Transactions of The Royal Society of Tropical Medicine and Hygiene最新文献_第2页

Accelerating access to diagnostic tools: perspectives from the joint international tropical medicine meeting 2023. 加速获得诊断工具：来自2023年国际热带医学联合会议的观点。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-10-01 DOI: 10.1093/trstmh/traf022

Puttarin Kulchaitanaroaj, Philip J Turner, Cheikh T Diagne, Maytouch Lojanarungsiri, Maneerat Ekkapongpisit, Rosanna Ŵ Peeling

引用次数: 0

Leprosy relapse near pilgrimage sites in the Cariri region of Brazil. 在巴西卡里里地区的朝圣地附近麻风病复发。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-10-01 DOI: 10.1093/trstmh/traf057

Albério A Cavalcante, Franciely G Gonçalves, João Marcos F L Silva, Gabriel Z Laporta

{"title":"Leprosy relapse near pilgrimage sites in the Cariri region of Brazil.","authors":"Albério A Cavalcante, Franciely G Gonçalves, João Marcos F L Silva, Gabriel Z Laporta","doi":"10.1093/trstmh/traf057","DOIUrl":"10.1093/trstmh/traf057","url":null,"abstract":"Background: Leprosy relapse remains a challenge to Brazil's elimination efforts, particularly in regions where Mycobacterium leprae persists in the environment. While multidrug therapy (MDT) is effective, patients exposed to ongoing transmission may develop reinfections over time. This study investigates whether proximity to pilgrimage sites influences leprosy relapse in the Cariri region.Methods: Leprosy relapses in the Cariri region (2010-2022) were georeferenced based on patients' residences. A geostatistical model assessed relapse proximity to pilgrimage sites, classifying cases (2-18 km) and controls (18-102 km) by spatial dependence. Logistic regression assessed relapse odds near pilgrimage sites, comparing reinfections (≥5 y) to insufficient therapy (<5 y), adjusted for age, gender, cure outcome, disease severity and patient mobility.Results: A total of 337 leprosy relapses were identified across 45 municipalities in the Cariri region. Spatial analysis indicated that individuals living near pilgrimage sites had nearly twice the odds of experiencing a relapse ≥5 y after MDT treatment (OR=1.76, 95% CI 1.09 to 2.85), supporting the hypothesis that pilgrimage sites may act as transmission hotspots.Conclusions: Leprosy elimination in Brazil requires context-dependent measures. Pilgrimage sites, where individuals seek healing but may contribute to transmission, should be prioritized for active surveillance and targeted interventions.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1192-1199"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-resistant tuberculosis treatment outcomes among Saharia: a marginalized community of Madhya Pradesh, India. 撒哈拉地区：印度中央邦边缘社区的耐药结核病治疗结果。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-10-01 DOI: 10.1093/trstmh/traf046

Prashant Mishra, Jyothi Bhat, Ravendra K Sharma, Rajiv Yadav, Malaisamy Muniyandi, Mercy Aparna Lingala, Samridhi Nigam, Vikas G Rao

{"title":"Drug-resistant tuberculosis treatment outcomes among Saharia: a marginalized community of Madhya Pradesh, India.","authors":"Prashant Mishra, Jyothi Bhat, Ravendra K Sharma, Rajiv Yadav, Malaisamy Muniyandi, Mercy Aparna Lingala, Samridhi Nigam, Vikas G Rao","doi":"10.1093/trstmh/traf046","DOIUrl":"10.1093/trstmh/traf046","url":null,"abstract":"Background: Few attempts have been made to explore the drug-resistant tuberculosis (DR-TB) outcomes and associated factors among underprivileged communities. This study aimed to determine DR-TB treatment outcomes and associated factors in the Saharia tribal group (TGs), a community with a high TB burden in Madhya Pradesh, India.Methods: TB cases were detected through active case finding and were treated under the National Tuberculosis Elimination Programme. All the patients who were initiated on DR-TB treatment and had outcomes at the end of treatment were included in the study. The DR-TB treatment outcomes and associated factors were recorded.Findings: Of 323 patients included in the analysis, 216 patients (66.8%) had successful treatment outcomes, including 70 (21.7%) who were cured and another 146 (45.2%) who completed treatment. Among the rest, 36 (11.1%) died, 66 (20.4%) were lost to follow-up and 5 (1.5%) had treatment failure. A total of 83% of patients were rifampicin resistant (RR)/multidrug resistant (MDR).Conclusions: Although the program's recommended target of >75% could not be achieved, the treatment success rate in the study is still admirable in a hard-to-reach high-TB-risk tribal area. The findings show that with community-based approaches, favourable treatment outcomes can be achieved in DR-TB patients from resource-poor settings.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1135-1140"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Projecting high-level dengue increases during low-incidence months in a large endemic urban area. 预测登革热在大城市流行地区的低发病率月份出现高水平上升。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-10-01 DOI: 10.1093/trstmh/traf052

Alexandre Cunha Costa, José Micael Ferreira da Costa, Rafaella Pessoa Moreira, Tahissa Frota Cavalcante, Luiz Martins de Araújo Júnior, Thamara Kely de Sousa Fernandes, Glauciano de Oliveira Ferreira, Jéssica Silva, Cleiton da Silva Silveira, Luciano Pamplona de Góes Cavalcanti

{"title":"Projecting high-level dengue increases during low-incidence months in a large endemic urban area.","authors":"Alexandre Cunha Costa, José Micael Ferreira da Costa, Rafaella Pessoa Moreira, Tahissa Frota Cavalcante, Luiz Martins de Araújo Júnior, Thamara Kely de Sousa Fernandes, Glauciano de Oliveira Ferreira, Jéssica Silva, Cleiton da Silva Silveira, Luciano Pamplona de Góes Cavalcanti","doi":"10.1093/trstmh/traf052","DOIUrl":"10.1093/trstmh/traf052","url":null,"abstract":"Background: Climate change projections impact dengue transmission in tropical regions, creating diverse and complex public health challenges. The aim of this study was to project future seasonal dengue incidence in a large tropical urban area of Brazil, where dengue is endemic, by systematically analyzing climatic and dengue case time series.Methods: An epidemiological dengue model was developed using time series analysis techniques and forced with statistical downscaling from various Coupled Model Intercomparison Project Phase 6 (CMIP6) climate models based on Shared Socioeconomic Pathway (SSP) scenarios for the late twenty-first century (2071-2100). The ecological time-series investigation analyzed 193 618 dengue cases from January 2008 to December 2018. Statistical downscaling transformed low-resolution Global Climate Models' outputs into high-resolution data, based on a 30-y climate baseline.Results: The results indicated significant climate changes in seasonal temperature and precipitation by the end of the century. Under both SSP2-4.5 and SSP5-8.5 scenarios, substantial increases in dengue cases are projected during current low-incidence months, resulting in a reduced seasonality of dengue.Conclusions: The findings represent considerable challenges for future public health systems, which may face sustained high levels of dengue incidence throughout the year.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1164-1176"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydroxynaphthol blue-based loop-mediated isothermal amplification for the rapid detection of Burkholderia pseudomallei. 基于羟基酚蓝的环介导等温扩增快速检测假马氏伯克氏菌。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-10-01 DOI: 10.1093/trstmh/traf053

Wiphat Klayut, Panatda Aramrueang, Benjawan Phetsuksiri, Sopa Srisungngam, Watcharee Saisongkorh, Ballang Uppapong, Janisara Rudeeaneksin

{"title":"Hydroxynaphthol blue-based loop-mediated isothermal amplification for the rapid detection of Burkholderia pseudomallei.","authors":"Wiphat Klayut, Panatda Aramrueang, Benjawan Phetsuksiri, Sopa Srisungngam, Watcharee Saisongkorh, Ballang Uppapong, Janisara Rudeeaneksin","doi":"10.1093/trstmh/traf053","DOIUrl":"10.1093/trstmh/traf053","url":null,"abstract":"Background: Melioidosis is a potentially life-threatening disease caused by Burkholderia pseudomallei. It is endemic in Southeast Asia and northern Australia and is increasingly distributed in other tropical and subtropical regions. Fast and accurate detection of B. pseudomallei is crucial for initiating prompt and effective treatment.Methods: Loop-mediated isothermal amplification (LAMP) using hydroxynaphthol blue (HNB) for visual detection has been developed and evaluated to detect B. pseudomallei.Results: The assay amplified B. pseudomallei TTSS1-orf2 at 63°C with a 60-min reaction and no cross-amplification was observed. The detection limit was 1.85×102 fg/µl of B. pseudomallei DNA or 2.08×102 CFU/ml of B. pseudomallei spiked in blood, sputum and urine samples. Clinical evaluation using 191 residual specimens revealed 100% negative agreement in detecting 48 of 49 culture-positive samples. Overall, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value were 97.96%, 100%, 99.48%, 100% and 99.30%, respectively, while the κ index showed substantial agreement with the culture method (κ=0.99).Conclusions: This LAMP assay demonstrated good performance, with easy operation and low cost for the rapid detection of B. pseudomallei. It has the potential to be an alternative molecular tool for the early diagnosis of melioidosis in clinical settings.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1177-1183"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AI4PEP: strengthening public health systems through the responsible application of artificial intelligence-lessons from the Dominican Republic. AI4PEP：通过负责任地应用人工智能加强公共卫生系统——来自多米尼加共和国的经验教训。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-10-01 DOI: 10.1093/trstmh/traf104

Manuel Colomé-Hidalgo, Cielo Desiree Batista Pozo, Mariana Dauhajre Pimentel, Demian Arturo Herrera Morban

引用次数: 0

Exploring the spectrum of headaches in neurocysticercosis: a systematic review and meta-analysis. 探索脑囊虫病头痛的频谱：一项系统回顾和荟萃分析。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-10-01 DOI: 10.1093/trstmh/traf066

Ravindra Kumar Garg, Imran Rizvi, Raza Abbas Mahdi, Ravi Uniyal, Vinay Suresh

{"title":"Exploring the spectrum of headaches in neurocysticercosis: a systematic review and meta-analysis.","authors":"Ravindra Kumar Garg, Imran Rizvi, Raza Abbas Mahdi, Ravi Uniyal, Vinay Suresh","doi":"10.1093/trstmh/traf066","DOIUrl":"10.1093/trstmh/traf066","url":null,"abstract":"Background: Understanding the prevalence, characteristics, diagnosis and management of headaches associated with neurocysticercosis (NCC) is essential for optimizing patient care.Methods: This systematic review and meta-analysis followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We examined case reports, case series and cohort studies that explored headaches in NCC patients. The review protocol was registered in PROSPERO (CRD42024530164).Results: A total of 53 isolated NCC cases presenting with headache and 8 cohort studies were included. Severe or progressive headaches, often resembling migraines, were most prevalent (35.2%). Brain parenchymal cysts were the most frequently observed lesion type (39.6%), followed by ventricular cysts (28.3%). Treatment primarily consisted of cysticidal therapy (66.2%), with surgical intervention required in 25.4% of cases. The majority of patients (96.2%) experienced clinical improvement. The meta-analysis addressed three key questions. Patients with primary headaches exhibited a significantly higher prevalence of calcified NCC (odds ratio [OR] 2.82, I2=0%). Likewise, primary headaches were more common in individuals with calcified NCC (OR 2.82, I2=0%). However, headache frequency (mean difference=1.93, I2=86%) and severity (mean difference=4.45, I2=99%) did not differ significantly.Conclusions: Brain parenchymal cysts, particularly ring or disk-enhancing colloidal cysts, may present with new-onset headaches mimicking primary headache syndromes. Our meta-analysis indicates a significant association between calcified NCC and primary headaches, but no substantial differences were found in headache frequency or severity.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1113-1134"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vulnerability of French overseas territories: the 2018-2022 hepatitis A outbreak in New Caledonia. 法国海外领土的脆弱性：新喀里多尼亚2018-2022年甲型肝炎爆发。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-10-01 DOI: 10.1093/trstmh/traf051

Ann-Claire Gourinat, Laura Dupont, Noémie Bargeolle, Anne Pfannstiel, Charlotte Duval, Vincent Portet-Sulla, Lina Mouna, Arnaud Cannet, Anne-Marie Roque-Afonso

{"title":"Vulnerability of French overseas territories: the 2018-2022 hepatitis A outbreak in New Caledonia.","authors":"Ann-Claire Gourinat, Laura Dupont, Noémie Bargeolle, Anne Pfannstiel, Charlotte Duval, Vincent Portet-Sulla, Lina Mouna, Arnaud Cannet, Anne-Marie Roque-Afonso","doi":"10.1093/trstmh/traf051","DOIUrl":"10.1093/trstmh/traf051","url":null,"abstract":"Background: Hepatitis A virus (HAV) typically causes asymptomatic infection, especially in children <6 y of age. New Caledonia has low HAV endemicity, but a surge in cases between 2018 and 2022 prompted an analysis of epidemiological and virological features.Methods: A retrospective study analysed confirmed HAV cases (2018-2022), examining demographics, hospitalisations and alanine aminotransferase (ALT) levels. Phylogenetic analysis was conducted on isolated strains.Results: In mid-2018, imported cases from Vanuatu triggered the outbreak. Higher incidence rates were observed in the Loyalty Islands, particularly Maré Island, with subsequent spread to other areas. From 2018 to 2022, 672 cases were identified, with a median age of 13 y. Children <6 y of age accounted for 8.9% of cases, those ages 6-14 y for 54.2% and individuals ≥15 y for 36.9%. Hospitalisation occurred in 32.3% of cases. ALT levels were higher in hospitalised patients (p<0.001), but children <5 y of age had lower ALT levels overall. HAV genotyping from 16 available sera revealed subgenotype IA strains, with 14 of them linked to Vanuatu.Conclusions: The outbreak, triggered by imported strains from Vanuatu, was facilitated by environmental and infrastructural vulnerabilities. It highlights the need for improved vaccination, especially for travellers, and the critical role of water management in preventing future outbreaks. This also underscores the importance of tracking viral circulation in the Pacific region.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1157-1163"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Male sex is associated with a higher risk of multibacillary leprosy and leprosy-associated disability in northeast Brazil. 在巴西东北部，男性与多菌性麻风病和麻风病相关残疾的高风险相关。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-10-01 DOI: 10.1093/trstmh/traf048

Julia S Barreto, Rodrigo A Cazzaniga, Márcio Bezerra-Santos, Lenise F Albuquerque, Daniela T de Oliveira, Jonnia Maria S Araujo, Angela M da Silva, Camilla Natália O Santos, Amelia R de Jesus, Lucas S Magalhães

引用次数: 0

The utility of artificial intelligence in the management of dengue fever: a perspective on future directions. 人工智能在登革热管理中的应用：对未来方向的展望。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-10-01 DOI: 10.1093/trstmh/traf103

Mohammed Hussein, Elshimaa Ali, Yassin Kamal, Ali Elhouni, E L Mardi Ems, Yousif Eltayeb, Ali Awadallah Saeed, Ahmed Hassan Fahal

{"title":"The utility of artificial intelligence in the management of dengue fever: a perspective on future directions.","authors":"Mohammed Hussein, Elshimaa Ali, Yassin Kamal, Ali Elhouni, E L Mardi Ems, Yousif Eltayeb, Ali Awadallah Saeed, Ahmed Hassan Fahal","doi":"10.1093/trstmh/traf103","DOIUrl":"10.1093/trstmh/traf103","url":null,"abstract":"Dengue fever remains a significant public health challenge, particularly in tropical and subtropical regions. With millions affected each year and the increasing prevalence of the disease due to urbanisation and climate change, effective management strategies are crucial. The incorporation of artificial intelligence (AI) in healthcare presents transformative possibilities for the management of dengue fever. AI-driven systems can improve disease surveillance by analyzing extensive volumes of epidemiological, environmental, and socio-behavioral data to identify early warning indicators and forecast outbreak trends. Enhanced diagnostic instruments driven by AI algorithms can expedite and refine case identification, especially in resource-constrained environments. Moreover, AI can enhance targeted vector control tactics by pinpointing high-risk areas and optimizing the implementation of preventive measures. AI can optimize resource allocation in healthcare institutions. These applications have the potential to substantially alleviate the burden of dengue fever, enhance patient outcomes, and fortify health system resilience. As AI technologies progress, their influence in public health is expected to grow, facilitating creative, data-driven strategies that correspond with the United Nations Sustainable Development Goals (SDGs) to enhance global health equity and disease prevention. Continued research, collaboration, and community engagement will be crucial to realising the full potential of AI in addressing this pressing public health challenge.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1215-1221"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0