Transactions of The Royal Society of Tropical Medicine and Hygiene最新文献_第7页

Comment on: Antibody response following rabies vaccination: a retrospective cohort study from a tertiary centre in Kerala, India. 评论：狂犬病疫苗接种后的抗体反应：来自印度喀拉拉邦三级中心的回顾性队列研究。

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-08-07 DOI: 10.1093/trstmh/trag090

Hasan Tahsin Gozdas

引用次数: 0

Persistent high burden and determinants of intestinal parasitic infections in schoolchildren from vulnerable communities in Costa Rica: an epidemiological analysis of 12 years of data (2008-19). 哥斯达黎加脆弱社区学龄儿童肠道寄生虫感染的持续高负担和决定因素：对12年数据（2008-19年）的流行病学分析

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-08-06 DOI: 10.1093/trstmh/trag087

Alberto Solano-Barquero, Juan José Romero-Zúñiga, Bernardo Vargas-Leitón, Alicia Rojas, Javier Mora

{"title":"Persistent high burden and determinants of intestinal parasitic infections in schoolchildren from vulnerable communities in Costa Rica: an epidemiological analysis of 12 years of data (2008-19).","authors":"Alberto Solano-Barquero, Juan José Romero-Zúñiga, Bernardo Vargas-Leitón, Alicia Rojas, Javier Mora","doi":"10.1093/trstmh/trag087","DOIUrl":"https://doi.org/10.1093/trstmh/trag087","url":null,"abstract":"Objectives: Intestinal parasites have higher prevalences in poor tropical countries. In Costa Rica, the problem in vulnerable zones has not been epidemiologically characterized over the last two decades. This study aimed to characterize the intestinal parasitic infections among schoolchildren in vulnerable zones of Costa Rica and to explore their multidimensional determinants.Methods: Data from faecal tests results from schoolchildren living in vulnerable zones of Costa Rica (2008-2019) was compiled with social, climatic and other environmental variables to perform descriptive epidemiological and comparative analyses. Prevalence calculations and maps of protozoan and helminth infections were generated.Results: Intestinal protozoan and soil-transmitted helminth infections affected 46.7% and 26.2% of children, respectively. Prevalence was highest in the Caribbean region: Limoncito and Chirripó led for both soil transmitted helminths (38.1% and 36.6%) and intestinal protozoans (62.8% and 59.5%), with Telire reaching 62.8% for intestinal protozoans. The 7-9-year age group had the highest burden for both infection types. Logistic regression identified geographic inaccessibility, composite socioeconomic-educational-housing scores, and climatic conditions as significant predictors for parasite infections risk.Conclusion: Data demonstrate the persistence of high rates of intestinal parasitic infections in vulnerable communities of Costa Rica, highlighting potential associations that reflect the multidimensional nature of the problem.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dose-response relationships, Plasmodium species, and trimester-specific effects of malaria on stunting in Papua, Indonesia. 印度尼西亚巴布亚的剂量反应关系、疟原虫种类和疟疾对发育迟缓的妊娠特异性影响。

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-08-06 DOI: 10.1093/trstmh/trag089

Muhamad Sahiddin, I Rai Ngardita, Masrif, Budi Kristanto, Asrianto, Noor Faradillah Abdullah

{"title":"Dose-response relationships, Plasmodium species, and trimester-specific effects of malaria on stunting in Papua, Indonesia.","authors":"Muhamad Sahiddin, I Rai Ngardita, Masrif, Budi Kristanto, Asrianto, Noor Faradillah Abdullah","doi":"10.1093/trstmh/trag089","DOIUrl":"https://doi.org/10.1093/trstmh/trag089","url":null,"abstract":"Objectives: Malaria and stunting are highly prevalent in Papua, Indonesia, yet their association remains poorly understood. We examined dose-response relationships between postnatal malaria and stunting, trimester-specific prenatal effects, effect modification by insecticide-treated net (ITN) use, and risk by Plasmodium species.Methods: Unmatched case-control study of 1301 children 12-60 months (435 cases; 866 controls) from 25 primary health centres. Exposure was ascertained from health centre registers and maternal cohort records. Multivariable logistic regression with cluster-robust standard errors was used; ITN effect modification was assessed using an interaction term.Results: One postnatal malaria episode was associated with increased stunting odds [adjusted OR (aOR) 1.52; 95% CI 1.02-2.29], with a significant dose-response trend compared with no malaria exposure. Prenatal malaria was not significant after adjustment. Low birth weight was the strongest predictor (aOR 2.22; 95% CI 1.29-3.82). ITN use modified the malaria-stunting association (interaction aOR 0.37; 95% CI 0.18-0.73). Plasmodium falciparum was associated with increased stunting odds vs no prenatal malaria (OR 1.84; 95% CI 1.18-2.89).Conclusion: Recurrent postnatal malaria is associated with stunting in a dose-response pattern, modified by ITN use. Findings support malaria control and nutrition programme integration in endemic settings.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on: Cerebral malaria: of mice and men. 评论：脑疟疾：小鼠和人。

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-08-05 DOI: 10.1093/trstmh/trag053

Leonardo J M Carvalho, Guilherme S Sanches

引用次数: 0

Antibody response following rabies vaccination: a retrospective cohort study from a tertiary centre in Kerala, India. 狂犬病疫苗接种后的抗体反应：来自印度喀拉拉邦三级中心的回顾性队列研究。

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-08-05 DOI: 10.1093/trstmh/trag055

Rahul Suresh, Chintha Sujatha, Amala Panackal Saju, Aparna Sujatha, Anjana Nalinakumari Kesavan Nair, Prathiush Prathapan Rema, Sanjay Devarajan, Anuja Usha, Sreejith Lalitha Krishnankutty, Thekkumkara Surendran Anish

{"title":"Antibody response following rabies vaccination: a retrospective cohort study from a tertiary centre in Kerala, India.","authors":"Rahul Suresh, Chintha Sujatha, Amala Panackal Saju, Aparna Sujatha, Anjana Nalinakumari Kesavan Nair, Prathiush Prathapan Rema, Sanjay Devarajan, Anuja Usha, Sreejith Lalitha Krishnankutty, Thekkumkara Surendran Anish","doi":"10.1093/trstmh/trag055","DOIUrl":"10.1093/trstmh/trag055","url":null,"abstract":"Background: Globally accelerated efforts are underway to eliminate dog-mediated rabies, underscoring the importance of effective anti-rabies prophylaxis. This study aims to assess the antibody response and its long-term persistence following rabies vaccination, their determinants, and suggest the optimal timing for a booster dose.Methods: We performed a retrospective cohort study among 150 participants, at the preventive clinic of Government Medical College, Thiruvananthapuram. Anti-rabies antibody titer in serum samples was estimated with the Rapid Fluorescent Foci Inhibition Test. To estimate the optimal timing for booster doses, the receiver operating characteristic (ROC) curve was plotted.Results: Protective antibody titers (0.5 IU/ml) were observed in 92.7% of participants, with a mean titer of 3.81 (3.31) IU/ml. ROC analysis identified 5 years as a cut-off for booster dose. Regression analysis indicated a shorter time duration since last vaccination (P = .003) and intramuscular route (P = .005) as predictors of high antibody titers. However, the achievement of protective antibody titer was comparable for intramuscular and intradermal schedules.Conclusions: Achievement of protective antibody titers is universal and long-lasting following anti-rabies vaccination, irrespective of the route of vaccination. Five years since the last dose could be used as an optimal cut-off for booster dose.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"886-894"},"PeriodicalIF":1.6,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxocara infection in children with asthma: a systematic review and meta-analysis. 哮喘患儿的弓形虫感染：一项系统综述和荟萃分析。

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-08-05 DOI: 10.1093/trstmh/trag062

Shreya Singh, Sumeeta Khurana, Rimjhim Kanaujia

{"title":"Toxocara infection in children with asthma: a systematic review and meta-analysis.","authors":"Shreya Singh, Sumeeta Khurana, Rimjhim Kanaujia","doi":"10.1093/trstmh/trag062","DOIUrl":"10.1093/trstmh/trag062","url":null,"abstract":"Evidence linking zoonotic nematode Toxocara and asthma is mounting in children. We aimed to estimate the pooled prevalence of Toxocara seropositivity in asthmatic children and quantify the association. We searched PubMed, Embase and Web of Science for studies (through 18 June 2025) reporting Toxocara seropositivity in asthmatic children. A random effects model was used to estimate pooled seroprevalence and odds ratios (ORs). Heterogeneity was explored using τ2, I2 and Cochran's Q test, subgroup analyses, meta-regression and sensitivity analysis. Publication bias assessment (Egger's test, funnel plots, trim and fill) and risk of bias evaluation (Newcastle-Ottawa Scale) was performed. Twenty-six studies comprising 3246 asthmatic children were included, of which 7 were high-quality studies. Pooled Toxocara seropositivity among asthma was 22% (95% confidence interval 16 to 29) with significant country-wise heterogeneity. In 23 studies comparing cases and controls, asthmatic children had significantly higher odds of Toxocara seropositivity (pooled OR 2.56, p<0.0001), with significant variation by geographic region (p<0.0001) and asthma case definitions (p=0.0004), with stronger associations observed in studies using rigorous definitions such as the Global Initiative for Asthma criteria. Sensitivity analyses showed that while the direction of association remained consistent, the magnitude was influenced by a few outlier studies. There is a significant association between Toxocara seropositivity and childhood asthma; however, the strength of this association should be interpreted cautiously due to heterogeneity, potential cross-reactivity in serological assays and methodological differences across studies. Prospective longitudinal studies and randomized controlled trials evaluating the impact of antiparasitic treatment are needed to clarify temporal relationships and establish causality.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"827-839"},"PeriodicalIF":1.6,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148006833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When coverage is high: rethinking the role of caregiver perceptions in childhood vaccination uptake in Uganda. 当覆盖率高时：重新思考照顾者观念在乌干达儿童接种疫苗方面的作用。

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-08-05 DOI: 10.1093/trstmh/trag045

Annika K Gunderson, Taeim Kwon, Yohhan Kumarasinghe, Yuanyuan Yan, Joyce Choe, Qikai Jiang, Emmanuel Baguma, Shem Bwambale, John R Barber, Raquel Reyes, Moses Ntaro, Paul L Delamater, Edgar M Mulogo, Ross M Boyce

{"title":"When coverage is high: rethinking the role of caregiver perceptions in childhood vaccination uptake in Uganda.","authors":"Annika K Gunderson, Taeim Kwon, Yohhan Kumarasinghe, Yuanyuan Yan, Joyce Choe, Qikai Jiang, Emmanuel Baguma, Shem Bwambale, John R Barber, Raquel Reyes, Moses Ntaro, Paul L Delamater, Edgar M Mulogo, Ross M Boyce","doi":"10.1093/trstmh/trag045","DOIUrl":"10.1093/trstmh/trag045","url":null,"abstract":"Background: Beliefs of a child's primary caregiver are known to influence immunization uptake. As coverage increases, the characteristics of households with undervaccinated children may be shifting.Methods: We conducted a cross-sectional survey of households with a child 12-23 months of age. Vaccine status was verified by inspection of immunization cards or caregiver report. Composite scores captured caregiver beliefs and experiences with vaccination. Associations between these measures and vaccination status were evaluated using weighted logistic regression.Results: Caregivers of 1689 children were surveyed. The odds of full vaccination were not associated with composite beliefs (adjusted odds ratio [aOR] 1.04 [95% confidence interval {CI} 0.95 to 1.14]) or experiences scores (aOR 1.04 [95% CI 0.96 to 1.13]). Specific beliefs that vaccines prevent severe disease (aOR 2.68 [95% CI 1.64 to 4.37]) and protect the community (aOR 1.67 [95% CI 1.10 to 2.53]) were positively associated, whereas beliefs that children receive too many vaccines (aOR 0.60 [95% CI 0.44 to 0.83]) were negatively associated with full vaccination. Positive experiences, including knowing someone affected by a vaccine-preventable disease (aOR 2.10 [95% CI 1.47 to 3.00]) were also linked to full vaccination.Conclusions: Although composite scores were not associated with immunization status, individual beliefs and experiences may still factor into caregiver decisions to vaccinate their children.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"862-872"},"PeriodicalIF":1.6,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13437236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into the factors contributing to artemisinin resistance in Plasmodium falciparum. 恶性疟原虫对青蒿素耐药因素的研究。

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-08-05 DOI: 10.1093/trstmh/trag049

Priyanka Sharma, Kanika Verma, Suchi Tyagi, Kuldeep Singh, Praveen Kumar Bharti

引用次数: 0

Simple clinical decision model for predicting leptospirosis: a secondary analysis of a randomized controlled trial. 预测钩端螺旋体病的简单临床决策模型：随机对照试验的二次分析。

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-08-05 DOI: 10.1093/trstmh/trag046

Nitin Gupta, Tirlangi Praveen Kumar, Steven Van Den Broucke, Erika Vlieghe, Emmanuel Bottieau

{"title":"Simple clinical decision model for predicting leptospirosis: a secondary analysis of a randomized controlled trial.","authors":"Nitin Gupta, Tirlangi Praveen Kumar, Steven Van Den Broucke, Erika Vlieghe, Emmanuel Bottieau","doi":"10.1093/trstmh/trag046","DOIUrl":"10.1093/trstmh/trag046","url":null,"abstract":"Background: Leptospirosis is a major cause of febrile illness in tropical regions, but early diagnosis is challenging due to overlapping clinical features and delayed serological confirmation. We developed a simple bedside decision model using readily available clinical variables.Methods: This secondary analysis used archived data from a randomized controlled trial of adults with undifferentiated febrile illness (October 2020-February 2021) of 5-15 days' duration. Independent predictors of IgM-ELISA positive leptospirosis were identified using multivariable logistic regression. A simplified score assigning one point per predictor was derived. Discrimination was assessed using ROC analysis, and post-test probabilities were modelled for clinical combinations and simulated rapid diagnostic testing.Results: Among 190 patients, 48 (25.3%) were serologically positive for leptospirosis. Conjunctival suffusion, icterus and acute kidney injury were independent predictors. The score (0-3) showed good discrimination (AUC 0.801), with sensitivity 68.8% and specificity 82.4% at ≥2. An exploratory proteinuria-based model demonstrated moderate discrimination (AUC 0.741). Probability increased from 25% at baseline to 91% when all three predictors were present and to 97%-99% when combined with a positive rapid test.Conclusions: A simple bedside score substantially increases the probability of diagnosing leptospirosis in patients with undifferentiated febrile illness of 5-15 days' duration, particularly when integrated with rapid testing.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"873-878"},"PeriodicalIF":1.6,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Clinico-epidemiological study of snakebite: an audit of 13 years of data from a community-based treatment centre in eastern Nepal. 修正：蛇咬伤的临床流行病学研究：对尼泊尔东部社区治疗中心13年数据的审计。

IF 1.6 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2026-08-05 DOI: 10.1093/trstmh/trag068

引用次数: 0