Transactions of The Royal Society of Tropical Medicine and Hygiene最新文献

{"title":"Knowledge, attitudes and practices of the general population towards Marburg virus disease in sub-Saharan African countries: a cross-sectional study.","authors":"Mohamed Fakhry Hussein, Assem Gebreal, Marina Saleeb, Eyerusalem Amossa Tessema, Debra Okeh, Gori Gaitano, Marc Nathanson, Nthabiseng Tsoeu, Eshun Gilbert, Khadija Swalehe Ally, Ahmed Elsayed Said Noureldin, Mai Hussein, Ramy Mohamed Ghazy","doi":"10.1093/trstmh/trae122","DOIUrl":"https://doi.org/10.1093/trstmh/trae122","url":null,"abstract":"<p><strong>Background: </strong>Marburg virus disease (MVD) is categorized among viral hemorrhagic fevers. MVD is associated with high rates of morbidity and mortality. This study aimed to identify factors affecting MVD knowledge, attitudes and practices in sub-Saharan African countries.</p><p><strong>Methods: </strong>Using a validated questionnaire, a cross-sectional survey was conducted from 21 April to 23 May 2023 in eight English-speaking sub-Saharan African countries (Ethiopia, Ghana, Kenya, Lesotho, Nigeria, Senegal, South Africa and Tanzania).</p><p><strong>Results: </strong>Of 3142 participants, 51% were males, 66.0% were aged 18-29 y, 74.4% were living in urban areas, 47.9% completed their university education and 21.7% were healthcare workers (HCWs). Tanzanians had the highest good knowledge (89%), while Kenyans had the lowest (26%). Tanzanians had the highest positive attitude (82%), while Nigerians had the highest negative attitude (95%). The best practices exhibited were by Ethiopians (70%), and the poorest practices exhibited were by Ghanaians (94%). The predictors of good knowledge were marital status (adjusted OR [aOR]=0.75; 95% CI 0.59 to 0.94; p=0.013), knowing the correct mode of transmission (aOR=18.31; 95% CI 13.31 to 25.66; p<0.001), whether the participant has heard before about MVD (aOR=2.24; 95% CI 1.82 to 2.75; p<0.001), whether they modified their working habits (aOR=2.79; 95% CI 2.12 to 3.67; p<0.001), nationality (p<0.001) and being a HCW (aOR=2.71; 95% CI 2.01 to 3.67; p<0.001). The predictors of good attitude were being female (aOR=0.71; 95% CI 0.60 to 0.85; p<0.001), age (aOR=0.99; 95% CI 0.98 to 0.99; p=0.01), place of residence (aOR=3.13; 95% CI 2.46 to 3.99; p<0.001), level of education (aOR=1.67; 95% CI 1.37 to 2.04; p<0.001), knowing the correct mode of transmission (aOR=1.59; 95% CI 1.28 to 1.98; p<0.001), modification of working habits (aOR=1.30; 95% CI 1.01 to 1.68; p=0.039) and nationality (p<0.001). The predictors of practice were being female (aOR=1.17; 95% CI 1.01 to 1.37; p=0.042), place of residence (aOR=1.23; 95% CI 1.02 to 1.48; p=0.033), marital status (aOR=0.65; 95% CI 0.55 to 0.78; p<0.001), knowing the correct mode of transmission (aOR=0.46; 95% CI 0.38 to 0.56; p<0.001), modification of working habits (aOR=0.40; 95% CI 0.32 to 0.49; p<0.001) and occupation (aOR=0.37; 95% CI 0.30 to 0.46; p<0.001).</p><p><strong>Conclusions: </strong>Different modifiable and non-modifiable risk factors can be targeted to improve population perspectives towards MVD.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing an artificial intelligence system into a diabetic eye screening programme in Tanzania.","authors":"Charles R Cleland, William U Makupa, Bernadetha R Shilio, Justus Rwiza, David Macleod, Covadonga Bascaran, Matthew J Burton","doi":"10.1093/trstmh/trae132","DOIUrl":"https://doi.org/10.1093/trstmh/trae132","url":null,"abstract":"<p><p>Tanzania has the highest age-adjusted prevalence of diabetes in sub-Saharan Africa. Diabetic retinopathy, a common complication, is a significant cause of vision loss; but with effective screening and treatment this often can be prevented. However, with very few specialist eye care staff in Tanzania this is a major challenge. Artificial intelligence (AI) systems, which automate clinical decision making and therefore task-shift away from specialist staff, could contribute to improved diabetic retinopathy screening services in low-resource settings. This article describes our experiences of selecting, procuring and implementing an AI system into a regional diabetic eye screening programme in northern Tanzania.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"False-positive dengue non-structural protein 1 in pregnancy.","authors":"Tonnii Sia, Tze-Cheng Wong, Yee-Chiing Ong","doi":"10.1093/trstmh/trae134","DOIUrl":"https://doi.org/10.1093/trstmh/trae134","url":null,"abstract":"<p><p>Dengue is a vector-borne infection, which contributes to significant morbidity and mortality in endemic areas. It manifests rapidly within 2 wk from febrile, critical to recovery phase. The point-of-care test (POCT) comprises the non-structural protein 1 (NS1) antigen, IgM and IgG, which aids rapid diagnosis, leading to timely treatment. Despite the high specificity of various POCTs, a few false-positive NS1 cases have been reported. We report the first case of false-positive NS1 antigen in pregnancy. A 24-y-old female in her second trimester of pregnancy presented with fever and chills for 9 d and a non-productive cough for 3 d. The dengue POCT showed NS1 antigen positive, IgM and IgG negative. Her symptoms were resolved with treatment of urinary tract infection with cefuroxime. Urine culture subsequently yielded Escherichia coli. Her recovery and delivery were uneventful. Her NS1 antigen was persistently positive for 18 d. The confirmatory real time-PCR for dengue and pan-Flaviviruses was negative.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Entomological investigation after an outbreak of dengue at the riverside of Rio Doce, Espírito Santo State, Brazil.","authors":"Helder Ricas Rezende, Creuza Rachel Vicente, Samira Chahad-Ehlers, Orlei Amaral Cardoso, Crispim Cerutti, Camila Malta Romano, Caio Santos de Souza, Giovana Santos Caleiro, Bruno Luiz Miranda Guedes, Lucas Mendes Ferreira, Filomena Euridice Carvalho de Alencar","doi":"10.1093/trstmh/trae123","DOIUrl":"https://doi.org/10.1093/trstmh/trae123","url":null,"abstract":"<p><strong>Background: </strong>In 2019, a dengue outbreak involving Aedes albopictus occurred in a rural area of Espírito Santo, Brazil, motivating our study in Sooretama and Linhares.</p><p><strong>Methods: </strong>We set traps to sample immature mosquito larvae at 40 sites, with weekly inspections from July 2022 to January 2023. Adult specimens were collected monthly at 19 sites, each collection lasting 15 min. The collections were performed during daylight using a Castro vacuum device, a small electric vacuum suction device, a net capture device and insect cages. We conducted molecular analyses of adult Aedes to identify arbovirus infection.</p><p><strong>Results: </strong>Among 20 217 immature forms, we identified Aedes aegypti (n=16 340), Aedes albopictus (n=3403), Culex quinquefasciatus (n=426) and Limatus durhami Theobald 1901 (n=48). Of the 3026 adult specimens, there were C. quinquefasciatus (n=2857), A. aegypti (n=141) and A. albopictus (n=28). Each site had an average of 159 adult specimens, 16 per house. Among the 159 specimens, 150 were C. quinquefasciatus. The average frequency of adult A. aegypti per house was 1.2 (0.08 per minute of collection). Adult Aedes were not infected.</p><p><strong>Conclusions: </strong>Entomological surveillance should consider A. albopictus and A. aegypti in rural areas, providing proper vector control strategies to prevent the spread of arboviruses.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human T-lymphotropic Virus infection among Quilombo communities in Central Brazil.","authors":"Carolina Amianti, Larissa M Bandeira, Lívia A Lima, Bárbara V do Lago, Antonio C R Vallinoto, Ana Rita C Motta-Castro","doi":"10.1093/trstmh/trae127","DOIUrl":"https://doi.org/10.1093/trstmh/trae127","url":null,"abstract":"<p><strong>Background: </strong>This study estimated the sociodemographic characteristics and prevalence of Human T-lymphotropic Virus (HTLV) infection among Afro-Brazilians in the two largest remnant Quilombo communities in Mato Grosso do Sul State.</p><p><strong>Methods: </strong>Participants were interviewed from October 2015 to October 2016. Blood samples were collected and screened for anti-HTLV-1/2 antibodies using a commercial ELISA kit.</p><p><strong>Results: </strong>No positive results for HTLV-1/2 infection were detected among the 316 screened samples.</p><p><strong>Conclusions: </strong>These findings provide additional information on the sociodemographic characteristics and HTLV status of Quilombos in Mato Grosso do Sul State.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of clinical and laboratory data between hantavirus infection and leptospirosis: a retrospective case series study in southern Taiwan.","authors":"Shih-Hao Lo, Tun-Chieh Chen, Chun-Yu Lin, Hsiao-Chen Hsieh, Ping-Chang Lai, Wei-Li Lien, Yen-Cheng Yeh, Ing-Kit Lee, Yen-Hsu Chen, Po-Liang Lu, Ko Chang","doi":"10.1093/trstmh/trae121","DOIUrl":"https://doi.org/10.1093/trstmh/trae121","url":null,"abstract":"<p><strong>Background: </strong>Leptospirosis (LS) and hantavirus (HV) are rodent-borne diseases and share similar clinical manifestations, posing diagnostic challenges.</p><p><strong>Methods: </strong>This retrospective study compared clinical characteristics, laboratory data, complications and outcomes of 33 LS and nine HV cases in Kaohsiung, Taiwan, from 2006 to 2021.</p><p><strong>Results: </strong>Both LS and HV diseases had high rates of acute kidney injury (84.8% vs 66.7%) and hepatitis (65.6% vs 88.9%); LS showed more hyperbilirubinemia (70% vs 12.5% in HV, p=0.005), higher initial creatinine levels (2.9 vs 1.37, p=0.018) and elevated initial C-reactive protein (218.3 vs 28.6 mg/dl, p<0.001), but lower initial lymphocyte percentage (6.63% vs 14.2%, p=0.005) and platelets (138.7/mm3 vs 68.9, p=0.016) compared with HV. Microscopic hematuria was significantly more prevalent in LS (80% vs 28.65% in HV, p=0.016). Notably, the LS and HV groups exhibited statistically significant differences in thrombocytopenia (57.5% vs 100%, p=0.019), hyperbilirubinemia (70% vs 12.5%, p=0.005), shock (45.5% vs 0%, p=0.016) and hematuria (80% vs 28.6%, p=0.016). Neither group experienced fatalities.</p><p><strong>Conclusions: </strong>Fever, thrombocytopenia and acute kidney injury alert physicians to consider LS and HV for differential diagnosis. Elevated bilirubin, along with hematuria or shock, suggests a preferred diagnosis for LS.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution of the schistosome intermediate snail host Biomphalaria pfeifferi in East Africa's river systems and the prevalence of Schistosoma mansoni infection.","authors":"Victor O Magero, Sammy Kisara, Mbaruk A Suleman, Christopher M Wade","doi":"10.1093/trstmh/trae115","DOIUrl":"https://doi.org/10.1093/trstmh/trae115","url":null,"abstract":"<p><strong>Background: </strong>There is a need for current and more detailed information on the distribution of Biomphalaria pfeifferi snails in East Africa's river systems. B. pfeifferi is arguably the most important snail intermediate host in the transmission of schistosomiasis, a disease ranked second to malaria in terms of tropical diseases of public health importance.</p><p><strong>Methods: </strong>We assessed the occurrence and geographical distribution of B. pfeifferi snails in Kenya, Uganda and Tanzania. Maximum entropy modelling was used to predict the potential distribution of B. pfeifferi snails and malacological surveys were conducted guided by MaxEnt predictions and information from previous studies. Malacological surveys were conducted at a total of 172 sites, including streams, rivers, dams, irrigation schemes and springs over a 3-y period from 2018 to 2020, with geospatial, ecological and physicochemical information recorded for each site.</p><p><strong>Results: </strong>B. pfeifferi snails were found at 23 of the 172 sites and inhabited a variety of habitat types. Of the 23 sites where B. pfeifferi snails were found, 15 (65.2%) were streams, 3 rivers (13.04%), 2 dams (8.7%), 2 springs (8.7%) and 1 an irrigation scheme (4.35%). B. pfeifferi abundance showed a significant positive correlation with increasing water temperature and decreasing water depth. In Kenya, B. pfeifferi snails were found around the Lake Victoria basin, the Mwea irrigation scheme and in parts of the former Eastern Province of Kenya. In Uganda, B. pfeifferi snails were found in Jinja District, Ntoroko District and Soroti District. In Tanzania, B. pfeifferi snails were found in the Iringa, Tabora and Kigoma Regions. We observed moderate to high prevalence of Schistosoma mansoni infection, with S. mansoni-infected snails found at 11 of 23 sites and with an average prevalence of 24.9% at infected sites. In Kenya, S. mansoni-infected snails were found in the Lake Victoria basin (22.5% prevalence at infected sites) and the former Eastern Province (13.5% prevalence at infected sites). In Uganda, infected snails were found in Ntoroko District (100% infected) and Soroti District (20% infected). In Tanzania, infected snails were found in the Kigoma Region, with a prevalence of 10% at the infected site.</p><p><strong>Conclusion: </strong>This information on the distribution of B. pfeifferi snails and S. mansoni infection in East Africa's river systems can aid in developing better prevention and control strategies for human schistosomiasis. Regular surveys of the river systems for snail intermediate hosts followed by molecular detection of schistosome infection could form a basis for the development of a prompt and cost-effective surveillance system for schistosomiasis in the region.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foetal outcome of Leptospira and Rickettsial infections during pregnancy: a systematic review.","authors":"Mallika Sengupta, Latha T, Soumitra Mandal, Kaushik Mukhopadhyay","doi":"10.1093/trstmh/trae053","DOIUrl":"10.1093/trstmh/trae053","url":null,"abstract":"<p><strong>Background: </strong>Leptospirosis and rickettsial infections are bacterial zoonoses prevalent in different geographical locations and presents with overlapping symptoms.</p><p><strong>Objective: </strong>To identify foetal outcomes in pregnant women diagnosed with rickettsial infections, including scrub typhus and leptospirosis, along with their associated factors.</p><p><strong>Methods: </strong>A comprehensive search was conducted in MEDLINE/PubMed, Scopus, CENTRAL (Cochrane), Web of Science, PsycINFO, Academic Search Premier, CINAHL, and Embase using defined search terms. Studies involving pregnant women with diagnosed leptospirosis and rickettsial infections, including scrub typhus, were selected. Two independent reviewers screened titles and abstracts using the Rayyan Web interface. Data extraction was performed in Microsoft Excel, with Zotero for reference management. Study quality was assessed using Joanna Briggs Institute Critical Appraisal tools. Data synthesis included narrative analysis.</p><p><strong>Results: </strong>Fifty-four studies were included: 22 on scrub typhus, 14 on rickettsial infection, 16 on leptospirosis, and 2 on all three infections. Of 176 scrub typhus cases, 53 resulted in foetal loss and 3 in neonatal death. Among 38 rickettsial infection cases, 4 had foetal loss. Out of 63 leptospirosis cases, 13 experienced foetal loss. Six maternal deaths occurred due to scrub typhus and one due to Rocky Mountain spotted fever.</p><p><strong>Conclusion: </strong>Leptospirosis and rickettsial infections, including scrub typhus, are important causes of pregnancy loss. Further research is needed to better understand and mitigate these risks in pregnant women.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"814-828"},"PeriodicalIF":1.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A combined tropical medicine and psychiatry approach to patients with possible delusional infestation.","authors":"S B Squire, M Taegtmeyer, Q Javed, T O'Dempsey, C Kullu, P Lepping","doi":"10.1093/trstmh/trae054","DOIUrl":"10.1093/trstmh/trae054","url":null,"abstract":"<p><strong>Background: </strong>Delusional infestation (DI) is a well-recognized delusional disorder presenting as the persisting belief of being infested. Combined clinics have been run by dermatology and psychiatry in a small number of centres. In this article we focus on our Liverpool University Hospitals NHS Foundation Trust clinic hosted at the Liverpool School of Tropical Medicine, UK, where we run a specialist clinic for DI.</p><p><strong>Methods: </strong>We describe the specific set-up and approach of our clinic as a guide for clinicians working in specialties likely to see patients with DI (including tropical medicine, infectious diseases and dermatology) who may either want to set up similar clinics or be better equipped to manage DI patients promptly within existing practice.</p><p><strong>Results: </strong>We describe the details of the clinic's approach. Between 2018 and 2023, the service saw 208 patients, of which 82.7% could be assessed and 55.7% had DI. The female:male ratio was 2:1.</p><p><strong>Conclusion: </strong>Interdisciplinary combined clinics with medical and psychiatry consultants working together offer an approach to managing this rare, challenging and high-consequence condition.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"808-813"},"PeriodicalIF":1.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Podoconiosis in Uganda: prevalence, geographical distribution and risk factors.","authors":"Ivan Masete, Hope Simpson, Gabriel Matwale, Francis Mutebi, Marlene Thielecke, Fred Nuwaha, George Mukone, Kebede Deribe, Gail Davey","doi":"10.1093/trstmh/trae046","DOIUrl":"10.1093/trstmh/trae046","url":null,"abstract":"<p><strong>Background: </strong>Podoconiosis is a neglected debilitating yet preventable disease. Despite its public health significance, podoconiosis is often misdiagnosed and confused with lymphatic filariasis. No appropriate diagnostic tests exist, contributing to underestimation and the absence of control interventions.</p><p><strong>Methods: </strong>A population-based cross-sectional survey was conducted in seven districts with suspected or reported cases of podoconiosis or an altitude of 1200 m above sea level. Conducted from 30 January to 19 March 2023, the survey employed multilevel stratified sampling to reach eligible household members.</p><p><strong>Results: </strong>Of the 10 023 participants sampled, 187 (confidence interval 1.25 to 2.78) had clinical features of podoconiosis. The highest prevalence was recorded in Nakapiripirit (7.2% [58/809]) and Sironko (2.8 [44/1564]) and the lowest in Kasese (0.3% [5/1537]), but ranged from 1.1 to 1.8% in Zombo, Rukungiri, Gomba and Hoima districts. The duration of podoconiosis was reported to range from 1 to 57 y. Factors associated with podoconiosis occurrence included advanced age, tungiasis, household cleanliness and personal hygiene. Sleeping on a bed, bathing daily, use of soap and use of footwear in at least moderate condition were protective against podoconiosis.</p><p><strong>Conclusions: </strong>Podoconiosis occurred in all the sampled districts and was linked to personal hygiene. Long-standing cases suggest an absence of treatment. There is potential for early intervention using a holistic care model in managing this condition. Urgent action and stakeholder engagement are essential for effective podoconiosis management.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"790-798"},"PeriodicalIF":1.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}