Transactions of The Royal Society of Tropical Medicine and Hygiene最新文献_第8页

Using the AS04C-adjuvanted hepatitis B vaccine in patients classified as non-responders. 在分类为无应答的患者中使用AS04C佐剂乙肝疫苗。

IF 2.2 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-03-04 DOI: 10.1093/trstmh/trad078

Sara Fernández Sánchez-Escalonilla, Jesus Gonzalez-Rubio, Alberto Najera, Jose Miguel Cantero Escribano, Francisco Jesús Molina Cabrero, Jesús García Guerrero

{"title":"Using the AS04C-adjuvanted hepatitis B vaccine in patients classified as non-responders.","authors":"Sara Fernández Sánchez-Escalonilla, Jesus Gonzalez-Rubio, Alberto Najera, Jose Miguel Cantero Escribano, Francisco Jesús Molina Cabrero, Jesús García Guerrero","doi":"10.1093/trstmh/trad078","DOIUrl":"10.1093/trstmh/trad078","url":null,"abstract":"Background: Chronic hepatitis B (HB) remains a significant global health concern, despite the widespread availability of the HB vaccine. While the standard vaccine demonstrates an impressive serological response rate exceeding 90%, a subset of individuals exhibit suboptimal immunity. This study aims to elucidate the efficacy of the AS04C-adjuvanted HB vaccine in addressing non-responsiveness.Methods: Conducted at the Preventive Medicine Service of the University Albacete Hospital in Spain from 2017 to 2021, this single-center observational study enrolled 195 patients. Among them, 126 (65%) were classified as non-responders following one or two complete standard vaccination courses.Results: After the administration of a complete four-dose regimen of the AS04C-adjuvanted vaccine, 73.81% of non-responder patients exhibited antibody titers indicative of robust immunity (anti-HBs >10).Conclusions: These findings underscore the pivotal role of the AS04C-adjuvanted HB vaccine in addressing non-responsiveness, emphasizing its potential as a crucial tool in augmenting immunization strategies for various populations. This includes non-responders to standard vaccination, individuals with chronic kidney disease, those requiring seroprotection due to factors like immunosuppression or occupational hazards, as well as patients for whom conventional revaccination strategies have proven futile. Additional research is needed to expand on the promising results obtained through our protocol.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66784342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scrub typhus in Northeast India: epidemiology, clinical presentations, and diagnostic approaches. 印度东北部的丛林斑疹伤寒:流行病学、临床表现和诊断方法。

IF 2.2 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-03-04 DOI: 10.1093/trstmh/trad082

Beyau M Konyak, Monika Soni, Shyamalima Saikia, Tochi Chang, Indrani Gogoi, Ibakmensi Khongstid, Chung-Ming Chang, Mohan Sharma, Ramendra Pati Pandey

{"title":"Scrub typhus in Northeast India: epidemiology, clinical presentations, and diagnostic approaches.","authors":"Beyau M Konyak, Monika Soni, Shyamalima Saikia, Tochi Chang, Indrani Gogoi, Ibakmensi Khongstid, Chung-Ming Chang, Mohan Sharma, Ramendra Pati Pandey","doi":"10.1093/trstmh/trad082","DOIUrl":"10.1093/trstmh/trad082","url":null,"abstract":"Scrub typhus is one of the most neglected tropical diseases, a leading cause of acute undifferentiated febrile illness in areas of the 'tsutsugamushi triangle', diagnosed frequently in South Asian countries. The bacteria Orientia tsutsugamushi is the causative agent of the disease, which enters the human body through the bite of trombiculid mites (also known as chiggers) of the genus Leptotrombidium deliense. Diagnosis of the disease is challenging, as its early symptoms mimic other febrile illnesses like dengue, influenza and corona viruses. Lack of rapid, reliable and cost-effective diagnostic methods further complicates the identification process. Northeast India, a mountainous region with a predominantly rural tribal population, has witnessed a resurgence of scrub typhus cases in recent years. Various ecological factors, including rodent populations, habitat characteristics and climatic conditions, influence its prevalence. Entomological investigations have confirmed the abundance of vector mites, highlighting the importance of understanding their distribution and the probability of transmission of scrub typhus in the region. Proper diagnosis, awareness campaigns and behavioural interventions are essential for controlling scrub typhus outbreaks and reducing its impact on public health in Northeast India. Further research and community-based studies are necessary to accurately assess the disease burden and implement effective prevention strategies.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary healthcare service delivery for older people with progressive multimorbidity in low- and middle-income countries: a systematic review. 低收入和中等收入国家为患有渐进性多发病的老年人提供初级医疗服务：一项系统综述。

IF 2.2 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-03-04 DOI: 10.1093/trstmh/trad068

Duncan Kwaitana, Felix Chisoni, Dorothee van Breevoort, Thomas Mildestvedt, Eivind Meland, Jane Bates, Eric Umar

{"title":"Primary healthcare service delivery for older people with progressive multimorbidity in low- and middle-income countries: a systematic review.","authors":"Duncan Kwaitana, Felix Chisoni, Dorothee van Breevoort, Thomas Mildestvedt, Eivind Meland, Jane Bates, Eric Umar","doi":"10.1093/trstmh/trad068","DOIUrl":"10.1093/trstmh/trad068","url":null,"abstract":"Ensuring primary healthcare (PHC) accessibility to older people with multimorbidity is vital in preventing unnecessary health deterioration. However, older people ≥50 y of age in low- and middle-income countries (LMICs) face challenges in effectively accessing and utilizing PHC. A systematic review was conducted adopting the Andersen-Newman theoretical framework for health services utilization to assess evidence on factors that affect access to PHC by older people. This framework predicts that a series of factors (predisposing, enabling and need factors) influence the utilization of health services by people in general. Seven publications were identified and a narrative analytical method revealed limited research in this area. Facilitating factors included family support, closeness to the PHC facility, friendly service providers and improved functional status of the older people. Barriers included long distance and disjointed PHC services, fewer health professionals and a lack of person-centred care. The following needs were identified: increasing the number of health professionals, provision of PHC services under one roof and regular screening services. There is a need for more investment in infrastructure development, coordination of service delivery and capacity building of service providers in LMICs to improve access and utilization of PHC services for older people.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41158369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The spectrum of central nervous system manifestations in leprosy: a systematic review of published case reports and case series. 麻风病的中枢神经系统表现谱：对已发表的病例报告和病例系列的系统回顾。

IF 2.2 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-03-04 DOI: 10.1093/trstmh/trad072

Ravindra Kumar Garg, Ravi Uniyal, Shweta Pandey, Nidhi Tejan, Imran Rizvi, Praveen Kumar Sharma, Neeraj Kumar, Hardeep Singh Malhotra

{"title":"The spectrum of central nervous system manifestations in leprosy: a systematic review of published case reports and case series.","authors":"Ravindra Kumar Garg, Ravi Uniyal, Shweta Pandey, Nidhi Tejan, Imran Rizvi, Praveen Kumar Sharma, Neeraj Kumar, Hardeep Singh Malhotra","doi":"10.1093/trstmh/trad072","DOIUrl":"10.1093/trstmh/trad072","url":null,"abstract":"Background: This systematic review aimed to investigate central nervous system (CNS) involvement in leprosy by analysing multiple cohort studies, individual cases and case series.Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. PubMed, Scopus and Embase databases were searched up to 8 July 2023, using a predefined search strategy. Inclusion criteria included patients diagnosed with leprosy with evidence of CNS involvement. The quality of the included cases was evaluated using the Joanna Briggs Institute checklist.Results: A total of 34 records were identified, including 18 cohort studies and 16 reports describing 27 isolated cases. Autopsies revealed macroscopic changes in the spinal cord, neurofibrillary tangles and senile plaques. Mycobacterium leprae was detected in neurons of the medulla oblongata and spinal cord using PCR and phenolic glycolipid 1 staining. Cerebrospinal fluid (CSF) analysis showed inflammatory changes, increased gamma globulins and detection of Mycobacterium leprae antigens and antibodies. In 21 patients (78%), spinal cord/brachial plexus abnormities were detected. In the majority, MRI revealed T2/fluid-attenuated inversion recovery (FLAIR) hyperintensity in the cervical cord. In patients with brainstem involvement, T2/FLAIR hyperintensity was noted in the cerebellar peduncles, facial nerve nuclei and/or other cranial nerve nuclei. Brain parenchymal involvement was noted in three patients.Conclusions: This systematic review provides evidence of CNS involvement in leprosy, based on autopsy findings, neuroimaging, CSF analysis and neurophysiological studies.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41238744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Newly detected paediatric melioidosis cases in a single referral children's hospital in Ho Chi Minh City indicate the probable underrecognition of melioidosis in South Vietnam. 在胡志明市的一家转诊儿童医院新发现的儿科类鼻疽病例表明，在越南南部可能对类鼻疽的认识不足。

IF 2.2 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-03-04 DOI: 10.1093/trstmh/trad080

Thai Son Pham, Elisabeth König, The Trung Bui, Thi Ngoc Anh Vu, Tran Nam Nguyen, Chau Viet Do, Sabine Lichtenegger, Nguyen Hai Linh Bui, Huu Tung Trinh, Ivo Steinmetz, Thanh Trung Trinh

{"title":"Newly detected paediatric melioidosis cases in a single referral children's hospital in Ho Chi Minh City indicate the probable underrecognition of melioidosis in South Vietnam.","authors":"Thai Son Pham, Elisabeth König, The Trung Bui, Thi Ngoc Anh Vu, Tran Nam Nguyen, Chau Viet Do, Sabine Lichtenegger, Nguyen Hai Linh Bui, Huu Tung Trinh, Ivo Steinmetz, Thanh Trung Trinh","doi":"10.1093/trstmh/trad080","DOIUrl":"10.1093/trstmh/trad080","url":null,"abstract":"Background: The epidemiology of melioidosis in Vietnam, a disease caused by the soil bacterium Burkholderia pseudomallei, remains unclear. This study aimed to detect paediatric melioidosis in South Vietnam and describe clinical features and the geographic distribution.Methods: We introduced a simple laboratory algorithm for detecting B. pseudomallei from clinical samples at Children's Hospital 2 in Ho Chi Minh City in July 2015. A retrospective observational study of children <16 y of age with culture-confirmed melioidosis between July 2015 and August 2019 was undertaken.Results: Thirty-five paediatric cases of melioidosis were detected, with cases originating from 13 of 32 provinces and cities in South Vietnam. The number of paediatric melioidosis cases detected from a certain region correlated with the overall number of inpatients originating from the respective geographic area. Suppurative parotitis (n=15 [42.8%]) was the most common clinical presentation, followed by lung infection (n=10 [28.6%]) and septicaemia (n=7 [20%]). Fourteen (40%) children had disseminated disease, including all cases of lung infection, four cases with central nervous system symptoms and four (11.4%) deaths.Conclusions: The patients' origin indicates a wide distribution of melioidosis in South Vietnam. It seems probable that cases not only in children, but also in adults, remain grossly undiagnosed. Further awareness raising and laboratory capacity strengthening are needed in this part of the country.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138435119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fighting the neglected tropical disease: Cameroon's battle against river blindness. 与被忽视的热带疾病作斗争：喀麦隆与河盲症作斗争。

IF 2.2 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-03-04 DOI: 10.1093/trstmh/trad073

Prakasini Satapathy, Gurmanjeet Kaur, Mubarick Nungbaso Asumah, Isah Idris Ainavi, Sarvesh Rustagi, Keerti Bhusan Pradhan, Zahraa Haleem Al-Qaim, Ranjit Sah, Bijaya K Padhi

引用次数: 0

National health insurance scheme improves access and optimization of antimicrobial use in the Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria. 国家健康保险计划改善了尼日利亚Ile-Ife的奥巴费米·阿沃洛沃大学教学医院综合医院获得和优化抗微生物药物的使用。

IF 2.2 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-03-04 DOI: 10.1093/trstmh/trad083

Temitope O Obadare, Taiwo O Ogundipe, Adeyemi T Adeyemo, Caleb M Aboderin, Doyin R Abiola, Naheemot O Sule, Aaron O Aboderin

{"title":"National health insurance scheme improves access and optimization of antimicrobial use in the Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.","authors":"Temitope O Obadare, Taiwo O Ogundipe, Adeyemi T Adeyemo, Caleb M Aboderin, Doyin R Abiola, Naheemot O Sule, Aaron O Aboderin","doi":"10.1093/trstmh/trad083","DOIUrl":"10.1093/trstmh/trad083","url":null,"abstract":"Background: Nigeria instituted the National Health Insurance Scheme (NHIS) for universal health coverage. This study compared the NHIS and out-of-pocket (OOP) antibiotic prescribing with the World Health Organization (WHO) optimal values.Methods: A total of 2190 prescription forms from the NHIS and OOP were included in this study conducted at Obafemi Awolowo University Teaching Hospitals Complex, Nigeria from January 2021 to December 2022 and analysed using WHO drug prescribing guidelines.Results: The average number of drugs per encounter was higher in the NHIS prescribing (χ2=58.956, p=0.00) than in OOP prescribing. The percentage of encounters with an antibiotic prescribed is higher in NHIS prescribing (χ2=46.034, p=0.000) than in OOP prescribing. The percentage of parenteral antibiotic prescribing is higher in OOP prescribing (χ2=25.413, p=0.000) than in NHIS prescribing. The percentage of antibiotic prescribed from the National Essential Medicine List is higher in NHIS prescribing (χ2=8.227, p=0.000) as well as the antibiotics prescribed from the Access category of the WHO Access, Watch and Reserve (AWaRe) Classification of antibiotics (χ2=23.946, p=0.000) when compared with OOP prescribing.Conclusions: Prescribing indicators show better performances with NHIS antibiotic prescribing and are closer to the WHO-recommended optimal values than in OPP prescribing. Hence NHIS prescribing can be an easy target for hospital antibiotic stewardship intervention for optimal antibiotic prescribing.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138452657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Syndecan-1 levels predict septic shock in critically ill patients with COVID-19. Syndecan-1水平预测新冠肺炎危重患者感染性休克。

IF 2.2 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-03-04 DOI: 10.1093/trstmh/trad077

Nilcyeli Linhares Aragão, Marza de Sousa Zaranza, Gdayllon Cavalcante Meneses, Ana Paula Pires Lázaro, Álvaro Rolim Guimarães, Alice Maria Costa Martins, Natalia Linhares Ponte Aragão, Andrea Mazza Beliero, Geraldo Bezerra da Silva Júnior, Sandra Mara Brasileiro Mota, Polianna Lemos Moura Moreira Albuquerque, Elizabeth De Francesco Daher, Veralice Meireles Sales De Bruin, Pedro Felipe Carvalhedo de Bruin

{"title":"Syndecan-1 levels predict septic shock in critically ill patients with COVID-19.","authors":"Nilcyeli Linhares Aragão, Marza de Sousa Zaranza, Gdayllon Cavalcante Meneses, Ana Paula Pires Lázaro, Álvaro Rolim Guimarães, Alice Maria Costa Martins, Natalia Linhares Ponte Aragão, Andrea Mazza Beliero, Geraldo Bezerra da Silva Júnior, Sandra Mara Brasileiro Mota, Polianna Lemos Moura Moreira Albuquerque, Elizabeth De Francesco Daher, Veralice Meireles Sales De Bruin, Pedro Felipe Carvalhedo de Bruin","doi":"10.1093/trstmh/trad077","DOIUrl":"10.1093/trstmh/trad077","url":null,"abstract":"Background: The clinical picture of coronavirus disease 2019 (COVID-19)-associated sepsis is similar to that of sepsis of other aetiologies. The present study aims to analyse the role of syndecan-1 (SDC-1) as a potential predictor of septic shock in critically ill patients with COVID-19.Methods: This is a prospective study of 86 critically ill patients due to COVID-19 infection. Patients were followed until day 28 of hospitalization. Vascular biomarkers, such as vascular cell adhesion protein-1, SDC-1, angiopoietin-1 and angiopoietin-2, were quantified upon admission and associated with the need for vasopressors in the first 7 d of hospitalization.Results: A total of 86 patients with COVID-19 (mean age 60±16 y; 51 men [59%]) were evaluated. Thirty-six (42%) patients died during hospitalization and 50 (58%) survived. The group receiving vasopressors had higher levels of D-dimer (2.46 ng/ml [interquartile range {IQR} 0.6-6.1] vs 1.01 ng/ml [IQR 0.62-2.6], p=0.019) and lactate dehydrogenase (929±382 U/l vs 766±312 U/l, p=0.048). The frequency of deaths during hospitalization was higher in the group that received vasoactive amines in the first 24 h in the intensive care unit (70% vs 30%, p=0.002). SDC-1 levels were independently associated with the need for vasoactive amines, and admission values >269 ng/ml (95% CI 0.524 to 0.758, p=0.024) were able to predict the need for vasopressors during the 7 d following admission.Conclusions: Syndecan-1 levels predict septic shock in critically ill patients with COVID-19.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66784341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An intervention study investigating the effectiveness of contextualizing multimodal strategy on improving hand hygiene at a tertiary hospital in Nigeria. 一项干预研究，调查了尼日利亚一家三级医院在改善手部卫生方面采用情境化多模式策略的有效性。

IF 2.2 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-03-04 DOI: 10.1093/trstmh/trad081

Yahaya Yaqub, Zainab Lamido Tanko, Aliyu Aminu, Usman Yahya Umar, Joan Ejembi

{"title":"An intervention study investigating the effectiveness of contextualizing multimodal strategy on improving hand hygiene at a tertiary hospital in Nigeria.","authors":"Yahaya Yaqub, Zainab Lamido Tanko, Aliyu Aminu, Usman Yahya Umar, Joan Ejembi","doi":"10.1093/trstmh/trad081","DOIUrl":"10.1093/trstmh/trad081","url":null,"abstract":"Background: Hand hygiene (HH) is a proven low-cost means to curtail the problem of hospital-acquired infection (HAI). However, a low HH compliance rate of 17.1% was found among surgical health workers at Ahmadu Bello University Teaching Hospital (ABUTH) in Zaria, Nigeria.Methods: This was an intervention study conducted utilizing mixed methods to investigate the effectiveness of the World Health Organization (WHO) multimodal strategy to improve the HH compliance rate of doctors at ABUTH Zaria. The study was conducted between June and August 2022 and included delivering a behavioural change HH workshop to doctors followed by data collection in the surgical wards that had received environmental modification through the provision of an alcohol-based hand rub (ABHR), HH posters and nurses for visual and/or verbal reminders.Results: The cumulative HH compliance rate was 69% (n=1774) and was significantly different from the baseline HH compliance rate of 17.1% (confidence interval 45.5 to 57.7, p<0.001). Observed HH was highest in the ward with both visual and verbal reminders (78%) and lowest (59%) where neither visual nor verbal reminders were provided (n=444 per ward). All respondents reported motivation to perform HH with the presence of ABHR.Conclusions: The WHO multimodal strategy is good for enhancing HH among health workers in the context of low- and middle-income countries. More research is needed to understand how much of a reduction in HAI is directly associated with efficient HH by health workers.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138296079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artesunate-mefloquine therapy for uncomplicated Plasmodium falciparum malaria: an updated systematic review and meta-analysis of efficacy and safety. Artesunate mefloquine治疗无并发症恶性疟原虫疟疾：疗效和安全性的最新系统综述和荟萃分析。

IF 2.2 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-02-01 DOI: 10.1093/trstmh/trad069

Beatriz Sales de Freitas, Gabriel Haiek Fernandes, Ana Carolina Esteves da Silva Pereira, Henry Maia Peixoto

{"title":"Artesunate-mefloquine therapy for uncomplicated Plasmodium falciparum malaria: an updated systematic review and meta-analysis of efficacy and safety.","authors":"Beatriz Sales de Freitas, Gabriel Haiek Fernandes, Ana Carolina Esteves da Silva Pereira, Henry Maia Peixoto","doi":"10.1093/trstmh/trad069","DOIUrl":"10.1093/trstmh/trad069","url":null,"abstract":"To provide a continuous update on the safety and efficacy of artesunate-mefloquine (ASMQ) compared with other artemisinin combination therapy (ACT) schemes used in the treatment of uncomplicated malaria caused by Plasmodium falciparum, this study updated and expanded the results of the systematic literature review published in 2016. Only randomised controlled clinical trials published from 1 January 2001 to 12 June 2023 from five databases were included in this study. The results related to efficacy, expressed through RR, were summarized in meta-analyses, performed according to the compared ACTs and with the intention-to-treat and per-protocol analyses. The results related to safety were synthesized in a descriptive manner. Thirty-two studies were included, of which 24 had been analysed in the 2016 review and eight new ones were added. Although the methodological quality of most studies was considered moderate, the body of evidence gathered indicates that ASMQ continues to be safe and effective for the treatment of uncomplicated infections caused by P. falciparum compared with other ACTs. However, the inclusion of two new studies, which identified failure rates exceeding 10%, suggests a possible reduction in the efficacy of ASMQ in the analysed locations. The incidence of serious adverse effects, such as seizure, encephalopathy and cardiac arrhythmia, was infrequent in both the ASMQ group and the comparison groups. After including new evidence, ASMQ is still recommended as a first-line treatment of uncomplicated malaria caused by P. falciparum, although local aspects need to be considered.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41166480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0