Reactivation of cutaneous leishmaniasis in the context of non-HIV immunosuppression: a literature analysis.

IF 1.9 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-04-16 DOI:10.1093/trstmh/traf038

Regina Maia de Souza, Felipe Francisco Tuon, Leticia Ramos Dantas, Rui Imamura, Alexandre Pereira Funari, Beatriz Julieta Celeste, Valdir Sabbaga Amato

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引用次数: 0

Abstract

Background: Immunosuppression increases the risk of primary cutaneous leishmaniasis (CL) infection and its reactivation. This systematic review examined CL reactivation in immunosuppressed patients, including those with autoimmune diseases and solid organ transplant recipients.

Methods: A comprehensive literature search was conducted across multiple databases for studies published between May 1990 and May 2024.

Results: Nine cases were selected, involving CL reactivation associated with immunosuppressive therapy for autoimmune diseases, such as rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis, or following renal transplantation.

Conclusions: The management of CL during immunosuppressive therapy is challenging, necessitating different approaches for reactivation management.

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在非hiv免疫抑制的背景下皮肤利什曼病的再激活：文献分析。

背景：免疫抑制增加原发性皮肤利什曼病（CL）感染及其再激活的风险。本系统综述研究了免疫抑制患者的淋巴细胞再激活，包括自身免疫性疾病患者和实体器官移植受者。方法：对1990年5月至2024年5月间发表的多个数据库进行综合文献检索。结果：我们选择了9例病例，包括CL再激活与免疫抑制治疗相关的自身免疫性疾病，如类风湿关节炎、强直性脊柱炎和银屑病关节炎，或肾移植后。结论：免疫抑制治疗期间CL的治疗是具有挑战性的，需要不同的再激活治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transactions of The Royal Society of Tropical Medicine and Hygiene 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.00

自引率

9.10%

发文量

115

审稿时长

4-8 weeks

期刊介绍： Transactions of the Royal Society of Tropical Medicine and Hygiene publishes authoritative and impactful original, peer-reviewed articles and reviews on all aspects of tropical medicine.