Small Methods最新文献_第10页

Supramolecular Microspheres Fabricated from Macrocycle-Incorporated Polymers and Their Biomedical Applications Based on Host-Guest Recognition 基于主客识别的高分子聚合物制备超分子微球及其生物医学应用。

IF 9.1 2区材料科学

Small Methods Pub Date : 2025-09-02 DOI: 10.1002/smtd.202501053

Yangfan Wang, Xiangyu Yang, Miya Zhang, Jiaqi Lei, Shaolong Qi, Kai Yang, Yongcan Li, Wenjie Zhang, Meiqi Cheng, Sheng Wang, Jinqun Gan, Fangfang Cao, Ruibing Wang, Guocan Yu

{"title":"Supramolecular Microspheres Fabricated from Macrocycle-Incorporated Polymers and Their Biomedical Applications Based on Host-Guest Recognition","authors":"Yangfan Wang, Xiangyu Yang, Miya Zhang, Jiaqi Lei, Shaolong Qi, Kai Yang, Yongcan Li, Wenjie Zhang, Meiqi Cheng, Sheng Wang, Jinqun Gan, Fangfang Cao, Ruibing Wang, Guocan Yu","doi":"10.1002/smtd.202501053","DOIUrl":"10.1002/smtd.202501053","url":null,"abstract":"Microspheres have emerged as a pivotal platform for micron-scale drug delivery, yet their utility has been greatly hindered by limitations in biodegradability, drug loading efficiency, and release kinetics, underscoring the urgent need for a next-generation microsphere platform that integrates high performance, scalability, and multifunctionality. Leveraging host–guest recognition, a series of macrocycle-incorporated polymers is synthesized and engineered a new class of supramolecular microspheres, which feature precisely tunable components, including host molecules, guest cargoes, and polymer components, as well as customizable morphologies, while enabling cost-effective, large-scale production. Following systematic validation of the host–guest recognition between β-cyclodextrin (β-CD) and lanreotide, we developed supramolecular microspheres (LAN@S-CPMs) that achieve a drug loading capacity and release duration approximately twice that of conventional microspheres, effectively curbing the disease progression of acromegaly. Beyond sustained release, porous supramolecular microspheres (S-P[5]PMs-p) fabricated from the pillar[5]arene (P[5])-incorporated polymer exhibit exceptional efficiency in spermine adsorption, while mineralized supramolecular microspheres (SORA@S-CPMs-p@CaCO3) loaded with sorafeinib (SORA) are successfully employed in embolization therapy, achieving more complete vascular occlusion compared to non-mineralized microspheres. The modular design of supramolecular microspheres and facile scalability in production offer a transformative platform to overcome the multifaceted challenges currently faced by microsphere-based delivery systems.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":"9 9","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidation State Manipulation of NiO_x for High Performance and Light-Soaking Stability of Perovskite Solar Modules. 钙钛矿太阳能组件高性能和光浸泡稳定性的氧化态操纵。

IF 9.1 2区材料科学

Small Methods Pub Date : 2025-09-02 DOI: 10.1002/smtd.202501325

Yongseok Yoo, Heesuk Jung, Hee Jeong Park, Jichan Kim, Kun Soo Jung, Hye Ryeong Lee, Junseop Byeon, Haram Lee, Woosum Cho, Sung Hoan Kim, Se-Woong Baek, Sungkoo Lee, Min Jae Ko, Gabseok Seo, Yung-Eun Sung, Seunghwan Bae

{"title":"Oxidation State Manipulation of NiOx for High Performance and Light-Soaking Stability of Perovskite Solar Modules.","authors":"Yongseok Yoo, Heesuk Jung, Hee Jeong Park, Jichan Kim, Kun Soo Jung, Hye Ryeong Lee, Junseop Byeon, Haram Lee, Woosum Cho, Sung Hoan Kim, Se-Woong Baek, Sungkoo Lee, Min Jae Ko, Gabseok Seo, Yung-Eun Sung, Seunghwan Bae","doi":"10.1002/smtd.202501325","DOIUrl":"https://doi.org/10.1002/smtd.202501325","url":null,"abstract":"NiOx is widely used for hole-transporting layers in p-i-n-type perovskite solar cells (PSCs) due to its stability, wide bandgap (≈3.5 eV), and solution processability. However, during solution processing, oxygen exposure can induce non-stoichiometry, forming Ni≥3 +. While Ni≥3 + enhances hole mobility, it also promotes redox reactions at the interface, undermining long-term stability. To utilize the improved mobility without sacrificing stability, bilayer NiOx films with controlled Ni≥3 + concentrations can be fabricated. Sputtering is ideal for this, enabling precise control of oxygen partial pressure during deposition. This study utilizes sputtering to regulate Ni≥3 + levels and optimize the ratio of two NiOx layers in bilayer films, improving charge extraction and transport. A fabricated perovskite module with a 16.0 cm2 aperture area achieves a photo-conversion efficiency (PCE) of 16.5%. Additionally, the module retains 80% of its initial PCE after 1000 h under continuous 1-sun illumination, thanks to the stable bilayer NiOx structure.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e01325"},"PeriodicalIF":9.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wireless Electrotactile System with Hydrogel-Based Electrodes for Conformal Tactile Interaction 基于水凝胶电极的共形触觉交互无线电触觉系统。

IF 9.1 2区材料科学

Small Methods Pub Date : 2025-09-02 DOI: 10.1002/smtd.202501142

Yunting Lan, Kuanming Yao, Pujing Shi, Yu Xue, Ji Liu

引用次数: 0

Recent Development in Emerging 2D Rare Earth Materials: Compositions, Syntheses, and Applications 新兴二维稀土材料的最新发展：组成、合成和应用。

IF 9.1 2区材料科学

Small Methods Pub Date : 2025-09-02 DOI: 10.1002/smtd.202501216

Deli Cheng, Liqian Xiong, Yuan Lu, Minting Lei, Min Yue, Xinji Hong, Xu Wei, Tangyu Lu, Qiao Yan, Yinan Wang, Chao Zou, Lei Zhao, Kenan Zhang, Mei Zhao, Lijie Zhang, Shun Wang

{"title":"Recent Development in Emerging 2D Rare Earth Materials: Compositions, Syntheses, and Applications","authors":"Deli Cheng, Liqian Xiong, Yuan Lu, Minting Lei, Min Yue, Xinji Hong, Xu Wei, Tangyu Lu, Qiao Yan, Yinan Wang, Chao Zou, Lei Zhao, Kenan Zhang, Mei Zhao, Lijie Zhang, Shun Wang","doi":"10.1002/smtd.202501216","DOIUrl":"10.1002/smtd.202501216","url":null,"abstract":"2D rare earth (RE) materials have recently attracted extensive research interests owing to the unique optical, electronic, and magnetic properties, exhibiting great potential applications in next-generation lighting, optoelectronics, and magnetic devices. However, reviews on 2D RE materials are rare and only focus on certain families despite their importance. Herein, a comprehensive review of the recent progress of 2D RE materials is presented, covering structures, properties, syntheses, and applications. First, the crystal structure and electronic structure of 2D RE materials are introduced. Then, typical properties such as luminescence and magnetism are discussed. Next, the fabrication methods are summarized, including mechanical exfoliation, solution synthesis, and vapor deposition. Furthermore, the promising applications in transistors, photodetectors, and encryption are elaborated. Finally, the existing challenges and prospects of future research on 2D RE materials are evaluated.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":"9 9","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autonomous Bayesian Optimization-Based Control System for Droplet Generation. 基于自治贝叶斯优化的液滴生成控制系统。

IF 9.1 2区材料科学

Small Methods Pub Date : 2025-09-02 DOI: 10.1002/smtd.202500984

Seongsu Cho, Haengyeong Kim, Seonghun Shin, Minki Lee, Jinkee Lee

{"title":"Autonomous Bayesian Optimization-Based Control System for Droplet Generation.","authors":"Seongsu Cho, Haengyeong Kim, Seonghun Shin, Minki Lee, Jinkee Lee","doi":"10.1002/smtd.202500984","DOIUrl":"https://doi.org/10.1002/smtd.202500984","url":null,"abstract":"Droplet generation has been utilized in various applications, including drug delivery, the fabrication of functional particles, and material synthesis. Achieving the goals of these applications requires droplet generation of a desired size. Microfluidic droplet generation offers precise control of droplet dimensions. However, the flow rates of the droplet and medium phases depend on the channel configuration and properties of the working fluids, and their optimization is a labor-intensive and time-consuming process. To overcome these limitations, an autonomous Bayesian optimization (BO)-based control system for droplet generation (ABCD) is developed. In ABCD, BO is employed to inform decision-making and refine the experimental conditions. Additionally, computer vision techniques, including image processing and convolutional neural networks, are utilized to analyze the experimental results and provide a dataset for use in decision-making. The ABCD identified the optimal flow rates to achieve desired droplet sizes and generation frequencies via precise and efficient searches, regardless of the droplet generation target, working fluids, channel geometry, and droplet morphology, within 15 iterations on average. It is anticipated that this system will contribute to the acceleration of research utilizing droplet-based microfluidic systems while also extending microfluidic process automation in various industrial applications.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e00984"},"PeriodicalIF":9.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-Molecule Nanopore Detection of Non-Canonical Thymine-Melamine Hydrogen Bonding Base Pair in DNA Abasic Site. 非典型胸腺嘧啶-三聚氰胺碱基对DNA碱基单分子纳米孔检测。

IF 9.1 2区材料科学

Small Methods Pub Date : 2025-09-02 DOI: 10.1002/smtd.202501445

Shilong Liu, Jing Li, Yunjiao Wang, Zhirui Zhang, Yan Wang, Lebing Wang, Liang Wang

{"title":"Single-Molecule Nanopore Detection of Non-Canonical Thymine-Melamine Hydrogen Bonding Base Pair in DNA Abasic Site.","authors":"Shilong Liu, Jing Li, Yunjiao Wang, Zhirui Zhang, Yan Wang, Lebing Wang, Liang Wang","doi":"10.1002/smtd.202501445","DOIUrl":"https://doi.org/10.1002/smtd.202501445","url":null,"abstract":"The binding of small molecules to DNA may represent a mutagenic process capable of inducing genomic structural alterations and functional impairment. Melamine (MA), a toxic small molecule, exhibits a hydrogen-bonding interface structurally analogous to adenine, enabling to form non-canonical thymine-melamine (T-MA) base pairs like Watson-Crick pairing. This property allows MA to program DNA nanostructure formation. Given MA's documented biological consequences, such as kidney disease, reproductive toxicity, and central nervous system dysfunction, sensitive detection of MA-DNA interactions has become critically important. However, such subtle structural changes remain challenging to identify because of the paucity of effective detection approaches in a high-resolution manner. To overcome this limitation, nanopore measurement is employed to identify T-MA hydrogen bonding base pairing in DNA. Results demonstrate that nanopore enables unambiguous identification of T-MA hydrogen bonding via mechanically unzipping thymine-melamine-thymine (T-MA-T) triplets in DNA structures. The approach achieves single-base-pair resolution, as evidenced by nucleotide substitutions flanking the abasic site in complex DNA structures. In addition, nanopore-based kinetic analysis reveals an enhanced intramolecular stability in MA-binding DNA compared to those consisting of complete canonical DNA pairs. This research establishes a powerful platform for high-resolution interrogation of DNA-small molecule interactions and quantitative biophysical characterization of mutagenic modifications at the nanoscale.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e01445"},"PeriodicalIF":9.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional Sponge Enables the High-Efficient Photocatalytic Degradation of Dyes and Tetracycline through ZnS@Bi₂S₃@HNTs. 多功能海绵通过ZnS@Bi2S3@HNTs实现染料和四环素的高效光催化降解。

IF 9.1 2区材料科学

Small Methods Pub Date : 2025-09-02 DOI: 10.1002/smtd.202501031

Hongliang Zhang, Zhiguang Guo

{"title":"Multifunctional Sponge Enables the High-Efficient Photocatalytic Degradation of Dyes and Tetracycline through ZnS@Bi2S3@HNTs.","authors":"Hongliang Zhang, Zhiguang Guo","doi":"10.1002/smtd.202501031","DOIUrl":"https://doi.org/10.1002/smtd.202501031","url":null,"abstract":"Photocatalytic technology has garnered considerable attention in wastewater treatment, but its application to complex wastewater remains challenged by particle aggregation and the difficulty of separating the catalyst from water. In this study, the heterojunction composite catalyst ZnS@Bi2S3 and halloysite nanotubes (HNTs) are immobilized onto a sponge substrate to enhance photocatalytic performance. SEM, XRD, XPS, FTIR, and UV-Vis analyses are conducted to characterize the morphology and evaluate the organic degradation performance of PPG/HNTs/ZnS@Bi2S3. The results show that the photocatalytic properties of ZnS@Bi2S3 are enhanced compared with ZnS. Incorporation of HNTs into PPG/HNTs/ZnS@Bi2S3 further accelerates the adsorption of organic pollutants. PPG/HNTs/ZnS@Bi2S3 demonstrates outstanding photocatalytic degradation performance against various dyes (RHB, MO, MB), achieving efficiencies exceeding 98% and retaining over 73% efficiency after five consecutive catalytic cycles. The photocatalytic degradation efficiency of tetracycline (TC) reaches 97.3%. The photodegradation mainly originated from hydroxyl radicals. This method has potential for an efficient photocatalytic system in environmental remediation.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e01031"},"PeriodicalIF":9.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design Strategies and Advanced Methods for Cathode Engineering in Aqueous Zinc-Iodine Batteries 含水锌碘电池阴极工程设计策略与先进方法。

IF 9.1 2区材料科学

Small Methods Pub Date : 2025-09-01 DOI: 10.1002/smtd.202501287

Derong Liu, Zhao Wang, Dian Zhao, Shaojie Guo, Liangzeyu Zhang, Yanzhu Luo, Feifei Cao

引用次数: 0

Dual-Modal Ex Vivo Vascular Culture and Imaging System Facilitates Research on Vascular Changes under Hyperglycemic and Hypoxic Conditions 双模离体血管培养和成像系统促进了高血糖和缺氧条件下血管变化的研究。

IF 9.1 2区材料科学

Small Methods Pub Date : 2025-09-01 DOI: 10.1002/smtd.202500585

Qingdong Zhang, Liang Xu, Zhiyuan Zheng, Yang Zhang, Pengwu Song, Jie Gao, Shilu Zhu, Shuwei Shen, Mingzhai Sun, Peng Yao, Min Ye, Peng Liu, Ronald X. Xu

{"title":"Dual-Modal Ex Vivo Vascular Culture and Imaging System Facilitates Research on Vascular Changes under Hyperglycemic and Hypoxic Conditions","authors":"Qingdong Zhang, Liang Xu, Zhiyuan Zheng, Yang Zhang, Pengwu Song, Jie Gao, Shilu Zhu, Shuwei Shen, Mingzhai Sun, Peng Yao, Min Ye, Peng Liu, Ronald X. Xu","doi":"10.1002/smtd.202500585","DOIUrl":"10.1002/smtd.202500585","url":null,"abstract":"Diabetic microvascular complications result from complex vascular remodeling influenced by hyperglycemia and hypoxia. However, there is currently no comprehensive method for systematically studying their combined effects on overall vascular morphology and perfusion function. To address this, a dual-modal ex vivo vascular culture and imaging system is developed. First, an ex vivo chick chorioallantoic membrane (CAM) model is established as a vascular culture platform. Then a dual-modal imaging system integrating incoherent bright-field imaging and laser speckle imaging is constructed for vascular imaging. Following this, a vascular structure and perfusion analysis algorithm is employed to achieve full-scale characterization of vascular structural and perfusion changes in the CAM model. Using this system, vascular changes under different oxygen and glucose conditions are systematically investigated, revealing that normal vasculature exhibits a certain degree of resistance to oxygen fluctuations, whereas hyperglycemia impairs the vascular adaptive response to hypoxia. Furthermore, variations in oxygen levels are identified as a key factor contributing to the differential vascular changes observed under hyperglycemic conditions. This study highlights the synergistic effects of hyperglycemia and hypoxia on vascular remodeling and provides an innovative real-time imaging platform for investigating microvascular pathology. This system has significant potential for advancing research on vascular-related diseases.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":"9 9","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Sulfur-Doped PtRuNi Alloy Catalyst for Efficient Hydrogen Evolution Reaction. 硫掺杂PtRuNi合金高效析氢催化剂的合成。

IF 9.1 2区材料科学

Small Methods Pub Date : 2025-09-01 DOI: 10.1002/smtd.202501316

Minki Kim, Yesol Kim, Gukbo Kim, Aqil Jamal, Issam Gereige, Hee-Tae Jung

{"title":"Synthesis of Sulfur-Doped PtRuNi Alloy Catalyst for Efficient Hydrogen Evolution Reaction.","authors":"Minki Kim, Yesol Kim, Gukbo Kim, Aqil Jamal, Issam Gereige, Hee-Tae Jung","doi":"10.1002/smtd.202501316","DOIUrl":"https://doi.org/10.1002/smtd.202501316","url":null,"abstract":"Green hydrogen production via electrocatalytic water splitting is a promising strategy for enabling renewable energy technologies. To improve hydrogen generation efficiency, extensive efforts have been devoted to developing electrocatalysts with lower energy requirements and higher stability. Among these, randomly mixed alloy catalysts have attracted significant attention due to their ability to exhibit synergistic effects surpassing those of single-component materials. Here, the synthesis of a sulfur-doped PtRuNi alloy catalyst for efficient hydrogen evolution reaction (HER) using carbothermal shock (CTS) method is reported. This rapid, high temperature synthesis technique enabled the formation of PtRuNi/S alloy nanoparticles with a finely tuned local electronic structure, driven by sulfur incorporation. The resulting catalyst exhibited outstanding HER activity in both acidic and alkaline solution, with overpotentials of 23.3 and 23.9 mV, respectively. Compared to Pt catalyst synthesized on the same substrate, the sulfur-doped alloy demonstrated positive overpotential shifts of ≈50 mV in acidic and 90 mV in alkaline environment, as well as significantly enhanced kinetics and electrochemical stability. This work not only presents an efficient and scalable synthesis strategy for heteroatom-doped alloy catalysts but also provides a promising platform for broader applications in other fields requiring tunable electronic structures and long-term durability.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e01316"},"PeriodicalIF":9.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0