃塞俄比亚：回顾性和前瞻性研究方法。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-04-18 DOI: 10.1093/trstmh/traf043

Abebe M Aga, Demise Mulugeta, Abera Motuma, Bilise Wakitole, Kedir Mohammed, Fanos Tadesse Woldemariyam, Henok Ferede, Zinash Teferi, Shambel Tadesse, Jemal Mohammed, Anberber Alemu, Dejene Getachew, Dassalegn Muleta, Dereje Nigussie

{"title":"Snakebite cases and treatment outcomes in the Afar region, Ethiopia: a retrospective and prospective study approach.","authors":"Abebe M Aga, Demise Mulugeta, Abera Motuma, Bilise Wakitole, Kedir Mohammed, Fanos Tadesse Woldemariyam, Henok Ferede, Zinash Teferi, Shambel Tadesse, Jemal Mohammed, Anberber Alemu, Dejene Getachew, Dassalegn Muleta, Dereje Nigussie","doi":"10.1093/trstmh/traf043","DOIUrl":"https://doi.org/10.1093/trstmh/traf043","url":null,"abstract":"Background: Snakebite envenomation remains a public health issue, particularly in rural areas. Quick and accurate case identification, coupled with timely treatment, is essential to prevent fatalities and complications.Methods: Retrospective and prospective data consisted of 245 snakebite cases admitted to hospitals in the Afar region, Ethiopia, from September 2023 to July 2024 (retrospective), while prospective data were collected from July to October 2024. The analysis focused on case prevalence, time to treatment, service availability, treatment received, length of hospital stays, recovery times and patient outcomes.Results: Of 245 cases, 66.1% (n=162) were retrospective and 33.9% (n=83) prospective. Most patients were male (71.6%); the largest age group was 15-29 y (59.6%); most patients required hospital stays of 2-3 d (56.7%). In the majority of cases, recovery took 4-7 d (36.23%). The fatality rate was 3.3%; >46.54% of patients received treatment >7 d after snakebite, mainly because of the long distance traveled to reach healthcare facilities with access to antivenom.Conclusions: It is essential to strengthen community health units by equipping them with trained personnel and sufficient antivenom supplies to ensure prompt care. Implementing public awareness and promoting local antivenom production could reduce treatment costs and improve patient outcomes.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reactivation of cutaneous leishmaniasis in the context of non-HIV immunosuppression: a literature analysis. 在非hiv免疫抑制的背景下皮肤利什曼病的再激活：文献分析。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-04-16 DOI: 10.1093/trstmh/traf038

Regina Maia de Souza, Felipe Francisco Tuon, Leticia Ramos Dantas, Rui Imamura, Alexandre Pereira Funari, Beatriz Julieta Celeste, Valdir Sabbaga Amato

引用次数: 0

Snakebite envenoming in India: it is time we look beyond the concept of the Big Four species. 印度毒蛇咬伤事件：是时候超越四大物种的概念了。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-04-14 DOI: 10.1093/trstmh/traf042

Jaideep C Menon, T P Sreekrishnan, Sabarish B Nair, Vijay V Pillay, Srikanta Kanungo, M S Aravind, Omesh K Bharti, Joseph K Joseph, Sanghamitra Pati

{"title":"Snakebite envenoming in India: it is time we look beyond the concept of the Big Four species.","authors":"Jaideep C Menon, T P Sreekrishnan, Sabarish B Nair, Vijay V Pillay, Srikanta Kanungo, M S Aravind, Omesh K Bharti, Joseph K Joseph, Sanghamitra Pati","doi":"10.1093/trstmh/traf042","DOIUrl":"https://doi.org/10.1093/trstmh/traf042","url":null,"abstract":"India faces substantial challenges from snakebite envenoming secondary to the high morbidity, mortality and financial burden, particularly in rural communities. While concentrated on the 'Big Four' venomous species, recent research indicates a necessity to expand the focus to encompass additional medically relevant species. This review emphasizes the geographic heterogeneity in venom among these snakes, which impacts antivenom effectiveness and necessitating region-specific formulations. This analysis highlights the shortcomings of current antivenoms and identifies non-Big Four species involved in snakebite envenoming, advocating for an urgent shift to inclusive antivenom strategies that integrate local venom profiles to enhance treatment effectiveness and thereby reduce snakebite-related morbidity and mortality. Improved training for healthcare providers and enhancements in anti-snake venom quality are essential for meeting the World Health Organization's 2030 Sustainable Development Goal objective of halving snakebite-related fatalities and disabilities. Incorporating snakebite management into national health programs and conducting epidemiological research systematically are crucial to mitigating this preventable health concern.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Orthohantavirus seoulense as a cause of acute, dengue-negative febrile illness in southern Vietnam. 正汉坦病毒seoulense是越南南部急性登革热阴性发热性疾病的一种病因。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-04-12 DOI: 10.1093/trstmh/traf041

Mai Thi Quynh Le, Kumiko Yoshimatsu, Haruka Abe, Thuy Thi Nguyen, Hang Le Khanh Nguyen, Trang Thi Hong Ung, Phuong Vu Mai Hoang, Nobuo Koizumi, Futoshi Hasebe, Kozue Miura

{"title":"Orthohantavirus seoulense as a cause of acute, dengue-negative febrile illness in southern Vietnam.","authors":"Mai Thi Quynh Le, Kumiko Yoshimatsu, Haruka Abe, Thuy Thi Nguyen, Hang Le Khanh Nguyen, Trang Thi Hong Ung, Phuong Vu Mai Hoang, Nobuo Koizumi, Futoshi Hasebe, Kozue Miura","doi":"10.1093/trstmh/traf041","DOIUrl":"https://doi.org/10.1093/trstmh/traf041","url":null,"abstract":"Background: Dengue fever has surged in Vietnam since 2021; however, the aetiology of non-dengue undifferentiated febrile illnesses remains poorly understood.Methods: Fifty whole blood samples that tested negative in rapid tests for anti-dengue virus antibodies (IgM and IgG) and NS1 viral antigen at Vung Tau General Hospital, southern Vietnam, were subjected to nucleic acid amplification tests for flaviviruses, hantaviruses, Leptospira spp. and Orientia tsutsugamushi, followed by DNA sequencing. The plasma samples were also tested for anti-hantavirus IgM and IgG antibodies using ELISA.Results: Of the 50 samples, eight were PCR-positive for flaviviruses and two were positive for hantaviruses. Sequencing analysis revealed that three and five of the eight flavivirus-positive samples were dengue virus type 1 and dengue virus type 2, respectively. The hantavirus species was identified as Orthohantavirus seoulense (SEOV). None of the patients tested positive for Leptospira spp. or O. tsutsugamushi. Anti-hantavirus IgM and IgG antibodies were detected in five and four patients, respectively.Conclusions: This study suggests that SEOV is a notable contributor to dengue-negative febrile illnesses in southern Vietnam.Accession number: LC822654.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating Pfk13 mutations in Plasmodium falciparum natural populations from two malaria-endemic areas of Cameroon. 调查喀麦隆两个疟疾流行区恶性疟原虫自然种群的Pfk13突变。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-04-12 DOI: 10.1093/trstmh/traf040

Charlotte S Milong Melong, Loick P Kojom Foko, Francis N Nkemngo, Cyrille Ndo, Nathalie Amvongo-Adjia, Gianluca Russo, Ousman Tamgue, François Tchoumbougnang, Daniel P Morse, Giacomo M Paganotti

{"title":"Investigating Pfk13 mutations in Plasmodium falciparum natural populations from two malaria-endemic areas of Cameroon.","authors":"Charlotte S Milong Melong, Loick P Kojom Foko, Francis N Nkemngo, Cyrille Ndo, Nathalie Amvongo-Adjia, Gianluca Russo, Ousman Tamgue, François Tchoumbougnang, Daniel P Morse, Giacomo M Paganotti","doi":"10.1093/trstmh/traf040","DOIUrl":"https://doi.org/10.1093/trstmh/traf040","url":null,"abstract":"Background: The emergence of Plasmodium falciparum resistance to artemisinin is a huge concern in Africa. We investigated and characterized mutations of Pfk13 propeller sequences from P. falciparum isolates across two endemic areas with different eco-geographical settings in Cameroon.Methods: A total of 259 dried blood spot samples were collected through a cross-sectional survey in two health facilities located in Bimengue (rural area) and the Efoulan District Hospital in Yaoundé (urban area). The molecular analysis of Pfk13 was performed using nested polymerase chain reaction followed by Sanger sequencing.Results: Our findings highlight that of the 23 mutations found, most of the genetic variants were observed in Yaoundé, suggesting a possible higher drug pressure in this locality. Three Pfk13 mutations (F446S, C469W and A681D) were found in polymorphic sites known to be associated with artemisinin resistance, but with different amino acid substitutions. In addition, three other mutations have already been reported to circulate in other African countries, with an unknown impact on delayed response to artemisinin therapy (P475L, S477F and F628L).Conclusions: Although there is an absence of validated artemisinin resistance-associated polymorphisms in the study, the results highlight the need for further studies to quantify the frequency of these and other Pfk13 gene polymorphisms over time.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are intestinal parasites in dogs an infection risk to children in the same household? An investigation in Cuba. 狗体内的肠道寄生虫会对同一家庭的儿童造成感染风险吗？一项在古巴的调查。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-04-09 DOI: 10.1093/trstmh/traf039

Luis Enrique Jerez Puebla, Edel La Rosa Osoria, Fidel A Núñez Fernández, Jorge Fraga Nodarse, Lissette Pérez Santos, Iraís Atencio Millán, Lázara Rojas Rivera, Iredys Cruz Rodríguez, Rigoberto Fimia-Duarte, Lucy J Robertson

{"title":"Are intestinal parasites in dogs an infection risk to children in the same household? An investigation in Cuba.","authors":"Luis Enrique Jerez Puebla, Edel La Rosa Osoria, Fidel A Núñez Fernández, Jorge Fraga Nodarse, Lissette Pérez Santos, Iraís Atencio Millán, Lázara Rojas Rivera, Iredys Cruz Rodríguez, Rigoberto Fimia-Duarte, Lucy J Robertson","doi":"10.1093/trstmh/traf039","DOIUrl":"https://doi.org/10.1093/trstmh/traf039","url":null,"abstract":"Background: Zoonotic transmission of intestinal parasites from dogs has been documented, but the extent of such transmission is unclear. This is particularly relevant in low- and middle-income countries, where people share living space with their domestic animals. We investigated whether dog ownership was associated with intestinal parasitoses in children in Cuba.Methods: Faecal samples were collected from children from 108 households in a rural village in Cuba, of which 66 owned a dog and 42 did not. Samples were also collected from the dogs. Samples were examined for intestinal parasites by microscopy and molecular methods.Results: The most commonly identified intestinal parasites in children were Giardia duodenalis and Blastocystis spp., occurring significantly more frequently among children with a dog. However, there was no significant association when these parasites were considered separately. Among dogs, the most commonly detected intestinal parasites were Ancylostoma spp. (in 29 dogs; 44%) and Giardia (in 25 dogs; 38%). Although Ancylostoma spp. can be zoonotic, infection in people is not intestinal; cutaneous larval migrans was not evident in these children.Conclusions: Although our data do not indicate extensive zoonotic transmission of intestinal parasites from dogs, children living in a household with a dog were more likely to be infected with Giardia and/or Blastocystis, than those without dogs.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0