Transactions of The Royal Society of Tropical Medicine and Hygiene最新文献

Antibody response following rabies vaccination: a retrospective cohort study from a tertiary centre in Kerala, India. 狂犬病疫苗接种后的抗体反应：来自印度喀拉拉邦三级中心的回顾性队列研究。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-05-09 DOI: 10.1093/trstmh/trag055

Rahul Suresh, Chintha Sujatha, Amala Panackal Saju, Aparna Sujatha, Anjana Nalinakumari Kesavan Nair, Prathiush Prathapan Rema, Sanjay Devarajan, Anuja Usha, Sreejith Lalitha Krishnankutty, Thekkumkara Surendran Anish

{"title":"Antibody response following rabies vaccination: a retrospective cohort study from a tertiary centre in Kerala, India.","authors":"Rahul Suresh, Chintha Sujatha, Amala Panackal Saju, Aparna Sujatha, Anjana Nalinakumari Kesavan Nair, Prathiush Prathapan Rema, Sanjay Devarajan, Anuja Usha, Sreejith Lalitha Krishnankutty, Thekkumkara Surendran Anish","doi":"10.1093/trstmh/trag055","DOIUrl":"https://doi.org/10.1093/trstmh/trag055","url":null,"abstract":"Background: Globally accelerated efforts are underway to eliminate dog-mediated rabies, underscoring the importance of effective anti-rabies prophylaxis. This study aims to assess the antibody response and its long-term persistence following rabies vaccination, their determinants, and suggest the optimal timing for a booster dose.Methods: We performed a retrospective cohort study among 150 participants, at the preventive clinic of Government Medical College, Thiruvananthapuram. Anti-rabies antibody titer in serum samples was estimated with the Rapid Fluorescent Foci Inhibition Test. To estimate the optimal timing for booster doses, the receiver operating characteristic (ROC) curve was plotted.Results: Protective antibody titers (0.5 IU/ml) were observed in 92.7% of participants, with a mean titer of 3.81 (3.31) IU/ml. ROC analysis identified 5 years as a cut-off for booster dose. Regression analysis indicated a shorter time duration since last vaccination (P = .003) and intramuscular route (P = .005) as predictors of high antibody titers. However, the achievement of protective antibody titer was comparable for intramuscular and intradermal schedules.Conclusions: Achievement of protective antibody titers is universal and long-lasting following anti-rabies vaccination, irrespective of the route of vaccination. Five years since the last dose could be used as an optimal cut-off for booster dose.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Armadillo meat consumption and Hansen's disease (leprosy): a case-control study in Brazil. 犰狳肉消费与汉森病（麻风病）：巴西的病例对照研究。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-05-08 DOI: 10.1093/trstmh/trag054

Taynah A R Repsold, Simon M Collin, Bianca B C Amorim, Liana M M de Sena, Roger Bongestab, Patrícia D Deps

{"title":"Armadillo meat consumption and Hansen's disease (leprosy): a case-control study in Brazil.","authors":"Taynah A R Repsold, Simon M Collin, Bianca B C Amorim, Liana M M de Sena, Roger Bongestab, Patrícia D Deps","doi":"10.1093/trstmh/trag054","DOIUrl":"https://doi.org/10.1093/trstmh/trag054","url":null,"abstract":"Background: Hansen's disease (HD, leprosy) had a global incidence of approximately 200 000 new cases per annum over the last decade. Armadillos are recognized reservoirs of Mycobacterium leprae in the Americas and HD is considered a zoonosis in the USA. Our aim was to evaluate the association between armadillo meat consumption and HD in Brazil.Methods: We conducted a case-control study (n=59 patients with HD, n=59 controls) in the state of Espírito Santo, Brazil, between February and December 2025. Data collected included clinical and sociodemographic, armadillo meat consumption and known (human) case contacts (KCCs).Results: Armadillo meat consumption was much more frequent among cases (59.3%) than controls (8.5%). Consumption was the strongest independent predictor of HD, with 15-fold higher odds of exposure (adjusted odds ratio [aOR] 16.5 [95% confidence interval {CI} 5.2 to 52.5], p<0.001) among cases. Odds of KCCs were five-fold higher among cases (aOR 6.0 [95% CI 2.2 to 16.8], p=0.001).Conclusions: This study provides evidence that armadillo meat consumption is an independent transmission pathway for human M. leprae infection in Brazil. Zoonotic transmission likely accounts for some of the HD 'contact gap' in this setting, supporting the need for a paradigm shift towards One Health surveillance of HD in the Americas.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic health manifestations following hump-nosed pit viper (Hypnale spp.) bites: an authenticated case series. 驼峰鼻蝮蛇（Hypnale spp.）咬伤后的慢性健康表现：一个经过验证的病例系列。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-05-04 DOI: 10.1093/trstmh/traf148

R M M K Namal Rathnayaka, P E Anusha Nishanthi Ranathunga, S A M Kularatne

{"title":"Chronic health manifestations following hump-nosed pit viper (Hypnale spp.) bites: an authenticated case series.","authors":"R M M K Namal Rathnayaka, P E Anusha Nishanthi Ranathunga, S A M Kularatne","doi":"10.1093/trstmh/traf148","DOIUrl":"10.1093/trstmh/traf148","url":null,"abstract":"Background: Hump-nosed pit vipers (genus Hypnale) are the most common cause of venomous snakebites in Sri Lanka, accounting for more than one-third of all snakebites, as they are widely distributed throughout the country. It is a highly medically important snake in Sri Lanka. Even though several life-threatening complications, including venom-induced consumption coagulopathy, acute kidney injury, venom-induced thrombotic microangiopathy and cardiac effects, are reported following their bites, no antivenom is currently available for Hypnale - envenomed patients either in Sri Lanka or India. Apart from the acute manifestations of snakebites, chronic health effects have rarely been described in the literature.Methods: A case series of 11 patients who developed long-term health effects following hump-nosed pit viper bites was prospectively studied at the Teaching Hospital, Ratnapura, Sri Lanka, from June 2015 to May 2021. Data on clinical presentation, examination findings, investigations, management and two-year follow-up were collected.Results: This case series describes some of the chronic health manifestations following hump-nosed pit viper bites in 11 patients, including chronic kidney disease, fasciotomy-related injuries, musculoskeletal disabilities and pulmonary effects.Conclusion: Hump-nosed pit viper bites can cause severe long-term sequelae that require follow-up. Physicians should be aware of these manifestations when managing patients and this case series highlights the need for an effective antivenom for Hypnale bites.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"486-496"},"PeriodicalIF":1.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146114059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accuracy of inflammatory biomarkers in assessing outcomes in Chagas disease: a scoping review. 炎症生物标志物在评估恰加斯病预后中的准确性：范围综述

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-05-04 DOI: 10.1093/trstmh/traf150

Matheus Ribeiro Ávila, Lucas Fróis Fernandes de Oliveira, Whesley Tanor Silva, Sanny Cristina de Castro Faria, Mauro Felippe Felix Mediano, Manoel Otávio da Costa Rocha, Henrique Silveira Costa, Daniel Menezes-Souza

{"title":"Accuracy of inflammatory biomarkers in assessing outcomes in Chagas disease: a scoping review.","authors":"Matheus Ribeiro Ávila, Lucas Fróis Fernandes de Oliveira, Whesley Tanor Silva, Sanny Cristina de Castro Faria, Mauro Felippe Felix Mediano, Manoel Otávio da Costa Rocha, Henrique Silveira Costa, Daniel Menezes-Souza","doi":"10.1093/trstmh/traf150","DOIUrl":"10.1093/trstmh/traf150","url":null,"abstract":"Chagas disease (CD) is a global health issue with acute and chronic forms that cause severe complications, especially affecting the heart. Inflammatory biomarkers have been proposed as potential predictors of adverse outcomes in CD, however, their clinical utility remains uncertain. We conducted a scoping review of five databases, including observational studies evaluating the diagnostic and/or prognostic accuracy of inflammatory biomarkers in CD. Two reviewers independently screened and extracted data. Of 239 articles screened, 5 met the inclusion criteria. Adiponectin was associated with an increased risk of mortality and heart transplantation (hazard ratio 1.042 [95% confidence interval 1.013 to 1.072], area under the curve [AUC] 0.68, cut-off >38 μg/ml). Tumour necrosis factor α (TNF-α) and C-C motif chemokine ligand 2 (CCL2) were associated with left ventricular dysfunction (TNF-α: AUC 0.90; CCL2: AUC 0.69). Combined hepatocyte growth factor (HGF) and interleukin-12p40 (IL-12p40) predicted 3-y survival (accuracy 81.9%). Other biomarkers, including macrophage migration inhibitory factor, C-X-C motif chemokine ligand 12, monokine induced by interferon γ (MIG), transforming growth factor β1 and matrix metalloproteinases 2 and 9, showed limited utility. While TNF-α and HGF/IL-12p40 showed promise, most inflammatory biomarkers demonstrated limited accuracy, specifically for outcome prediction in CD; however, this does not preclude their potential usefulness for other clinical or experimental applications. Current evidence does not support the clinical use of this approach and further studies are needed.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"425-435"},"PeriodicalIF":1.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facing pediatric snakebites unarmed: knowledge gaps and first-aid response challenges among parents in rural Sri Lanka. 面对手无寸铁的儿童蛇咬伤：斯里兰卡农村父母的知识差距和急救反应挑战。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-05-04 DOI: 10.1093/trstmh/traf147

Kavinda Dayasiri, Gihan Gunarathna, Indika Gawarammana, Shaluka Jayamanne

{"title":"Facing pediatric snakebites unarmed: knowledge gaps and first-aid response challenges among parents in rural Sri Lanka.","authors":"Kavinda Dayasiri, Gihan Gunarathna, Indika Gawarammana, Shaluka Jayamanne","doi":"10.1093/trstmh/traf147","DOIUrl":"10.1093/trstmh/traf147","url":null,"abstract":"Background: Pediatric snakebites remain a neglected public health threat in rural Sri Lanka, where limited access to emergency care places children at heightened risk. Despite the high burden, there is a striking lack of research focused on strengthening preparedness in vulnerable communities.Methods: A descriptive cross-sectional study was conducted in two high-incidence districts: Ampara and Polonnaruwa. Using cluster sampling, 518 parents of children aged <5 y completed structured, self-administered questionnaires assessing knowledge of snake identification and prehospital care interventions. Associations between sociodemographic variables and knowledge were analyzed using χ2 tests.Results: Although 98.3% correctly identified the Indian cobra, only 34.6% recognized Russell's viper, and 82% misclassified the non-venomous rat snake as venomous. Prior first-aid training was significantly associated with improved knowledge on snake identification (p=0.02), symptoms and complications (p=0.00) and pre-hospital care (p=0.01). Misconceptions persisted: 29.3% believed antivenom should be given to all bite victims. Higher socioeconomic status was linked to better prehospital care knowledge (p=0.00), while lower parental education was associated with poorer knowledge (p=0.00). Personal or household snakebite experience showed no significant association (p>0.05).Conclusions: Despite high exposure risk, caregiver preparedness is low. Community-based education targeting high-risk families is urgently needed to reduce preventable pediatric snakebite morbidity and mortality.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"472-485"},"PeriodicalIF":1.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of hepatitis B virus surface gene mutations from Huzhou, eastern China. 湖州地区乙型肝炎病毒表面基因突变特征分析

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-05-04 DOI: 10.1093/trstmh/trag001

Zihan Han, Fang Jin, Peng Luo, Dongli Li, Jianfeng Zhong, Zhaowei Tong, Fuchu Qian

{"title":"Characterization of hepatitis B virus surface gene mutations from Huzhou, eastern China.","authors":"Zihan Han, Fang Jin, Peng Luo, Dongli Li, Jianfeng Zhong, Zhaowei Tong, Fuchu Qian","doi":"10.1093/trstmh/trag001","DOIUrl":"10.1093/trstmh/trag001","url":null,"abstract":"Background: Amino acid (AA) substitutions in the hepatitis B virus (HBV) S gene are key drivers of diagnostic evasion, vaccine breakthrough infections and immune escape. Understanding regional mutation profiles is essential for public health intervention. This study aimed to characterize the prevalence and mutation patterns of the HBV S gene in eastern China.Methods: In this cross-sectional study, serum samples from 244 patients with chronic HBV infection were collected. The S gene was amplified by nested polymerase chain reaction, followed by genotyping and AA substitution analysis using Geno2pheno HBV and the MEGA 11.0 platform. Concurrent laboratory assessments included serological (HBsAg, anti-HBs, HBeAg, anti-HBe), biochemical (ALT, AST) and virological (HBV DNA load).Results: Mutation frequencies were 38.9% (95/244) in the major hydrophilic region and 22.1% (54/244) in the α determinant. Hotspot mutations included Q101R/K, I/T126S/T/V/A/I, Q129H/R, M133L/T, G145R/T/A and F/Y161Y/F. Notably, AA substitutions including L104F/W, T113S, T123P, I126V and G145T differed from previously reported variants. Additional novel mutation sites P105L, S117R/T and W156L were identified. The I92T, Y100C/S and I126S/T/V mutations showed specific associations with genotype C, whereas Y161F was exclusively detected in genotype B.Conclusions: This study documents a high frequency of S gene mutations within critical immune regions among chronic HBV-infected patients in eastern China, alongside novel mutation sites and distinct genotype-dependent patterns. HBV genotype and age were independently associated with S gene mutation. These findings provide a molecular basis for optimizing regional diagnostic strategies and future vaccine design.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"504-511"},"PeriodicalIF":1.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antivenom shortages and emergency preparedness in Vietnam: a silent public health crisis. 越南抗蛇毒血清短缺和应急准备：无声的公共卫生危机。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-05-04 DOI: 10.1093/trstmh/trag016

Thai Ngoc Dang, Hoang Hai Truong Dang, Thanh Long Tran, Eman Fathy Abdeltwab Hassan, Xuan Thang Dang, Yoshihiro Aoki, Nguyen Tien Huy

引用次数: 0

Quality of life in Indian people affected by leprosy? A systematic review from the country with the highest burden of leprosy cases. 印度麻风病患者的生活质量？来自麻风病病例负担最重国家的系统审查。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-05-04 DOI: 10.1093/trstmh/trag008

Pitchaimani Govindharaj, Sanjana Agrawal, Senthilkumar Ramasamy, Suganya Panneerselvam, Sandhya Bharathi Shanmugasundaram

{"title":"Quality of life in Indian people affected by leprosy? A systematic review from the country with the highest burden of leprosy cases.","authors":"Pitchaimani Govindharaj, Sanjana Agrawal, Senthilkumar Ramasamy, Suganya Panneerselvam, Sandhya Bharathi Shanmugasundaram","doi":"10.1093/trstmh/trag008","DOIUrl":"10.1093/trstmh/trag008","url":null,"abstract":"Quality of life (QoL) is important for people with leprosy since the disease can cause physical and psychological problems. These problems may result in stigma and social discrimination. India reported 107 851 new leprosy cases for the year 2023-24, accounting for 61.6% of new cases detected globally. This systematic review was conducted to assess the QoL among people affected by leprosy in India using existing literature. The Scopus, PubMed and Infolep databases were searched for articles for this systematic review and included only studies conducted in India. The critical appraisal tool of cross-sectional studies (AXIS) was used to assess the study quality and risk of bias. The search identified 253 articles. After screening titles and abstracts, 23 full-text articles were assessed for eligibility and 12 studies were included in the systematic review. The World Health Organization Quality of Life-Bref instrument was used to measure QoL. Of the 12 studies, the factors of disability (9 studies) and old age (8 studies) were highly associated with low levels of QoL. Five studies identified that low levels of QoL are associated with being female with the leprosy. Early identification and prevention of disabilities are important steps in improving the QoL. Increased investment is needed in leprosy programmatic activities and research to achieve the target of zero leprosy.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"436-443"},"PeriodicalIF":1.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outstanding presence of New Delhi metallo-beta-lactamase in carbapenem-resistant Enterobacterales and exceptionally potent in vitro activity of cefiderocol and aztreonam-avibactam emphasises their immediate access in India. 在碳青霉烯耐药肠杆菌中发现了新德里金属β -内酰胺酶，头孢地罗和氨曲南-阿维巴坦的体外活性特别强，这些都强调了它们在印度的直接可及性。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-05-04 DOI: 10.1093/trstmh/trag022

Mallika Sengupta, Kshetrimayum Ammy, Indranil Banik, Ujjala Ghoshal, Sayantan Banerjee

{"title":"Outstanding presence of New Delhi metallo-beta-lactamase in carbapenem-resistant Enterobacterales and exceptionally potent in vitro activity of cefiderocol and aztreonam-avibactam emphasises their immediate access in India.","authors":"Mallika Sengupta, Kshetrimayum Ammy, Indranil Banik, Ujjala Ghoshal, Sayantan Banerjee","doi":"10.1093/trstmh/trag022","DOIUrl":"10.1093/trstmh/trag022","url":null,"abstract":"Background: Therapeutic options for critical infections by carbapenem-resistant Enterobacterales (CRE) are largely limited to polymyxins in India. They have significant toxicity, unpredictable kinetics and prohibitive cost. The objective of the current study was to find the mechanisms of resistance in CRE and to evaluate the in vitro efficacy of potential treatment options.Methods: In a prospective study performed during October 2023-March 2024, all Enterobacterales clinical isolates of our laboratory were screened for carbapenem resistance. All CRE isolates were phenotypically and genotypically tested for mechanisms of resistance and underwent extended antimicrobial susceptibility testing.Results: During the study period, 12.90% (100/775) of Enterobacterales were CRE, among which 99% (99/100) were multidrug resistant. Phenotypic metallo-beta-lactamase screening was positive in 87/100 (87%) of isolates. Aztreonam-avibactam was found to effectively inhibit 96% of isolates, while cefiderocol effectively inhibited 87%. Two isolates resistant to aztreonam-avibactam were susceptible to cefiderocol, both of which harboured blaNDM. The blaNDM gene was detected in 87% of the isolates, one of which also co-harboured blaKPC.Conclusions: Our study showed an exceptionally high prevalence of the blaNDM gene among CRE clinical isolates. Either aztreonam-avibactam or cefiderocol was found to be effective against 98% of CRE isolates highlighting the immediate need of making these two drugs accessible to patients in India.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"575-581"},"PeriodicalIF":1.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147499790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 vaccine uptake, barriers and facilitators among key populations living with HIV/AIDS in Rivers State, Nigeria: a cross-sectional quantitative study. 尼日利亚河流州主要艾滋病毒/艾滋病感染者COVID-19疫苗接种、障碍和促进因素：一项横断面定量研究

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-05-04 DOI: 10.1093/trstmh/trag005

Uebari Korfii, Golden Owhonda, Rogers Bariture Kanee, Ihuoma Aaron Wali, Viome Amakuro Showers, Eric Aigbogun, Mueka Edna Neenwi, Dennis Akpona, Ngozi Ajaero, Adedamola Ade-Dosumu, Fauwzia Sanusi, Damilola Bashorun, Etukokwu Ijeoma Uchechukwu

{"title":"COVID-19 vaccine uptake, barriers and facilitators among key populations living with HIV/AIDS in Rivers State, Nigeria: a cross-sectional quantitative study.","authors":"Uebari Korfii, Golden Owhonda, Rogers Bariture Kanee, Ihuoma Aaron Wali, Viome Amakuro Showers, Eric Aigbogun, Mueka Edna Neenwi, Dennis Akpona, Ngozi Ajaero, Adedamola Ade-Dosumu, Fauwzia Sanusi, Damilola Bashorun, Etukokwu Ijeoma Uchechukwu","doi":"10.1093/trstmh/trag005","DOIUrl":"10.1093/trstmh/trag005","url":null,"abstract":"Background: The study evaluated COVID-19 vaccine uptake and the barriers and facilitators influencing COVID-19 vaccine uptake among key populations living with HIV/AIDS in Rivers State, Nigeria.Methods: A key population-based cross-sectional study employed purposive sampling to recruit 458 participants from one-stop shops between April-June 2024. Data collection tools were integrated into a Kobo database. SPSS version 27 (IBM, Armonk, USA) for descriptive and inferential statistics (Chi-square and bivariate logistic regression) analysed vaccine uptake and associated factors, with significance determined at p<0.05.Results: The COVID-19 vaccine uptake was 54.1%, with 22.3% partially vaccinated and 31.8% fully vaccinated. Pfizer-BioNTech (43.5%) and Moderna (22.2%) were the most administered vaccines. Key barriers included lack of information (91.7%), vaccine side effects concerns (88.0%), and distrust in vaccine safety (95.2%). Younger participants, those with shorter antiretroviral therapy (ART) durations, single individuals, and unemployed participants showed significantly lower vaccine uptake (χ²=48.266, 37.689, 29.131, and 62.136; p<0.001).Conclusions: Moderate vaccine uptake highlights gaps in COVID-19 vaccination among key populations. To improve vaccine uptake, tailored interventions addressing stigma, misinformation, and access barriers are recommended. Leveraging community leaders and integrating vaccines into HIV/AIDS care programs can enhance acceptance and delivery.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"522-532"},"PeriodicalIF":1.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146150607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0