Christiane Maria Ayo, Amarilis Giaretta de Moraes, Laise Nayana Sala Elpídio, Aléia Harumi Uchibaba Yamanaka, Victor Hugo de Souza, Fernanda Morselli Lo Ré, Tainara Pinho, Maurício Lacerda Nogueira, Cinara de Cássia Brandão, Lígia Consentino Junqueira Franco Spegiorin, Denise Cristina Moz Vaz Oliani, Nathalia Zini, Ieda Bernadete Volkweis Langer, Greicy Cezar do Amaral, Quirino Alves de Lima Neto, Luiz Carlos de Mattos, Jeane Eliete Laguila Visentainer
{"title":"toll样受体3rs3775291与巴西寨卡病毒感染的关系","authors":"Christiane Maria Ayo, Amarilis Giaretta de Moraes, Laise Nayana Sala Elpídio, Aléia Harumi Uchibaba Yamanaka, Victor Hugo de Souza, Fernanda Morselli Lo Ré, Tainara Pinho, Maurício Lacerda Nogueira, Cinara de Cássia Brandão, Lígia Consentino Junqueira Franco Spegiorin, Denise Cristina Moz Vaz Oliani, Nathalia Zini, Ieda Bernadete Volkweis Langer, Greicy Cezar do Amaral, Quirino Alves de Lima Neto, Luiz Carlos de Mattos, Jeane Eliete Laguila Visentainer","doi":"10.1093/trstmh/traf063","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Zika virus (ZIKV) is an emergent pathogen known for the outbreak in early 2015, causing significant consequences, of which congenital ZIKV syndrome is the most severe manifestation. Toll-like receptors (TLRs) are important for the appropriate function of the innate immune response against pathogens. The presence of mutations in TLR genes can potentially result in altered susceptibility to diseases. Thus, this study aimed to investigate the influence of TLR2 rs5743708, TLR3 rs3775291, TLR4 rs4986790, TLR4 rs4986791, TLR6 rs5743810 and TLR7 rs179008 polymorphisms in ZIKV infection in a case-control study.</p><p><strong>Methods: </strong>The study enrolled 142 patients with ZIKV that sought medical care with ZIKV-related symptoms during the ZIKV outbreak and 142 controls. Genotyping was carried out by PCR-RFLP. Multivariate and χ2 analyses were performed to assess associations between polymorphisms and disease.</p><p><strong>Results: </strong>The dominant inheritance model revealed an increased risk for patients who were carriers of the TLR3 rs3775291 T allele. The C/T-T/T genotypes were significantly increased in patients rather than controls compared with the C/C genotype (OR=1.76, 95% CI 1.05 to 2.94; p=0.03).</p><p><strong>Conclusions: </strong>Our data support the literature and suggest that the variant rs3775291 in TLR3 may confer susceptibility to ZIKV infection in the Brazilian population.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of Toll-like receptor 3 rs3775291 with Zika virus infection in Brazil.\",\"authors\":\"Christiane Maria Ayo, Amarilis Giaretta de Moraes, Laise Nayana Sala Elpídio, Aléia Harumi Uchibaba Yamanaka, Victor Hugo de Souza, Fernanda Morselli Lo Ré, Tainara Pinho, Maurício Lacerda Nogueira, Cinara de Cássia Brandão, Lígia Consentino Junqueira Franco Spegiorin, Denise Cristina Moz Vaz Oliani, Nathalia Zini, Ieda Bernadete Volkweis Langer, Greicy Cezar do Amaral, Quirino Alves de Lima Neto, Luiz Carlos de Mattos, Jeane Eliete Laguila Visentainer\",\"doi\":\"10.1093/trstmh/traf063\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Zika virus (ZIKV) is an emergent pathogen known for the outbreak in early 2015, causing significant consequences, of which congenital ZIKV syndrome is the most severe manifestation. Toll-like receptors (TLRs) are important for the appropriate function of the innate immune response against pathogens. The presence of mutations in TLR genes can potentially result in altered susceptibility to diseases. Thus, this study aimed to investigate the influence of TLR2 rs5743708, TLR3 rs3775291, TLR4 rs4986790, TLR4 rs4986791, TLR6 rs5743810 and TLR7 rs179008 polymorphisms in ZIKV infection in a case-control study.</p><p><strong>Methods: </strong>The study enrolled 142 patients with ZIKV that sought medical care with ZIKV-related symptoms during the ZIKV outbreak and 142 controls. Genotyping was carried out by PCR-RFLP. Multivariate and χ2 analyses were performed to assess associations between polymorphisms and disease.</p><p><strong>Results: </strong>The dominant inheritance model revealed an increased risk for patients who were carriers of the TLR3 rs3775291 T allele. The C/T-T/T genotypes were significantly increased in patients rather than controls compared with the C/C genotype (OR=1.76, 95% CI 1.05 to 2.94; p=0.03).</p><p><strong>Conclusions: </strong>Our data support the literature and suggest that the variant rs3775291 in TLR3 may confer susceptibility to ZIKV infection in the Brazilian population.</p>\",\"PeriodicalId\":23218,\"journal\":{\"name\":\"Transactions of The Royal Society of Tropical Medicine and Hygiene\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-07-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Transactions of The Royal Society of Tropical Medicine and Hygiene\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/trstmh/traf063\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transactions of The Royal Society of Tropical Medicine and Hygiene","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/trstmh/traf063","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Association of Toll-like receptor 3 rs3775291 with Zika virus infection in Brazil.
Background: Zika virus (ZIKV) is an emergent pathogen known for the outbreak in early 2015, causing significant consequences, of which congenital ZIKV syndrome is the most severe manifestation. Toll-like receptors (TLRs) are important for the appropriate function of the innate immune response against pathogens. The presence of mutations in TLR genes can potentially result in altered susceptibility to diseases. Thus, this study aimed to investigate the influence of TLR2 rs5743708, TLR3 rs3775291, TLR4 rs4986790, TLR4 rs4986791, TLR6 rs5743810 and TLR7 rs179008 polymorphisms in ZIKV infection in a case-control study.
Methods: The study enrolled 142 patients with ZIKV that sought medical care with ZIKV-related symptoms during the ZIKV outbreak and 142 controls. Genotyping was carried out by PCR-RFLP. Multivariate and χ2 analyses were performed to assess associations between polymorphisms and disease.
Results: The dominant inheritance model revealed an increased risk for patients who were carriers of the TLR3 rs3775291 T allele. The C/T-T/T genotypes were significantly increased in patients rather than controls compared with the C/C genotype (OR=1.76, 95% CI 1.05 to 2.94; p=0.03).
Conclusions: Our data support the literature and suggest that the variant rs3775291 in TLR3 may confer susceptibility to ZIKV infection in the Brazilian population.
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Transactions of the Royal Society of Tropical Medicine and Hygiene publishes authoritative and impactful original, peer-reviewed articles and reviews on all aspects of tropical medicine.
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