Transactions of The Royal Society of Tropical Medicine and Hygiene最新文献

Seroprevalence and risk factors of Anisakis simplex in Makoko schoolchildren: insights from a Lagos, Nigeria slum. 马科科学童单纯异尖线虫的血清患病率和危险因素：来自尼日利亚拉各斯贫民窟的见解。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-05-29 DOI: 10.1093/trstmh/traf055

Chia-Kwung Fan, Ting-Wu Chuang, Hon-Ian Lei, Vincent P Gyang, Tyng-Shiuan Hsieh, Po-Ching Cheng, Chia-Mei Chou, Olaoluwa P Akinwale

{"title":"Seroprevalence and risk factors of Anisakis simplex in Makoko schoolchildren: insights from a Lagos, Nigeria slum.","authors":"Chia-Kwung Fan, Ting-Wu Chuang, Hon-Ian Lei, Vincent P Gyang, Tyng-Shiuan Hsieh, Po-Ching Cheng, Chia-Mei Chou, Olaoluwa P Akinwale","doi":"10.1093/trstmh/traf055","DOIUrl":"https://doi.org/10.1093/trstmh/traf055","url":null,"abstract":"Background: Anisakis simplex is a parasitic zoonosis associated with consuming raw or undercooked fish. Despite its global relevance, data from Africa are scarce. This study assessed the seroprevalence and risk factors of A. simplex infection among primary schoolchildren (PSC) in Makoko, an urban slum in Lagos, Nigeria.Methods: A cross-sectional study was conducted from November 2013 to March 2014 involving 196 PSC from three government schools. Serodiagnosis was performed using enzyme-linked immunosorbent assay (ELISA) with recombinant Ani s 1 and Ani s 7 allergens. Stool samples were examined for soil-transmitted helminths (STHs) using the Kato-Katz method. Structured questionnaires gathered demographic and dietary information.Results: The overall seroprevalence of A. simplex infection was 12.25%. No significant association was found with gender or raw fish consumption. However, parental education and occupation influenced seropositivity. Interestingly, co-infection with STHs was inversely associated with A. simplex seropositivity. ELISA demonstrated high specificity with minimal cross-reactivity to STHs.Conclusions: This study provides the first seroepidemiological data on A. simplex in Nigerian children. Public health interventions, particularly fish-handling education, are warranted. Further research is needed to understand the clinical relevance of A. simplex sensitization in African settings.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An enigmatic case of lepromatous leprosy: unveiling the role of inoculation. 一个谜样的麻风病病例：揭示接种的作用。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-05-24 DOI: 10.1093/trstmh/traf054

Kiranmayee Chandaluri, Sudhir Babu Karri, Vinod Hanumanthu

引用次数: 0

Hydroxynaphthol blue-based loop-mediated isothermal amplification for the rapid detection of Burkholderia pseudomallei. 基于羟基酚蓝的环介导等温扩增快速检测假马氏伯克氏菌。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-05-23 DOI: 10.1093/trstmh/traf053

Wiphat Klayut, Panatda Aramrueang, Benjawan Phetsuksiri, Sopa Srisungngam, Watcharee Saisongkorh, Ballang Uppapong, Janisara Rudeeaneksin

{"title":"Hydroxynaphthol blue-based loop-mediated isothermal amplification for the rapid detection of Burkholderia pseudomallei.","authors":"Wiphat Klayut, Panatda Aramrueang, Benjawan Phetsuksiri, Sopa Srisungngam, Watcharee Saisongkorh, Ballang Uppapong, Janisara Rudeeaneksin","doi":"10.1093/trstmh/traf053","DOIUrl":"https://doi.org/10.1093/trstmh/traf053","url":null,"abstract":"Background: Melioidosis is a potentially life-threatening disease caused by Burkholderia pseudomallei. It is endemic in Southeast Asia and northern Australia and is increasingly distributed in other tropical and subtropical regions. Fast and accurate detection of B. pseudomallei is crucial for initiating prompt and effective treatment.Methods: Loop-mediated isothermal amplification (LAMP) using hydroxynaphthol blue (HNB) for visual detection has been developed and evaluated to detect B. pseudomallei.Results: The assay amplified B. pseudomallei TTSS1-orf2 at 63°C with a 60-min reaction and no cross-amplification was observed. The detection limit was 1.85×102 fg/µl of B. pseudomallei DNA or 2.08×102 CFU/ml of B. pseudomallei spiked in blood, sputum and urine samples. Clinical evaluation using 191 residual specimens revealed 100% negative agreement in detecting 48 of 49 culture-positive samples. Overall, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value were 97.96%, 100%, 99.48%, 100% and 99.30%, respectively, while the κ index showed substantial agreement with the culture method (κ=0.99).Conclusions: This LAMP assay demonstrated good performance, with easy operation and low cost for the rapid detection of B. pseudomallei. It has the potential to be an alternative molecular tool for the early diagnosis of melioidosis in clinical settings.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Projecting high-level dengue increases during low-incidence months in a large endemic urban area. 预测登革热在大城市流行地区的低发病率月份出现高水平上升。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-05-22 DOI: 10.1093/trstmh/traf052

Alexandre Cunha Costa, José Micael Ferreira da Costa, Rafaella Pessoa Moreira, Tahissa Frota Cavalcante, Luiz Martins de Araújo Júnior, Thamara Kely de Sousa Fernandes, Glauciano de Oliveira Ferreira, Jéssica Silva, Cleiton da Silva Silveira, Luciano Pamplona de Góes Cavalcanti

{"title":"Projecting high-level dengue increases during low-incidence months in a large endemic urban area.","authors":"Alexandre Cunha Costa, José Micael Ferreira da Costa, Rafaella Pessoa Moreira, Tahissa Frota Cavalcante, Luiz Martins de Araújo Júnior, Thamara Kely de Sousa Fernandes, Glauciano de Oliveira Ferreira, Jéssica Silva, Cleiton da Silva Silveira, Luciano Pamplona de Góes Cavalcanti","doi":"10.1093/trstmh/traf052","DOIUrl":"https://doi.org/10.1093/trstmh/traf052","url":null,"abstract":"Background: Climate change projections impact dengue transmission in tropical regions, creating diverse and complex public health challenges. The aim of this study was to project future seasonal dengue incidence in a large tropical urban area of Brazil, where dengue is endemic, by systematically analyzing climatic and dengue case time series.Methods: An epidemiological dengue model was developed using time series analysis techniques and forced with statistical downscaling from various Coupled Model Intercomparison Project Phase 6 (CMIP6) climate models based on Shared Socioeconomic Pathway (SSP) scenarios for the late twenty-first century (2071-2100). The ecological time-series investigation analyzed 193 618 dengue cases from January 2008 to December 2018. Statistical downscaling transformed low-resolution Global Climate Models' outputs into high-resolution data, based on a 30-y climate baseline.Results: The results indicated significant climate changes in seasonal temperature and precipitation by the end of the century. Under both SSP2-4.5 and SSP5-8.5 scenarios, substantial increases in dengue cases are projected during current low-incidence months, resulting in a reduced seasonality of dengue.Conclusions: The findings represent considerable challenges for future public health systems, which may face sustained high levels of dengue incidence throughout the year.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vulnerability of French overseas territories: the 2018-2022 hepatitis A outbreak in New Caledonia. 法国海外领土的脆弱性：新喀里多尼亚2018-2022年甲型肝炎爆发。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-05-20 DOI: 10.1093/trstmh/traf051

Ann-Claire Gourinat, Laura Dupont, Noémie Bargeolle, Anne Pfannstiel, Charlotte Duval, Vincent Portet-Sulla, Lina Mouna, Arnaud Cannet, Anne-Marie Roque-Afonso

{"title":"Vulnerability of French overseas territories: the 2018-2022 hepatitis A outbreak in New Caledonia.","authors":"Ann-Claire Gourinat, Laura Dupont, Noémie Bargeolle, Anne Pfannstiel, Charlotte Duval, Vincent Portet-Sulla, Lina Mouna, Arnaud Cannet, Anne-Marie Roque-Afonso","doi":"10.1093/trstmh/traf051","DOIUrl":"https://doi.org/10.1093/trstmh/traf051","url":null,"abstract":"Background: Hepatitis A virus (HAV) typically causes asymptomatic infection, especially in children <6 y of age. New Caledonia has low HAV endemicity, but a surge in cases between 2018 and 2022 prompted an analysis of epidemiological and virological features.Methods: A retrospective study analysed confirmed HAV cases (2018-2022), examining demographics, hospitalisations and alanine aminotransferase (ALT) levels. Phylogenetic analysis was conducted on isolated strains.Results: In mid-2018, imported cases from Vanuatu triggered the outbreak. Higher incidence rates were observed in the Loyalty Islands, particularly Maré Island, with subsequent spread to other areas. From 2018 to 2022, 672 cases were identified, with a median age of 13 y. Children <6 y of age accounted for 8.9% of cases, those ages 6-14 y for 54.2% and individuals ≥15 y for 36.9%. Hospitalisation occurred in 32.3% of cases. ALT levels were higher in hospitalised patients (p<0.001), but children <5 y of age had lower ALT levels overall. HAV genotyping from 16 available sera revealed subgenotype IA strains, with 14 of them linked to Vanuatu.Conclusions: The outbreak, triggered by imported strains from Vanuatu, was facilitated by environmental and infrastructural vulnerabilities. It highlights the need for improved vaccination, especially for travellers, and the critical role of water management in preventing future outbreaks. This also underscores the importance of tracking viral circulation in the Pacific region.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis of Plasmodium falciparum malaria at very low parasitaemias using a commercially available LAMP assay and RDT. 利用市售LAMP检测和RDT诊断恶性疟原虫疟疾的极低寄生虫血症。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-05-20 DOI: 10.1093/trstmh/traf050

Ruth O Payne, Nick J Edwards, Yrene Themistocleous, Sarah E Silk, Jordan R Barrett, Thomas A Rawlinson, Ian W Lim, Simon J Draper, Angela M Minassian

{"title":"Diagnosis of Plasmodium falciparum malaria at very low parasitaemias using a commercially available LAMP assay and RDT.","authors":"Ruth O Payne, Nick J Edwards, Yrene Themistocleous, Sarah E Silk, Jordan R Barrett, Thomas A Rawlinson, Ian W Lim, Simon J Draper, Angela M Minassian","doi":"10.1093/trstmh/traf050","DOIUrl":"https://doi.org/10.1093/trstmh/traf050","url":null,"abstract":"Background: Malaria is the most common tropical infection in the UK. Current guidelines suggest that testing on 3 consecutive days is required following an initial negative result. This study aimed to see whether newer diagnostics (loop-mediated amplification assay [LAMP]) had sufficient sensitivity to support a change in diagnostic practice.Methods: Blood samples from 11 participants who had undergone controlled human malaria infection (CHMI) with Plasmodium falciparum malaria were assessed from day 6 (C+6) for malaria positivity using the Carestart Malaria rapid diagnostic test (RDT) and from C+4 using the Alethia Malaria LAMP assay. Quantitative polymerase chain reaction had been performed twice daily during CHMI follow-up. A retrospective analysis of samples submitted to the Sheffield Teaching Hospitals for malaria testing over a 5-y period was conducted, evaluating the combination of the Carestart RDT alongside blood film analysis, as per UK guidelines.Results: In CHMI samples, LAMP was positive for all parasitaemias >1000 parasites/ml, whereas RDTs were less reliable (59% positive for parasitaemias >1000 parasites/ml). The combination of RDT and blood films for clinical samples diagnosed most infections, but only a minority of negative samples had subsequent tests.Conclusions: LAMP has higher sensitivity than current UK recommended methods, with a potential to review the requirement for additional days of testing in the majority of patients.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ending nuclear weapons, before they end us†. 在核武器终结我们之前终结它们。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-05-19 DOI: 10.1093/trstmh/traf047

Kamran Abbasi, Parveen Ali, Virginia Barbour, Marion Birch, Inga Blum, Peter Doherty, Andy Haines, Ira Helfand, Richard Horton, Kati Juva, Jose F Lapena, Robert Mash, Olga Mironova, Arun Mitra, Carlos Monteiro, Elena N Naumova, David Onazi, Tilman Ruff, Peush Sahni, James Tumwine, Carlos Umaña, Paul Yonga, Chris Zielinski

引用次数: 0

Waist circumference and waist-to-height ratio are better predictors of body mass index changes in adolescents in Ho Chi Minh City. 腰围和腰高比是胡志明市青少年体质指数变化的较好预测因子。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-05-13 DOI: 10.1093/trstmh/traf049

Hong K Tang, Trang H H Nguyen, Michael J Dibley

{"title":"Waist circumference and waist-to-height ratio are better predictors of body mass index changes in adolescents in Ho Chi Minh City.","authors":"Hong K Tang, Trang H H Nguyen, Michael J Dibley","doi":"10.1093/trstmh/traf049","DOIUrl":"https://doi.org/10.1093/trstmh/traf049","url":null,"abstract":"Background: This study was conducted to assess the correlation between baseline waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), triceps skinfold thickness (TSFT) and subscapular skinfold thickness (SSFT) with body mass index (BMI) at follow-up and to identify the anthropometric parameters accounting for the highest proportion of the BMI variation among junior high school students in Ho Chi Minh City.Methods: This was a 5-y prospective cohort study; 761 students were followed annually. Data collected included height, weight, WC, TSFT and SSFT. Pearson correlation coefficients were calculated to investigate the correlations between baseline anthropometric parameters with BMI at follow-up. Multilevel mixed-effect models with linear regression analyses and Poisson regression were used to assess the relationship between all listed variables with BMI changes as well as the risk of being overweight/obesity.Results: BMI, WC, TSFT, SSFT, WHtR, the sum of four skinfold thicknesses and % body fat at baseline were all strongly correlated with BMI at follow-up (p<0.001). Among multiple linear regression models, the models with WC or WHtR accounted for the highest variation in BMI changes (approximately 74.5%) (p<0.001), while the model with WHR explained only 22.7% of the variation in BMI changes.Conclusion: WC is a simple anthropometric indicator, which can be easily used to assess adiposity and is significantly associated with BMI changes over time.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Male sex is associated with a higher risk of multibacillary leprosy and leprosy-associated disability in northeast Brazil. 在巴西东北部，男性与多菌性麻风病和麻风病相关残疾的高风险相关。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-05-13 DOI: 10.1093/trstmh/traf048

Julia S Barreto, Rodrigo A Cazzaniga, Márcio Bezerra-Santos, Lenise F Albuquerque, Daniela T de Oliveira, Jonnia Maria S Araujo, Angela M da Silva, Camilla Natália O Santos, Amelia R de Jesus, Lucas S Magalhães

引用次数: 0

Drug-resistant tuberculosis treatment outcomes among Saharia: a marginalized community of Madhya Pradesh, India. 撒哈拉地区：印度中央邦边缘社区的耐药结核病治疗结果。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-05-08 DOI: 10.1093/trstmh/traf046

Prashant Mishra, Jyothi Bhat, Ravendra K Sharma, Rajiv Yadav, Malaisamy Muniyandi, Mercy Aparna Lingala, Samridhi Nigam, Vikas G Rao

{"title":"Drug-resistant tuberculosis treatment outcomes among Saharia: a marginalized community of Madhya Pradesh, India.","authors":"Prashant Mishra, Jyothi Bhat, Ravendra K Sharma, Rajiv Yadav, Malaisamy Muniyandi, Mercy Aparna Lingala, Samridhi Nigam, Vikas G Rao","doi":"10.1093/trstmh/traf046","DOIUrl":"https://doi.org/10.1093/trstmh/traf046","url":null,"abstract":"Background: Few attempts have been made to explore the drug-resistant tuberculosis (DR-TB) outcomes and associated factors among underprivileged communities. This study aimed to determine DR-TB treatment outcomes and associated factors in the Saharia tribal group (TGs), a community with a high TB burden in Madhya Pradesh, India.Methods: TB cases were detected through active case finding and were treated under the National Tuberculosis Elimination Programme. All the patients who were initiated on DR-TB treatment and had outcomes at the end of treatment were included in the study. The DR-TB treatment outcomes and associated factors were recorded.Findings: Of 323 patients included in the analysis, 216 patients (66.8%) had successful treatment outcomes, including 70 (21.7%) who were cured and another 146 (45.2%) who completed treatment. Among the rest, 36 (11.1%) died, 66 (20.4%) were lost to follow-up and 5 (1.5%) had treatment failure. A total of 83% of patients were rifampicin resistant (RR)/multidrug resistant (MDR).Conclusions: Although the program's recommended target of >75% could not be achieved, the treatment success rate in the study is still admirable in a hard-to-reach high-TB-risk tribal area. The findings show that with community-based approaches, favourable treatment outcomes can be achieved in DR-TB patients from resource-poor settings.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0