Transactions of The Royal Society of Tropical Medicine and Hygiene最新文献_第5页

Tunnel sign in patients with melioidosis: a case series from South India. 瓜虫病患者的隧道征：南印度的一个病例系列。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-06-05 DOI: 10.1093/trstmh/trae097

Nitin Gupta, Sundeep Malla, Tirlangi Praveen Kumar, Sonali Singh, Muralidhar Varma, Chiranjay Mukhopadhyay

引用次数: 0

Primary health system strengthening and system-level interventions for tackling snakebite envenoming in India. 加强初级卫生系统和处理印度蛇咬伤事件的系统级干预措施。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-06-05 DOI: 10.1093/trstmh/trae106

Priyanka Kadam, Stuart Ainsworth, Bhupeshwari Patel

引用次数: 0

Evaluation of suitability of two tools for the diagnosis of canine visceral leishmaniasis. 两种工具诊断犬内脏利什曼病的适用性评价。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-06-05 DOI: 10.1093/trstmh/traf012

Valeria S Garcia, Maira S Gutiérrez, Verónica D G Gonzalez, Luis M Gugliotta, Alexis Burna, Diego Eiras, Matías S Cabeza, Diego G Arias, Sergio A Guerrero

{"title":"Evaluation of suitability of two tools for the diagnosis of canine visceral leishmaniasis.","authors":"Valeria S Garcia, Maira S Gutiérrez, Verónica D G Gonzalez, Luis M Gugliotta, Alexis Burna, Diego Eiras, Matías S Cabeza, Diego G Arias, Sergio A Guerrero","doi":"10.1093/trstmh/traf012","DOIUrl":"10.1093/trstmh/traf012","url":null,"abstract":"Background: Leishmaniasis still imposes a heavy burden on many health systems and remains a public health problem. Early diagnosis in dogs, which act as a major reservoir for the pathogen, is central. The intention of epidemiologic studies is to identify the disease early, allowing rapid intervention to reduce its effects. This study aimed to develop two types of diagnostics tools, an enzyme-linked immunosorbent assay (ELISA) and a lateral flow immunochromatography assay for recognizing canine visceral leishmaniasis (CVL).Methods: Multiwell ELISA plates were sensitized and strips were designed with the same chimeric recombinant antigen from Leishmania spp. (LeQuiDi) and the results were compared. The sera panel contained 409 samples, including 244 positives and 165 negatives. Of the 165 negative sera, 67 were obtained from Corrientes city, an endemic area for CVL in Argentina, and 98 of this group from La Plata city, a non-endemic area in Argentina (they were seropositive for other infections, as specificity control).Results: Serum with an elevated concentration of lipids, or bilirubin, or a variable percentage of haemolysis were tested without interference. Both the sensitivity and specificity of the LeQuiDi-based tests were high: ≥93% for ELISA and ≥87% for LFIA.Conclusions: Our study introduces LeQuiDi as a promising antigen for CVL diagnosis, regardless of the test format.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"606-612"},"PeriodicalIF":1.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementing an artificial intelligence system into a diabetic eye screening programme in Tanzania. 在坦桑尼亚的糖尿病眼科筛查项目中实施人工智能系统。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-06-05 DOI: 10.1093/trstmh/trae132

Charles R Cleland, William U Makupa, Bernadetha R Shilio, Justus Rwiza, David Macleod, Covadonga Bascaran, Matthew J Burton

引用次数: 0

Adjunctive nivolumab in combination with antibiotic therapy for the management of refractory melioidosis in a patient with metastatic breast cancer and chemotherapy-induced pancytopenia. 辅助纳沃单抗联合抗生素治疗转移性乳腺癌和化疗引起的全细胞减少症患者的难治性类鼻疽。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-06-05 DOI: 10.1093/trstmh/trae142

Praveen Kumar Tirlangi, Swathi Kiran, Vandana Ke, C Mukhopadhyay, Ramit Kundu, Ananth Pai, Priya Ps, Kavitha Saravu

引用次数: 0

Diagnostic sensitivity of formalin-fixed faecal microscopy for the detection of soil-transmitted helminths. 福尔马林固定粪便显微镜检测土壤传播蠕虫的诊断敏感性。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-06-05 DOI: 10.1093/trstmh/traf011

Andrew Larkins, Boualay Keokhamphavanh, Breanna Knight, Kelly Taggart, Sarah Keatley, Bounnaloth Insisiengmay, Amanda Ash

{"title":"Diagnostic sensitivity of formalin-fixed faecal microscopy for the detection of soil-transmitted helminths.","authors":"Andrew Larkins, Boualay Keokhamphavanh, Breanna Knight, Kelly Taggart, Sarah Keatley, Bounnaloth Insisiengmay, Amanda Ash","doi":"10.1093/trstmh/traf011","DOIUrl":"10.1093/trstmh/traf011","url":null,"abstract":"Background: Faecal microscopy is the mainstay of soil-transmitted helminth diagnosis and commonly completed on formalin-fixed samples when resources are insufficient to analyse fresh samples. This study assessed the diagnostic sensitivity of microscopic techniques using formalin-fixed samples.Methods: Formalin-fixed faecal samples from 574 individuals were tested by the formalin-ethyl acetate concentration technique (FECT), Malachite smear, McMaster and McMaster2 methods. Agreement between tests was assessed by Kappa. Bayesian latent class models and a composite reference standard estimated the diagnostic sensitivity of each test.Results: Moderate-to-good agreement between tests was observed for A. lumbricoides. Agreement was poorer for hookworm and Trichuris trichiura. The FECT (72.70%, credible interval [CrI]: 68.92-76.56%) and McMaster2 method (67.93%, 95% CrIs: 62.41-73.31%) had the highest sensitivities for A. lumbricoides. For hookworm, the McMaster2 method (70.56%, 95% CrIs: 64.10-76.96%) was more sensitive than all other tests. For T. trichiura, the McMaster (90.10%, 95% CrIs: 83.29-94.67%) and McMaster2 (89.3%, 95% CrIs: 82.28-94.52%) methods were the most sensitive.Conclusions: The McMaster2 method is a viable alternative to FECT and provides important information on the intensity of infection. The effect of formalin-fixation on test performance may not be as great as previously assumed. This study reports formalin-fixed sensitivities similar to previous estimates using fresh samples.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"596-605"},"PeriodicalIF":1.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leprosy relapse near pilgrimage sites in the Cariri region of Brazil. 在巴西卡里里地区的朝圣地附近麻风病复发。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-06-05 DOI: 10.1093/trstmh/traf057

Albério A Cavalcante, Franciely G Gonçalves, João Marcos F L Silva, Gabriel Z Laporta

{"title":"Leprosy relapse near pilgrimage sites in the Cariri region of Brazil.","authors":"Albério A Cavalcante, Franciely G Gonçalves, João Marcos F L Silva, Gabriel Z Laporta","doi":"10.1093/trstmh/traf057","DOIUrl":"https://doi.org/10.1093/trstmh/traf057","url":null,"abstract":"Background: Leprosy relapse remains a challenge to Brazil's elimination efforts, particularly in regions where Mycobacterium leprae persists in the environment. While multidrug therapy (MDT) is effective, patients exposed to ongoing transmission may develop reinfections over time. This study investigates whether proximity to pilgrimage sites influences leprosy relapse in the Cariri region.Methods: Leprosy relapses in the Cariri region (2010-2022) were georeferenced based on patients' residences. A geostatistical model assessed relapse proximity to pilgrimage sites, classifying cases (2-18 km) and controls (18-102 km) by spatial dependence. Logistic regression assessed relapse odds near pilgrimage sites, comparing reinfections (≥5 y) to insufficient therapy (<5 y), adjusted for age, gender, cure outcome, disease severity and patient mobility.Results: A total of 337 leprosy relapses were identified across 45 municipalities in the Cariri region. Spatial analysis indicated that individuals living near pilgrimage sites had nearly twice the odds of experiencing a relapse ≥5 y after MDT treatment (OR=1.76, 95% CI 1.09 to 2.85), supporting the hypothesis that pilgrimage sites may act as transmission hotspots.Conclusions: Leprosy elimination in Brazil requires context-dependent measures. Pilgrimage sites, where individuals seek healing but may contribute to transmission, should be prioritized for active surveillance and targeted interventions.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Snakebite envenomation through a gender intersectionality lens in low- and middle-income countries. 从性别交叉性的角度看中低收入国家的蛇咬中毒。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-06-05 DOI: 10.1093/trstmh/trae085

Innocent Ayesiga, Shamim Naggayi, Jonathan Mawutor Gmanyami, Alex Akaka, Olivier Kubwimana, Gertrude Ahenewaa Gyabaah, Elizabeth Katusiime, Ukasha Musa Hashim, Ivan Kahwa

{"title":"Snakebite envenomation through a gender intersectionality lens in low- and middle-income countries.","authors":"Innocent Ayesiga, Shamim Naggayi, Jonathan Mawutor Gmanyami, Alex Akaka, Olivier Kubwimana, Gertrude Ahenewaa Gyabaah, Elizabeth Katusiime, Ukasha Musa Hashim, Ivan Kahwa","doi":"10.1093/trstmh/trae085","DOIUrl":"10.1093/trstmh/trae085","url":null,"abstract":"Snakebite envenomation continues to affect lives globally, with >1.2 million envenomations and approximately 120 000 annual mortalities. Unfortunately, low- and middle-income countries (LMICs) contribute to >80% of these global statistics. With different targets set to minimize the impact of snakebite envenoming, such as halving the envenoming cases by 2030 from the World Health Organization (WHO), multiple initiatives are inevitable. Gender intersectionality and tropical disease research for infectious diseases of poverty, developed by the WHO, has championed the exploration of neglected diseases, stratifying them using gendered domains. However, minimal research using the gender intersectionality framework has been conducted to explore snakebite envenoming, especially among LMICs. Exploring snakebite envenomation through a gendered lens is critical in developing gender-specific interventions for the prevention and treatment of envenomation. This narrative review explores the available literature about snakebite envenomation in LMICs through a gender intersectionality lens. It provides insights into the existing gaps, especially regarding research using intersectionality frameworks and the gendered matrix. It further proposes avenues of research using these domains to understand snakebite envenomation, especially through the intersectionality lens.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"665-670"},"PeriodicalIF":1.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Snakebite-associated acute kidney injury in South Asia: narrative review on epidemiology, pathogenesis and management. 南亚毒蛇咬伤相关急性肾损伤：流行病学、发病机制和治疗的叙述综述。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-06-05 DOI: 10.1093/trstmh/trae077

Bhawani Yasassri Alvitigala, Lallindra Viranjan Gooneratne, Christeine Ariaranee Gnanathasan, Eranga Sanjeewa Wijewickrama

{"title":"Snakebite-associated acute kidney injury in South Asia: narrative review on epidemiology, pathogenesis and management.","authors":"Bhawani Yasassri Alvitigala, Lallindra Viranjan Gooneratne, Christeine Ariaranee Gnanathasan, Eranga Sanjeewa Wijewickrama","doi":"10.1093/trstmh/trae077","DOIUrl":"10.1093/trstmh/trae077","url":null,"abstract":"Snakebite-associated acute kidney injury (AKI) poses a significant health burden in the South Asia region, resulting in considerable morbidity and mortality. Multiple factors contribute to the pathogenesis of AKI following snakebites, including hypotension, intravascular haemolysis, disseminated intravascular coagulation, rhabdomyolysis, thrombotic microangiopathy (TMA) and direct nephrotoxicity. Clinical features manifest as anuria, oliguria, haematuria, abdominal pain and hypertension. Diagnosis is supported by elevated serum creatinine levels and urine output monitoring. Renal histology studies revealed a spectrum of lesions, including acute tubular necrosis, renal cortical necrosis, glomerulonephritis and TMA. Management strategies centre around timely administration of antivenom, fluid and electrolyte balance and dialysis to improve renal outcomes. While dialysis has demonstrated efficacy in reducing AKI-related mortality rates, the use of fresh frozen plasma and therapeutic plasma exchange may be the subject of some controversy. Understanding the pathophysiological link between coagulopathy, TMA and AKI is important for tailoring effective treatment approaches. Species-specific randomized controlled trials are imperative to evaluate targeted interventions. In tackling the complexities of snakebite-associated AKI and chronic kidney disease, a multidisciplinary approach integrating clinical management with rigorous research efforts is essential. This collaborative endeavour aims to confront the challenges posed by these conditions and improve patient outcomes in the affected regions.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"648-664"},"PeriodicalIF":1.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteogenomic approaches for snake venom protein-based drug development: current trends and challenges. 基于蛇毒蛋白的药物开发的蛋白质基因组学方法：当前趋势和挑战。

IF 1.9 4区医学

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-06-05 DOI: 10.1093/trstmh/trae073

Sandeep Kumar Jhade, Karthik Kalidoss, Poonam Kumari Pathak, Rahul Shrivastava

{"title":"Proteogenomic approaches for snake venom protein-based drug development: current trends and challenges.","authors":"Sandeep Kumar Jhade, Karthik Kalidoss, Poonam Kumari Pathak, Rahul Shrivastava","doi":"10.1093/trstmh/trae073","DOIUrl":"10.1093/trstmh/trae073","url":null,"abstract":"Snake venom proteins have long been recognized for their therapeutic potential. Proteogenomic strategies, integrating transcriptomics and proteomics, have emerged as powerful tools for identifying and characterizing venom proteins for the development of novel therapeutic agents. Analytical techniques like mass spectrometry and next-generation sequencing enable comprehensive analysis, identifying key venom components and their variants. Recent studies unveil the diversity and complexity of snake venom, highlighting species-specific variations in toxin composition. Structural biology techniques, including x-ray crystallography and cryo-electron microscopy, provide insights into venom enzyme structures and mechanisms of action, facilitating drug design. Bioinformatics tools aid in data analysis and prediction of venom protein functions, enhancing drug discovery efforts. Despite advancements, challenges persist, including toxicity, formulation stability and clinical validation. This review describes the current as well as future options for research and development and emphasizes the critical role of proteogenomic techniques in developing snake venom protein-based drugs.","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":"638-647"},"PeriodicalIF":1.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0