Transactions of The Royal Society of Tropical Medicine and Hygiene最新文献_第8页

Serial evaluation of local changes in snakebite envenomation using infrared thermal imaging. 利用红外热成像技术对蛇咬伤中毒局部变化进行系列评价。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-04 DOI: 10.1093/trstmh/trae056

Paramasivam Sabitha, Ramu Ramadoss, Chanaveerappa Bammigatti, Tamilarasu Kadhiravan

{"title":"Serial evaluation of local changes in snakebite envenomation using infrared thermal imaging.","authors":"Paramasivam Sabitha, Ramu Ramadoss, Chanaveerappa Bammigatti, Tamilarasu Kadhiravan","doi":"10.1093/trstmh/trae056","DOIUrl":"10.1093/trstmh/trae056","url":null,"abstract":"Background: There is a lack of objective tools to assess the local changes following snakebite envenomation. We aimed to describe the progression of local changes in envenomed patients using serial infrared thermal imaging.Methods: In a prospective sample of patients with snakebite envenomation, clinical assessment and infrared imaging of local changes were done at enrolment and 6 h and 24 h later, followed by once daily until hospital discharge or day 7, whichever was earlier. Infrared images were interpreted by an investigator masked to clinical findings.Results: We studied 39 patients with snakebite envenomation. Their mean age was 44.6±12.7 y and 25 (64%) were men. The median time to stability of local changes was 24.6 h (interquartile range [IQR] 17.0-30.1) on clinical examination and 28.0 h (IQR 13.7-55.2) on infrared imaging. At 24 h there was simple agreement between the two methods on whether the local changes were progressing or not in 31 of 39 patients (80%; Cohen's κ=0.59, p<0.001). The maximum proximal extent of local changes assessed using the two methods had a good correlation (Spearman's ρ=0.713, p<0.001). However, the extent of thermal changes on infrared images often exceeded the upper limit of swelling detected clinically.Conclusions: Infrared imaging could be used to objectively document the local changes caused by snakebite envenomation.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"175-181"},"PeriodicalIF":1.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular diagnosis and duration of eschar swab sample positivity post-doxycycline therapy in scrub typhus patients. 恙虫病患者接受多西环素治疗后的分子诊断和脓痂拭子样本阳性持续时间。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-04 DOI: 10.1093/trstmh/trae092

Rimjhim Kanaujia, Harpreet Singh, Kamlesh Bisht, Shriya Goel, Suresh Selvam, Jasleen Kaur, Karthi Nallasamy, Navneet Sharma, Manisha Biswal

{"title":"Molecular diagnosis and duration of eschar swab sample positivity post-doxycycline therapy in scrub typhus patients.","authors":"Rimjhim Kanaujia, Harpreet Singh, Kamlesh Bisht, Shriya Goel, Suresh Selvam, Jasleen Kaur, Karthi Nallasamy, Navneet Sharma, Manisha Biswal","doi":"10.1093/trstmh/trae092","DOIUrl":"10.1093/trstmh/trae092","url":null,"abstract":"Background: An eschar is not always present in all scrub typhus patients. Furthermore, such patients may present to tertiary care hospitals after administration of doxycycline. The present study aimed to determine the usefulness of using the swab from eschar sites in the diagnosis of scrub typhus in patients who present post-doxycycline therapy.Methods: Blood, eschar scraping and swab samples were collected daily until patient discharge/death. Real-time SYBR green PCR targeting the groEl gene, TaqMan probe PCR targeting the 47 kDa gene and nested PCR targeting the 56 kDa gene of Orientia tsutsugamushi were carried out. Partial sequences of the 56 kDa gene of O. tsutsugamushi were sequenced by the Sanger method and phylogenetic analysis was performed using Mega X.Results: In total, 42 samples (19 eschar scraping and 23 eschar swab samples) were collected from 22 patients. A high positivity of eschar scraping samples (89.5%, 17/19) in comparison to blood (63.2%, 12/19) was observed. The nested PCR for eschar swab samples was positive in 10 (43.5%), 47 kDa gene in nine (39.1%) and groEl in three (13%) samples. The swabs remained positive for 1-4 d after doxycycline was started. The majority of the sequences clustered with Karp-like strains.Conclusion: The eschar swab is a good alternative sample for the diagnosis and genotyping of scrub typhus. It also has the added advantage of persistent positivity despite doxycycline administration.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"107-112"},"PeriodicalIF":1.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospect of using ethnobotanicals to manage snakebites in a cost-effective manner: validating Senegalia mellifera extract's inhibitory potential on Naja nigricincta nigricincta (zebra cobra) venom. 利用民族植物药经济有效地治理蛇咬伤的前景：验证塞内加尔草提取物对斑马眼镜蛇（Naja nigricincta nigricincta）的抑制潜力。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-04 DOI: 10.1093/trstmh/trae055

Charlize L Rix, Percy M Chimwamurombe, Lamech M Mwapagha

{"title":"Prospect of using ethnobotanicals to manage snakebites in a cost-effective manner: validating Senegalia mellifera extract's inhibitory potential on Naja nigricincta nigricincta (zebra cobra) venom.","authors":"Charlize L Rix, Percy M Chimwamurombe, Lamech M Mwapagha","doi":"10.1093/trstmh/trae055","DOIUrl":"10.1093/trstmh/trae055","url":null,"abstract":"Background: Despite Naja nigricincta nigricincta being responsible for most snake envenomation in remote Namibian regions, an effective intervention against its venom remains undiscovered. This study aimed to scientifically validate Namibian folklore claims about Senegalia mellifera extract's efficacy against snake envenomation.Methods: In vitro assays were conducted to assess the inhibitory potential of S. mellifera stem bark extract on snake venom phospholipase A2 (svPLA2) activity from N. n. nigricincta venom. Gas chromatography-mass spectrometry (GC-MS) and molecular docking predicted phytochemicals responsible for inhibitory effects on venom proteins.Results: The svPLA2 activity assay demonstrated significant inhibitory potential of the extract, reducing enzyme activity from 100% to as low as 66.99%. GC-MS analysis indicated an abundant presence of terpenes having antisnake venom activity. Molecular docking identified phytochemicals of S. mellifera capable of neutralizing prevalent cobra toxins, that is, stigmasterol acetate, beta-Sitosterol acetate, vitamin E, kaur-15-ene, squalene and 4,6-Cholestadien-3beta-ol.Conclusions: This plant extract cannot be considered as a discrete treatment against venom. It may serve as a transient remedy to impede the toxic effects or supplement the action of antivenoms. Future research should be aimed at finding other plants with greater antivenom potential to increase the prospect of using ethnobotanicals to manage snakebites in a cost-effective manner.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"166-174"},"PeriodicalIF":1.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scleromalacia perforans: a rare and sight-threatening complication of chronic erythema nodosum leprosum. 硬膜穿孔症：慢性结节性红斑麻风病的一种罕见且危及视力的并发症。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-04 DOI: 10.1093/trstmh/trae080

Kittu Malhi, Vinod Hanumanthu, Sukhdeep Singh, Anuradha Bishnoi, Debajyoti Chatterjee, Reema Bansal, Sunil Dogra, Tarun Narang

引用次数: 0

Pulmonary melioidosis mimicking lung cancer: a diagnostic challenge. 模仿肺癌的肺梅里埃病：诊断难题。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-02-04 DOI: 10.1093/trstmh/trae089

Xiaohong Yang, Zhuopeng Ying, Yuefu Zhan, Jianqiang Chen

{"title":"Pulmonary melioidosis mimicking lung cancer: a diagnostic challenge.","authors":"Xiaohong Yang, Zhuopeng Ying, Yuefu Zhan, Jianqiang Chen","doi":"10.1093/trstmh/trae089","DOIUrl":"10.1093/trstmh/trae089","url":null,"abstract":"Background: The overlapping clinical and radiographic features of pulmonary melioidosis and lung cancer present diagnostic challenges to healthcare providers in endemic settings.Methods: We compared the clinical, laboratory and imaging characteristics of 19 pulmonary melioidosis cases with those of 15 cases of small cell lung cancer (SCLC) and 17 cases of non-small cell lung cancer (NSCLC).Results: Compared with SCLC/NSCLC cases, those with pulmonary melioidosis were more likely to have diabetes, have fever, neutrophilia and leukocytosis on presentation (p<0.05). While certain CT imaging features were shared between pulmonary melioidosis and SCLC ('frozen mediastinum sign', 'vascular encasement sign'), extensive liquefactive necrosis, uneven ring-enhancement, circular lesions and 'air-bubble' signs were more commonly seen in pulmonary melioidosis cases than in those with SCLC/NSCLC (p<0.05).Conclusions: Despite the similarities in presentation of pulmonary melioidosis, SCLC and NSCLC, several clinical, laboratory and imaging factors may help delineate these diagnoses and improve patient care.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"125-134"},"PeriodicalIF":1.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review of variables associated with snakebite risk in spatial and temporal analyses. 在空间和时间分析中与蛇咬伤风险相关的变量的系统回顾。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-01-16 DOI: 10.1093/trstmh/trae131

Shelui Collinson, Thomas Lamb, Iara A Cardoso, Peter J Diggle, David G Lalloo

{"title":"A systematic review of variables associated with snakebite risk in spatial and temporal analyses.","authors":"Shelui Collinson, Thomas Lamb, Iara A Cardoso, Peter J Diggle, David G Lalloo","doi":"10.1093/trstmh/trae131","DOIUrl":"https://doi.org/10.1093/trstmh/trae131","url":null,"abstract":"Background: Snakebite is a priority neglected tropical disease, but incidence data are lacking; current estimates rely upon incomplete health facility reports or ad hoc surveys. Spatial analysis methods harness statistical associations between case incidence and spatially varying factors to improve estimates. This systematic review aimed to identify variables associated with snakebite risk in spatial and temporal analyses for inclusion in geospatial studies to improve risk estimation accuracy.Methods: We searched MEDLINE, Global Health, PubMed and Web of Science in January 2023 for studies published since 1980 assessing snakebite outcomes and spatially varying factors at the setting level. Study quality was assessed using an adapted Joanna Briggs Institute tool. The results are presented by narrative synthesis.Results: Thirty-five studies were eligible; the majority were from Central and South America (18), then Asia (11). Climate and environment were most frequently assessed, with temperature, humidity and tree cover predominantly positively associated with snakebite risk, drought negatively associated and altitude negative/mixed. Crop and livestock variables mostly showed positive associations; population density and urban residence overwhelmingly displayed negative associations.Conclusions: This review identifies key variables that should be considered in future snakebite risk research. Limitations include low research availability from the highest risk regions. There is an evident need for greater research into snakebite risk variation, particularly in sub-Saharan Africa.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143011976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-M2-pyruvate kinase autoantibodies are correlated with digestive damage in human Chagas disease. 抗m2 -丙酮酸激酶自身抗体与人恰加斯病的消化损伤相关。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-01-13 DOI: 10.1093/trstmh/trae144

Denis Dantas da Silva, Nathalie de Sena Pereira, Daniela Ferreira Nunes, Ramayana Morais de Medeiros Brito, Luanderson Cardoso Pereira, Andressa Noronha Barbosa da Silva, Carlos Ramon do Nascimento Brito, Cléber de Mesquita Andrade, Lúcia Maria da Cunha Galvão, Antonia Claudia Jácome da Câmara, Manuela Sales Lima Nascimento, Paulo Marcos Matta Guedes

{"title":"Anti-M2-pyruvate kinase autoantibodies are correlated with digestive damage in human Chagas disease.","authors":"Denis Dantas da Silva, Nathalie de Sena Pereira, Daniela Ferreira Nunes, Ramayana Morais de Medeiros Brito, Luanderson Cardoso Pereira, Andressa Noronha Barbosa da Silva, Carlos Ramon do Nascimento Brito, Cléber de Mesquita Andrade, Lúcia Maria da Cunha Galvão, Antonia Claudia Jácome da Câmara, Manuela Sales Lima Nascimento, Paulo Marcos Matta Guedes","doi":"10.1093/trstmh/trae144","DOIUrl":"https://doi.org/10.1093/trstmh/trae144","url":null,"abstract":"Background: Determining esophageal and colon involvement in patients with Chagas disease occurs through invasive and uncomfortable examinations, which in most cases are not performed. The objective of this study was to assess the involvement of anti-M2-pyruvate kinase (M2-PK) autoantibodies in the development of digestive alterations and/or in the diagnosis of the digestive form of human Chagas disease.Methods: The total IgG and isotype (IgG1, IgG2, IgG3, IgG4) production was quantified using the antigen of Trypanosoma cruzi and the human M2-PK recombinant protein via the ELISA technique. The tests were conducted with serum samples from patients with indeterminate, cardiac, digestive and cardiodigestive clinical forms of Chagas disease, and the results were correlated with the dilatation degree of the esophagus and colon.Results: Patients with the digestive form of Chagas disease had higher IgG4 anti-M2-PK autoantibody production compared with patients with the indeterminate and cardiac forms and the healthy control group. Furthermore, a positive correlation was observed between sigmoid and rectum size with IgG4 anti-M2-PK autoantibody production.Conclusions: These results demonstrate that IgG4 anti-M2-PK autoantibodies correlate with digestive damage in human Chagas disease, and their presence may also be implicated in the development of digestive lesions.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is new in the treatment of snakebite envenoming? Opportunities and challenges. 治疗蛇咬伤有什么新进展？机遇与挑战。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-01-13 DOI: 10.1093/trstmh/trae145

David A Warrell

引用次数: 0

Redefining the severity of orofacial tissue damage caused by noma: a novel classification approach. 重新定义由坏疽性口面部组织损伤的严重程度：一种新的分类方法。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-01-08 DOI: 10.1093/trstmh/trae137

Heron Gezahegn Gebretsadik

{"title":"Redefining the severity of orofacial tissue damage caused by noma: a novel classification approach.","authors":"Heron Gezahegn Gebretsadik","doi":"10.1093/trstmh/trae137","DOIUrl":"https://doi.org/10.1093/trstmh/trae137","url":null,"abstract":"Background: Noma is a severe orofacial disease with high mortality and morbidity. Although severity scales exist, they fail to fully capture the extent of damage caused by the disease.Methods: This study analysed 404 photos of 260 noma cases from Facing Africa (n=228) and Project Harar (n=32) to create a new severity classification system. Photos were displayed on a large screen for better visualization. Tissue damage was assessed in terms of width, depth and surface area using the American Burn Association's grading system. A mathematical formula was also developed to quantify the extent of noma-induced orofacial damage.Results: Fifteen orofacial anatomical units vulnerable to noma were identified, leading to the development of a new severity classification system that enhances the assessment of noma. This system evaluates tissue damage qualitatively as minor, moderate or major and quantitatively using a purpose-built mathematical formula.Conclusions: Current classification systems inadequately capture noma severity due to vague definitions and limited consideration of the affected anatomical units. The new approach addresses these gaps by considering all tissue damage, including dentition, and allows for precise qualitative and quantitative assessment of disease severity. Continued research and validation are essential to refine this method, improving its clinical and research applications and enhancing outcomes for noma patients worldwide.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142955695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of IL-6, TNF-α and VCAM-1 as predictors of renal impairment in patients with spontaneous bacterial peritonitis. IL-6、TNF-α和VCAM-1在自发性细菌性腹膜炎患者肾损害预测中的作用

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-01-06 DOI: 10.1093/trstmh/trae139

Maissa El Raziky, Mennatallah Rashwan, Hend Hamed Tamim, Shimaa Afify, Rania M Lithy

{"title":"Role of IL-6, TNF-α and VCAM-1 as predictors of renal impairment in patients with spontaneous bacterial peritonitis.","authors":"Maissa El Raziky, Mennatallah Rashwan, Hend Hamed Tamim, Shimaa Afify, Rania M Lithy","doi":"10.1093/trstmh/trae139","DOIUrl":"https://doi.org/10.1093/trstmh/trae139","url":null,"abstract":"Background: Multiple mechanisms may contribute to the occurrence of renal impairment (RI) in patients with spontaneous bacterial peritonitis (SBP). One such mechanism is systemic inflammatory response syndrome, which involves the release of pro-inflammatory cytokines (tumour necrosis factor [TNF]-α, interleukin [IL]-6 and vascular cell adhesion molecule [VCAM]-1). The goal of this research was to evaluate the role of IL-6, TNF-α and VCAM-1 as potential predictors of RI and mortality in cirrhotic patients with SBP.Methods: This study included 90 cirrhotic patients with SBP, divided into two equal groups: group A was patients without RI and group B was patients with RI. Based on mortality outcomes, the patients were further categorized into group 1 (recovery, n=70) and group 2 (death, n=20). TNF-α, IL-6 and VCAM-1 serum levels were measured using enzyme-linked immunosorbent assay.Results: RI occurred in 50% (45/90) of the study population. Among the 90 patients, 10 (11.1%) had elevated IL-6 levels, 8 (8.9%) had elevated TNF-α levels and 6 (6.7%) had elevated VCAM-1 levels. There were no significant variations in cytokine levels between groups A and B. With an area under the curve of 0.5, the three cytokines showed comparable sensitivity and specificity as predictors of RI.Conclusions: The use of TNF-α, IL-6 and VCAM-1 as predictive markers for RI and mortality in SBP patients is not recommended, as these biomarkers demonstrated limited diagnostic value.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0