Medically important snakes in Sudan: an overview of distribution, clinical features and present challenges.

Abstract

Snakebite envenomation (SBE) is a neglected tropical disease. It causes substantial morbidity and mortality in Sudan. Despite its endemicity, there is a substantial lack of up-to-date data on venomous snakes and their geographical distribution in Sudan, with most information dating back to the early twentieth century. To address this gap, we conducted a narrative review of the literature on snakes and SBE in Sudan. This review involved systematic searches of databases, historical publications and online resources from 1908 to 2024. Integrating literature findings with personal field experiences to provide a comprehensive overview of the SBE situation in Sudan, we identified 19 medically significant snake species in Sudan from four families. These species exhibit a range of venom types and clinical effects, including neurotoxic, hemotoxic and cytotoxic envenomation. The most dangerous and important species are the carpet viper (Echis pyramidum), the Nubian cobra (Naja nubiae) and the Sudan burrowing asp (Atractaspis phillipsi). Challenges in snakebite management include the non-availability of specific antivenoms, inadequate healthcare infrastructure and reliance on traditional medicine. We recommend establishing a national snakebite registry, improving healthcare infrastructure, developing training programs for healthcare professionals and increasing public awareness. Strengthening international collaborations for antivenom production and investing in molecular research are also crucial for reducing the severity and associated morbidity of SBE in Sudan.