Epidemiological insights into the co-circulation of Zika and dengue viruses in Yangon, Myanmar (2017-2019).

IF 1.5 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2025-09-24 DOI:10.1093/trstmh/traf102

Maurine Mumo Mutua, Mya Myat Ngwe Tun, Khine Mya Nwe, Htin Lin, Merveille Kapandji, Shingo Inoue, Kyaw Zin Thant, Yuki Takamatsu, Wah Wah Aung, Aye Aye Khin, Hlaing Myat Thu, Takeshi Urano, Kouichi Morita

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引用次数: 0

Abstract

Background: Zika virus (ZIKV) is a mosquito-borne flavivirus mainly transmitted by Aedes aegypti and Aedes albopictus. While well-studied in the Americas, data from Southeast Asia, especially Myanmar, remain limited. This study assessed ZIKV infection among dengue-suspected patients in Yangon, Myanmar, from 2017 to 2019.

Methods: This was a cross-sectional retrospective study that collected serum samples from 1162 clinically dengue-suspected patients. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) was used to detect ZIKV RNA and serological assays were used to identify ZIKV-specific immunoglobulin M (IgM), IgG and neutralizing antibodies. The age, gender, clinical manifestations and coinfections with dengue virus (DENV) were determined.

Results: Of the 1162 samples, 23 (2.0%) were positive for ZIKV by RT-qPCR. Among these, nine samples showed coinfection with DENV: four with DENV-1, two with DENV-3 and three with DENV-4. Of the 111 (9.6%) samples that tested positive for ZIKV IgM, 11 (9.9%) had neutralizing antibodies against ZIKV, with 9 (8.1%) confirmed as ZIKV positive and 2 (1.8%) classified as probable cases.

Conclusions: Our study reported that 32 cases (2.8%) were confirmed as ZIKV infections by molecular and serological detection. The findings underscore the need for improved surveillance, diagnostic accuracy and public health interventions to mitigate the impact of ZIKV.

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2017-2019年缅甸仰光寨卡病毒和登革热病毒共传播的流行病学见解

背景：寨卡病毒（ZIKV）是一种主要由埃及伊蚊和白纹伊蚊传播的蚊媒黄病毒。虽然在美洲进行了充分的研究，但来自东南亚，特别是缅甸的数据仍然有限。本研究评估了2017年至2019年缅甸仰光登革热疑似患者中的寨卡病毒感染情况。方法：采用横断面回顾性研究方法，收集1162例临床疑似登革热患者的血清样本。采用逆转录定量聚合酶链反应（RT-qPCR）检测寨卡病毒RNA，采用血清学方法鉴定寨卡病毒特异性免疫球蛋白M （IgM）、IgG和中和抗体。测定年龄、性别、临床表现及合并感染登革热病毒（DENV）情况。结果：1162份样本中，23份（2.0%）经RT-qPCR检测呈寨卡病毒阳性。共感染登革热病毒9份，1型4份，3型2份，4型3份。在111份（9.6%）寨卡病毒IgM检测呈阳性的样本中，11份（9.9%）具有抗寨卡病毒的中和抗体，其中9份（8.1%）被确认为寨卡病毒阳性，2份（1.8%）被列为可能病例。结论：经分子及血清学检测，确诊寨卡病毒感染32例（2.8%）。这些发现强调需要改进监测、诊断准确性和公共卫生干预措施，以减轻寨卡病毒的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transactions of The Royal Society of Tropical Medicine and Hygiene 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.00

自引率

9.10%

发文量

115

审稿时长

4-8 weeks

期刊介绍： Transactions of the Royal Society of Tropical Medicine and Hygiene publishes authoritative and impactful original, peer-reviewed articles and reviews on all aspects of tropical medicine.