Transactions of The Royal Society of Tropical Medicine and Hygiene最新文献_第2页

The One Health approach to Strongyloides stercoralis.

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-14 DOI: 10.1093/trstmh/traf003

Jiayin Lyu, Xiaoyin Fu, Dengyu Liu

引用次数: 0

Evaluation of suitability of two tools for the diagnosis of canine visceral leishmaniasis.

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-13 DOI: 10.1093/trstmh/traf012

Valeria S Garcia, Maira S Gutiérrez, Verónica D G Gonzalez, Luis M Gugliotta, Alexis Burna, Diego Eiras, Matías S Cabeza, Diego G Arias, Sergio A Guerrero

{"title":"Evaluation of suitability of two tools for the diagnosis of canine visceral leishmaniasis.","authors":"Valeria S Garcia, Maira S Gutiérrez, Verónica D G Gonzalez, Luis M Gugliotta, Alexis Burna, Diego Eiras, Matías S Cabeza, Diego G Arias, Sergio A Guerrero","doi":"10.1093/trstmh/traf012","DOIUrl":"https://doi.org/10.1093/trstmh/traf012","url":null,"abstract":"Background: Leishmaniasis still imposes a heavy burden on many health systems and remains a public health problem. Early diagnosis in dogs, which act as a major reservoir for the pathogen, is central. The intention of epidemiologic studies is to identify the disease early, allowing rapid intervention to reduce its effects. This study aimed to develop two types of diagnostics tools, an enzyme-linked immunosorbent assay (ELISA) and a lateral flow immunochromatography assay for recognizing canine visceral leishmaniasis (CVL).Methods: Multiwell ELISA plates were sensitized and strips were designed with the same chimeric recombinant antigen from Leishmania spp. (LeQuiDi) and the results were compared. The sera panel contained 409 samples, including 244 positives and 165 negatives. Of the 165 negative sera, 67 were obtained from Corrientes city, an endemic area for CVL in Argentina, and 98 of this group from La Plata city, a non-endemic area in Argentina (they were seropositive for other infections, as specificity control).Results: Serum with an elevated concentration of lipids, or bilirubin, or a variable percentage of haemolysis were tested without interference. Both the sensitivity and specificity of the LeQuiDi-based tests were high: ≥93% for ELISA and ≥87% for LFIA.Conclusions: Our study introduces LeQuiDi as a promising antigen for CVL diagnosis, regardless of the test format.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges in managing hump-nosed pit viper envenomation in southern India: a case study.

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-12 DOI: 10.1093/trstmh/traf016

Anil M Philip, Jim O John, Lina J George, Sethu Rajan

引用次数: 0

The impact of multiple infections and community knowledge on engagement with a historical deworming programme: hookworm and Ascaris in Jamaica, 1913-1936.

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-12 DOI: 10.1093/trstmh/traf010

Jonathan David Roberts, Lorna L Waddington, Rupert J Quinnell, Alison M Dunn

{"title":"The impact of multiple infections and community knowledge on engagement with a historical deworming programme: hookworm and Ascaris in Jamaica, 1913-1936.","authors":"Jonathan David Roberts, Lorna L Waddington, Rupert J Quinnell, Alison M Dunn","doi":"10.1093/trstmh/traf010","DOIUrl":"https://doi.org/10.1093/trstmh/traf010","url":null,"abstract":"Introduction: Community engagement with public health efforts often depends on existing knowledge of a health issue.Methods: Here, qualitative analysis of archival material from the Jamaica Hookworm Commission (1919-1936) and quantitative analysis of prevalence data are used to assess knowledge of and ecological interactions between different helminths during a historical hookworm eradication campaign.Results: Archival sources demonstrate that Jamaicans were familiar with Ascaris lumbricoides. Surveys revealed a high prevalence of hookworm (62% of individuals infected), Ascaris (30%) and Trichuris trichiura (32%) in communities targeted for hookworm control. Community prevalence of Trichuris was positively associated with the prevalence of Ascaris and hookworm. Many individuals were infected with more than one parasite. At an individual level, data from hospital patients and soldiers showed significant associations between all three parasites. The co-occurrence of hookworm and Ascaris, alongside folk treatment of Ascaris with the same plant used by the Hookworm Commission (Chenopodium ambrisoides) to treat hookworm, made biomedical claims about hookworm credible and biomedical treatment more acceptable. Expulsions of Ascaris following treatment also provided dramatic proof of the effectiveness of treatment, further facilitating engagement.Discussion/conclusion: Knowledge of Ascaris and other helminths directly shaped engagement with hookworm treatment, demonstrating how folk medical knowledge, grounded in the biology of the worms, aided a biomedical public health program.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From relief to resistance: implications of self-medication practice for malaria elimination in India.

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-10 DOI: 10.1093/trstmh/traf008

Kanika Verma, Nitika Nitika, Praveen Kumar Bharti

引用次数: 0

Phototherapy in lymphoproliferative and inflammatory diseases associated with human T-lymphotropic virus.

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-10 DOI: 10.1093/trstmh/traf009

Brena Andrade de Lima Lobato, João Augusto Gomes de Souza Monteiro de Brito, José Maria de Castro Abreu Junior, Maísa Silva de Sousa, Carlos Augusto Moreira Silva, Thiago Xavier Carneiro, Rita Catarina Medeiros Sousa, Marília Brasil Xavier

{"title":"Phototherapy in lymphoproliferative and inflammatory diseases associated with human T-lymphotropic virus.","authors":"Brena Andrade de Lima Lobato, João Augusto Gomes de Souza Monteiro de Brito, José Maria de Castro Abreu Junior, Maísa Silva de Sousa, Carlos Augusto Moreira Silva, Thiago Xavier Carneiro, Rita Catarina Medeiros Sousa, Marília Brasil Xavier","doi":"10.1093/trstmh/traf009","DOIUrl":"https://doi.org/10.1093/trstmh/traf009","url":null,"abstract":"Background: Dermatological manifestations affect 5% of patients with human T-lymphotropic virus (HTLV).Methods: Thirteen patients with inflammatory or lymphoproliferative dermatological diseases, both HTLV-positive and HTLV-negative, were selected for treatment with ultraviolet B narrowband (UVB-NB) phototherapy. Clinical and histopathological evaluations were conducted before and after 120 d of phototherapy.Results: All seven HTLV-positive patients evaluated were type 1. Clinical evaluation showed improvement in all 13 patients. In the histopathological examination, all patients with lymphoproliferative diseases and five with inflammatory diseases showed regression in most of the assessed parameters.Conclusions: The present research suggests that UVB-NB phototherapy is a promising treatment for lymphoproliferative and inflammatory skin diseases in HTLV-1 patients.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking the potential of blood-stage vaccines for malaria elimination.

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-08 DOI: 10.1093/trstmh/traf013

Shrikant Nema, Sumit Rathore, Asif Mohmmed, Pawan Malhotra

引用次数: 0

Special Issue Editorial: Sustainably reducing snakebite burden by prioritising research(ers) in high-risk areas.

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-08 DOI: 10.1093/trstmh/traf007

Frank-Leonel Tianyi, Maya Gopalakrishnan, Thomas Pinfield

引用次数: 0

Diagnostic sensitivity of formalin-fixed faecal microscopy for the detection of soil-transmitted helminths.

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-08 DOI: 10.1093/trstmh/traf011

Andrew Larkins, Boualay Keokhamphavanh, Breanna Knight, Kelly Taggart, Sarah Keatley, Bounnaloth Insisiengmay, Amanda Ash

{"title":"Diagnostic sensitivity of formalin-fixed faecal microscopy for the detection of soil-transmitted helminths.","authors":"Andrew Larkins, Boualay Keokhamphavanh, Breanna Knight, Kelly Taggart, Sarah Keatley, Bounnaloth Insisiengmay, Amanda Ash","doi":"10.1093/trstmh/traf011","DOIUrl":"https://doi.org/10.1093/trstmh/traf011","url":null,"abstract":"Background: Faecal microscopy is the mainstay of soil-transmitted helminth diagnosis and commonly completed on formalin-fixed samples when resources are insufficient to analyse fresh samples. This study assessed the diagnostic sensitivity of microscopic techniques using formalin-fixed samples.Methods: Formalin-fixed faecal samples from 574 individuals were tested by the formalin-ethyl acetate concentration technique (FECT), Malachite smear, McMaster and McMaster2 methods. Agreement between tests was assessed by Kappa. Bayesian latent class models and a composite reference standard estimated the diagnostic sensitivity of each test.Results: Moderate-to-good agreement between tests was observed for A. lumbricoides. Agreement was poorer for hookworm and Trichuris trichiura. The FECT (72.70%, credible interval [CrI]: 68.92-76.56%) and McMaster2 method (67.93%, 95% CrIs: 62.41-73.31%) had the highest sensitivities for A. lumbricoides. For hookworm, the McMaster2 method (70.56%, 95% CrIs: 64.10-76.96%) was more sensitive than all other tests. For T. trichiura, the McMaster (90.10%, 95% CrIs: 83.29-94.67%) and McMaster2 (89.3%, 95% CrIs: 82.28-94.52%) methods were the most sensitive.Conclusions: The McMaster2 method is a viable alternative to FECT and provides important information on the intensity of infection. The effect of formalin-fixation on test performance may not be as great as previously assumed. This study reports formalin-fixed sensitivities similar to previous estimates using fresh samples.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of repeat testing in tuberculosis patients with a trace call on Xpert MTB/RIF Ultra: a retrospective cohort study.

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-08 DOI: 10.1093/trstmh/traf002

Suyash Jha, Nitin Gupta, Tirlangi Praveen Kumar, Kiran Chawla, Vishnu P Shenoy, Muralidhar Varma, Mohan K Manu

引用次数: 0