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Engineering Pt Single-Atom Doped SeS2/Ti3CNTx MXene with Molecularly Imprinted Polymer for Precision Pancreatic Cancer Diagnostics: DFT and Molecular Dynamics Perspectives. 工程Pt单原子掺杂SeS2/Ti3CNTx MXene分子印迹聚合物用于精确胰腺癌诊断:DFT和分子动力学观点。
IF 10.7 2区 材料科学
Small Methods Pub Date : 2025-05-27 DOI: 10.1002/smtd.202500475
Sathish Panneer Selvam, Shanmugasundaram Kamalakannan, Agalya Mathivanan, Sungbo Cho
{"title":"Engineering Pt Single-Atom Doped SeS<sub>2</sub>/Ti<sub>3</sub>CNT<sub>x</sub> MXene with Molecularly Imprinted Polymer for Precision Pancreatic Cancer Diagnostics: DFT and Molecular Dynamics Perspectives.","authors":"Sathish Panneer Selvam, Shanmugasundaram Kamalakannan, Agalya Mathivanan, Sungbo Cho","doi":"10.1002/smtd.202500475","DOIUrl":"https://doi.org/10.1002/smtd.202500475","url":null,"abstract":"<p><p>Cyclophilin-B (CypB) is overexpressed in pancreatic cancer, thus, the potential screening of CypB in biofluids and tissue samples may boost the identification of early-stage pancreatic cancer. A novel strategy of CypB detection utilizing the molecularly imprinted polymer platform, comprising higher binding affinity exhibiting cavities against the CypB protein was developed. Specifically, a nanocatalyst consisting of Pt single atom (Pt<sub>sa</sub>)-doped selenium disulfide (SeS<sub>2</sub>)/Ti<sub>3</sub>CNT<sub>x</sub> MXene nanocomposite is designed. The sluggish diffusion of Pt<sub>sa</sub> caused by the highest migration energy barrier of 6.39 eV unveils exceptionally high stability (2.89 ×10<sup>88</sup> d (300 K) and 1.053 × 10<sup>24</sup> d (750 K)) with (SeS<sub>2</sub>)/Ti<sub>3</sub>CNT<sub>x</sub> surface. The Pt<sub>sa</sub> boosted charge transfer kinetics paves the improved performance of the CypB sensor, while SeS<sub>2</sub>/Ti<sub>3</sub>CNT<sub>x</sub> supports the stable current density overall. The system establishes a dynamic linear range from 0.12 to 250 nm of CypB detection which correlates with the physiological existence of the CypB in human biofluids and tissues and the excellent detection limit of 80 pm. The liquid chromatography integrated mass spectrometer investigation warranted the significant enhancement of CypB associates with the progression of pancreatic cancer.</p>","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500475"},"PeriodicalIF":10.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrically Pumped Valley Emitter in Transition Metal Dichalcogenides with Magnetic Manipulation. 磁操纵下过渡金属二硫族化合物的电泵浦谷发射极。
IF 10.7 2区 材料科学
Small Methods Pub Date : 2025-05-27 DOI: 10.1002/smtd.202500156
Yilin Liu, Haiyang Liu, Fanglu Qin, Aosai Yang, Sheng Liu, Li Zhang, Mengqi Zeng, Junyong Wang, Lei Fu, Ruitao Lv, Kai Zhang, Fengcheng Wu, Hao Wang, Ting Yu
{"title":"Electrically Pumped Valley Emitter in Transition Metal Dichalcogenides with Magnetic Manipulation.","authors":"Yilin Liu, Haiyang Liu, Fanglu Qin, Aosai Yang, Sheng Liu, Li Zhang, Mengqi Zeng, Junyong Wang, Lei Fu, Ruitao Lv, Kai Zhang, Fengcheng Wu, Hao Wang, Ting Yu","doi":"10.1002/smtd.202500156","DOIUrl":"https://doi.org/10.1002/smtd.202500156","url":null,"abstract":"<p><p>Optical pumping has been extensively employed as a straightforward and efficient method for the investigation of excitonic effects in 2D transition metal dichalcogenides (TMDCs). However, the challenge of achieving well-matched resonant excitation makes it difficult to conduct a comprehensive and rigorous comparative study across different TMDCs systems. In this work, electrical pumping is utilized on quantum well structures of TMDCs, enabling equivalent carrier injection with similar kinetic energy while effectively mitigating the effects of non-resonant excitation. Valley-polarized electroluminescence (VP-EL) is systematically investigated under varying magnetic fields, demonstrating that without magnetic electrodes or substrates, reversing the magnetic field direction induces a corresponding reversal in the EL valley polarization. A comparative analysis of VP-EL from monolayer WS<sub>2</sub>, its homobilayer (WS<sub>2</sub>/WS<sub>2</sub>), and heterobilayer (WS<sub>2</sub>/WSe<sub>2</sub>) reveals that large spin-orbit coupling (SOC) and dark exciton ground state of WS<sub>2</sub> enable the polarization reversal tunable by interlayer charge transfer and spin-matched interlayer hopping. This work elucidates the roles of SOC and the excitonic states for magneto-electroluminescence and demonstrates electrical pumping as a vital technique for the exploration of optical properties of 2D semiconductors.</p>","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500156"},"PeriodicalIF":10.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On-Tip Polymerization Method for Multimodal Characterization of Nanoparticles with Electron/Ion Imaging and Atom Probe Tomography. 用电子/离子成像和原子探针层析技术表征纳米颗粒多模态的尖端聚合方法。
IF 10.7 2区 材料科学
Small Methods Pub Date : 2025-05-26 DOI: 10.1002/smtd.202500622
Aristide Djoulde, Anup Sharma, Alfred Bekoe Appiagyei, Levi Tegg, Yang Liu, Lian Zhang, Julie M Cairney, Yunlong Tang, Jing Fu
{"title":"On-Tip Polymerization Method for Multimodal Characterization of Nanoparticles with Electron/Ion Imaging and Atom Probe Tomography.","authors":"Aristide Djoulde, Anup Sharma, Alfred Bekoe Appiagyei, Levi Tegg, Yang Liu, Lian Zhang, Julie M Cairney, Yunlong Tang, Jing Fu","doi":"10.1002/smtd.202500622","DOIUrl":"https://doi.org/10.1002/smtd.202500622","url":null,"abstract":"<p><p>This work presents a novel method for exploring the structures and chemistry of nanoparticles (NPs), addressing challenges in multimodal and correlative microscopy analysis. The proposed method utilizes a \"needle-eye\" design, featuring a through-microchannel fabricated at the needle tip. The microchannel and its surface are tuned via focused ion beam (FIB) milling and plasma treatment, enabling NPs dispersed in a resin precursor to be confined in the microchannel due to a pressure gradient upon immersion. The retained suspension is promptly polymerized in situ on the tip and shaped by FIB milling into specific geometries, including but not limited to a micropillar, lamella, and nanoneedle. Here, to demonstrate its applicability, a mixed metal oxide catalyst prepared by the needle-eye approach is characterized with energy-dispersive X-ray spectroscopy (EDX), FIB secondary ion mass spectrometry (FIB-SIMS), (scanning) transmission electron microscopy ((S)TEM), and atom probe tomography (APT). The results validate the ability of the method to achieve multimodal, combining correlative and complementary high-resolution structural and chemical imaging of individuals and clustered NPs. The proposed method confines picoliter-scale samples (6-60 pL) at a tip, eliminating lift-out and microtomy while enabling comprehensive analysis via combined microscopy techniques.</p>","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500622"},"PeriodicalIF":10.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving Spatial Transcriptomics with Membrane-Based Boundary Definition and Enhanced Single-Cell Resolution (Small Methods 5/2025) 利用基于膜的边界定义和增强的单细胞分辨率改进空间转录组学(小方法5/2025)
IF 10.7 2区 材料科学
Small Methods Pub Date : 2025-05-24 DOI: 10.1002/smtd.202570034
Li Song, Liqun Wang, Zitian He, Xiao Cui, Cheng Peng, Jie Xu, Zhouying Yong, Yanmei Liu, Ji-Feng Fei
{"title":"Improving Spatial Transcriptomics with Membrane-Based Boundary Definition and Enhanced Single-Cell Resolution (Small Methods 5/2025)","authors":"Li Song,&nbsp;Liqun Wang,&nbsp;Zitian He,&nbsp;Xiao Cui,&nbsp;Cheng Peng,&nbsp;Jie Xu,&nbsp;Zhouying Yong,&nbsp;Yanmei Liu,&nbsp;Ji-Feng Fei","doi":"10.1002/smtd.202570034","DOIUrl":"https://doi.org/10.1002/smtd.202570034","url":null,"abstract":"<p><b>Single-Cell Resolution</b></p><p>In article number 2401056, Yanmei Liu, Ji-Feng Fei, and co-workers introduce a cell membrane genetic-labeling model to precisely define cell boundaries in sequencing-based spatial transcriptomics. This work demonstrates that cell segmentation based on cell membranes more accurately represents the true single cells in actual tissues and organs compared to nucleus or algorithmic-based methods, particularly in the case of irregular and multinucleated cells, thereby improving single-cell resolution and enhancing the analytical power of spatial transcriptomics.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":229,"journal":{"name":"Small Methods","volume":"9 5","pages":""},"PeriodicalIF":10.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smtd.202570034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatial Transcriptomics: Biotechnologies, Computational Tools, and Neuroscience Applications (Small Methods 5/2025) 空间转录组学:生物技术、计算工具和神经科学应用(Small Methods 5/2025)
IF 10.7 2区 材料科学
Small Methods Pub Date : 2025-05-24 DOI: 10.1002/smtd.202570033
Qianwen Wang, Hongyuan Zhu, Lin Deng, Shuangbin Xu, Wenqin Xie, Ming Li, Rui Wang, Liang Tie, Li Zhan, Guangchuang Yu
{"title":"Spatial Transcriptomics: Biotechnologies, Computational Tools, and Neuroscience Applications (Small Methods 5/2025)","authors":"Qianwen Wang,&nbsp;Hongyuan Zhu,&nbsp;Lin Deng,&nbsp;Shuangbin Xu,&nbsp;Wenqin Xie,&nbsp;Ming Li,&nbsp;Rui Wang,&nbsp;Liang Tie,&nbsp;Li Zhan,&nbsp;Guangchuang Yu","doi":"10.1002/smtd.202570033","DOIUrl":"https://doi.org/10.1002/smtd.202570033","url":null,"abstract":"<p><b>Computational Tools</b></p><p>The image features spatial transcriptomics, displaying a brain section against a digital backdrop. This technology precisely maps gene expression in brain tissue, driving advances across multiple fields, from cell atlas to disease diagnostics, revolutionizing brain molecular research. More in article number 2401107 by Guangchuang Yu and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":229,"journal":{"name":"Small Methods","volume":"9 5","pages":""},"PeriodicalIF":10.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smtd.202570033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Learning Phenotype Associated Signature in Spatial Transcriptomics with PASSAGE (Small Methods 5/2025) 通过通道学习空间转录组学中的表型相关特征(小方法5/2025)
IF 10.7 2区 材料科学
Small Methods Pub Date : 2025-05-24 DOI: 10.1002/smtd.202570035
Chen-Kai Guo, Chen-Rui Xia, Guangdun Peng, Zhi-Jie Cao, Ge Gao
{"title":"Learning Phenotype Associated Signature in Spatial Transcriptomics with PASSAGE (Small Methods 5/2025)","authors":"Chen-Kai Guo,&nbsp;Chen-Rui Xia,&nbsp;Guangdun Peng,&nbsp;Zhi-Jie Cao,&nbsp;Ge Gao","doi":"10.1002/smtd.202570035","DOIUrl":"https://doi.org/10.1002/smtd.202570035","url":null,"abstract":"<p><b>Spatial Signature Identification</b></p><p>The cover image depicts a novel deep learning framework, PASSAGE, designed to automatically identify phenotype-associated spatial signatures across large-scale heterogeneous spatial transcriptomics cohorts, schematically represented by intertwining passages connecting different puzzle pieces (spatial transcriptomics record the ground-truth spatial location of cells, a process akin to reconstructing a scattered puzzle into its original landscape). More in article number 2401451 by Guangdun Peng, Zhi-Jie Cao, and Ge Gao and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":229,"journal":{"name":"Small Methods","volume":"9 5","pages":""},"PeriodicalIF":10.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smtd.202570035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Robust Kernel-Based Workflow for Niche Trajectory Analysis (Small Methods 5/2025) 基于鲁棒核的生态位轨迹分析工作流(Small Methods 5/2025)
IF 10.7 2区 材料科学
Small Methods Pub Date : 2025-05-24 DOI: 10.1002/smtd.202570031
Wen Wang, 王文, Sujung Crystal Shin, Joselyn Cristina Chávez-Fuentes, Guo-Cheng Yuan
{"title":"A Robust Kernel-Based Workflow for Niche Trajectory Analysis\t(Small Methods 5/2025)","authors":"Wen Wang,&nbsp;王文,&nbsp;Sujung Crystal Shin,&nbsp;Joselyn Cristina Chávez-Fuentes,&nbsp;Guo-Cheng Yuan","doi":"10.1002/smtd.202570031","DOIUrl":"https://doi.org/10.1002/smtd.202570031","url":null,"abstract":"<p><b>Niche Trajectory Analyses</b></p><p>In article number 2401199, Guo-Cheng Yuan and co-workers develop a kernel-based machine learning method for niche trajectory analysis. This method enables biologists to dissect the spatially continuous variations of tissue microenvironment from spatial omics data. This method is technology agnostic and does not require cell type annotation information.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":229,"journal":{"name":"Small Methods","volume":"9 5","pages":""},"PeriodicalIF":10.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smtd.202570031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dual-Functional Thermal Metamaterials: Decoupling Heat Flux and Temperature Fields for Advanced Thermal Management. 双功能热超材料:用于高级热管理的解耦热通量和温度场。
IF 10.7 2区 材料科学
Small Methods Pub Date : 2025-05-24 DOI: 10.1002/smtd.202500469
Yixin Liu, Xianrong Cao, Jiachang Li, Yinuo Zhou, Zifeng Tong, Zihao Zhang, Ziang Zhang, Dongsheng Jiao, Zhengdong Cheng, Liqun He
{"title":"Dual-Functional Thermal Metamaterials: Decoupling Heat Flux and Temperature Fields for Advanced Thermal Management.","authors":"Yixin Liu, Xianrong Cao, Jiachang Li, Yinuo Zhou, Zifeng Tong, Zihao Zhang, Ziang Zhang, Dongsheng Jiao, Zhengdong Cheng, Liqun He","doi":"10.1002/smtd.202500469","DOIUrl":"https://doi.org/10.1002/smtd.202500469","url":null,"abstract":"<p><p>Thermal metamaterials offer a powerful platform for precise thermal management, with exceptional potential in applications such as thermal camouflage, protection, and energy utilization. However, the inherent coupling of heat flux and temperature fields, governed by Fourier's law, limits existing thermal metamaterials to single functionality. For instance, in a classic thermal cloak, both heat flux and temperature gradients are absent within the cloaked region, repelling both fields similarly. Here, a design theory is proposed for dual-functional metamaterials that decouples the functions of heat flux and temperature fields through coordinate transformations along field lines, enabling their independent control. As proof of concept, six dual-functional meta-devices are developed, where the heat flux and temperature fields independently exhibit functions such as cloak, concentrator, and rotation. Furthermore, the Finite Element Method (FEM) is extended, enabling the programmable design of dual-functional thermal metamaterials. The work not only provides a universal design framework for independent functionality in coupled physical fields, but also offers potential applications extending to fields such as electronics, acoustics, and mechanics.</p>","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500469"},"PeriodicalIF":10.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Coordination Supramolecular Network Janus Separator Boost Sulfur Redox Dynamics in Lithium-Sulfur Batteries. 配位超分子网络Janus分离器提高锂硫电池中硫氧化还原动力学。
IF 10.7 2区 材料科学
Small Methods Pub Date : 2025-05-24 DOI: 10.1002/smtd.202500562
Zhao Chen, Yuanming Tan, Kaiji Lin, Shimei Lai, Chunshan Zhou, Shilin Huang, Yangyi Yang
{"title":"A Coordination Supramolecular Network Janus Separator Boost Sulfur Redox Dynamics in Lithium-Sulfur Batteries.","authors":"Zhao Chen, Yuanming Tan, Kaiji Lin, Shimei Lai, Chunshan Zhou, Shilin Huang, Yangyi Yang","doi":"10.1002/smtd.202500562","DOIUrl":"https://doi.org/10.1002/smtd.202500562","url":null,"abstract":"<p><p>Lithium-sulfur (Li-S) batteries are limited in practical application due to the dissolution and shuttle effect of lithium polysulfides (LiPSs) intermediates. Herein, a multifunctional Janus separator is designed that integrates the zirconium-based coordination supramolecular network (Zr-CSN) with the polypropylene (PP) membrane to fabricate Zr-CSN@PP. The Zr-CSN@PP constructs a barrier on the side of the sulfur cathode to block the passage of polysulfides, and the nanoporous structure of Zr-CSN transfers lithium ions quickly. The active zirconium sites and abundant oxygen-containing groups of Zr-CSN adsorb and catalyze the polysulfides effectively, which has been proved by experiments and theoretical calculations. Zr-CSN@PP promotes the migration of Li<sup>+</sup> (the lithium-ion transference number is 0.63) and improves the kinetics of sulfur evolution reactions, enhancing the electrochemical performance of Li-S batteries. The Li-S battery with Zr-CSN@PP separator has a capacity of 650.63 mAh g<sup>-1</sup> after 280 cycles at 0.5 C (average decay of 0.2% per cycle), and a capacity of 422.48 mAh g<sup>-1</sup> after 400 cycles at 2 C. This concept of porous coordination supramolecular networks Janus separator provides a broad prospect for advanced Li-S batteries.</p>","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500562"},"PeriodicalIF":10.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sainsc: A Computational Tool for Segmentation-Free Analysis of In Situ Capture Data (Small Methods 5/2025) Sainsc:现场捕获数据无分割分析的计算工具(Small Methods 5/2025)
IF 10.7 2区 材料科学
Small Methods Pub Date : 2025-05-24 DOI: 10.1002/smtd.202570036
Niklas Müller-Bötticher, Sebastian Tiesmeyer, Roland Eils, Naveed Ishaque
{"title":"Sainsc: A Computational Tool for Segmentation-Free Analysis of In Situ Capture Data (Small Methods 5/2025)","authors":"Niklas Müller-Bötticher,&nbsp;Sebastian Tiesmeyer,&nbsp;Roland Eils,&nbsp;Naveed Ishaque","doi":"10.1002/smtd.202570036","DOIUrl":"https://doi.org/10.1002/smtd.202570036","url":null,"abstract":"<p><b>Segmentation-Free Analyses</b></p><p>Sainsc: a new tool for efficient whole organism spatial transcriptomics data analysis at the nanometre scale. Shown is a blended composite spatial map of total gene expression (top), cell types (middle) and assignment confidence (bottom) of a mouse embryo Stereo-seq dataset from Chen et al. 2022. More in article number 2401123 by Naveed Ishaque and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":229,"journal":{"name":"Small Methods","volume":"9 5","pages":""},"PeriodicalIF":10.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smtd.202570036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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