Transactions of The Royal Society of Tropical Medicine and Hygiene最新文献_第2页

Armadillo meat consumption and Hansen's disease (leprosy): a case-control study in Brazil. 犰狳肉消费与汉森病（麻风病）：巴西的病例对照研究。

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-10-05 DOI: 10.1093/trstmh/trag054

Taynah A R Repsold, Simon M Collin, Bianca B C Amorim, Liana M M de Sena, Roger Bongestab, Patrícia D Deps

{"title":"Armadillo meat consumption and Hansen's disease (leprosy): a case-control study in Brazil.","authors":"Taynah A R Repsold, Simon M Collin, Bianca B C Amorim, Liana M M de Sena, Roger Bongestab, Patrícia D Deps","doi":"10.1093/trstmh/trag054","DOIUrl":"10.1093/trstmh/trag054","url":null,"abstract":"Background: Hansen's disease (HD, leprosy) had a global incidence of approximately 200 000 new cases per annum over the last decade. Armadillos are recognized reservoirs of Mycobacterium leprae in the Americas and HD is considered a zoonosis in the USA. Our aim was to evaluate the association between armadillo meat consumption and HD in Brazil.Methods: We conducted a case-control study (n=59 patients with HD, n=59 controls) in the state of Espírito Santo, Brazil, between February and December 2025. Data collected included clinical and sociodemographic, armadillo meat consumption and known (human) case contacts (KCCs).Results: Armadillo meat consumption was much more frequent among cases (59.3%) than controls (8.5%). Consumption was the strongest independent predictor of HD, with 15-fold higher odds of exposure (adjusted odds ratio [aOR] 16.5 [95% confidence interval {CI} 5.2 to 52.5], p<0.001) among cases. Odds of KCCs were five-fold higher among cases (aOR 6.0 [95% CI 2.2 to 16.8], p=0.001).Conclusions: This study provides evidence that armadillo meat consumption is an independent transmission pathway for human M. leprae infection in Brazil. Zoonotic transmission likely accounts for some of the HD 'contact gap' in this setting, supporting the need for a paradigm shift towards One Health surveillance of HD in the Americas.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1006-1011"},"PeriodicalIF":1.6,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dolutegravir-lamivudine dual therapy in subtype C HIV: implications for India and beyond. 多替地韦-拉米夫定双重治疗C型HIV：对印度及其他地区的影响。

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-10-05 DOI: 10.1093/trstmh/trag067

Praveen Kumar Tirlangi, Carl Boodman, Bayode R Adegbite, Martin P Grobusch, Nitin Gupta

引用次数: 0

Integrated and sustainable community approach to malaria prevention in Gulu District, Northern Uganda. 乌干达北部古卢地区疟疾预防的综合和可持续社区方法。

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-10-05 DOI: 10.1093/trstmh/trag073

Humphrey Atwijukiire, Anne Otwiine

{"title":"Integrated and sustainable community approach to malaria prevention in Gulu District, Northern Uganda.","authors":"Humphrey Atwijukiire, Anne Otwiine","doi":"10.1093/trstmh/trag073","DOIUrl":"10.1093/trstmh/trag073","url":null,"abstract":"Objectives: About one-half of the world's population is endangered by malaria, particularly those in underdeveloped countries. Because of poor prevention measures, in 2023, the WHO Africa region accounted for 95% of cases and 96% of deaths. Malaria is a prevalent tropical disease with high morbidity, mortality, and economic and social impact. The WHO recommends integrated vector management for malaria control, which has shown promise in reducing the diseas e burden.Methods: We conducted a cross-sectional qualitative study in Unyama and Koro subcounties in Gulu District. We collected data from eight focus group discussions and 10 in-depth interviews with community members, leaders, and health workers. We analysed data using thematic content analysis and Atlas ti software.Results: The facilitators for community-integrated malaria control were government mosquito net distribution, village health teams, and combined preventive methods. The barriers were inconsistent preventive practices, financial and resource constraints, misuse of mosquito nets, cultural misconceptions, and limited support for volunteers.Conclusion: Although integrated malaria-prevention approaches have demonstrated effectiveness, their full implementation in Uganda remains constrained. Persistent socioeconomic barriers undermine both uptake and long-term sustainability at the community level. Addressing these structural and contextual challenges is essential to translate proven interventions into sustained malaria-control gains.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1049-1057"},"PeriodicalIF":1.6,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality of life, stigma, and mental health, in individuals affected by leprosy: a cross-sectional study. 麻风病患者的生活质量、病耻感和精神健康：一项横断面研究

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-10-05 DOI: 10.1093/trstmh/trag064

Temesgen K Chala, Emily S Garsleitner, Guenter Froeschl, Esayas K Gudina, Kristina Adorjan

{"title":"Quality of life, stigma, and mental health, in individuals affected by leprosy: a cross-sectional study.","authors":"Temesgen K Chala, Emily S Garsleitner, Guenter Froeschl, Esayas K Gudina, Kristina Adorjan","doi":"10.1093/trstmh/trag064","DOIUrl":"10.1093/trstmh/trag064","url":null,"abstract":"Background: Leprosy rarely causes death but leads to disfigurement, stigma, and disability, resulting in socioeconomic consequences. Understanding these inter-related factors is essential for developing effective interventions. This study aimed to assess QoL and mental health among individuals affected by leprosy and to examine identify QoL predictors.Methods: A cross-sectional study was conducted in urban leprosy rehabilitation centres in Ethiopia. A total of 370 individuals were enrolled. Correlation and multivariable regression analyses were used to examine associations and identify predictors of QoL.Results: Participants were predominantly male (54.1%) and aged ≥61 years (42.8%). Most had no education (57.3%), while only 4.3% had secondary education or above; one-half were married. Poor living conditions were reported in 84.05% of participants, while delayed diagnosis (≥2 years after symptom onset) was observed in 53% of cases. The median social relationship QoL score was 7 (IQR 5-9), while that for overall QoL was 61 (IQR 56-68). Median sleep score was 8 (IQR 6-11). Stigma correlated positively with anxiety (r = 0.206) and depression (r = 0.269) and negatively with QoL (r = -0.251). Anxiety and depression were strongly correlated (r = 0.794, P < .001).Conclusions: Stigma, psychological distress and poor sleep impair QoL among people affected by leprosy, highlighting the need for multidisciplinary interventions.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1027-1039"},"PeriodicalIF":1.6,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13635672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148043939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Climate change as an amplifier of hantavirus risk in South Asia: a neglected nexus. 气候变化是南亚汉坦病毒风险的扩大器：一个被忽视的联系。

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-10-05 DOI: 10.1093/trstmh/trag082

Muhammad Talha

引用次数: 0

Prevalence and factors associated with cardiac involvement in hospitalized patients with dengue: a cross-sectional study. 登革热住院患者心脏受累的患病率和相关因素：一项横断面研究

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-10-05 DOI: 10.1093/trstmh/trag059

Sadeed Araf Reza, Abeeda Tasnim Reza, Nighat Islam, A Q M Reza, Aparajita Karim, Abdur Rafi, Mohammad Jahid Hasan

{"title":"Prevalence and factors associated with cardiac involvement in hospitalized patients with dengue: a cross-sectional study.","authors":"Sadeed Araf Reza, Abeeda Tasnim Reza, Nighat Islam, A Q M Reza, Aparajita Karim, Abdur Rafi, Mohammad Jahid Hasan","doi":"10.1093/trstmh/trag059","DOIUrl":"10.1093/trstmh/trag059","url":null,"abstract":"Background: Cardiac involvement is an underrecognized but potentially life-threatening complication of dengue fever. We aimed to estimate the prevalence and identify predictors of cardiac involvement among hospitalized patients with dengue.Methods: We conducted a cross-sectional study including 919 patients with confirmed dengue. Cardiac involvement was defined based on clinical features (e.g. chest pain, dyspnoea, syncope), electrocardiogram (ECG) changes, elevated cardiac biomarkers (high-sensitivity troponin I [hs-troponin I] or N-terminal pro-hormone of brain natriuretic peptide) or echocardiographic abnormalities. We performed multivariable logistic regression to identify independent predictors and developed a classification and regression tree (CART) model for risk stratification.Results: Overall, 14% of patients had cardiac involvement such as pericardial effusion (26%), elevated hs-troponin I (38%) and ECG abnormalities (10%). Significant associated factors were age >60 y (adjusted odds ratio [aOR] 3.05 [95% confidence interval {CI} 1.53 to 6.08]), warning signs (aOR 2.77 [95% CI 1.76 to 4.37]), anaemia (aOR 1.84 [95% CI 1.16 to 2.95]), thrombocytopenia (aOR 1.82 [95% CI 1.09 to 3.11]), elevated serum creatinine (aOR 2.20 [95% CI 1.34 to 3.60]), hypoalbuminaemia (aOR 3.06 [95% CI 1.74 to 5.57]) and elevated D-dimer levels (aOR 5.90 [95% CI 3.67 to 9.54]). The CART model identified age, warning signs, D-dimer and platelet count as significant predictors.Conclusions: Cardiac complications are common in dengue and should be considered in the management of high-risk patients.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1012-1020"},"PeriodicalIF":1.6,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148043963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal schistosomiasis among pre-school age children in a selected rural community in Sengerema District, Tanzania. 坦桑尼亚Sengerema地区一个选定农村社区的学龄前儿童肠道血吸虫病

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-10-05 DOI: 10.1093/trstmh/trag066

Mussa H Bago, Mtoro J Mtoro, Dinah B Gasarasi, David Zadock Munisi

{"title":"Intestinal schistosomiasis among pre-school age children in a selected rural community in Sengerema District, Tanzania.","authors":"Mussa H Bago, Mtoro J Mtoro, Dinah B Gasarasi, David Zadock Munisi","doi":"10.1093/trstmh/trag066","DOIUrl":"10.1093/trstmh/trag066","url":null,"abstract":"Background: Schistosomiasis control has transitioned from focusing on morbidity control to elimination of the disease. Nevertheless, preschool-age children (PSAC) are left out of control programs and consequently serve as a source of continued transmission. This study determined the prevalence and predictors of Schistosoma mansoni infection among PSAC.Methods: An analytical cross-sectional study was conducted among 417 PSAC. The infection prevalence and intensity was determined using the Kato-Katz technique and a structured questionnaire was used to collect demographic and risk profile. A logistic regression model was used to determine factors associated with S. mansoni infection.Results: The prevalence of S. mansoni infection was 14.4% (95% confidence interval [CI] 11.2 to 18.1) and the geometric mean eggs per gram of faeces was 77.2 (95% CI 61.7 to 96.6) with 33.3% and 5.0% having moderate and heavy infections, respectively. Passive water contact (adjusted odds ratio [AOR] 7.19 [95% CI 2.34 to 21.81]) and living within 500 m of a water body (AOR 16.25 [95% CI 4.97 to 53.21]) were significantly associated with S. mansoni infection (p<0.001).Conclusion: PSAC are at risk for S. mansoni infection and accumulating moderate to heavy infections. Proximity to a water body and engaging in passive water contact activities were significant predictors of infection. These findings call for the inclusion of PSAC in the ongoing praziquantel mass drug administration programs. There is an urgent need for improved water supply, sanitation and public health education to reduce population exposure to infested freshwater bodies.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1040-1048"},"PeriodicalIF":1.6,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148164625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predisposition to Ascaris lumbricoides reinfection in the Geshiyaro project in southern Ethiopia. 埃塞俄比亚南部Geshiyaro项目蚓类蛔虫再感染易感性。

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-10-05 DOI: 10.1093/trstmh/trag075

Olivia Simmonds, Rosie Maddren, Benjamin Collyer, Birhan Abtew, Ewnetu Firdawek Liyew, Melkie Chernet, Getachew Tollera, Geremew Tasew, Esayas Knife, Mahlet Belachew, Mesay Hailu, Yasin Awol, Roy M Anderson

{"title":"Predisposition to Ascaris lumbricoides reinfection in the Geshiyaro project in southern Ethiopia.","authors":"Olivia Simmonds, Rosie Maddren, Benjamin Collyer, Birhan Abtew, Ewnetu Firdawek Liyew, Melkie Chernet, Getachew Tollera, Geremew Tasew, Esayas Knife, Mahlet Belachew, Mesay Hailu, Yasin Awol, Roy M Anderson","doi":"10.1093/trstmh/trag075","DOIUrl":"10.1093/trstmh/trag075","url":null,"abstract":"Objectives: Predisposition to reinfection is characterized by certain individuals repeatedly acquiring infection at higher rates than others in the population despite treatment. As endemic regions approach low prevalence levels, such individuals will act as reservoirs of infection and contribute to sustaining transmission cycles in communities. This study investigated evidence for individual-level predisposition to Ascaris lumbricoides infections using longitudinal data from the Geshiyaro project in southern Ethiopia.Methods: Longitudinal parasitological data collected over 7 years were analysed. Kendall's tau (τ) correlation coefficient was used to assess temporal persistence of infection between successive survey rounds, and Kendall's coefficient of concordance (W) was used to evaluate long-term stability in individuals' relative infection risk over many years of survey rounds.Results: Positive correlations in infection status between survey rounds were observed (τ = 0.10-0.30, P < .001). Moderate concordance in infection ranking across the study period was also detected (W = 0.43, 95% CI: 0.42-0.45; P < .001), indicating persistent individual-level predisposition over many years of treatment and reinfection.Conclusion: These findings demonstrate sustained heterogeneity in infection risk within endemic communities. As transmission declines, identifying individuals predisposed to reinfection may help inform targeted or complementary 'test-and-treat' strategies to support interruption of A. lumbricoides transmission.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1068-1077"},"PeriodicalIF":1.6,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13635670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Geographical and temporal patterns of cutaneous leishmaniasis in Pakistan: insight from a decade of epidemiology. 巴基斯坦皮肤利什曼病的地理和时间模式：来自十年流行病学的见解。

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-10-05 DOI: 10.1093/trstmh/trag085

Rehana Shaheen, Razia Bibi, Muhammad Aurongzeb, Yasmeen Rashid, Mudassar Khan, Syed Ikhlaq Hussain, Shumaila Naz

{"title":"Geographical and temporal patterns of cutaneous leishmaniasis in Pakistan: insight from a decade of epidemiology.","authors":"Rehana Shaheen, Razia Bibi, Muhammad Aurongzeb, Yasmeen Rashid, Mudassar Khan, Syed Ikhlaq Hussain, Shumaila Naz","doi":"10.1093/trstmh/trag085","DOIUrl":"10.1093/trstmh/trag085","url":null,"abstract":"Background: Cutaneous leishmaniasis (CL) is a major public health concern in Pakistan. This systematic review aimed to assess geographical distribution, prevalence trends and epidemiological risk factors associated with CL from 2014 to 2024.Methods: A systematic literature search was conducted using PubMed, ScienceDirect and Google Scholar for studies published from January 2014 to December 2024. Keywords included 'cutaneous leishmaniasis', 'epidemiology', 'Pakistan' and 'geographical distribution'. Of 1000 retrieved publications, 600 were screened and 25 met predefined inclusion and quality criteria. The extracted data included study area, research design, diagnostic methods, gender distribution and Leishmania species.Results: A total of 27 380 confirmed CL cases were reported. The highest burden was in Khyber Pakhtunkhwa (60%), followed by Balochistan (16%), Sindh (8%), Punjab (8%) and Azad Jammu and Kashmir and Chitral (4%). A male predominance (approximately 60-65%) was reported. The dominant species were Leishmania tropica and Leishmania major. Diagnosis relied mainly on microscopy (80%), with an annual incidence rate of 8-10% over the previous decade.Conclusions: CL shows a widespread and increasing distribution pattern in Pakistan. The main factors involve poverty, vectors, climate change and migration. These findings focus on the need to improve the surveillance network, molecular diagnostic methods and public awareness to decrease the growing impact of the disease.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"995-1005"},"PeriodicalIF":1.6,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Snakebite envenoming in India: it is time we look beyond the concept of the Big Four species. 更正：印度发生蛇咬伤事件：是时候超越四大物种的概念了。

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-10-05 DOI: 10.1093/trstmh/trag081

引用次数: 0