Small Methods最新文献

Advancing Topoisomerase Research Using DNA Nanotechnology (Small Methods 6/2025) 利用DNA纳米技术推进拓扑异构酶的研究（Small Methods） 6/2025

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-22 DOI: 10.1002/smtd.202570040

Doron Yesodi, Adi Katz, Yossi Weizmann

引用次数: 0

Advancements in Engineering Tetrahedral Framework Nucleic Acids for Biomedical Innovations (Small Methods 6/2025) 生物医学创新工程四面体框架核酸研究进展（小方法6/2025）

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-22 DOI: 10.1002/smtd.202570039

Qin Fan, Bicheng Sun, Jie Chao

引用次数: 0

Multifunctional DNA-Metal Nanohybrids Derived From DNA-MgPPi Microhybrids by Rolling Circle Amplification (Small Methods 6/2025) 从DNA-MgPPi微杂交体中提取多功能dna -金属纳米杂交体（小方法6/2025）

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-22 DOI: 10.1002/smtd.202570037

Young Min Kim, Keonwook Nam, Hee Yeon Kim, Kyungjik Yang, Byeong-Su Kim, Dan Luo, Young Hoon Roh

引用次数: 0

Ferroelectric Domains and Evolution Dynamics in Twisted CuInP₂S₆ Bilayers. 扭曲CuInP2S6双分子层的铁电畴及其演化动力学。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-20 DOI: 10.1002/smtd.202500683

Dongyu Bai, Junxian Liu, Yihan Nie, Yuantong Gu, Dongchen Qi, Arkady Krasheninnikov, Liangzhi Kou

{"title":"Ferroelectric Domains and Evolution Dynamics in Twisted CuInP2S6 Bilayers.","authors":"Dongyu Bai, Junxian Liu, Yihan Nie, Yuantong Gu, Dongchen Qi, Arkady Krasheninnikov, Liangzhi Kou","doi":"10.1002/smtd.202500683","DOIUrl":"https://doi.org/10.1002/smtd.202500683","url":null,"abstract":"Polar domains and their manipulation-particularly the creation and dynamic control-have garnered significant attention, owing to their rich physics and promising applications in digital memory devices. In this work, using density functional theory (DFT) and deep learning molecular dynamics (DLMD) simulations, it is demonstrated that polar domains can be created and manipulated in twisted bilayers of ferroelectric CuInP2S6, as a result of interfacial ferroelectric (antiferroelectric) coupling in AA (AB) stacked region. Unlike the topological polar vortex and skyrmions observed in superlattices of (PbTiO3)n/(SrTiO3)n and sliding bilayers of BN and MoS2, the underlying mechanism of polar domain formation in this system arises from stacking-dependent energy barriers for ferroelectric switching and variations in switching speeds under thermal perturbations. Notably, the thermal stability and polarization lifetimes are highly sensitive to twist angles and temperature, and can be further manipulated by external electric fields and strain. Through multi-scale simulations, this study provides a novel approach to exploring how twist angles influence domain evolution and underscores the potential for controlling local polarization in ferroelectric materials via rotational manipulation.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500683"},"PeriodicalIF":10.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of Polarity Reversal of Bilayer AlN/Sc_0.2Al_0.8N Films and Its Influence on Film Bulk Acoustic Resonators. 双层AlN/Sc0.2Al0.8N薄膜极性反转及其对薄膜体声谐振器影响的研究

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-20 DOI: 10.1002/smtd.202500147

Yupeng Zheng, Tingting Yang, Binghui Lin, Xiaoming Huang, Qinwen Xu, Yuqi Ren, Yaxin Wang, Haiyang Li, Shishang Guo, Yao Cai, Chengliang Sun

{"title":"Investigation of Polarity Reversal of Bilayer AlN/Sc0.2Al0.8N Films and Its Influence on Film Bulk Acoustic Resonators.","authors":"Yupeng Zheng, Tingting Yang, Binghui Lin, Xiaoming Huang, Qinwen Xu, Yuqi Ren, Yaxin Wang, Haiyang Li, Shishang Guo, Yao Cai, Chengliang Sun","doi":"10.1002/smtd.202500147","DOIUrl":"https://doi.org/10.1002/smtd.202500147","url":null,"abstract":"Polarity is one of the key properties that affect the functionality of piezoelectric materials. For typical piezoelectric materials, aluminum nitride (AlN) and scandium-doped aluminum nitride (ScAlN), the polarity of the films will affect the electromechanical performance of their acoustic devices. Here, metal organic chemical vapor deposition (MOCVD) and physical vapor deposition (PVD) are used to grow an AlN seed layer on a silicon substrate, and then use PVD to grow Sc0.2Al0.8N on the AlN layer. The polarity of bilayer AlN/Sc0.2Al0.8N is investigated theoretically by density functional theory based on a simplified atomic structure model, and is observed experimentally at the atomic scale with scanning transmission electron microscopy. It's found that AlN grown on silicon shows Al polarity while Sc0.2Al0.8N shows N polarity. Furthermore, film bulk acoustic wave resonators (FBARs) are fabricated based on these films, which show that the electromechanical performance of FBARs is changed sharply when the polarity of Sc0.2Al0.8N is opposite to AlN. After removing the AlN seed layer, the effective electromechanical coupling coefficient of the FBAR increases from 5.82% to 11.85%. This work proves the impact of the polarity reversal and provides a basis for the design of FBARs based on bilayer AlN/Sc0.2Al0.8N at the theoretical and experimental aspects.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500147"},"PeriodicalIF":10.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CMOS-Compatible ScAlN Ferroelectric Thin Films with Enhanced Polarization for High-Performance FeFET Memory and Artificial Synapses. 用于高性能ffet记忆和人工突触的具有增强极化的cmos兼容ScAlN铁电薄膜。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-19 DOI: 10.1002/smtd.202500842

Bingqian Xu, Yao Cai, Zekai Wang, Qinwen Xu, Yuqi Ren, Xiang Chen, Chenxi Hu, Xiaohui Li, Jianping Shi, Chengliang Sun, Shishang Guo

{"title":"CMOS-Compatible ScAlN Ferroelectric Thin Films with Enhanced Polarization for High-Performance FeFET Memory and Artificial Synapses.","authors":"Bingqian Xu, Yao Cai, Zekai Wang, Qinwen Xu, Yuqi Ren, Xiang Chen, Chenxi Hu, Xiaohui Li, Jianping Shi, Chengliang Sun, Shishang Guo","doi":"10.1002/smtd.202500842","DOIUrl":"https://doi.org/10.1002/smtd.202500842","url":null,"abstract":"ScAlN is an emerging nitride ferroelectric material that exhibits exceptional remnant polarization (Pr) at ultrathin scales (<50 nm), stable single-phase ferroelectricity, and CMOS compatibility, making it highly promising for next-generation low-power, high-density memory and neuromorphic devices. However, ScAlN films deposited by conventional physical vapor deposition (PVD) faces challenges such as Sc precipitation and crystal orientation degradation at high Sc concentrations (>20%) and reduced thicknesses, leading to deteriorated ferroelectricity and increased leakage. In this work, it is demonstrated that an optimized substrate structure enables PVD-grown Sc0.2Al0.8N films to achieve significantly enhanced ferroelectric properties compared to conventional substrates, retaining high Pr even at 20 nm thickness. This improvement is further validated with Sc0.3Al0.7N and Sc0.35Al0.65N films across varying thicknesses. Additionally, a Sc0.2Al0.8N-based FeFET fabricated on this substrate exhibits a 17 V memory window, >103 switching ratio, >104 s retention, and >104 cycle endurance. When configured as an artificial synapse, the device achieves 98.7% recognition accuracy in neural network training under encoded pulse voltages, highlighting its potential for energy-efficient computing.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500842"},"PeriodicalIF":10.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient Photoelectrochemical Hydrogen Evolution via Hydrogen-Bond-Driven Self-Assembly of 1D Covalent Organic Frameworks. 通过氢键驱动的1D共价有机框架自组装的高效光电化学析氢。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-19 DOI: 10.1002/smtd.202500641

Qing Li, Guchuan Liang, Zhenshou Zhang, Boying Zhang, Jiapei Liu, Zhibo Zhang, Hongxing Han, Yue Wang

{"title":"Efficient Photoelectrochemical Hydrogen Evolution via Hydrogen-Bond-Driven Self-Assembly of 1D Covalent Organic Frameworks.","authors":"Qing Li, Guchuan Liang, Zhenshou Zhang, Boying Zhang, Jiapei Liu, Zhibo Zhang, Hongxing Han, Yue Wang","doi":"10.1002/smtd.202500641","DOIUrl":"https://doi.org/10.1002/smtd.202500641","url":null,"abstract":"Covalent organic frameworks (COFs) have shown significant application potential in the field of photoelectrochemical hydrogen evolution. However, it is a pressing scientific challenge to improve their processing performance to meet the requirements of photoelectrode films. In this study, a 1D COF (BC1COF) has been developed successfully, which can form a stable and easily processable solution through hydrogen bonding interactions. Moreover, the presence of hydrogen bonds promotes the self-assembly behavior of the material during the solution spin-coating process, enabling the preparation of smooth and flat COF films. The obtained COF films not only exhibit controllable thickness and excellent stability but also significantly enhance the carrier density and photoresponse characteristics of the material, thereby greatly improving its photoelectrocatalytic hydrogen evolution performance. The prepared photoelectrode film exhibited a photocurrent density of up to 97.5 µA cm- 2 at 0.4 V versus the reversible hydrogen electrode (RHE), which is ≈40 times that of the bulk photoelectrode. This synthesis strategy of COF films with controllable thickness provides the possibility for them to exhibit excellent performance in the field of photoelectrocatalysis.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500641"},"PeriodicalIF":10.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analyzing DNA Origami Nanostructure Assembly by Dynamic Light Scattering and Nanoparticle Tracking Analysis. 动态光散射和纳米粒子跟踪分析DNA折纸纳米结构组装。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-19 DOI: 10.1002/smtd.202500295

Qiaochu Zhang, Xu Chang, Alireza Ebrahimimojarad, Akshay Shah, Fei Zhang, Jinglin Fu

{"title":"Analyzing DNA Origami Nanostructure Assembly by Dynamic Light Scattering and Nanoparticle Tracking Analysis.","authors":"Qiaochu Zhang, Xu Chang, Alireza Ebrahimimojarad, Akshay Shah, Fei Zhang, Jinglin Fu","doi":"10.1002/smtd.202500295","DOIUrl":"https://doi.org/10.1002/smtd.202500295","url":null,"abstract":"The field of nucleic acid self-assembly has advanced significantly, enabling the creation of multi-dimensional nanostructures with precise sizes and shapes. These nanostructures hold great potential for various applications, including biocatalysis, smart materials, molecular diagnosis, and therapeutics. Here, dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) are employed to investigate DNA origami nanostructures, focusing on size distribution and particle concentration. Compared to DLS, NTA provided higher resolution in size measurement with a smaller full-width at half-maximum (FWHM), making it particularly suitable for characterizing DNA nanostructure. To enhance sensitivity, a fluorescent NTA method is developed by incorporating an intercalation dye to amplify the fluorescence signals of DNA origami. This method is validated by analyzing various DNA origami structures, ranging from 1 and 2D flexible structures to 3D compact shapes, and evaluating structural assembly yields. Additionally, NTA is used to analyze dynamic DNA nanocages that undergo conformational switches among linear, square, and pyramid shapes in response to the addition of trigger strands. Quantitative size distribution data is crucial not only for production quality control but also for providing mechanistic insights into the various applications of DNA nanomaterials.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500295"},"PeriodicalIF":10.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic Shielding of Arsenic-loaded Transferrin with Calcium Manganese Carbonate Potentiates Antitumor Effects via Self-enhanced Synergistic Therapy. 碳酸钙锰动态屏蔽负载砷的转铁蛋白通过自我增强协同治疗增强抗肿瘤作用。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-18 DOI: 10.1002/smtd.202500665

Xiaoyang Gao, Zhaowei Li, Yanwei Zhang, Haina Tian, Xiaolu Li, Fengying Shao, Changlong Wang

{"title":"Dynamic Shielding of Arsenic-loaded Transferrin with Calcium Manganese Carbonate Potentiates Antitumor Effects via Self-enhanced Synergistic Therapy.","authors":"Xiaoyang Gao, Zhaowei Li, Yanwei Zhang, Haina Tian, Xiaolu Li, Fengying Shao, Changlong Wang","doi":"10.1002/smtd.202500665","DOIUrl":"https://doi.org/10.1002/smtd.202500665","url":null,"abstract":"Arsenic trioxide is a frontline drug for leukemia treatment; however, its successful application in solid tumors has not yet been fully achieved. Transferrin is an endogenous protein containing iron-binding sites that can be used for loading arsenic for targeted delivery to solid tumors. However, the nonspecific expression of the transferrin receptor greatly limits transferrin-based nanomedicines. Herein, the dynamic shielding of arsenic-loaded transferrin with calcium manganese carbonate is proposed to potentiate strong antitumor effects via self-enhanced synergistic therapy. The nanocloak enhances tumor accumulation and realizes responsive release in an acidic tumor microenvironment. The re-exposed arsenic-loaded transferrin penetrates deep into the tumor, binds specifically to the receptor, and exerts cytotoxicity via chemotherapy. Along with this process, the protein levels of NOX4, which is responsible for H2O2 production, are upregulated. This biological effect facilitates self-enhanced chemodynamic therapy and the co-loaded glucose oxidase further ensures the initiation of this reaction. The released manganese ions catalyze the conversion of H2O2 into hydroxyl radicals and effectively activate the cGAS-STING signaling pathway for tumor inhibition. Collectively, these findings reveal the potent antitumor effects of the biomineralized nanomedicine and pave the way for translating arsenic into solid tumor therapy via targeted delivery and synergistic therapy.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500665"},"PeriodicalIF":10.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Near-Infrared Imaging of Localized Longitudinal Nanoparticle Transport in Living Animals. 活体动物体内纳米颗粒局部纵向传输的近红外成像。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-18 DOI: 10.1002/smtd.202402012

Chenxi Duan, Meiling Yan, Tingting Zuo, Xue Liu, Yiyang Wang, Qian Li, Jiang Li, Ying Zhu, Daishun Ling, Chunhai Fan, Yanhong Sun

{"title":"Near-Infrared Imaging of Localized Longitudinal Nanoparticle Transport in Living Animals.","authors":"Chenxi Duan, Meiling Yan, Tingting Zuo, Xue Liu, Yiyang Wang, Qian Li, Jiang Li, Ying Zhu, Daishun Ling, Chunhai Fan, Yanhong Sun","doi":"10.1002/smtd.202402012","DOIUrl":"https://doi.org/10.1002/smtd.202402012","url":null,"abstract":"Visualizing the in vivo dynamic transport behavior of substances following acupoint injection has remained a significant challenge due to the limitations of conventional imaging techniques. Near-infrared (NIR) imaging, with its superior tissue penetration, reduced autofluorescence, and real-time tracking capability, presents a promising approach for acupoint-associated imaging; however, its application in this context is yet to be experimentally validated. Here, NIR imaging is utilized to uncover highly localized, longitudinal transport of nanoparticles on the body surface in an acupoint-injection mouse model. By employing three distinct NIR fluorophores-Cy5, Cy5-labeled tetrahedral DNA nanostructures (TDN-Cy5), and silver sulfide (Ag2S) nanocrystals-it is demonstrated that acupoint injection induces directional migration along tissue-specific pathways, with nanoparticles exhibiting significantly prolonged retention compared to small molecules like Cy5. Notably, nanoparticles display minimal systemic distribution, with organ accumulation reduced to ≈1/50th of that observed with intravenous injection. This study underscores the unique capability of NIR imaging to visualize acupoint-associated transport dynamics, establishing a robust methodological framework to explore meridian-based substance delivery and its translational biomedical potential.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2402012"},"PeriodicalIF":10.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0