Transactions of The Royal Society of Tropical Medicine and Hygiene最新文献_第8页

Reported snakebite mortality and state compensation payments in Madhya Pradesh, India, from 2020 to 2022. 2020 年至 2022 年印度中央邦报告的蛇咬伤死亡率和邦政府支付的赔偿金。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-08-06 DOI: 10.1093/trstmh/trae045

Priyanka Kadam, Bhupeshwari Patel, Maya Gopalakrishnan, Freston M Sirur, Omesh K Bharti, Amit Agrawal, Md Yunus, Dayal B Majumdar, Stuart Ainsworth

{"title":"Reported snakebite mortality and state compensation payments in Madhya Pradesh, India, from 2020 to 2022.","authors":"Priyanka Kadam, Bhupeshwari Patel, Maya Gopalakrishnan, Freston M Sirur, Omesh K Bharti, Amit Agrawal, Md Yunus, Dayal B Majumdar, Stuart Ainsworth","doi":"10.1093/trstmh/trae045","DOIUrl":"10.1093/trstmh/trae045","url":null,"abstract":"Background: India experiences the highest snakebite burden globally, with 58 000 predicted deaths annually. The central Indian state of Madhya Pradesh is thought to have a substantial snakebite burden and provides compensation to families who can demonstrate by postmortem and hospital treatment reports that their relatives have died due to snakebite. This study represents the first report on the frequency of distribution of compensation for snakebite deaths in Madhya Pradesh.Methods: Statewide snakebite death compensation data from 2020-2021 and 2021-2022, provided by the Madhya Pradesh health authorities, were analysed alongside interviews with 15 families that described the events that ultimately led to their compensation claims.Results: Compensation was paid to a total of 5728 families, with a total value equating to 22 912 Lakhs (approximately US${$}$27.94 million). Families described commonly recognised snakebite risk factors and behaviours in the events that resulted in their relatives' deaths.Conclusions: The snakebite burden in Madhya Pradesh is significant, both in terms of mortality and economic expenditure of the state. Sustained investment in preventative interventions, as well as monitoring of the rate of compensation payouts due to snakebite death as a measure of intervention effectiveness, should be considered to substantially reduce snakebite incidence and mortality.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accuracy of commercial ELISA and ICT for screening schistosomiasis infections at a low endemicity area in Brazil. 商用酶联免疫吸附试验和信息通信技术在巴西低流行区筛查血吸虫病感染的准确性。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-08-05 DOI: 10.1093/trstmh/trae005

Lida M S Ramos, Danielle S C A Pereira, Laila O V Oliveira, Carlos Graeff-Teixeira

{"title":"Accuracy of commercial ELISA and ICT for screening schistosomiasis infections at a low endemicity area in Brazil.","authors":"Lida M S Ramos, Danielle S C A Pereira, Laila O V Oliveira, Carlos Graeff-Teixeira","doi":"10.1093/trstmh/trae005","DOIUrl":"10.1093/trstmh/trae005","url":null,"abstract":"Background: Control interventions recommended by the World Health Organization have successfully resulted in low-intensity schistosomiasis transmission areas. To achieve elimination of transmission, new diagnostic screening tools are needed to overcome less than adequate sensitivity of the currently used Kato-Katz faecal thick smear method. Ideally, in-house serological tests should be avoided due to not having a continuous supply of kits as would be necessary for large population studies. Quality assurance provided by manufacturers and proper performance evaluations are also needed. We evaluated the accuracy of two commercially available serology tests as screening methods for detecting light schistosomiasis infections.Methods: Serum samples were collected in 2015 from individuals living in a low-endemicity locality in northeastern Brazil and deposited in a biorepository. We evaluated immunoglobulin G (IgG) and IgM enzyme-linked immunosorbent assays (ELISAs) and an immunochromatographic test (ICT). The Helmintex method was used to define true-positive samples.Results: Overall sensitivity was close to 90% for both the IgG ELISA and ICT, yet specificity was 28% and 18%, respectively. For the IgM ELISA, the values were estimated to be 55% and 43%, respectively.Conclusions: Poor specificity and positive predictive values prevent these tests from being recommended for screening populations in low-intensity schistosomiasis-endemic areas.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"514-519"},"PeriodicalIF":1.9,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139944500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aligning antimicrobial resistance surveillance with schistosomiasis research: an interlinked One Health approach. 将抗菌药耐药性监测与血吸虫病研究相结合：相互关联的 "一体健康 "方法。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-08-05 DOI: 10.1093/trstmh/trae035

Angus M O'Ferrall, Janelisa Musaya, J Russell Stothard, Adam P Roberts

{"title":"Aligning antimicrobial resistance surveillance with schistosomiasis research: an interlinked One Health approach.","authors":"Angus M O'Ferrall, Janelisa Musaya, J Russell Stothard, Adam P Roberts","doi":"10.1093/trstmh/trae035","DOIUrl":"10.1093/trstmh/trae035","url":null,"abstract":"One Health surveillance involves the analysis of human, animal and environmental samples, recognising their interconnectedness in health systems. Such considerations are crucial to investigate the transmission of many pathogens, including drug-resistant bacteria and parasites. The highest rates of antimicrobial resistance (AMR)-associated deaths are observed in sub-Saharan Africa, where concurrently the waterborne parasitic disease schistosomiasis can be highly endemic in both humans and animals. Although there is growing acknowledgment of significant interactions between bacteria and parasites, knowledge of relationships between schistosomes, microbes and AMR remains inadequate. In addition, newly emergent research has revealed the previously underappreciated roles of animals and the environment in both AMR and schistosomiasis transmission. We consider shared environmental drivers and colonisation linkage in this narrative review, with a focus on extended-spectrum beta-lactamase-mediated resistance among bacteria from the Enterobacteriaceae family, which is exceedingly prevalent and responsible for a high burden of AMR-associated deaths. Then we examine novel findings from Malawi, where the landscapes of AMR and schistosomiasis are rapidly evolving, and make comparisons to other geographic areas with similar co-infection epidemiology. We identify several knowledge gaps that could be addressed in future research, including the need to characterise the impact of intestinal schistosomiasis and freshwater contact on intestinal AMR colonisation, before proposing a rationale for connecting AMR surveillance and schistosomiasis research within a One Health framework.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"498-504"},"PeriodicalIF":1.9,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The usefulness of patient-reported outcome measures in decision making in Chagas cardiomyopathy: a scoping review. 恰加斯病心肌病决策过程中患者报告结果测量的实用性：范围界定综述。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-08-05 DOI: 10.1093/trstmh/trae025

Whesley Tanor Silva, Keity Lamary Souza Silva, Diego Mendes Xavier, Matheus Ribeiro Ávila, Lucas Frois Fernandes de Oliveira, Vittor de Moura Colicchio, Igor Lucas Geraldo Izalino de Almeida, Alessandra de Carvalho Bastone, Marcus Alessandro Alcantara, Ana Cristina Rodrigues Lacerda, Vanessa Pereira Lima, Luciano Fonseca Lemos de Oliveira, Mauro Felippe Felix Mediano, Pedro Henrique Scheidt Figueiredo, Henrique Silveira Costa

{"title":"The usefulness of patient-reported outcome measures in decision making in Chagas cardiomyopathy: a scoping review.","authors":"Whesley Tanor Silva, Keity Lamary Souza Silva, Diego Mendes Xavier, Matheus Ribeiro Ávila, Lucas Frois Fernandes de Oliveira, Vittor de Moura Colicchio, Igor Lucas Geraldo Izalino de Almeida, Alessandra de Carvalho Bastone, Marcus Alessandro Alcantara, Ana Cristina Rodrigues Lacerda, Vanessa Pereira Lima, Luciano Fonseca Lemos de Oliveira, Mauro Felippe Felix Mediano, Pedro Henrique Scheidt Figueiredo, Henrique Silveira Costa","doi":"10.1093/trstmh/trae025","DOIUrl":"10.1093/trstmh/trae025","url":null,"abstract":"Chagas cardiomyopathy (ChC) presents many biopsychosocial complexities, highlighting the need to have patient self-report questions. This study demonstrates the scope of the use of patient-reported outcome measures (PROMs) in patients with ChC and highlights the main research gaps. This is a scoping review and the search strategy was performed in the Online Medical Literature Analysis and Retrieval System (MEDLINE), Excerpta Medica database (EMBASE), Accumulated Index of Nursing and Allied Health Literature (CINAHL), Cochrane Central, Latin American Literature and Caribbean in Health Sciences (LILACS) and Diagnostic Test Accuracy (DITA). The search identified 4484 studies and 20 studies met the inclusion criteria. The Short-Form of 36 items (SF-36) had potential prognostic value and the ability to identify systolic dysfunction. The Human Activity Profile was able to screen for functional impairment, and the New York Heart Association showed potential prognostic value. The SF-36 and Minnesota Living with Heart Failure Questionnaire were responsive to interventions. The pharmaceutical care affected adherence to treatment as assessed by the Morisky score and also for SF-36. Despite the increased use of PROMs, there are still a large number of gaps in the literature, and further studies using PROMs are needed.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"491-497"},"PeriodicalIF":1.9,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140877433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The first insight into Mycobacterium tuberculosis complex isolates in the lower northern region in Thailand. 首次深入了解泰国北部下游地区的结核分枝杆菌复合菌株。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-08-05 DOI: 10.1093/trstmh/trae014

Janisara Rudeeaneksin, Supranee Bunchoo, Benjawan Phetsuksiri, Sopa Srisungngam, Ratchaneeporn Khummin, Jeewan Thapa, Chie Nakajima, Yasuhiko Suzuki

{"title":"The first insight into Mycobacterium tuberculosis complex isolates in the lower northern region in Thailand.","authors":"Janisara Rudeeaneksin, Supranee Bunchoo, Benjawan Phetsuksiri, Sopa Srisungngam, Ratchaneeporn Khummin, Jeewan Thapa, Chie Nakajima, Yasuhiko Suzuki","doi":"10.1093/trstmh/trae014","DOIUrl":"10.1093/trstmh/trae014","url":null,"abstract":"Background: Tuberculosis (TB) remains an important infectious disease and different genotypes have been reported. This study aimed to investigate the genetic diversity and molecular epidemiology of TB in the lower northern region of Thailand, where genotyping data are limited.Methods: A total of 159 Mycobacterium tuberculosis complex (MTBC) isolates from this region were genotyped by spoligotyping and the major spoligotypes were further subdivided by the mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) method.Results: Spoligotyping identified 34 types and classified them into 14 clusters. East African-Indian (EAI) groups were the most frequent (44.7%), followed by Beijing (36.5%), with a higher prevalence of drug resistance. By 15-loci MIRU-VNTR typing, the major groups of the Beijing and EAI2_NTB were further differentiated into 44 and 21 subtypes forming 9 and 5 subclusters with cluster rates of 0.26 and 0.44, respectively. The Hunter-Gaston Discriminatory Index among the Beijing and EAI2_NTB groups were 0.987 and 0.931, respectively, indicating high diversity.Conclusions: This is the first look at the MTBC genotypes in the lower northern region of Thailand, which could aid in understanding the distribution and potential spread of MTBC and Mycobacterium bovis in the target region to support TB control in Thailand.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"527-536"},"PeriodicalIF":1.9,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140330182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

'We no longer experience the same pain': a cross-sectional study assessing the impact of Heart and Sole Africa's podoconiosis prevention education program. 我们不再经历同样的痛苦"：一项横断面研究，评估非洲心与足的足癣预防教育计划的影响。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-08-05 DOI: 10.1093/trstmh/trae007

Agazi Fitsum Gebreselassie, Natnael Shimelash, Ahamed Kallon, George Mkondo, Tonya Huston, Janna M Schurer

{"title":"'We no longer experience the same pain': a cross-sectional study assessing the impact of Heart and Sole Africa's podoconiosis prevention education program.","authors":"Agazi Fitsum Gebreselassie, Natnael Shimelash, Ahamed Kallon, George Mkondo, Tonya Huston, Janna M Schurer","doi":"10.1093/trstmh/trae007","DOIUrl":"10.1093/trstmh/trae007","url":null,"abstract":"Background: Podoconiosis is a non-infectious neglected tropical disease caused by long-term exposure to irritant volcanic soils. It results in severe physical, psychological and financial consequences. Heart and Sole Africa (HASA) is a non-governmental, community-based organization providing management to podoconiosis patients in Rwanda. We sought to analyze the impact of their program on the lives of patients.Methods: Quantitative surveys recorded the participants' demographics, adherence to HASA's management recommendations and changes in quality of life (QOL). Qualitative questions were used to gather respondent perspectives on HASA programming.Results: We interviewed 127 patients from HASA's Musanze (n=47) and Burera (n=80) clinics. Almost all participants (98.4%) reported statistically significant (p<0.01) improvements in their QOL, and more than one-half (51.2%) had a favorable adherence score of >80%. Qualitative feedback identified specific challenges to adherence and recognition of program success in symptom management.Conclusions: Our study demonstrated the value of community-based podoconiosis programming in improving the lives of patients. Practices such as regular feet washing, emollient application, shoe wearing and limb raising can result in a marked reduction of morbidity. Our findings support the argument for scaling up these management practices across Rwanda.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"520-526"},"PeriodicalIF":1.9,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140094626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal trends and space-time distribution of leprosy relapse in Brazil from 2001 to 2021. 2001 至 2021 年巴西麻风病复发的时间趋势和时空分布。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-08-05 DOI: 10.1093/trstmh/trae021

Reagan Nzundu Boigny, Kellyn Kessiene de Sousa Cavalcante, Caroline Mary Gurgel Dias Florencio, Paula Sacha Frota Nogueira, Ciro Martins Gomes, Carlos Henrique Alencar

引用次数: 0

The COVID-19 pandemic impacted the activities of the Schistosomiasis Control Program in Brazil: is the goal of controlling the disease by 2030 at risk? COVID-19 大流行对巴西血吸虫病控制计划活动的影响：到 2030 年控制该疾病的目标是否面临风险？

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-08-05 DOI: 10.1093/trstmh/trae024

Lucas Almeida Andrade, Wandklebson Silva da Paz, Rosália E Santos Ramos, Welde N Borges de Santana, Thuelly Juvêncio da Rocha, Flávia Silva Damasceno, Allan Dantas Dos Santos, Débora Dos Santos Tavares, Rodrigo Feliciano do Carmo, Carlos Dornels Freire de Souza, Deborah Aparecida Negrão-Corrêa, Ricardo Toshio Fujiwara, Abelardo Silva-Júnior, Wagnner José Nascimento Porto, Márcio Bezerra-Santos

{"title":"The COVID-19 pandemic impacted the activities of the Schistosomiasis Control Program in Brazil: is the goal of controlling the disease by 2030 at risk?","authors":"Lucas Almeida Andrade, Wandklebson Silva da Paz, Rosália E Santos Ramos, Welde N Borges de Santana, Thuelly Juvêncio da Rocha, Flávia Silva Damasceno, Allan Dantas Dos Santos, Débora Dos Santos Tavares, Rodrigo Feliciano do Carmo, Carlos Dornels Freire de Souza, Deborah Aparecida Negrão-Corrêa, Ricardo Toshio Fujiwara, Abelardo Silva-Júnior, Wagnner José Nascimento Porto, Márcio Bezerra-Santos","doi":"10.1093/trstmh/trae024","DOIUrl":"10.1093/trstmh/trae024","url":null,"abstract":"Background: Schistosomiasis continues to represent a serious public health problem in Brazil. With the coronavirus disease 2019 (COVID-19) pandemic, several control strategies were suspended, probably compromising the goals of eradicating the disease in the country. We aimed to assess the impact of the COVID-19 pandemic on Schistosomiasis Control Program (PCE) actions in all endemic states of Brazil.Methods: We performed an ecological study using spatial analysis techniques. The PCE variables assessed were the population surveyed, the number of Kato-Katz tests, positive cases of schistosomiasis and the percentage of cases treated between 2015 and 2021. The percent change was calculated to verify if there was an increase or decrease in 2020 and 2021, along with time trend analyses provided by the Joinpoint model. Spatial distribution maps were elaborated considering the percent change.Results: The surveyed population decreased in 2020 (-65.38%) and 2021 (-37.94%) across Brazil. There was a proportional reduction in the number of Kato-Katz tests (2020, -67.48%; 2021, -40.52%), a decrease in the percentage of positive cases (2020, -71.16%; 2021, -40.5%) and a reduction in the percentage of treated cases (2020, -72.09%; 2021, -41.67%). Time trend analyses showed a decreasing trend in most PCE variables.Conclusions: The PCE activities were impacted by the COVID-19 pandemic in Brazil and PCE strategies must be urgently reviewed, focusing on investments in all endemic areas.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"550-559"},"PeriodicalIF":1.9,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infections following rattlesnake envenomation and use of antibiotics. 响尾蛇中毒后的感染和抗生素的使用。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-07-29 DOI: 10.1093/trstmh/trae044

Stephen A Klotz, Geoffrey T Smelski, Sarah A Watkins, F Mazda Shirazi

{"title":"Infections following rattlesnake envenomation and use of antibiotics.","authors":"Stephen A Klotz, Geoffrey T Smelski, Sarah A Watkins, F Mazda Shirazi","doi":"10.1093/trstmh/trae044","DOIUrl":"https://doi.org/10.1093/trstmh/trae044","url":null,"abstract":"Background: There are 7000-8000 venomous snake bites annually in the USA. Antibiotics are commonly administered to bite victims because infection is difficult to differentiate from local tissue injury following envenomation.Methods: The Arizona Poison and Drug Information Center (APDIC) in Tucson oversees antivenom administration for 14 Arizona counties. Records (1999-2021) were searched for antibiotic use and confirmed infections after a rattlesnake bite.Results: There were 4160 calls to APDIC regarding rattlesnakes. After excluding bites to animals, 'dry bites', prisoners and records with missing data, 2059 records were evaluated. Systemic antibiotics were administered to 206 patients (10% of bite victims). Twenty patients (0.97%) had confirmed infections, including cellulitis (n=10), fasciitis (n=4), abscess (n=3) and osteomyelitis (n=3). Five of the victims had positive blood cultures. The presence of tissue necrosis, leukocytosis, fever and elevated fibrinogen levels did not discriminate between toxic effects of venom and infection.Conclusions: Confirmed infections following a rattlesnake bite are uncommon (0.97% of bites). Physicians should refrain from prescribing antibiotics, as they are not justified for most rattlesnake bite victims and the variety of pathogens encountered precludes use of any single effective antibiotic.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the latency period in Chagas disease: duration and determinants in a cohort from Colombia. 探索南美锥虫病的潜伏期：哥伦比亚队列中的潜伏期和决定因素。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-07-05 DOI: 10.1093/trstmh/trae004

Mario Javier Olivera, Lyda Muñoz

{"title":"Exploring the latency period in Chagas disease: duration and determinants in a cohort from Colombia.","authors":"Mario Javier Olivera, Lyda Muñoz","doi":"10.1093/trstmh/trae004","DOIUrl":"10.1093/trstmh/trae004","url":null,"abstract":"Background: Chagas disease has a varying latency period, the time between infection and onset of cardiac symptoms, due to multiple factors. This study seeks to identify and understand these factors to enhance our knowledge of the disease.Methods: A retrospective follow-up study was conducted in Colombia on patients with indeterminate chronic Chagas disease. Medical files were examined to evaluate the disease latency time using time ratios (TRs) and the AFT Weibull model.Results: The study followed 578 patients, of whom 309 (53.5%) developed cardiac disease, with a median latency period of 18.5 (95% CI 16 to 20) y for the cohort. Those with the TcISyl genotype (TR 0.72; 95% CI 0.61 to 0.80), individuals who lived 5-15 y (TR 0.80; 95% CI 0.67 to 0.95), 15-30 y (TR 0.63; 95% CI 0.53 to 0.74) or >30 y (vs 5 y) in areas with high disease prevalence had shorter latency periods. On the other hand, undergoing treatment increased the latency period (TR: 1.74; 95% CI 1.52 to 1.87).Conclusions: The latency period of Chagas disease was found to be independently related to male gender, receipt of etiological treatment, length of time spent in an endemic area and the TcISyl genotype. The implications of these findings are discussed.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"440-447"},"PeriodicalIF":1.9,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139973615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0