Small Methods最新文献_第8页

Improving Tumor Targeting and Penetration for Nanoparticle-Mediated Cancer Therapy.

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-09 DOI: 10.1002/smtd.202401860

Zhangyi Luo, Chien-Yu Chen, Song Li

引用次数: 0

Magic Defect Site for Modulating Electron-Correlated Properties in Monolayer T-NbSe₂.

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-07 DOI: 10.1002/smtd.202500038

Mengmeng Niu, Jiaqi Dai, Weikang Zhou, Chun Huang, Linlu Wu, Pengjie Guo, Cong Wang, Xu Wu, Wei Ji, Yeliang Wang, Jingsi Qiao

{"title":"Magic Defect Site for Modulating Electron-Correlated Properties in Monolayer T-NbSe2.","authors":"Mengmeng Niu, Jiaqi Dai, Weikang Zhou, Chun Huang, Linlu Wu, Pengjie Guo, Cong Wang, Xu Wu, Wei Ji, Yeliang Wang, Jingsi Qiao","doi":"10.1002/smtd.202500038","DOIUrl":"https://doi.org/10.1002/smtd.202500038","url":null,"abstract":"Defect engineering provides a precise and controlled approach to modify the localized electronic properties through crystalline interruption. In 2D electron-correlated materials, periodic lattice distortions often coexist with charge density waves (CDWs) and Mott insulating states, which are highly sensitive to local electronic environments. However, the influence of complex, inequivalent defect sites on electron-correlated properties, particularly Mott behavior, remains poorly understood. Here, density functional theory calculation is utilized to investigate the electron-correlated properties of monolayer T-NbSe2 with various single selenium/niobium vacancies. It is found that a single vacancy can induce geometric alterations over several nanometers, distinguished from typical 2D materials. A unique selenium vacancy site can precisely eliminate Mott electrons of T-NbSe2 and gradually lead the transitions from a ferromagnetic charge transfer insulator into a non-magnetic band insulator. Moreover, writing in and erasing Mott electrons can be flexibly manipulated by substituting the selenium site with arsenic, bromine, and potassium elements. The modulation mechanism by selenium vacancy originates from a synergistic combination of compressive strain and electron doping. The results systematically reveal that defect engineering is an ingenious strategy for atomically manipulating electron-correlated properties and manufacturing electronic patterns, enabling the control of Mott electrons in 2D materials.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500038"},"PeriodicalIF":10.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2D MXenes-Based Gas Sensors: Progress, Applications, and Challenges.

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-06 DOI: 10.1002/smtd.202402179

Shuguo Yu, Peng Li, Hanqin Ding, Chongyu Liang, Xiaojun Wang

引用次数: 0

Achieving Precision Phototherapy from Start to Finish: Integrating Endosomal Escape, Respiration Inhibition, and ROS Release in a Single Upconversion Nanoparticle.

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-06 DOI: 10.1002/smtd.202401742

Jing Wang, Hejingying Niu, Huadong Chen, Shanshan Yuan, Shanshan Zheng, Tonghan Zhao, Yihan Wu, Jinliang Liu, Hailong Che, Yong Zhang, Xiaohui Zhu

{"title":"Achieving Precision Phototherapy from Start to Finish: Integrating Endosomal Escape, Respiration Inhibition, and ROS Release in a Single Upconversion Nanoparticle.","authors":"Jing Wang, Hejingying Niu, Huadong Chen, Shanshan Yuan, Shanshan Zheng, Tonghan Zhao, Yihan Wu, Jinliang Liu, Hailong Che, Yong Zhang, Xiaohui Zhu","doi":"10.1002/smtd.202401742","DOIUrl":"https://doi.org/10.1002/smtd.202401742","url":null,"abstract":"Precision phototherapy requires tight control over several therapeutic steps, which traditional methods often struggle to achieve. Here, this study reports an orthogonal trichromatic upconversion nanoparticle with a rather simple nanoarchitecture, NaErF4@NaYbF4@NaYbF4:Nd@NaYF4:Yb,Tm. Unlike conventional designs that rely on multiple activators and complicated multi-shelled structures (up to six nanoshells), the reported triple-shelled UCNPs utilize only two activator ions (Er3⁺ and Tm3⁺) but still enables to release red, green, and blue colors in response to three different NIR light excitations, thus significantly reducing structural complexity and synthetic workload. Integrating these UCNPs with photosensitizers and nitric oxide (NO) donors further achieve to a precision photodynamic therapy, which allows for step-wise control throughout the entire PDT process by independent activation of bioimaging, photochemical internalization, respiration prohibition via NO release, and ROS generation via specific light illuminations. Both in vitro and in vivo results demonstrate high efficiency of presented methodology, highlighting its great potential for NIR light-activated precision phototherapy.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2401742"},"PeriodicalIF":10.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface Organic Nanostructures Mediated by Extrinsic Components: from Assembly to Reaction.

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-06 DOI: 10.1002/smtd.202402118

Chi Zhang, Rujia Hou, Wei Xu

{"title":"Surface Organic Nanostructures Mediated by Extrinsic Components: from Assembly to Reaction.","authors":"Chi Zhang, Rujia Hou, Wei Xu","doi":"10.1002/smtd.202402118","DOIUrl":"https://doi.org/10.1002/smtd.202402118","url":null,"abstract":"Surface organic nanostructures demonstrate great potential across multidisciplinary fields ranging from molecular electronics to energy conversion and storage. In the regime of surface chemistry, their preparation generally relies on intrinsic components originally involved in the molecule-substrate systems to drive molecular assembly and reaction. The recent paradigm shift employs extrinsic components as functional mediators to precisely regulate nanostructure formation pathways and the resulting molecular nanostructures. This review highlights three categories of extrinsic modulators, including small gas molecules, metals, and their combinations, that allow the construction and modification of surface organic nanostructures through tailored assembly and reaction. In addition, their detailed roles and regulatory mechanisms at the single-molecule level are also discussed. This emerging extrinsic-components-mediated assembly and reaction methodology displayed herein enriches the preparation toolbox for surface organic nanostructures and further allows the modification of their physicochemical properties, opening new frontiers in supramolecular engineering, nanomaterials development, etc.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2402118"},"PeriodicalIF":10.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal Halide Perovskite Single-Crystal Thin Films: From Films Growth to Light-Emitting Application.

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-05 DOI: 10.1002/smtd.202401861

Hengyu Cao, Weiyu Cheng, Chen Wang, Lutao Li, Ruonan Wang, Xiangle Sun, Huahai Lai, Xinke Feng, Fengcheng Zhang, Guifu Zou

引用次数: 0

STExplore: An Integrated Online Platform for Comprehensive Analysis and Visualization of Spatial Transcriptomics Data.

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-05 DOI: 10.1002/smtd.202401272

Yongtian Wang, Jintian Luo, Shaoqing Jiao, Xiaohan Xie, Tao Wang, Jie Liu, Xuequn Shang, Jiajie Peng

{"title":"STExplore: An Integrated Online Platform for Comprehensive Analysis and Visualization of Spatial Transcriptomics Data.","authors":"Yongtian Wang, Jintian Luo, Shaoqing Jiao, Xiaohan Xie, Tao Wang, Jie Liu, Xuequn Shang, Jiajie Peng","doi":"10.1002/smtd.202401272","DOIUrl":"https://doi.org/10.1002/smtd.202401272","url":null,"abstract":"Spatial transcriptomics revolutionizes the understanding of tissue organization and cellular interactions by combining high-resolution spatial information with gene expression profiles. Existing spatial transcriptomics analysis platforms face challenges in accommodating diverse techniques, integrating multi-omics data, and providing comprehensive analytical workflows. STExplore, an advanced online platform, is developed to address these limitations. STExplore supports a wide range of technologies, including sequencing-based and image-based methods, and offers a complete analysis workflow encompassing preprocessing, integration with single-cell RNA sequencing (scRNA-seq), cluster-level and gene-level analyses, and cell-cell communication studies. The platform features dynamic parameter adjustments and interactive visualizations at each analytical stage, enabling users to gain deeper insights into the spatial transcriptomic landscape. Case studies on neurogenesis in embryonic brain development, Alzheimer's disease, and brain tissue architecture demonstrate STExplore's capabilities in enhancing gene expression analysis, revealing cellular spatial organizations, and uncovering intercellular communication patterns. STExplore provides a comprehensive and user-friendly solution for the expanding demands of spatial transcriptomics research. The platform is accessible at http://120.77.47.2:3000/.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2401272"},"PeriodicalIF":10.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stabilizing Oxidation State of Cu via Ce Doping into La₂CuO₄ for Enhanced Electroreduction of CO₂ to Multicarbon Products.

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-04 DOI: 10.1002/smtd.202500005

Tingting Wan, Chunmei Lv, Ke Ye, Mingchan Ma, Di Hu, Juanxiu Xiao, Wei Xiao

{"title":"Stabilizing Oxidation State of Cu via Ce Doping into La2CuO4 for Enhanced Electroreduction of CO2 to Multicarbon Products.","authors":"Tingting Wan, Chunmei Lv, Ke Ye, Mingchan Ma, Di Hu, Juanxiu Xiao, Wei Xiao","doi":"10.1002/smtd.202500005","DOIUrl":"https://doi.org/10.1002/smtd.202500005","url":null,"abstract":"Stabilizing oxidation state of Cu (Cuδ+, δ > 0) sites is the key-enabling issue for electrocatalytic carbon dioxide (CO2) reduction reaction (eCO2RR) to multicarbon (C2+) products. The present study addresses this challenge by introducing cerium (Ce) doping into La2CuO4. The Ce doping facilitates f-d orbital coupling between Ce 4f and Cu 3d orbitals, suppressing electron enrichment around Cu atoms by transferring electrons from Cu 3d orbitals to Ce 4f orbitals via a Cu-O-Ce chain. These changes modulate the electronic structure of Cu, reduce the distance between neighboring Cu atoms, optimize the binding energy of surface-adsorbed CO (*CO), and lower the reaction energy barrier for *CO dimerization. As a result, the La1.95Ce0.05CuO4 catalyst achieves a Faradaic efficiency up to 81% for C2+ products and maintains high stability over 50 h operation. This work highlights the unique role of Ce doping in stabilizing Cuδ+ sites and hence enhancing C-C coupling, providing a pathway for designing efficient catalysts for eCO2RR.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500005"},"PeriodicalIF":10.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controllable Synthesis of Monodispersed Zirconia Submicrospheres Based on Oligomer Aggregation Mechanism for Enhanced Scattering Manipulation. 基于低聚物聚合机制的单分散氧化锆亚微球的可控合成，用于增强散射操纵。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-04 DOI: 10.1002/smtd.202401990

Hao Gong, Xiaokun Song, Hongchao Li, Liping Tong, Zhongyang Wang, Tongxiang Fan, Xiao Zhou

{"title":"Controllable Synthesis of Monodispersed Zirconia Submicrospheres Based on Oligomer Aggregation Mechanism for Enhanced Scattering Manipulation.","authors":"Hao Gong, Xiaokun Song, Hongchao Li, Liping Tong, Zhongyang Wang, Tongxiang Fan, Xiao Zhou","doi":"10.1002/smtd.202401990","DOIUrl":"https://doi.org/10.1002/smtd.202401990","url":null,"abstract":"Oxide submicrospheres with a high refractive index are essential for enhancing scattering and manipulating light transmission at submicrometer scale in photonic applications. However, achieving precise control over the diameter and monodispersity of transition metal oxide submicrospheres remains challenging, due to the unclear formation mechanism and lack of effective synthesis strategy. Here, a nonclassical mechanism of oligomer aggregation for controllable synthesis of monodispersed ZrO2 submicrospheres (ZS) with mean diameters ranging from 0.263 to 1.295 µm and polydispersity indices almost below 0.1 is presented. Oligomers are identified as the fundamental building units, and their aggregation behavior governs the formation of ZS. Moreover, the precise regulation of homogeneous oligomer formation and aggregation is achieved through the introduction of alkanoic acids and amines. This adjustment, driven by steric effect, hydrogen bonding strength, reaction priority, and quantity, enables control over spherical morphology, monodispersity, and diameter. Compared to SiO2 and polystyrene submicrospheres, ZS exhibits enhanced, tunable scattering behavior and superior chemical stability. The findings suggest that the oligomer aggregation mechanism, along with its controllable strategy, provides a new framework for synthesizing monodispersed transition metal oxide submicrospheres, broadening the range of materials available for photonic applications.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2401990"},"PeriodicalIF":10.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Magnetic Field on the Kinetics of Ho(III) Solvent Extraction Using D2EHPA: A Comprehensive Study. 磁场对使用 D2EHPA 溶剂萃取 Ho(III) 动力学的影响：综合研究。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-04 DOI: 10.1002/smtd.202402002

Konrad Wojtaszek, Andrea Cristofolini, Arturo Popoli, Karolina Kołczyk Siedlecka, Robert P Socha, Maria Owińska, Marek Wojnicki

{"title":"Influence of Magnetic Field on the Kinetics of Ho(III) Solvent Extraction Using D2EHPA: A Comprehensive Study.","authors":"Konrad Wojtaszek, Andrea Cristofolini, Arturo Popoli, Karolina Kołczyk Siedlecka, Robert P Socha, Maria Owińska, Marek Wojnicki","doi":"10.1002/smtd.202402002","DOIUrl":"https://doi.org/10.1002/smtd.202402002","url":null,"abstract":"The kinetics of Ho(III) extraction using di(2-ethylhexyl)phosphoric acid (D2EHPA) under the influence magnetic field are examined. The methodology for kinetics research is based on spectrophotometric techniques. Initial experiments without a magnetic field assess the influence of Ho(III) concentration (0.00625-0.1 m), pH (1-6), D2EHPA concentration (0.1-2 m), and temperatures (5-35 °C). Subsequent tests (5-35 °C) determine the influence of the magnetic field. Experimental considerations are supplemented with numerical simulations of the magnetic field affecting the extraction system. A white precipitate formed at the phase boundary is characterized using X-ray fluorescence (XRF), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and X-ray photoelectron spectroscopy (XPS) techniques. Post-extraction solutions are analyzed with nuclear magnetic resonance (NMR) spectroscopy to investigate the structure and magnetic properties of the D2EHPA-Ho(III) complex. The conducted research indicate that magnetic fields notably enhance kinetics of extraction above 25 °C, suggesting a possible change in the extraction mechanism.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2402002"},"PeriodicalIF":10.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0