Transactions of The Royal Society of Tropical Medicine and Hygiene最新文献_第2页

Snakebite envenoming in India: it is time we look beyond the concept of the Big Four species. 印度毒蛇咬伤事件：是时候超越四大物种的概念了。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-02 DOI: 10.1093/trstmh/traf042

Jaideep C Menon, T P Sreekrishnan, Sabarish B Nair, Vijay V Pillay, Srikanta Kanungo, M S Aravind, Omesh K Bharti, Joseph K Joseph, Sanghamitra Pati

{"title":"Snakebite envenoming in India: it is time we look beyond the concept of the Big Four species.","authors":"Jaideep C Menon, T P Sreekrishnan, Sabarish B Nair, Vijay V Pillay, Srikanta Kanungo, M S Aravind, Omesh K Bharti, Joseph K Joseph, Sanghamitra Pati","doi":"10.1093/trstmh/traf042","DOIUrl":"10.1093/trstmh/traf042","url":null,"abstract":"India faces substantial challenges from snakebite envenoming secondary to the high morbidity, mortality and financial burden, particularly in rural communities. While concentrated on the 'Big Four' venomous species, recent research indicates a necessity to expand the focus to encompass additional medically relevant species. This review emphasizes the geographic heterogeneity in venom among these snakes, which impacts antivenom effectiveness and necessitating region-specific formulations. This analysis highlights the shortcomings of current antivenoms and identifies non-Big Four species involved in snakebite envenoming, advocating for an urgent shift to inclusive antivenom strategies that integrate local venom profiles to enhance treatment effectiveness and thereby reduce snakebite-related morbidity and mortality. Improved training for healthcare providers and enhancements in anti-snake venom quality are essential for meeting the World Health Organization's 2030 Sustainable Development Goal objective of halving snakebite-related fatalities and disabilities. Incorporating snakebite management into national health programs and conducting epidemiological research systematically are crucial to mitigating this preventable health concern.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1016-1022"},"PeriodicalIF":1.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding leprosy: immune response, clinical manifestations and emerging diagnostic approaches. 解码麻风病：免疫反应，临床表现和新兴诊断方法。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-02 DOI: 10.1093/trstmh/traf058

Héctor Serrano-Coll, Lina Restrepo-Rivera, Yicenia Cuadros-Urrego, Nora Cardona-Castro

引用次数: 0

Response to comment by Andreas H. Laustsen on: 'What is new in the treatment of snakebite envenoming? Opportunities and challenges'. 对Andreas H. Laustsen的评论：“蛇咬伤的治疗有什么新进展？”机遇与挑战”。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-02 DOI: 10.1093/trstmh/traf024

David A Warrell

引用次数: 0

Are intestinal parasites in dogs an infection risk to children in the same household? An investigation in Cuba. 狗体内的肠道寄生虫会对同一家庭的儿童造成感染风险吗？一项在古巴的调查。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-02 DOI: 10.1093/trstmh/traf039

Luis Enrique Jerez Puebla, Edel La Rosa Osoria, Fidel A Núñez Fernández, Jorge Fraga Nodarse, Lissette Pérez Santos, Iraís Atencio Millán, Lázara Rojas Rivera, Iredys Cruz Rodríguez, Rigoberto Fimia-Duarte, Lucy J Robertson

{"title":"Are intestinal parasites in dogs an infection risk to children in the same household? An investigation in Cuba.","authors":"Luis Enrique Jerez Puebla, Edel La Rosa Osoria, Fidel A Núñez Fernández, Jorge Fraga Nodarse, Lissette Pérez Santos, Iraís Atencio Millán, Lázara Rojas Rivera, Iredys Cruz Rodríguez, Rigoberto Fimia-Duarte, Lucy J Robertson","doi":"10.1093/trstmh/traf039","DOIUrl":"10.1093/trstmh/traf039","url":null,"abstract":"Background: Zoonotic transmission of intestinal parasites from dogs has been documented, but the extent of such transmission is unclear. This is particularly relevant in low- and middle-income countries, where people share living space with their domestic animals. We investigated whether dog ownership was associated with intestinal parasitoses in children in Cuba.Methods: Faecal samples were collected from children from 108 households in a rural village in Cuba, of which 66 owned a dog and 42 did not. Samples were also collected from the dogs. Samples were examined for intestinal parasites by microscopy and molecular methods.Results: The most commonly identified intestinal parasites in children were Giardia duodenalis and Blastocystis spp., occurring significantly more frequently among children with a dog. However, there was no significant association when these parasites were considered separately. Among dogs, the most commonly detected intestinal parasites were Ancylostoma spp. (in 29 dogs; 44%) and Giardia (in 25 dogs; 38%). Although Ancylostoma spp. can be zoonotic, infection in people is not intestinal; cutaneous larval migrans was not evident in these children.Conclusions: Although our data do not indicate extensive zoonotic transmission of intestinal parasites from dogs, children living in a household with a dog were more likely to be infected with Giardia and/or Blastocystis, than those without dogs.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1023-1029"},"PeriodicalIF":1.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vector incrimination studies of lymphatic filariasis in rural areas of endemic Datia district of Madhya Pradesh, India. 印度中央邦流行的达蒂亚区农村地区淋巴丝虫病病媒的归罪研究。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-02 DOI: 10.1093/trstmh/traf045

Kumaramangalath Anjal, Vagisha Rawal, Satyendra Pandey, Manjini Harshavarthini, Anil K Verma, Braj Mohan, Shraddha Gurha, Gayatri Sondhiya, Afzal Ansari, Subbiah Kombiah, Suyesh Shrivastava, Pradip V Barde, Pushpendra Singh

{"title":"Vector incrimination studies of lymphatic filariasis in rural areas of endemic Datia district of Madhya Pradesh, India.","authors":"Kumaramangalath Anjal, Vagisha Rawal, Satyendra Pandey, Manjini Harshavarthini, Anil K Verma, Braj Mohan, Shraddha Gurha, Gayatri Sondhiya, Afzal Ansari, Subbiah Kombiah, Suyesh Shrivastava, Pradip V Barde, Pushpendra Singh","doi":"10.1093/trstmh/traf045","DOIUrl":"10.1093/trstmh/traf045","url":null,"abstract":"Background: Lymphatic filariasis is a neglected tropical disease caused by infections from Wuchereria bancrofti, Brugia malayi or Brugia timori. These infections are spread by mosquito species such as Culex, Anopheles, Aedes and Mansonia. With >50 million cases in 44 countries, it is the most important parasitic disease next to malaria. India initiated a mass drug administration (MDA) program in 2004 and a gradual reduction was seen in the cases; however, few pockets continue to record new cases. We conducted this study in Datia district of Madhya Pradesh, known to be endemic for filariasis, to understand the ongoing transmission and vector incrimination.Methods: Mosquitoes were collected from rural and urban localities of Datia district. Mosquitoes were identified, segregated and pooled. The pools were tested for the presence of W. bancrofti using molecular tools. The polymerase chain reaction (PCR) products were sequenced for confirmation of results.Results: Of 974 tested female mosquitoes, 45.8% were Culex quinquefasciatus and 50.8% were Anopheles subpictus. The mosquitoes were segregated in 55 pools; 8 (14.54%) pools were found positive for W. bancrofti by real-time PCR. All the positive pools were of C. quinquefasciatus and the species-specific pool positivity rate was 24.24%. All the positive pools were from Sarsai village. The sequencing results confirmed the presence of W. bancrofti.Conclusions: This study confirms ongoing transmission of W. bancrofti and C. quinquefasciatus as the vector species in the rural parts of district. The intervention protocols such as MDA and vector control activities need to be strengthened in rural parts of endemic districts to halt the transmission.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1059-1065"},"PeriodicalIF":1.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Orthohantavirus seoulense as a cause of acute, dengue-negative febrile illness in southern Vietnam. 正汉坦病毒seoulense是越南南部急性登革热阴性发热性疾病的一种病因。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-02 DOI: 10.1093/trstmh/traf041

Mai Thi Quynh Le, Kumiko Yoshimatsu, Haruka Abe, Thuy Thi Nguyen, Hang Le Khanh Nguyen, Trang Thi Hong Ung, Phuong Vu Mai Hoang, Nobuo Koizumi, Futoshi Hasebe, Kozue Miura

{"title":"Orthohantavirus seoulense as a cause of acute, dengue-negative febrile illness in southern Vietnam.","authors":"Mai Thi Quynh Le, Kumiko Yoshimatsu, Haruka Abe, Thuy Thi Nguyen, Hang Le Khanh Nguyen, Trang Thi Hong Ung, Phuong Vu Mai Hoang, Nobuo Koizumi, Futoshi Hasebe, Kozue Miura","doi":"10.1093/trstmh/traf041","DOIUrl":"10.1093/trstmh/traf041","url":null,"abstract":"Background: Dengue fever has surged in Vietnam since 2021; however, the aetiology of non-dengue undifferentiated febrile illnesses remains poorly understood.Methods: Fifty whole blood samples that tested negative in rapid tests for anti-dengue virus antibodies (IgM and IgG) and NS1 viral antigen at Vung Tau General Hospital, southern Vietnam, were subjected to nucleic acid amplification tests for flaviviruses, hantaviruses, Leptospira spp. and Orientia tsutsugamushi, followed by DNA sequencing. The plasma samples were also tested for anti-hantavirus IgM and IgG antibodies using ELISA.Results: Of the 50 samples, eight were PCR-positive for flaviviruses and two were positive for hantaviruses. Sequencing analysis revealed that three and five of the eight flavivirus-positive samples were dengue virus type 1 and dengue virus type 2, respectively. The hantavirus species was identified as Orthohantavirus seoulense (SEOV). None of the patients tested positive for Leptospira spp. or O. tsutsugamushi. Anti-hantavirus IgM and IgG antibodies were detected in five and four patients, respectively.Conclusions: This study suggests that SEOV is a notable contributor to dengue-negative febrile illnesses in southern Vietnam.Accession number: LC822654.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1041-1046"},"PeriodicalIF":1.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on: What is new in the treatment of snakebite envenoming? Opportunities and challenges. 点评：治疗蛇咬伤有什么新进展？机遇与挑战。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-02 DOI: 10.1093/trstmh/traf023

Andreas H Laustsen

引用次数: 0

Snakebite cases and treatment outcomes in the Afar region, Ethiopia: a retrospective and prospective study approach. 蛇咬伤病例和治疗结果在阿法尔地区，埃塞俄比亚：回顾性和前瞻性研究方法。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-02 DOI: 10.1093/trstmh/traf043

Abebe M Aga, Demise Mulugeta, Abera Motuma, Bilise Wakitole, Kedir Mohammed, Fanos Tadesse Woldemariyam, Henok Ferede, Zinash Teferi, Shambel Tadesse, Jemal Mohammed, Anberber Alemu, Dejene Getachew, Dassalegn Muleta, Dereje Nigussie

{"title":"Snakebite cases and treatment outcomes in the Afar region, Ethiopia: a retrospective and prospective study approach.","authors":"Abebe M Aga, Demise Mulugeta, Abera Motuma, Bilise Wakitole, Kedir Mohammed, Fanos Tadesse Woldemariyam, Henok Ferede, Zinash Teferi, Shambel Tadesse, Jemal Mohammed, Anberber Alemu, Dejene Getachew, Dassalegn Muleta, Dereje Nigussie","doi":"10.1093/trstmh/traf043","DOIUrl":"10.1093/trstmh/traf043","url":null,"abstract":"Background: Snakebite envenomation remains a public health issue, particularly in rural areas. Quick and accurate case identification, coupled with timely treatment, is essential to prevent fatalities and complications.Methods: Retrospective and prospective data consisted of 245 snakebite cases admitted to hospitals in the Afar region, Ethiopia, from September 2023 to July 2024 (retrospective), while prospective data were collected from July to October 2024. The analysis focused on case prevalence, time to treatment, service availability, treatment received, length of hospital stays, recovery times and patient outcomes.Results: Of 245 cases, 66.1% (n=162) were retrospective and 33.9% (n=83) prospective. Most patients were male (71.6%); the largest age group was 15-29 y (59.6%); most patients required hospital stays of 2-3 d (56.7%). In the majority of cases, recovery took 4-7 d (36.23%). The fatality rate was 3.3%; >46.54% of patients received treatment >7 d after snakebite, mainly because of the long distance traveled to reach healthcare facilities with access to antivenom.Conclusions: It is essential to strengthen community health units by equipping them with trained personnel and sufficient antivenom supplies to ensure prompt care. Implementing public awareness and promoting local antivenom production could reduce treatment costs and improve patient outcomes.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1047-1054"},"PeriodicalIF":1.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is new in the treatment of snakebite envenoming? Opportunities and challenges. 治疗蛇咬伤有什么新进展？机遇与挑战。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-02 DOI: 10.1093/trstmh/trae145

David A Warrell

引用次数: 0

Evaluation of a nanostructured CpG-ODN/ascorbyl palmitate as a safe and effective adjuvant for anticrotalic PLA2 serum. 纳米结构CpG-ODN/抗坏血酸棕榈酸酯作为抗血小板2血清安全有效佐剂的评价。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-02 DOI: 10.1093/trstmh/trae129

Luciano S Fusco, Gisela L Lopez, Franco Maslovski, Sofía Brignone, María G Chaves, Juan J Calvete, Yanet G Franco, David Hernandez, Andrea Van de Velde, Constanza Marin, Santiago Palma, Belkys Maletto, Gabriel Moron, Laura C Leiva

{"title":"Evaluation of a nanostructured CpG-ODN/ascorbyl palmitate as a safe and effective adjuvant for anticrotalic PLA2 serum.","authors":"Luciano S Fusco, Gisela L Lopez, Franco Maslovski, Sofía Brignone, María G Chaves, Juan J Calvete, Yanet G Franco, David Hernandez, Andrea Van de Velde, Constanza Marin, Santiago Palma, Belkys Maletto, Gabriel Moron, Laura C Leiva","doi":"10.1093/trstmh/trae129","DOIUrl":"10.1093/trstmh/trae129","url":null,"abstract":"Background: The WHO states that antivenom is the only safe and effective treatment to neutralize snake venom. Snakebite antivenom typically involves horse hyperimmunization with crude venom and Freund's adjuvant.Methods: In the current work, we analyzed the ascorbyl palmitate liquid crystal structure with snake protein or PLA2, the carrier charge capacity, and we evaluated the immune response induced by the enzyme P9a(Cdt-PLA2) formulated in a nanostructure using CpG-ODN, determining the titer of IgG antibodies. BALB/c mice were subcutaneously immunized on days 0, 15 and 30 with P9a(Cdt-PLA2)/CpG-ODN/Coa-ASC16 or P9a(Cdt-PLA2)/Freund's adjuvant (complete first and incomplete-booster). On day 48 the mice were sacrificed. The neutralization ability of antibodies from animals immunized with P9a(Cdt-PLA2)/CpG-ODN/Coa-ASC16 or P9a(Cdt-PLA2)/Freund's adjuvant was tested against PLA2 activity and venom lethality.Results: In both groups of immunized mice, the antibody titers in blood samples at the assayed time were high (approximately 1×105). The antibodies were able to neutralize P9a(Cdt-PLA2) activity in vitro and lethality in vivo. Microscopic analysis showed that P9a(Cdt-PLA2)/CpG-ODN/Coa-ASC16 produces minimal damage at injection sites compared with Freund's adjuvant.Conclusion: The Coa-ASC16/CpG-ODN formulation shows promise as a safe and effective adjuvant against crotalic PLA2, inducing a strong humoral response and reducing local tissue damage compared with Freund's adjuvant.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1070-1083"},"PeriodicalIF":1.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0