Transactions of The Royal Society of Tropical Medicine and Hygiene最新文献_第7页

Molecular detection of Toxoplasma gondii in paraffin blocks from patients diagnosed with various cancers. 不同癌症患者石蜡块中刚地弓形虫的分子检测。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-08-18 DOI: 10.1093/trstmh/traf083

Azadeh Pourahmad, Babak Shirazi Yeganeh, Amir Abdoli, Zahra Kargar Jahromi, Akbar Kazemi, Ali Taghipour, Ali Rezanezhad, Hassan Rezanezhad

{"title":"Molecular detection of Toxoplasma gondii in paraffin blocks from patients diagnosed with various cancers.","authors":"Azadeh Pourahmad, Babak Shirazi Yeganeh, Amir Abdoli, Zahra Kargar Jahromi, Akbar Kazemi, Ali Taghipour, Ali Rezanezhad, Hassan Rezanezhad","doi":"10.1093/trstmh/traf083","DOIUrl":"https://doi.org/10.1093/trstmh/traf083","url":null,"abstract":"This study aimed to investigate the prevalence of Toxoplasma gondii DNA in cancer tissue samples and explore potential associations with different cancer types. A total of 338 paraffin blocks from patients diagnosed with nine different cancers, including brain, lung, colon, breast, testis, prostate, uterus, ovary and eye, were analysed. The age distribution of the patients ranged from ≤30 to >70 y. The analysed sample consisted of 204 female and 134 male subjects. The molecular analysis revealed an overall prevalence of T. gondii DNA presence in 9.75% (33 cases) of the cancer tissue samples: 19 lung tissue samples, 6 colon samples, 5 breast samples and 1 sample each from the testis, prostate and uterus. Conversely, no T. gondii DNA was detected in the brain, ovary and eye samples. Statistical analysis using the χ2 test indicated a significant association between T. gondii and the type of cancer tissue, with a higher frequency in lung and colon tissues (p<0.001). However, there was no significant correlation observed between T. gondii infection and age or gender. These findings highlight potential links between T. gondii infection and specific cancer types, suggesting a need for further research to elucidate the underlying mechanisms and implications for cancer pathogenesis. Understanding the role of T. gondii in cancer development may offer new insights into preventive strategies and targeted treatments for T. gondii-associated malignancies. Further investigations are warranted to validate these associations, expand the sample size and explore the clinical significance of T. gondii infection in cancer patients.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utilising snake rescue data to understand snake-human conflict in Hooghly, West Bengal, India. 利用蛇救援数据来了解印度西孟加拉邦胡格利的蛇与人的冲突。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-08-08 DOI: 10.1093/trstmh/trae124

Sourish Kuttalam, John Benjamin Owens, Vishal Santra, Molla T Ahmed, Biswajit Das, Surojit Das, Ayan Koley, Rakesh Koley, Axel Barlow, Anita Malhotra

{"title":"Utilising snake rescue data to understand snake-human conflict in Hooghly, West Bengal, India.","authors":"Sourish Kuttalam, John Benjamin Owens, Vishal Santra, Molla T Ahmed, Biswajit Das, Surojit Das, Ayan Koley, Rakesh Koley, Axel Barlow, Anita Malhotra","doi":"10.1093/trstmh/trae124","DOIUrl":"10.1093/trstmh/trae124","url":null,"abstract":"Background: Snakebite envenoming, classified as a neglected tropical disease, poses a significant threat to life in India, where it is estimated to cause 58 000 fatalities as well as 140 000 morbidities annually. To reduce the occurrence of snakebite, we need a comprehensive understanding of human-snake conflict ecology. Snake rescue networks represent a vital resource for gathering such ecological data.Methods: In this study, we utilised snake rescue data from 520 rescue encounters carried out by a local rescue network in Hooghly, West Bengal, from July 2020 to October 2022, to investigate patterns of human-snake conflict and the influence of climatic factors on these patterns.Results: The spectacled cobra Naja naja was the most encountered of the five venomous species involved in 365 rescues. Our analysis revealed a significant correlation between rescue location and venomous/non-venomous encounters, with non-venomous encounters being more prevalent inside built-up locations. Rainfall on the previous day significantly increased encounters and influenced the species involved, while daily minimum temperature also influenced encounters with venomous species. We also found that both Bungarus (krait) species present were mostly encountered between 18:00 h and midnight.Conclusions: This study highlights the multifaceted factors influencing human-snake conflicts in the region, including seasonality, geographic location, rainfall patterns, and temperature dynamics. It underscores the potential of snake rescue data as a valuable resource for deepening our understanding of regional variations in snake-human interactions.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"971-981"},"PeriodicalIF":1.5,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12342939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statistical modeling of acute diarrhea in pediatric malnutrition based on the assessment of nutritional status and clinical manifestations: a retrospective study in South-Punjab, Pakistan. 基于营养状况和临床表现评估的小儿营养不良急性腹泻的统计建模：巴基斯坦南旁遮普省的一项回顾性研究

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-08-08 DOI: 10.1093/trstmh/traf036

Muhammad Muneeb Hassan, Muhammad Aman Ullah, Muhammad Ameeq, Qudsia Sarwar, Alpha Kargbo

{"title":"Statistical modeling of acute diarrhea in pediatric malnutrition based on the assessment of nutritional status and clinical manifestations: a retrospective study in South-Punjab, Pakistan.","authors":"Muhammad Muneeb Hassan, Muhammad Aman Ullah, Muhammad Ameeq, Qudsia Sarwar, Alpha Kargbo","doi":"10.1093/trstmh/traf036","DOIUrl":"10.1093/trstmh/traf036","url":null,"abstract":"Background: Childhood severe acute malnutrition (SAM) remains an imperative global health concern, particularly in low- and middle-income countries with limited access to healthcare and nutrition services. The co-occurrence of diarrhea, a common gastrointestinal ailment in children, alongside SAM, amplifies the complexity and danger of the situation. We conducted a thorough investigation into the nutritional and clinical conditions of pediatric patients with SAM and diarrhea, while also exploring any possible gender-related clinical differences.Methods: The study involved 550 children with SAM and diarrhea, ultimately analyzing 485 children aged 1-37 mo. Multinomial logistic regression analysis and descriptive statistics were conducted to determine the impact of various clinical factors on the nutritional status of pediatric diarrhea patients with SAM using statistical software SPSS (version 25) and (R-Studio).Results: The study revealed a predominantly male population (72.8%) aged 1-10 mo (74.80%). Anthropometric measurements varied among the children, emphasizing the need for individualized interventions due to the complexity of this group. The study also investigated gender-related clinical factors and identified a lower likelihood of vomiting in males.Conclusions: This study highlights the nutritional and clinical hurdles faced by pediatric patients with SAM and diarrhea. Although some gender-related distinctions were observed, the overall clinical presentation remained relatively consistent.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"902-910"},"PeriodicalIF":1.5,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global health initiatives and mycetoma management: the unmet promise. 全球卫生倡议和足菌肿管理：未实现的承诺。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-08-08 DOI: 10.1093/trstmh/traf001

Ahmed Hassan Fahal, Dallas J Smith, Ali Awadalla Saeed, Borna Nyaoke, Fabiana Alves, Kingsley Asiedu, Rod Hay

引用次数: 0

Reactivation of cutaneous leishmaniasis in the context of non-HIV immunosuppression: a literature analysis. 在非hiv免疫抑制的背景下皮肤利什曼病的再激活：文献分析。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-08-08 DOI: 10.1093/trstmh/traf038

Regina Maia de Souza, Felipe Francisco Tuon, Leticia Ramos Dantas, Rui Imamura, Alexandre Pereira Funari, Beatriz Julieta Celeste, Valdir Sabbaga Amato

引用次数: 0

Envenomation by 'dead' snakes: a review. “死”蛇的中毒：回顾。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-08-08 DOI: 10.1093/trstmh/trae125

B Sadananda Naik

引用次数: 0

Antivenom ineffectiveness in Echis carinatus sochureki envenoming: a five-year, single-centre experience from India. 抗蛇毒血清对黑腹鱼的无效：一项来自印度的5年单中心研究。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-08-08 DOI: 10.1093/trstmh/trae111

Maya Gopalakrishnan, Akhilesh Kumar Ph, Divya Tanwar, Samarth Bhat Ks, Bharat Choudhary, Mahendra K Garg

{"title":"Antivenom ineffectiveness in Echis carinatus sochureki envenoming: a five-year, single-centre experience from India.","authors":"Maya Gopalakrishnan, Akhilesh Kumar Ph, Divya Tanwar, Samarth Bhat Ks, Bharat Choudhary, Mahendra K Garg","doi":"10.1093/trstmh/trae111","DOIUrl":"10.1093/trstmh/trae111","url":null,"abstract":"Background: Snakebite is a neglected tropical disease that causes significant morbidity and mortality in India. In this study, we describe the clinical characteristics and outcomes of Echis carinatus sochureki envenoming from Western Rajasthan. We document the clinical ineffectiveness of the currently available Indian polyvalent antivenom in managing E. c. sochureki envenoming.Methods: In this ambispective study, conducted from 14 April 2019 to 15 April 2024, we enrolled all patients presenting to our emergency department at a tertiary care centre in Jodhpur, Rajasthan, with a history of snakebite. After they provided informed consent, the demographic details, bite geo-location, bite-to-antivenom time, antivenom dose, coagulation profile, mortality and duration of hospital stay of those patients with E. c. sochureki envenoming were recorded.Results: Of 210 patients screened, 105 had E. c. sochureki envenoming, 103 venom-induced consumption coagulopathy, 36 (34.3%) local bleeding and 55 (52.3%) systemic bleeding. The median bite-to-antivenom time was 2 (IQR: 1.13-4.0) h. The median antivenom dose was 22 (IQR: 10-30) vials. Of 92 patients who received antivenom, 63 (68.4%) were unresponsive. Total antivenom dose and geographical location (West zone) were significant predictors of antivenom unresponsiveness. Fifty-three of 70 patients (75.7%) had delayed hypofibrinogenaemia. The mean hospital stay was 8.3±7.1 d with nine (8.6%) mortalities.Conclusions: Our study highlights the alarming finding of poor antivenom response to E. c. sochureki envenoming, with significant clinical bleeding and delayed coagulopathy. There is an urgent need for region-specific antivenom in Western India.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"943-953"},"PeriodicalIF":1.5,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disparities in unmet need for family planning: a comparative study of urban and rural women in Kano State, Nigeria. 未满足计划生育需求方面的差异：尼日利亚卡诺州城乡妇女的比较研究。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-08-08 DOI: 10.1093/trstmh/traf019

Taiwo Ibinaiye, Babatunde Adelekan, Ummulkhulthum Bajoga, Sampson Ezikeanyi, Joachim Chijide, Collins Opiyo, Andat Dasogot, Koessan Kuawu

{"title":"Disparities in unmet need for family planning: a comparative study of urban and rural women in Kano State, Nigeria.","authors":"Taiwo Ibinaiye, Babatunde Adelekan, Ummulkhulthum Bajoga, Sampson Ezikeanyi, Joachim Chijide, Collins Opiyo, Andat Dasogot, Koessan Kuawu","doi":"10.1093/trstmh/traf019","DOIUrl":"10.1093/trstmh/traf019","url":null,"abstract":"This study investigated urban-rural differences in the prevalence of unmet need for family planning among women of reproductive age in Kano State, Nigeria, and identified factors contributing to these disparities. Rural-urban disparities in unmet need for family planning outcomes and women's characteristics were assessed. Univariate multilevel mixed-effect logistic regression models were employed to quantify the association between rural/urban residences and each unmet need for family planning and related outcomes. In urban areas, factors associated with unmet need for family planning included husband/partner (OR: 0.25, 95% CI 0.07 to 0.88, p=0.031) and joint decision-making about medical treatment (OR: 0.27, 95% CI 0.09 to 0.80, p=0.018). In rural areas, middle wealth categories (OR: 1.92, 95% CI 1.07 to 3.47, p=0.029), women with 3-4 (OR: 5.41, 95% CI 1.07 to 27.1, p=0.040) and ≥5 birth events (OR: 8.44, 95% CI 1.74 to 40.82, p=0.008) and those who work but are not paid in cash (OR: 0.46, 95% CI 0.21 to 0.99, p=0.049) were associated with unmet need for family planning. Tailored interventions considering socioeconomic, cultural and geographical factors are essential to reduce barriers to family planning services and promote informed decision-making among women in Kano State.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"839-847"},"PeriodicalIF":1.5,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First report on the enzootic maintenance of Dirofilaria sp. hongkongensis in the canine hosts and mosquito vector Armigeres subalbatus (Coquillet) in Puducherry. 香港Dirofilaria sph . hong gensis在Puducherry犬宿主和亚信天阿蚊（Coquillet）媒介中维持的首次报道。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-08-08 DOI: 10.1093/trstmh/traf037

Jagatheesh Manikannan, Uma Sambath, Krishan Kumar Sihag, Waseema Arif, Srikanth Srirama, Abiramy Prabavathy A, Kumar Raja, Manju Rahi, Mathivanan Ashokkumar, Panneer Devaraju

{"title":"First report on the enzootic maintenance of Dirofilaria sp. hongkongensis in the canine hosts and mosquito vector Armigeres subalbatus (Coquillet) in Puducherry.","authors":"Jagatheesh Manikannan, Uma Sambath, Krishan Kumar Sihag, Waseema Arif, Srikanth Srirama, Abiramy Prabavathy A, Kumar Raja, Manju Rahi, Mathivanan Ashokkumar, Panneer Devaraju","doi":"10.1093/trstmh/traf037","DOIUrl":"10.1093/trstmh/traf037","url":null,"abstract":"Background: Dirofilariasis is a re-emerging zoonosis caused by the nematode Dirofilaria spp., parasitizing canines, felines and humans and transmitted by mosquito vectors of the Culicidae family. Currently, reports of human dirofilariasis are increasing in India and thus we explored the occurrence of Dirofilaria infection among dogs and mosquitoes in Puducherry, India.Methods: Two millilitres of blood collected from 293 dogs from Puducherry was subjected to microscopy and Dirofilaria screening polymerase chain reaction (PCR) targeting the ITS2 gene. Mosquitoes trapped from areas with filaria-positive dogs were also subjected to PCR and representative samples were dissected for microscopy. The partially amplified ITS1, COX1 and 12s recombinant RNA genes from positive samples were sequenced for phylogeny.Results: Only 4 among the 293 dogs tested positive for Dirofilaria by microscopy and PCR and the parasite was identified as Dirofilaria sp. hongkongensis. None of the mosquito pools (n=39) tested positive by PCR. However, the presence of microfilaria and larvae was evident in Armigeres subalbatus (n=2) mosquitoes.Conclusions: The abundance of the vectors, susceptible dog population and ecosystem in Puducherry confers a congenial niche for the parasite and poses a risk for human transmission. Implementation of one health-based control measure would help to curtail the infection.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"911-918"},"PeriodicalIF":1.5,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to: Haemotoxicity of snakes: a review of pathogenesis, clinical manifestations, novel diagnostics and challenges in management. 蛇的血液毒性：发病机制、临床表现、新诊断和管理挑战的综述。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-08-08 DOI: 10.1093/trstmh/traf021

引用次数: 0