{"title":"Social participation of people affected with leprosy in India: what does the literature tell us? A systematic review.","authors":"Pitchaimani Govindharaj, Sanjana Agrawal, Senthilkumar Ramasamy, Suganya Panneerselvam, Sandhya Bharathi Shanmugasundaram","doi":"10.1093/trstmh/traf110","DOIUrl":"https://doi.org/10.1093/trstmh/traf110","url":null,"abstract":"<p><p>Leprosy is a public health concern in India, with significant social stigma and exclusion faced by affected individuals. Social participation is a critical component of rehabilitation and overall well-being, yet limited evidence has been synthesized regarding the associated factors. Therefore, this systematic review aimed to provide an overview of the social participation of people affected by leprosy from the existing literature in India. Scopus, PubMed and InfoLep databases were searched to identify the articles for the systematic review, which only includes studies conducted in India. The critical appraisal tool of cross-sectional studies-AXIS-was used to assess the study quality and risk of bias. The search identified 458 articles; 23 full-text articles were considered for eligibility, six of which were included in the review. All studies used the Participation Scale to assess social participation in individuals with leprosy. Findings showed associations between older age, female gender, lower socioeconomic status, longer disease duration and the multibacillary form of leprosy with participation restrictions. To overcome the restrictions on the social activities of people affected by leprosy, a comprehensive approach, consisting of health promotion activities, early accessible healthcare and improved rehabilitation services, is needed.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Leprosy in India: challenges, advances and the path to eradication.","authors":"Sayanti Chatterjee, Pragya Santra, Riddhi Paul, Asesh Banerjee, Prabuddha Gupta","doi":"10.1093/trstmh/traf107","DOIUrl":"https://doi.org/10.1093/trstmh/traf107","url":null,"abstract":"<p><p>The fight against leprosy has entered the crucial final phase in India, with the government's announcement of a national plan for zero transmission by 2027. Presently, leprosy has pockets of high prevalence in India and unknown transmission chains. At this juncture, we focus on essential aspects of this disease to help everyone understand the basics of the causative agent, disease prognosis, epidemiology, disease-associated societal implications and prevention strategies. Our endeavour aims to inspire novel concepts among early career researchers for combating leprosy.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Smith L Chanelle, Primrose Magala, Ian Yeung, Ibrahim Bwaga, Moses W Mulimira, Tom Didimus Ediamu, Sheba G Nakacubo, Noreen Atwijukire, Innocent Ayesiga
{"title":"Global health partnerships in ophthalmology: lessons from the UK-Ugandan global health exchange placement.","authors":"Smith L Chanelle, Primrose Magala, Ian Yeung, Ibrahim Bwaga, Moses W Mulimira, Tom Didimus Ediamu, Sheba G Nakacubo, Noreen Atwijukire, Innocent Ayesiga","doi":"10.1093/trstmh/traf111","DOIUrl":"https://doi.org/10.1093/trstmh/traf111","url":null,"abstract":"<p><p>This article evaluates the outcomes and insights from a collaborative initiative between Moorfields Eye Hospital volunteers, Eye Health Africa and the Ubora Foundation Africa focused on strengthening ophthalmic services in Uganda, particularly at Hoima Regional Referral Hospital. Drawing on comparative insights from National Health Service facilities in the West Midlands (UK), the article reflects on infrastructure limitations; workforce constraints; the collaborative, system-level interventions that must be introduced; and some initial initiatives made possible through the exchange. Emphasis is placed on sustainability, local capacity building and bilateral learning, with implications for replicable models of ophthalmic care development in low-resource settings. Lessons learned reveal the importance of cultural humility, context-specific innovation and long-term investment in human resources for health in the global fight against avoidable blindness and improving patient outcomes while offering a framework for future global eye health partnerships.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luis A Chávez-Almazán, Hugo A Saldarriaga-Noreña, Diana Garibo-Ruiz, Ma Concepción Arcos-Cuevas
{"title":"Inhibition of butyrylcholinesterase in a population exposed to insecticides during a campaign against Aedes aegypti.","authors":"Luis A Chávez-Almazán, Hugo A Saldarriaga-Noreña, Diana Garibo-Ruiz, Ma Concepción Arcos-Cuevas","doi":"10.1093/trstmh/traf108","DOIUrl":"https://doi.org/10.1093/trstmh/traf108","url":null,"abstract":"<p><strong>Background: </strong>Chemical control remains a widely used strategy to reduce morbidity from vector-borne diseases such as dengue. However, the potential health risks to exposed populations necessitates ongoing monitoring, particularly due to the toxicity and volume of insecticides employed.</p><p><strong>Methods: </strong>This study assessed butyrylcholinesterase activity in residents of a city in southern Mexico during distinct periods of exposure to carbamate and organophosphate insecticides.</p><p><strong>Results: </strong>A statistically significant inhibition of enzymatic activity was observed during the rainy season, which coincided with an increase in insecticide application.</p><p><strong>Conclusions: </strong>These findings highlight the need for public health authorities to implement preventative measures aimed at minimizing poisoning risks associated with vector control activities.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chagas disease: host responses, parasite evasion and vaccine advances.","authors":"Héctor Serrano-Coll","doi":"10.1093/trstmh/traf109","DOIUrl":"https://doi.org/10.1093/trstmh/traf109","url":null,"abstract":"<p><p>Chagas disease is a parasitic infection caused by Trypanosoma cruzi. Although the host immune response has been extensively studied, important knowledge gaps remain, particularly regarding the complex and multifaceted immune evasion mechanisms employed by the parasite, both at the innate and adaptive levels. In recent years, multiple promising vaccine candidates have been developed, but further evaluation is needed across the different phases of clinical trials. Therefore, the aim of this review is to examine the host immune response to T. cruzi, the parasite's immune evasion strategies and recent advances in vaccine development aimed at controlling infection.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdul Rahman Kazim, Sze Yin Ng, Nur Adilla Zaini, Van Lun Low, Jamal Houssaini, Dennis Tappe, Chong Chin Heo
{"title":"Molecular detection of a relapsing fever Borrelia in Dermacentor auratus infesting a human, with a brief review of human otoacariasis cases in Malaysia.","authors":"Abdul Rahman Kazim, Sze Yin Ng, Nur Adilla Zaini, Van Lun Low, Jamal Houssaini, Dennis Tappe, Chong Chin Heo","doi":"10.1093/trstmh/traf106","DOIUrl":"https://doi.org/10.1093/trstmh/traf106","url":null,"abstract":"<p><p>This study reports the detection of a relapsing fever Borrelia in the gilded boar tick, Dermacentor auratus, extracted from the ear canal of a human patient in Kedah, Peninsular Malaysia. Molecular analysis of the flaB gene identified the Borrelia species as identical to Borrelia sp. isolate HNF1F2 from China (ON060668) and closely related (99.60%) to Borrelia theileri isolate B22 from Colombia (ON135433). This article also provides a comprehensive review of human otoacariasis cases in Malaysia and discusses the limitations associated with these cases.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unlocking the potential of blood-stage vaccines for malaria elimination.","authors":"Shrikant Nema, Sumit Rathore, Asif Mohmmed, Pawan Malhotra","doi":"10.1093/trstmh/traf013","DOIUrl":"10.1093/trstmh/traf013","url":null,"abstract":"<p><p>Malaria vaccines are crucial for advancing public health and achieving malaria elimination. Currently, pre-erythrocytic vaccines like RTS, S/AS01 and R21/Matrix-M are in use, but their effectiveness is limited. Ongoing research on blood-stage vaccine candidates such as RH5, MSP1 and MSP3 has shown promising results. Incorporating a blood-stage vaccine could greatly enhance malaria control by targeting the symptomatic phase of the infection, providing additional protection alongside pre-erythrocytic vaccines and other control methods. Understanding the structural biology and immunological interactions of blood-stage antigens is essential for developing effective vaccines. Combining pre-erythrocytic and erythrocytic-stage vaccines could lead to better protection, improved public health outcomes and significant progress toward malaria elimination.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1200-1203"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7617735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Waist circumference and waist-to-height ratio are better predictors of body mass index changes in adolescents in Ho Chi Minh City.","authors":"Hong K Tang, Trang H H Nguyen, Michael J Dibley","doi":"10.1093/trstmh/traf049","DOIUrl":"10.1093/trstmh/traf049","url":null,"abstract":"<p><strong>Background: </strong>This study was conducted to assess the correlation between baseline waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), triceps skinfold thickness (TSFT) and subscapular skinfold thickness (SSFT) with body mass index (BMI) at follow-up and to identify the anthropometric parameters accounting for the highest proportion of the BMI variation among junior high school students in Ho Chi Minh City.</p><p><strong>Methods: </strong>This was a 5-y prospective cohort study; 761 students were followed annually. Data collected included height, weight, WC, TSFT and SSFT. Pearson correlation coefficients were calculated to investigate the correlations between baseline anthropometric parameters with BMI at follow-up. Multilevel mixed-effect models with linear regression analyses and Poisson regression were used to assess the relationship between all listed variables with BMI changes as well as the risk of being overweight/obesity.</p><p><strong>Results: </strong>BMI, WC, TSFT, SSFT, WHtR, the sum of four skinfold thicknesses and % body fat at baseline were all strongly correlated with BMI at follow-up (p<0.001). Among multiple linear regression models, the models with WC or WHtR accounted for the highest variation in BMI changes (approximately 74.5%) (p<0.001), while the model with WHR explained only 22.7% of the variation in BMI changes.</p><p><strong>Conclusion: </strong>WC is a simple anthropometric indicator, which can be easily used to assess adiposity and is significantly associated with BMI changes over time.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1141-1148"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Malaria microscopy: a challenge in malaria elimination.","authors":"Ranjan Kumar Singh","doi":"10.1093/trstmh/traf014","DOIUrl":"10.1093/trstmh/traf014","url":null,"abstract":"","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"e8-e9"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chia-Kwung Fan, Ting-Wu Chuang, Hon-Ian Lei, Vincent P Gyang, Tyng-Shiuan Hsieh, Po-Ching Cheng, Chia-Mei Chou, Olaoluwa P Akinwale
{"title":"Seroprevalence and risk factors of Anisakis simplex in Makoko schoolchildren: insights from a Lagos, Nigeria slum.","authors":"Chia-Kwung Fan, Ting-Wu Chuang, Hon-Ian Lei, Vincent P Gyang, Tyng-Shiuan Hsieh, Po-Ching Cheng, Chia-Mei Chou, Olaoluwa P Akinwale","doi":"10.1093/trstmh/traf055","DOIUrl":"10.1093/trstmh/traf055","url":null,"abstract":"<p><strong>Background: </strong>Anisakis simplex is a parasitic zoonosis associated with consuming raw or undercooked fish. Despite its global relevance, data from Africa are scarce. This study assessed the seroprevalence and risk factors of A. simplex infection among primary schoolchildren (PSC) in Makoko, an urban slum in Lagos, Nigeria.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from November 2013 to March 2014 involving 196 PSC from three government schools. Serodiagnosis was performed using enzyme-linked immunosorbent assay (ELISA) with recombinant Ani s 1 and Ani s 7 allergens. Stool samples were examined for soil-transmitted helminths (STHs) using the Kato-Katz method. Structured questionnaires gathered demographic and dietary information.</p><p><strong>Results: </strong>The overall seroprevalence of A. simplex infection was 12.25%. No significant association was found with gender or raw fish consumption. However, parental education and occupation influenced seropositivity. Interestingly, co-infection with STHs was inversely associated with A. simplex seropositivity. ELISA demonstrated high specificity with minimal cross-reactivity to STHs.</p><p><strong>Conclusions: </strong>This study provides the first seroepidemiological data on A. simplex in Nigerian children. Public health interventions, particularly fish-handling education, are warranted. Further research is needed to understand the clinical relevance of A. simplex sensitization in African settings.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1184-1191"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}