Transactions of The Royal Society of Tropical Medicine and Hygiene最新文献_第6页

Orthohantavirus seoulense as a cause of acute, dengue-negative febrile illness in southern Vietnam. 正汉坦病毒seoulense是越南南部急性登革热阴性发热性疾病的一种病因。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-02 DOI: 10.1093/trstmh/traf041

Mai Thi Quynh Le, Kumiko Yoshimatsu, Haruka Abe, Thuy Thi Nguyen, Hang Le Khanh Nguyen, Trang Thi Hong Ung, Phuong Vu Mai Hoang, Nobuo Koizumi, Futoshi Hasebe, Kozue Miura

{"title":"Orthohantavirus seoulense as a cause of acute, dengue-negative febrile illness in southern Vietnam.","authors":"Mai Thi Quynh Le, Kumiko Yoshimatsu, Haruka Abe, Thuy Thi Nguyen, Hang Le Khanh Nguyen, Trang Thi Hong Ung, Phuong Vu Mai Hoang, Nobuo Koizumi, Futoshi Hasebe, Kozue Miura","doi":"10.1093/trstmh/traf041","DOIUrl":"10.1093/trstmh/traf041","url":null,"abstract":"Background: Dengue fever has surged in Vietnam since 2021; however, the aetiology of non-dengue undifferentiated febrile illnesses remains poorly understood.Methods: Fifty whole blood samples that tested negative in rapid tests for anti-dengue virus antibodies (IgM and IgG) and NS1 viral antigen at Vung Tau General Hospital, southern Vietnam, were subjected to nucleic acid amplification tests for flaviviruses, hantaviruses, Leptospira spp. and Orientia tsutsugamushi, followed by DNA sequencing. The plasma samples were also tested for anti-hantavirus IgM and IgG antibodies using ELISA.Results: Of the 50 samples, eight were PCR-positive for flaviviruses and two were positive for hantaviruses. Sequencing analysis revealed that three and five of the eight flavivirus-positive samples were dengue virus type 1 and dengue virus type 2, respectively. The hantavirus species was identified as Orthohantavirus seoulense (SEOV). None of the patients tested positive for Leptospira spp. or O. tsutsugamushi. Anti-hantavirus IgM and IgG antibodies were detected in five and four patients, respectively.Conclusions: This study suggests that SEOV is a notable contributor to dengue-negative febrile illnesses in southern Vietnam.Accession number: LC822654.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1041-1046"},"PeriodicalIF":1.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Comment on: What is new in the treatment of snakebite envenoming? Opportunities and challenges. 点评：治疗蛇咬伤有什么新进展？机遇与挑战。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-02 DOI: 10.1093/trstmh/traf023

Andreas H Laustsen

引用次数: 0

Snakebite cases and treatment outcomes in the Afar region, Ethiopia: a retrospective and prospective study approach. 蛇咬伤病例和治疗结果在阿法尔地区，埃塞俄比亚：回顾性和前瞻性研究方法。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-02 DOI: 10.1093/trstmh/traf043

Abebe M Aga, Demise Mulugeta, Abera Motuma, Bilise Wakitole, Kedir Mohammed, Fanos Tadesse Woldemariyam, Henok Ferede, Zinash Teferi, Shambel Tadesse, Jemal Mohammed, Anberber Alemu, Dejene Getachew, Dassalegn Muleta, Dereje Nigussie

{"title":"Snakebite cases and treatment outcomes in the Afar region, Ethiopia: a retrospective and prospective study approach.","authors":"Abebe M Aga, Demise Mulugeta, Abera Motuma, Bilise Wakitole, Kedir Mohammed, Fanos Tadesse Woldemariyam, Henok Ferede, Zinash Teferi, Shambel Tadesse, Jemal Mohammed, Anberber Alemu, Dejene Getachew, Dassalegn Muleta, Dereje Nigussie","doi":"10.1093/trstmh/traf043","DOIUrl":"10.1093/trstmh/traf043","url":null,"abstract":"Background: Snakebite envenomation remains a public health issue, particularly in rural areas. Quick and accurate case identification, coupled with timely treatment, is essential to prevent fatalities and complications.Methods: Retrospective and prospective data consisted of 245 snakebite cases admitted to hospitals in the Afar region, Ethiopia, from September 2023 to July 2024 (retrospective), while prospective data were collected from July to October 2024. The analysis focused on case prevalence, time to treatment, service availability, treatment received, length of hospital stays, recovery times and patient outcomes.Results: Of 245 cases, 66.1% (n=162) were retrospective and 33.9% (n=83) prospective. Most patients were male (71.6%); the largest age group was 15-29 y (59.6%); most patients required hospital stays of 2-3 d (56.7%). In the majority of cases, recovery took 4-7 d (36.23%). The fatality rate was 3.3%; >46.54% of patients received treatment >7 d after snakebite, mainly because of the long distance traveled to reach healthcare facilities with access to antivenom.Conclusions: It is essential to strengthen community health units by equipping them with trained personnel and sufficient antivenom supplies to ensure prompt care. Implementing public awareness and promoting local antivenom production could reduce treatment costs and improve patient outcomes.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1047-1054"},"PeriodicalIF":1.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Evaluation of a nanostructured CpG-ODN/ascorbyl palmitate as a safe and effective adjuvant for anticrotalic PLA2 serum. 纳米结构CpG-ODN/抗坏血酸棕榈酸酯作为抗血小板2血清安全有效佐剂的评价。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-02 DOI: 10.1093/trstmh/trae129

Luciano S Fusco, Gisela L Lopez, Franco Maslovski, Sofía Brignone, María G Chaves, Juan J Calvete, Yanet G Franco, David Hernandez, Andrea Van de Velde, Constanza Marin, Santiago Palma, Belkys Maletto, Gabriel Moron, Laura C Leiva

{"title":"Evaluation of a nanostructured CpG-ODN/ascorbyl palmitate as a safe and effective adjuvant for anticrotalic PLA2 serum.","authors":"Luciano S Fusco, Gisela L Lopez, Franco Maslovski, Sofía Brignone, María G Chaves, Juan J Calvete, Yanet G Franco, David Hernandez, Andrea Van de Velde, Constanza Marin, Santiago Palma, Belkys Maletto, Gabriel Moron, Laura C Leiva","doi":"10.1093/trstmh/trae129","DOIUrl":"10.1093/trstmh/trae129","url":null,"abstract":"Background: The WHO states that antivenom is the only safe and effective treatment to neutralize snake venom. Snakebite antivenom typically involves horse hyperimmunization with crude venom and Freund's adjuvant.Methods: In the current work, we analyzed the ascorbyl palmitate liquid crystal structure with snake protein or PLA2, the carrier charge capacity, and we evaluated the immune response induced by the enzyme P9a(Cdt-PLA2) formulated in a nanostructure using CpG-ODN, determining the titer of IgG antibodies. BALB/c mice were subcutaneously immunized on days 0, 15 and 30 with P9a(Cdt-PLA2)/CpG-ODN/Coa-ASC16 or P9a(Cdt-PLA2)/Freund's adjuvant (complete first and incomplete-booster). On day 48 the mice were sacrificed. The neutralization ability of antibodies from animals immunized with P9a(Cdt-PLA2)/CpG-ODN/Coa-ASC16 or P9a(Cdt-PLA2)/Freund's adjuvant was tested against PLA2 activity and venom lethality.Results: In both groups of immunized mice, the antibody titers in blood samples at the assayed time were high (approximately 1×105). The antibodies were able to neutralize P9a(Cdt-PLA2) activity in vitro and lethality in vivo. Microscopic analysis showed that P9a(Cdt-PLA2)/CpG-ODN/Coa-ASC16 produces minimal damage at injection sites compared with Freund's adjuvant.Conclusion: The Coa-ASC16/CpG-ODN formulation shows promise as a safe and effective adjuvant against crotalic PLA2, inducing a strong humoral response and reducing local tissue damage compared with Freund's adjuvant.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1070-1083"},"PeriodicalIF":1.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is new in the treatment of snakebite envenoming? Opportunities and challenges. 治疗蛇咬伤有什么新进展？机遇与挑战。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-02 DOI: 10.1093/trstmh/trae145

David A Warrell

引用次数: 0

Investigating Pfk13 mutations in Plasmodium falciparum natural populations from two malaria-endemic areas of Cameroon. 调查喀麦隆两个疟疾流行区恶性疟原虫自然种群的Pfk13突变。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-02 DOI: 10.1093/trstmh/traf040

Charlotte S Milong Melong, Loick P Kojom Foko, Francis N Nkemngo, Cyrille Ndo, Nathalie Amvongo-Adjia, Gianluca Russo, Ousman Tamgue, François Tchoumbougnang, Daniel P Morse, Giacomo M Paganotti

{"title":"Investigating Pfk13 mutations in Plasmodium falciparum natural populations from two malaria-endemic areas of Cameroon.","authors":"Charlotte S Milong Melong, Loick P Kojom Foko, Francis N Nkemngo, Cyrille Ndo, Nathalie Amvongo-Adjia, Gianluca Russo, Ousman Tamgue, François Tchoumbougnang, Daniel P Morse, Giacomo M Paganotti","doi":"10.1093/trstmh/traf040","DOIUrl":"10.1093/trstmh/traf040","url":null,"abstract":"Background: The emergence of Plasmodium falciparum resistance to artemisinin is a huge concern in Africa. We investigated and characterized mutations of Pfk13 propeller sequences from P. falciparum isolates across two endemic areas with different eco-geographical settings in Cameroon.Methods: A total of 259 dried blood spot samples were collected through a cross-sectional survey in two health facilities located in Bimengue (rural area) and the Efoulan District Hospital in Yaoundé (urban area). The molecular analysis of Pfk13 was performed using nested polymerase chain reaction followed by Sanger sequencing.Results: Our findings highlight that of the 23 mutations found, most of the genetic variants were observed in Yaoundé, suggesting a possible higher drug pressure in this locality. Three Pfk13 mutations (F446S, C469W and A681D) were found in polymorphic sites known to be associated with artemisinin resistance, but with different amino acid substitutions. In addition, three other mutations have already been reported to circulate in other African countries, with an unknown impact on delayed response to artemisinin therapy (P475L, S477F and F628L).Conclusions: Although there is an absence of validated artemisinin resistance-associated polymorphisms in the study, the results highlight the need for further studies to quantify the frequency of these and other Pfk13 gene polymorphisms over time.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"1030-1040"},"PeriodicalIF":1.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The hunter and the hunted: mpox in the Mkpot rainforest community of Nigeria. 猎人和猎物：尼日利亚Mkpot雨林社区的mpox。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-08-25 DOI: 10.1093/trstmh/traf085

Clement A Meseko, Nanven Maurice, Ismaila Shittu, Bernard A Onoja, Dennis Kabantiyok, Moses Oguche, Jolly Adole, Adeniyi Egbetade, Ifeanyi Abali, Henry Arikpo, Bassey Edet, Cole A Adekanmbi, Adeyinka J Adedeji

引用次数: 0

Integrated vector management for malaria control: a review of approaches and effectiveness. 疟疾控制的综合病媒管理：方法和有效性审查。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-08-23 DOI: 10.1093/trstmh/traf084

Gbeminiyi R Otolorin, María E Castellanos, Oyelola A Adegboye, Emma S McBryde

{"title":"Integrated vector management for malaria control: a review of approaches and effectiveness.","authors":"Gbeminiyi R Otolorin, María E Castellanos, Oyelola A Adegboye, Emma S McBryde","doi":"10.1093/trstmh/traf084","DOIUrl":"https://doi.org/10.1093/trstmh/traf084","url":null,"abstract":"Integrated vector management (IVM) is an effective strategy for reducing malaria transmission by combining various malaria vector control methods tailored to local contexts. The Web of Science, PubMed and Google/Google Scholar databases were used to gather studies related to IVM-based malaria control. This review synthesized findings from 14 studies published between 2009 and 2024 evaluating the impact of IVM on malaria control across different regions worldwide. The studies employed observational, quasi-experimental and cluster-randomized controlled trial designs, with outcome measures including malaria incidence, vector density, parasite prevalence, entomological inoculation rate and human biting rates. Integrated strategies consistently demonstrated greater effectiveness than single interventions, with six studies reporting statistically significant reductions in transmission (p<0.05) and several documenting notable declines in morbidity, mortality and entomological indicators. Longitudinal studies from Uganda, Ethiopia and Nigeria showed sustained reductions in malaria cases and vector populations, while large-scale programs in China and India illustrated the long-term success of coordinated, multisectoral IVM efforts. Emerging tools such as attractive targeted sugar baits, genetically modified mosquitoes and green-synthesized metallic nanoparticles offer more environmentally sustainable options. Combining traditional and innovative methods, IVM potentially provides a sustainable global malaria control and eradication solution.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Out-of-pocket expenditure of patients admitted with dengue in a public hospital in Bangladesh. 孟加拉国一家公立医院收治的登革热患者的自付费用。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-08-21 DOI: 10.1093/trstmh/traf087

Md Abur Rafi, Mahmuda Yesmin, Safayet Jamil, Avijit Sarker Jyoti, Shouvik Roy Subha, Plaban Chandra Sarker, Prachurjo Sarkar, Dewan Tasnia Azad, Mir Susmita Zaman, Mohammad Jahid Hasan

引用次数: 0

Impact of two dual active ingredient long-lasting insecticidal nets on pregnancy birth outcomes in Benin. 贝宁两种双活性成分长效杀虫蚊帐对妊娠分娩结果的影响。

IF 1.5 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-08-21 DOI: 10.1093/trstmh/traf082

Colette Sih, Landry Assongba, Edouard Dangbenon, Ulrich Gbatcho, Germain Gil Padonou, Martin C Akogbeto, Natacha Protopopoff, Jackie Cook, Manfred Accrombessi

{"title":"Impact of two dual active ingredient long-lasting insecticidal nets on pregnancy birth outcomes in Benin.","authors":"Colette Sih, Landry Assongba, Edouard Dangbenon, Ulrich Gbatcho, Germain Gil Padonou, Martin C Akogbeto, Natacha Protopopoff, Jackie Cook, Manfred Accrombessi","doi":"10.1093/trstmh/traf082","DOIUrl":"https://doi.org/10.1093/trstmh/traf082","url":null,"abstract":"Background: The WHO recently recommended the widespread use of new classes of long-lasting insecticidal nets (LLINs) to control malaria, but there is little evidence of their efficacy in pregnant women. This study aimed to assess the impact of two dual active ingredient (AI) LLINs on poor birth outcomes under pragmatic conditions.Methods: A community-based cross-sectional survey was conducted during March-May 2023 in 1644 women of reproductive age who delivered in the 3 y following net distribution. Multivariate logistic regression models with random effects were used to assess the dual AI LLINs effects on poor pregnancy birth outcomes.Results: Poor birth outcomes prevalence during pregnancy was 21.9%. Dual AI LLINs did not provide protection against poor birth outcomes in comparison with standard LLINs. However, among women who reported using allocated study nets, the odds of poor pregnancy birth outcomes were reduced in the pyriproxyfen-pyrethroid LLIN (adjusted OR [aOR] 0.50, 95% CI 0.31 to 0.82) and chlorfenapyr-pyrethroid LLIN (aOR 0.67, 95% CI 0.43 to 1.04) groups.Conclusion: Poor birth outcomes were similar for women living in the dual AI LLIN groups and those in the pyrethroid-only LLIN group, regardless of the type of net used. However, women using allocated dual AI LLINs were better protected than those using standard LLINs. National malaria control programmes should consider these new-generation LLINs for malaria control during pregnancy.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0