Small Methods最新文献

Manifesting p-d Orbital Hybridization Through Strategic D-Band Engineering: A Pathway to Boosted Bifunctional HER/OER Electrochemical Performance in Self-Templated Co-SnO₂ Grown Over Co-SnS₂ Nanosheets. 通过战略性d波段工程实现p-d轨道杂化：在Co-SnS2纳米片上生长的自模板Co-SnO2提高双功能HER/OER电化学性能的途径

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-05-29 DOI: 10.1002/smtd.202500712

Manash P Nath, Tanmoy Kalita, Suvankar Deka, Manju Kumari Jaiswal, Abhishek Borborah, Dhruba Jyoti Kalita, Lakshi Saikia, Biswajit Choudhury

{"title":"Manifesting p-d Orbital Hybridization Through Strategic D-Band Engineering: A Pathway to Boosted Bifunctional HER/OER Electrochemical Performance in Self-Templated Co-SnO2 Grown Over Co-SnS2 Nanosheets.","authors":"Manash P Nath, Tanmoy Kalita, Suvankar Deka, Manju Kumari Jaiswal, Abhishek Borborah, Dhruba Jyoti Kalita, Lakshi Saikia, Biswajit Choudhury","doi":"10.1002/smtd.202500712","DOIUrl":"https://doi.org/10.1002/smtd.202500712","url":null,"abstract":"In this study, Co-doped SnO2 is synthesized atop the hexagonal CoS template (CoSS) via direct air calcination of as-synthesized Co-doped SnS2 (CoS) nanosheets. The structural evolution facilitated the emergence of Co2+ and Co3+ states, complemented by surface-adsorbed sulfur oxyanions (SO4 2-, HSO3 -, SO3 2-). CoSS deposited over carbon cloth (CoSS/CC) exhibited superior bifunctional HER and OER, demonstrating higher stability and efficiency than their CoS/CC counterparts. Notably, CoSS/CC||CoSS/CC shows the overall water splitting at a minimum cell voltage of 1.5 V, significantly lower than CoS/CC||CoS/CC. Mechanistically, the Co3+ states serve as catalytically active sites that enhance OER, while the synergistic interaction between Co3+ and the sulfur oxyanions promotes HER activities. Density functional theory (DFT) calculations revealed an upshifted d-band centre (ɛd) and enhanced metal-oxygen covalency (Δ) in CoSS, with superior charge transfer and p-d hybridization. ATR-FTIR, Raman, and XPS investigations confirmed surface reconstruction of CoSS/CC electrodes with enhanced electrical conductivity. It is related that a highly strained system of VO-CoSS has more unfilled electronic states near the Fermi level (ɛF) to facilitate a stable interaction with HER/OER intermediates. Overall, this study underscores the superior bifunctional electrocatalytic efficiency of CoSS/CC over CoS/CC, establishing it as a promising candidate for efficient overall water splitting.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500712"},"PeriodicalIF":10.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introducing an Experimental Route to Identify and Unify Lab-Scale Redox-Flow Battery Cell Performances via Molar Fluxes and Cell Constants. 介绍了一种通过摩尔通量和电池常数来鉴定和统一实验室规模氧化还原液流电池性能的实验路线。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-05-28 DOI: 10.1002/smtd.202401670

Sebastian Fricke, Luuk Kortekaas, Martin Winter, Mariano Grünebaum

{"title":"Introducing an Experimental Route to Identify and Unify Lab-Scale Redox-Flow Battery Cell Performances via Molar Fluxes and Cell Constants.","authors":"Sebastian Fricke, Luuk Kortekaas, Martin Winter, Mariano Grünebaum","doi":"10.1002/smtd.202401670","DOIUrl":"https://doi.org/10.1002/smtd.202401670","url":null,"abstract":"Redox flow batteries (RFBs) are a promising technology for grid energy storage based on their high potential for scalability, design flexibility, high efficiency, and long durability, hence great effort has been invested in this area of research. However, due to the large differences in lab-scale RFB cell design and construction as well their operational performance, fundamental studies on innovative RFB components (e.g., active materials, separators, additives) compare poorly due to the lack of standard setups, settings, and procedures. This work introduces an experimental calibration route for aqueous as well as nonaqueous RFBs based on a simple mass transport model using molar fluxes, enabling one to compare dissimilar lab-scale RFB cell setups by introducing several RFB parameters: First, K1, which summarizes the operating parameters of an RFB to identify the critical ratio (K1critical) needed for efficient charge-discharge cycling using a simple overvoltage and charge efficiency evaluation; second, the RFB cell constant ζ, quantifying the influence of a lab-scale RFB setup on its performance; and finally, K2, ultimately enabling full comparison of (idealized) K1critical operating parameters across RFB cell setups.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2401670"},"PeriodicalIF":10.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatiotemporal Interrogation of Single Spheroids Using Multiplexed Nanoplasmonic-Fluorescence Imaging. 利用多路纳米等离子体荧光成像对单个球体进行时空探测。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-05-28 DOI: 10.1002/smtd.202500106

Saeid Ansaryan, Yung-Cheng Chiang, Yen-Cheng Liu, Jiayi Tan, Luis Francisco Lorenzo-Martín, Matthias P Lutolf, Genrich Tolstonog, Hatice Altug

{"title":"Spatiotemporal Interrogation of Single Spheroids Using Multiplexed Nanoplasmonic-Fluorescence Imaging.","authors":"Saeid Ansaryan, Yung-Cheng Chiang, Yen-Cheng Liu, Jiayi Tan, Luis Francisco Lorenzo-Martín, Matthias P Lutolf, Genrich Tolstonog, Hatice Altug","doi":"10.1002/smtd.202500106","DOIUrl":"https://doi.org/10.1002/smtd.202500106","url":null,"abstract":"Advances in organoid models, as ex vivo mini-organs, and the development of screening imaging technologies have continuously driven each other forward. A complete understanding of organoids requires detailed insights into the intertwined intraorganoid and extraorganoid activities and how they change across time and space. This study introduces a multiplexed imaging platform that integrates label-free nanoplasmonic biosensing with fluorescence microscopy to offer simultaneous monitoring of dynamics occurring within and around arrays of single spheroids with spatiotemporal resolution. The label-free module employs nanoplasmonic biosensors with extraordinary optical transmission to track biomolecular secretions into the surroundings, while concurrent fluorescence imaging enables structural analysis and viability assessment. To perform multiparametric interrogation of the data from different channels over extended periods, a deep-learning-augmented image analysis is incorporated. The platform is applied to tumor spheroids to investigate vascular endothelial growth factor A secretion alongside morphometric changes and viability, showcasing its ability to capture variations in secretion and growth dynamics between untreated and drug-treated groups. This integrated approach advances comprehensive insights into organoid models and can complement existing technologies to accelerate discoveries in disease modeling and drug development.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500106"},"PeriodicalIF":10.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components. 用于递送CRISPR基因编辑组件的脂质纳米颗粒。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-05-28 DOI: 10.1002/smtd.202401632

Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J Mitchell, Xuexiang Han

引用次数: 0

StableTi₃C₂T_x MXene Ink Formulation and High-Resolution Aerosol Jet Printing for High-Performance MXene Supercapacitors. 用于高性能MXene超级电容器的StableTi3C2Tx MXene油墨配方和高分辨率气溶胶喷射打印。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-05-28 DOI: 10.1002/smtd.202500499

Fereshteh Rajabi Kouchi, Tony Valayil Varghese, Hailey Burgoyne, Naqsh E Mansoor, Myeong-Lok Seol, Nicholas McKibben, Shruti Nirantar, Karthik Chinnathambi, Josh Eixenberger, Olivia Maryon, Christopher E Shuck, Yury Gogotsi, Jessica E Koehne, David Estrada

{"title":"StableTi3C2Tx MXene Ink Formulation and High-Resolution Aerosol Jet Printing for High-Performance MXene Supercapacitors.","authors":"Fereshteh Rajabi Kouchi, Tony Valayil Varghese, Hailey Burgoyne, Naqsh E Mansoor, Myeong-Lok Seol, Nicholas McKibben, Shruti Nirantar, Karthik Chinnathambi, Josh Eixenberger, Olivia Maryon, Christopher E Shuck, Yury Gogotsi, Jessica E Koehne, David Estrada","doi":"10.1002/smtd.202500499","DOIUrl":"https://doi.org/10.1002/smtd.202500499","url":null,"abstract":"Lightweight energy storage devices are essential for developing compact wearable and distributed electronics, and additive manufacturing offers a scalable, low-cost approach to fabricating such devices with complex geometries. However, additive manufacturing of high-performance, on-demand energy storage devices remains challenging due to the need for stable, multifunctional nanomaterial inks. Herein, the development of 2-dimensional (2D) titanium carbide (Ti3C2Tx MXene) ink that is compatible with aerosol jet printing for energy storage applications is demonstrated. The developed MXene ink demonstrates long-term chemical and physical stability, ensuring consistent printability and achieving high-resolution prints (≈45 µm width lines) with minimal overspray. The high-resolution aerosol-jet printed MXene supercapacitor achieves an areal capacitance of 122 mF cm-2 and a volumetric capacitance of 611 F cm-3, placing them among the highest-performing printed supercapacitors reported to date. These findings highlight the potential of aerosol jet printing with MXene inks for on-demand, scalable, and cost-effective fabrication of printed electronic and electrochemical devices.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500499"},"PeriodicalIF":10.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interpretable Differential Abundance Signature (iDAS). 可解释差异丰度特征（iDAS）。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-05-27 DOI: 10.1002/smtd.202500572

Lijia Yu, Yingxin Lin, Xiangnan Xu, Pengyi Yang, Jean Y H Yang

{"title":"Interpretable Differential Abundance Signature (iDAS).","authors":"Lijia Yu, Yingxin Lin, Xiangnan Xu, Pengyi Yang, Jean Y H Yang","doi":"10.1002/smtd.202500572","DOIUrl":"https://doi.org/10.1002/smtd.202500572","url":null,"abstract":"Single-cell technologies have revolutionized the understanding of cellular dynamics by allowing researchers to investigate individual cell responses under various conditions, such as comparing diseased versus healthy states. Many differential abundance methods have been developed in this field, however, the understanding of the gene signatures obtained from those methods is often incomplete, requiring the integration of cell type information and other biological factors to yield interpretable and meaningful results. To better interpret the gene signatures generated in the differential abundance analysis, iDAS is developed to classify the gene signatures into multiple categories. When applied to melanoma single-cell data with multiple cell states and treatment phenotypes, iDAS identified cell state- and treatment phenotype-specific gene signatures, as well as interaction effect-related gene signatures with meaningful biological interpretations. The iDAS model is further applied to a longitudinal study and spatially resolved omics data to demonstrate its versatility in different analytical contexts. These results demonstrate that the iDAS framework can effectively identify robust, cell-state specific gene signatures and is versatile enough to accommodate various study designs, including multi-factor longitudinal and spatially resolved data.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500572"},"PeriodicalIF":10.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering Pt Single-Atom Doped SeS₂/Ti₃CNT_x MXene with Molecularly Imprinted Polymer for Precision Pancreatic Cancer Diagnostics: DFT and Molecular Dynamics Perspectives. 工程Pt单原子掺杂SeS2/Ti3CNTx MXene分子印迹聚合物用于精确胰腺癌诊断：DFT和分子动力学观点。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-05-27 DOI: 10.1002/smtd.202500475

Sathish Panneer Selvam, Shanmugasundaram Kamalakannan, Agalya Mathivanan, Sungbo Cho

{"title":"Engineering Pt Single-Atom Doped SeS2/Ti3CNTx MXene with Molecularly Imprinted Polymer for Precision Pancreatic Cancer Diagnostics: DFT and Molecular Dynamics Perspectives.","authors":"Sathish Panneer Selvam, Shanmugasundaram Kamalakannan, Agalya Mathivanan, Sungbo Cho","doi":"10.1002/smtd.202500475","DOIUrl":"https://doi.org/10.1002/smtd.202500475","url":null,"abstract":"Cyclophilin-B (CypB) is overexpressed in pancreatic cancer, thus, the potential screening of CypB in biofluids and tissue samples may boost the identification of early-stage pancreatic cancer. A novel strategy of CypB detection utilizing the molecularly imprinted polymer platform, comprising higher binding affinity exhibiting cavities against the CypB protein was developed. Specifically, a nanocatalyst consisting of Pt single atom (Ptsa)-doped selenium disulfide (SeS2)/Ti3CNTx MXene nanocomposite is designed. The sluggish diffusion of Ptsa caused by the highest migration energy barrier of 6.39 eV unveils exceptionally high stability (2.89 ×1088 d (300 K) and 1.053 × 1024 d (750 K)) with (SeS2)/Ti3CNTx surface. The Ptsa boosted charge transfer kinetics paves the improved performance of the CypB sensor, while SeS2/Ti3CNTx supports the stable current density overall. The system establishes a dynamic linear range from 0.12 to 250 nm of CypB detection which correlates with the physiological existence of the CypB in human biofluids and tissues and the excellent detection limit of 80 pm. The liquid chromatography integrated mass spectrometer investigation warranted the significant enhancement of CypB associates with the progression of pancreatic cancer.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500475"},"PeriodicalIF":10.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrically Pumped Valley Emitter in Transition Metal Dichalcogenides with Magnetic Manipulation. 磁操纵下过渡金属二硫族化合物的电泵浦谷发射极。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-05-27 DOI: 10.1002/smtd.202500156

Yilin Liu, Haiyang Liu, Fanglu Qin, Aosai Yang, Sheng Liu, Li Zhang, Mengqi Zeng, Junyong Wang, Lei Fu, Ruitao Lv, Kai Zhang, Fengcheng Wu, Hao Wang, Ting Yu

{"title":"Electrically Pumped Valley Emitter in Transition Metal Dichalcogenides with Magnetic Manipulation.","authors":"Yilin Liu, Haiyang Liu, Fanglu Qin, Aosai Yang, Sheng Liu, Li Zhang, Mengqi Zeng, Junyong Wang, Lei Fu, Ruitao Lv, Kai Zhang, Fengcheng Wu, Hao Wang, Ting Yu","doi":"10.1002/smtd.202500156","DOIUrl":"https://doi.org/10.1002/smtd.202500156","url":null,"abstract":"Optical pumping has been extensively employed as a straightforward and efficient method for the investigation of excitonic effects in 2D transition metal dichalcogenides (TMDCs). However, the challenge of achieving well-matched resonant excitation makes it difficult to conduct a comprehensive and rigorous comparative study across different TMDCs systems. In this work, electrical pumping is utilized on quantum well structures of TMDCs, enabling equivalent carrier injection with similar kinetic energy while effectively mitigating the effects of non-resonant excitation. Valley-polarized electroluminescence (VP-EL) is systematically investigated under varying magnetic fields, demonstrating that without magnetic electrodes or substrates, reversing the magnetic field direction induces a corresponding reversal in the EL valley polarization. A comparative analysis of VP-EL from monolayer WS2, its homobilayer (WS2/WS2), and heterobilayer (WS2/WSe2) reveals that large spin-orbit coupling (SOC) and dark exciton ground state of WS2 enable the polarization reversal tunable by interlayer charge transfer and spin-matched interlayer hopping. This work elucidates the roles of SOC and the excitonic states for magneto-electroluminescence and demonstrates electrical pumping as a vital technique for the exploration of optical properties of 2D semiconductors.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500156"},"PeriodicalIF":10.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On-Tip Polymerization Method for Multimodal Characterization of Nanoparticles with Electron/Ion Imaging and Atom Probe Tomography. 用电子/离子成像和原子探针层析技术表征纳米颗粒多模态的尖端聚合方法。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-05-26 DOI: 10.1002/smtd.202500622

Aristide Djoulde, Anup Sharma, Alfred Bekoe Appiagyei, Levi Tegg, Yang Liu, Lian Zhang, Julie M Cairney, Yunlong Tang, Jing Fu

{"title":"On-Tip Polymerization Method for Multimodal Characterization of Nanoparticles with Electron/Ion Imaging and Atom Probe Tomography.","authors":"Aristide Djoulde, Anup Sharma, Alfred Bekoe Appiagyei, Levi Tegg, Yang Liu, Lian Zhang, Julie M Cairney, Yunlong Tang, Jing Fu","doi":"10.1002/smtd.202500622","DOIUrl":"https://doi.org/10.1002/smtd.202500622","url":null,"abstract":"This work presents a novel method for exploring the structures and chemistry of nanoparticles (NPs), addressing challenges in multimodal and correlative microscopy analysis. The proposed method utilizes a \"needle-eye\" design, featuring a through-microchannel fabricated at the needle tip. The microchannel and its surface are tuned via focused ion beam (FIB) milling and plasma treatment, enabling NPs dispersed in a resin precursor to be confined in the microchannel due to a pressure gradient upon immersion. The retained suspension is promptly polymerized in situ on the tip and shaped by FIB milling into specific geometries, including but not limited to a micropillar, lamella, and nanoneedle. Here, to demonstrate its applicability, a mixed metal oxide catalyst prepared by the needle-eye approach is characterized with energy-dispersive X-ray spectroscopy (EDX), FIB secondary ion mass spectrometry (FIB-SIMS), (scanning) transmission electron microscopy ((S)TEM), and atom probe tomography (APT). The results validate the ability of the method to achieve multimodal, combining correlative and complementary high-resolution structural and chemical imaging of individuals and clustered NPs. The proposed method confines picoliter-scale samples (6-60 pL) at a tip, eliminating lift-out and microtomy while enabling comprehensive analysis via combined microscopy techniques.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500622"},"PeriodicalIF":10.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving Spatial Transcriptomics with Membrane-Based Boundary Definition and Enhanced Single-Cell Resolution (Small Methods 5/2025) 利用基于膜的边界定义和增强的单细胞分辨率改进空间转录组学（小方法5/2025）

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-05-24 DOI: 10.1002/smtd.202570034

Li Song, Liqun Wang, Zitian He, Xiao Cui, Cheng Peng, Jie Xu, Zhouying Yong, Yanmei Liu, Ji-Feng Fei

引用次数: 0