{"title":"Utility of anakinra in Crimean Congo haemorrhagic fever with haemophagocyctic lymphohistiocytosis: a case report.","authors":"Ümit Çelik, Ayşe Hitay Telefon, Tuğba Kandemir Gülmez, Elif Afat Turgut, Rabia Miray Kisla Ekinci, Merve Kılıç Çil, Mehmet Deniz Erhan","doi":"10.1093/trstmh/traf056","DOIUrl":null,"url":null,"abstract":"<p><p>Crimean Congo haemorrhagic fever (CCHF) is an emerging, life-threatening tick-borne infection that can be fatal. As yet, there is no definitive treatment. In this case report we present a severe paediatric CCHF case that was successfully treated with anakinra. A previously healthy 13-year-old female presented with high fever, fatigue, rash and loss of appetite. Bone marrow aspiration showed rare haemophagocytocis and the patient's clinical condition continued to deteriorate. Anakinra was given on the day 5 of admission, as she was in the midst of cytokine storm syndrome. By the third day of anakinra, the patient's symptoms and laboratory tests improved. After 14 d of anakinra, she was discharged in full recovery. Anakinra may be a new therapeutic agent in CCHF, in which inflammation plays important role.</p>","PeriodicalId":23218,"journal":{"name":"Transactions of The Royal Society of Tropical Medicine and Hygiene","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transactions of The Royal Society of Tropical Medicine and Hygiene","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/trstmh/traf056","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0
Abstract
Crimean Congo haemorrhagic fever (CCHF) is an emerging, life-threatening tick-borne infection that can be fatal. As yet, there is no definitive treatment. In this case report we present a severe paediatric CCHF case that was successfully treated with anakinra. A previously healthy 13-year-old female presented with high fever, fatigue, rash and loss of appetite. Bone marrow aspiration showed rare haemophagocytocis and the patient's clinical condition continued to deteriorate. Anakinra was given on the day 5 of admission, as she was in the midst of cytokine storm syndrome. By the third day of anakinra, the patient's symptoms and laboratory tests improved. After 14 d of anakinra, she was discharged in full recovery. Anakinra may be a new therapeutic agent in CCHF, in which inflammation plays important role.
期刊介绍：
Transactions of the Royal Society of Tropical Medicine and Hygiene publishes authoritative and impactful original, peer-reviewed articles and reviews on all aspects of tropical medicine.
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