Small Methods最新文献_第2页

On-Chip Light-Scattering Enhancement Enabled by a Microlens Array for High-Performance Single-Particle Tracking under Conventional Bright-Field Microscopy. 利用微透镜阵列实现芯片上光散射增强，用于传统亮场显微镜下的高性能单粒子跟踪。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-18 DOI: 10.1002/smtd.202402238

Pengcheng Zhang, Tingting Zhan, Guoqiang Gu, Changle Li, Xiaotian Tan, Yi Zhang, Hui Yang

{"title":"On-Chip Light-Scattering Enhancement Enabled by a Microlens Array for High-Performance Single-Particle Tracking under Conventional Bright-Field Microscopy.","authors":"Pengcheng Zhang, Tingting Zhan, Guoqiang Gu, Changle Li, Xiaotian Tan, Yi Zhang, Hui Yang","doi":"10.1002/smtd.202402238","DOIUrl":"https://doi.org/10.1002/smtd.202402238","url":null,"abstract":"Scattering-based single-particle tracking (S-SPT) has revolutionized the label-free detection and characterization of nanoscopic objects, offering immense potential for diverse analytical applications. However, the high technical demands placed on optical systems have long impeded its widespread adoption. To address this, an on-chip microlens-based approach that significantly enhances light scattering, thereby reducing the requirements on back-end optical systems, is introduced. Unlike existing field enhancement techniques, which are limited by their highly localized field, this approach leverages enhanced long-range optical fields and complex interactions between nanoparticles and the microlens to achieve an enhancement range ten times greater. This method enables high-performance S-SPT using a conventional bright-field microscope under incoherent light sources with relatively low illumination powers. The approach achieves nanometer localization precision for 60 nm gold nanoparticles in an aqueous medium within a substantial 750 µm2 field of view at a 200 µs exposure time. This advancement will significantly facilitate the practical application of S-SPT in biosensors and related fields, making it more accessible and versatile for a broad range of research and industrial applications.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2402238"},"PeriodicalIF":10.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial-Temporal Scanning Kelvin Probe Microscopy for Evaluating Ionic Velocity in Solid-State Electrolytes. 时空扫描开尔文探针显微镜评价固态电解质中的离子速度。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-17 DOI: 10.1002/smtd.202401135

Fang Wang, Shi Cheng, Xuyang Wang, Chunlin Song, Jiangyu Li, Hongyun Jin, Boyuan Huang

{"title":"Spatial-Temporal Scanning Kelvin Probe Microscopy for Evaluating Ionic Velocity in Solid-State Electrolytes.","authors":"Fang Wang, Shi Cheng, Xuyang Wang, Chunlin Song, Jiangyu Li, Hongyun Jin, Boyuan Huang","doi":"10.1002/smtd.202401135","DOIUrl":"https://doi.org/10.1002/smtd.202401135","url":null,"abstract":"Solid-state electrolytes (SSEs) with high ionic conductivity are crucial for the development of high-performance all-solid-state batteries. While a growing number of strategies based on nanoengineering are emerging to enhance the ionic conductivity of SSEs, understanding nanoscale ionic transport remains a nontrivial challenge. In this work, a simple yet effective approach is developed for in situ measuring microscopic ionic velocity in SSEs. Ionic transport under an electric field is directly captured using spatial-temporal scanning Kelvin probe microscopy (SKPM). This method reliably quantifies the microscopic ionic conductivity of SSEs, consistent with the results of macroscopic electrochemical impedance spectra, while providing nanoscale spatial resolution that is essential for comprehending ionic migration in nanostructured systems. The spatial-temporal SKPM, validated on LiZr2(PO4)3 and Li1.05Zr1.95Fe0.05(PO4)3, can be further extended to other SSEs for direct visualization of ionic migration dynamics. This work contributes to the understanding of ionic transport mechanisms and paves the way for advancements in the ionic conductivity of SSEs.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2401135"},"PeriodicalIF":10.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Superconfinement Engineering of Hetero-Nanoparticles in Ultrathin Carbon Nanosheets Enables Highly-Efficient Water Splitting. 超薄碳纳米片中异纳米颗粒的超约束工程实现高效水分解。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-17 DOI: 10.1002/smtd.202500643

Yang-Yang Xie, Hao Chen, Ying-Ying Zhang, Si-Chong Chen, Gang Wu, Yu-Zhong Wang

{"title":"Superconfinement Engineering of Hetero-Nanoparticles in Ultrathin Carbon Nanosheets Enables Highly-Efficient Water Splitting.","authors":"Yang-Yang Xie, Hao Chen, Ying-Ying Zhang, Si-Chong Chen, Gang Wu, Yu-Zhong Wang","doi":"10.1002/smtd.202500643","DOIUrl":"https://doi.org/10.1002/smtd.202500643","url":null,"abstract":"Developing highly active and robust bifunctional electrocatalysts for overall water splitting is of great significance for the production of green hydrogen energy. Herein, heterostructured CoP/NiCoP nanoparticles that are encapsulated one-to-one in nano caves of soda-biscuit-like ultrathin carbon nanosheets (CoP/NiCoP/CMS) are prepared, using melamine-formaldehyde sponge (MS) that grew Co/NiCo hydroxides as precursor and phytic acid (PA) as phosphorus source. Especially, the PA-induced blowing behavior during pyrolysis not only transforms the 3D networks of MS into 2D ultrathin carbon nanosheets of CMS, but also achieves the uniform one-to-one superconfinement of hetero-nanoparticles within both the intralayer nanocaves and interlayer spaces of the carbon nanosheets. Benefit from the superconfinement and interface engineering, CoP/NiCoP/CMS shows low overpotentials of 247 and 124 mV at 10 mA cm-2, as well as good stabilities toward both oxygen and hydrogen evolution reactions, respectively. Moreover, CoP/NiCoP/CMS//CoP/NiCoP/CMS electrolyzer only requires 1.56 V to achieve 10 mA cm-2. Experimental and theoretical results demonstrate that heterojunction interfaces can well regulate the electronic structure and enhance the intrinsic activity of CoP/NiCoP/CMS, meanwhile, soda-biscuit-like architecture guarantees the compatibility of high activity and good stability. This work proposes a novel and universal strategy for designing advanced electrocatalysts for efficient overall water splitting.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500643"},"PeriodicalIF":10.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical Stable and Ion Pump Interface Design Through Heterogeneous Interphase Layer for Dendrite-Free Sodium Metal Batteries. 无枝晶钠金属电池非均质界面层机械稳定性及离子泵界面设计。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-17 DOI: 10.1002/smtd.202500531

Xinshuang Miao, Ao Zhong, Sihang Xia, Songling Wu, Haichao Wang, Hao Li, Haoqing Ma, Yao Liu, Chao Yang, Kangning Zhao

{"title":"Mechanical Stable and Ion Pump Interface Design Through Heterogeneous Interphase Layer for Dendrite-Free Sodium Metal Batteries.","authors":"Xinshuang Miao, Ao Zhong, Sihang Xia, Songling Wu, Haichao Wang, Hao Li, Haoqing Ma, Yao Liu, Chao Yang, Kangning Zhao","doi":"10.1002/smtd.202500531","DOIUrl":"https://doi.org/10.1002/smtd.202500531","url":null,"abstract":"Sodium-metal batteries (SMBs) emerge as a promising alternative to lithium-metal systems but face intrinsic challenges of unstable electrode/electrolyte interfaces and rampant dendrite growth, which compromise cyclability and safety. Here, a multifunctional heterogeneous interphase layer (IMS-Na) with an ion pumping function on metallic sodium is constructed. This is enabled via an in situ reaction of Sb2Se3 powder with Na at room temperature by forming a Na3Sb/Na2Se hybrid structure as an artificial SEI layer. This artificial SEI layer synergizes ion pumping Na3Sb with high ionic conductivity (adsorption energy: -1.31 eV, migration barrier: 0.49 eV) and mechanically stable Na2Se with electronic insulation (bandgap: 2.11 eV) and mechanical robustness (Young's modulus: 60.63 GPa). The ion pumping Na3Sb homogenizes the \"hot spot\" to suppress dendrite formation while the mechanically stable Na2Se ensures the durability of the interface, which synergically enables dendrite-free Na deposition. As a result, the IMS-Na anode achieves ultralow polarization (30 mV) and unprecedented cycling stability (1535 h at 0.5 mA cm-2) in carbonate electrolytes. Paired with a Na3V2(PO4)3 cathode, the full cell delivers long-term stability (1400 cycles) and high-rate capacity (102 mAh g-1 at 2 A g-1). This work establishes a design paradigm for artificial SEI layers, balancing ionic transport, electronic insulation, and mechanical resilience, critical for advancing high-energy-density metal batteries.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500531"},"PeriodicalIF":10.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pioneering Biomedical Applications with Intelligent Engineering. 以智能工程开拓生物医学应用。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-17 DOI: 10.1002/smtd.202501013

Zhi-Bei Qu, Tao Sun, Lu Zhou

引用次数: 0

Theoretical Explanation of Diatomic Synergies and Repulsion Interactions between ORR/OER Catalytic Intermediates. ORR/OER催化中间体间双原子协同作用和斥力相互作用的理论解释。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-17 DOI: 10.1002/smtd.202500310

Ninggui Ma, Chihon Leung, Yuhang Wang, Yaqin Zhang, Shuang Luo, Han Liu, Bochun Liang, Changxiong Huang, Zhanhua Wei, Yang Ren, Jun Fan

{"title":"Theoretical Explanation of Diatomic Synergies and Repulsion Interactions between ORR/OER Catalytic Intermediates.","authors":"Ninggui Ma, Chihon Leung, Yuhang Wang, Yaqin Zhang, Shuang Luo, Han Liu, Bochun Liang, Changxiong Huang, Zhanhua Wei, Yang Ren, Jun Fan","doi":"10.1002/smtd.202500310","DOIUrl":"https://doi.org/10.1002/smtd.202500310","url":null,"abstract":"Oxygen reduction reactions (ORR) and oxygen evolution reactions (OER) are pivotal in energy conversion. Herein, first-principles calculations are employed to explore cooperative catalysis's influence on catalysts with doping and adsorption configurations. Specifically, doped and adsorbed metal atoms are explored on MXene, analyze bimetallic system's electronic properties via density of states, and investigate catalytic activity in homonuclear and heteronuclear diatomic cooperative reactions. It is found that heteronuclear diatomic cooperation substantially enhances catalyst activity, unveiling high-efficacy catalysts like Ni&/Co*OOH (ηORR/OER/Bi = 0.29/0.37/0.66 V) and Ni&/Co*O (ηORR/OER/Bi = 0.40/0.16/0.56 V). Such ultra-high catalytic activity is primarily attributed to the repulsive interactions between catalytic intermediates at neighboring active sites, which modulate the charge distribution at the target sites during the catalytic process, as well as the density of atomic orbital centers of the catalytic atoms. The findings offer a potential explanation for the discrepancies observed between theoretical calculations and experimental results.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500310"},"PeriodicalIF":10.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revealing the Ferroelectric Fatigue Pathways in HfO₂ Film. 揭示HfO 2薄膜中的铁电疲劳途径。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-16 DOI: 10.1002/smtd.202402176

Yufeng Xue, Qi Hu, Zhongfei Xu, Tongcai Yue, Shuning Lv, Chuang Xue, Tingxiao Xie, Chuanjia Tong, Tengfei Cao, Gilberto Teobaldi, Li-Min Liu

{"title":"Revealing the Ferroelectric Fatigue Pathways in HfO₂ Film.","authors":"Yufeng Xue, Qi Hu, Zhongfei Xu, Tongcai Yue, Shuning Lv, Chuang Xue, Tingxiao Xie, Chuanjia Tong, Tengfei Cao, Gilberto Teobaldi, Li-Min Liu","doi":"10.1002/smtd.202402176","DOIUrl":"https://doi.org/10.1002/smtd.202402176","url":null,"abstract":"Hafnium oxide (HfO₂) has emerged as a transformative material for next-generation non-volatile memory technologies due to its unique ability to exhibit ferroelectricity in ultrathin films. Its practical application is critically hindered by polarization fatigue and depolarization phenomena, while the inherent complexity of these transitions between ferroelectric and paraelectric state in HfO₂ has posed significant challenges. Here, symmetry analysis and with first-principles calculations is leveraged to systematically explore all potential transition pathways from the ferroelectric oIII/oIV phases to the paraelectric mI/mII phases. The results demonstrate that multiple-pathways involving intermediate phases, such as <math> <semantics><mrow><mi>F</mi> <mi>m</mi> <mover><mn>3</mn> <mo>¯</mo></mover> <mi>m</mi></mrow> <annotation>$Fmbar 3m$</annotation></semantics> </math> , <math> <semantics><mrow><mi>P</mi> <msub><mn>4</mn> <mn>2</mn></msub> <mo>/</mo> <mi>nmc</mi></mrow> <annotation>$P{4}_{2}/textit{nmc}$</annotation></semantics> </math> , and <math> <semantics><mrow><mi>P</mi> <msub><mn>4</mn> <mn>2</mn></msub> <mo>/</mo> <mi>nmc</mi></mrow> <annotation>$P{4}_{2}/textit{nmc}$</annotation></semantics> </math> , require relatively high energy barriers ranging from 0.33 to 0.71 eV per unit cell. In contrast, a direct transition from oIII to mI requires overcoming an energy barrier of only 0.11 eV per unit cell, suggesting that ferroelectric fatigue can occur along the direct pathway rather than multiple ones. This direct transition induces an in-plane expansion of ≈4%, thus applying in-plane confinement or compressive strain can be effective in suppressing fatigue. These findings provide a comprehensive framework for elucidating the phase transition dynamics and mechanisms underlying ferroelectric fatigue in HfO₂, offering critical insights for optimizing its integration into advanced memory technologies.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2402176"},"PeriodicalIF":10.7,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Situ Analysis for Protein Corona: from Morphology, Composition, Structure to Dynamic Process. 蛋白质电晕的原位分析：从形态、组成、结构到动态过程。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-16 DOI: 10.1002/smtd.202500348

Shengtao Yu, Didar Baimanov, Zhenzhen Guo, Qing Gao, Chunying Chen, Mateus Borba Cardoso, Liming Wang

{"title":"In Situ Analysis for Protein Corona: from Morphology, Composition, Structure to Dynamic Process.","authors":"Shengtao Yu, Didar Baimanov, Zhenzhen Guo, Qing Gao, Chunying Chen, Mateus Borba Cardoso, Liming Wang","doi":"10.1002/smtd.202500348","DOIUrl":"https://doi.org/10.1002/smtd.202500348","url":null,"abstract":"The formation of a protein corona (PC) on the surface of nanoparticles (NPs) in biological environments is a critical factor influencing the fate and functionality of NPs in vivo. This biolayer affects NPs' biodistribution, immune recognition, cellular uptake, and therapeutic efficacy, making it essential for the rational design of nanomedicines. However, traditional analytical techniques often disrupt the native state of the PC, particularly its loosely bound soft corona (SC), leading to incomplete characterizations. In situ analysis methods offer a more accurate representation of PC composition, structure, and dynamics by preserving its native biological context. This review highlights critical advances in in situ PC analysis techniques, including methods for composition identification, structural visualization, and monitoring the dynamic evolution of the PC. It emphasizes the importance of real-time, non-disruptive analysis to better understand the nano-bio interface and its implications for nanomedicine design and safety. Additionally, it discusses challenges in current PC analysis methodologies and proposes future research directions to improve in situ characterization accuracy and standardization.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500348"},"PeriodicalIF":10.7,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding Charge Recombination and Extraction at Perovskite Interfaces with Transient Photoluminescence. 瞬态光致发光在钙钛矿界面上的解码电荷重组和萃取。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-16 DOI: 10.1002/smtd.202500396

Qianyu Huang, Wei Meng, Zhangyu Yuan, Hao Li, Fei Huang, Ning Li

{"title":"Decoding Charge Recombination and Extraction at Perovskite Interfaces with Transient Photoluminescence.","authors":"Qianyu Huang, Wei Meng, Zhangyu Yuan, Hao Li, Fei Huang, Ning Li","doi":"10.1002/smtd.202500396","DOIUrl":"https://doi.org/10.1002/smtd.202500396","url":null,"abstract":"Understanding charge carrier dynamics at buried interfaces is pivotal for the rational design of high-performance perovskite solar cells (PSCs). This study presents a novel methodology combining transient photoluminescence spectroscopy with a differential equation-based analytical framework to elucidate the interplay between charge extraction and recombination processes at perovskite interfaces. The results demonstrate that the superior efficiency of self-assembled monolayer (SAM)-based devices, in comparison to conventional semiconductor thin-film-based hole transport layers, is primarily attributed to a substantially reduced defect-mediated recombination rate. While the hole extraction efficiency of SAMs is relatively low, particularly under low carrier concentrations, the findings underscore that excessive optimization of charge extraction is not the primary determinant of device performance. Instead, precise regulation of interfacial defects and mitigation of Shockley-Read-Hall (SRH) recombination emerge as critical factors for performance enhancement. These insights provide a robust framework for the interface design and optimization of PSCs. Moreover, the proposed approach serves as a non-contact, high-throughput tool for evaluating the quality of buried interfaces, facilitating accelerated material discovery, and advancing energy research.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500396"},"PeriodicalIF":10.7,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomedicine for Oral Delivery: Strategies to Overcome the Biological Barriers. 口服纳米药物：克服生物障碍的策略。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-16 DOI: 10.1002/smtd.202500624

Luke J Kubiatowicz, Nima Pourafzal, Audrey T Zhu, Zhongyuan Guo, Ronnie H Fang, Liangfang Zhang

{"title":"Nanomedicine for Oral Delivery: Strategies to Overcome the Biological Barriers.","authors":"Luke J Kubiatowicz, Nima Pourafzal, Audrey T Zhu, Zhongyuan Guo, Ronnie H Fang, Liangfang Zhang","doi":"10.1002/smtd.202500624","DOIUrl":"https://doi.org/10.1002/smtd.202500624","url":null,"abstract":"Oral drug delivery is highly desirable for medical intervention due to its convenience, patient adherence, and non-invasiveness. Despite significant efforts, the successful oral delivery of therapeutics and prophylactics has been largely hindered by biological barriers that limit bioavailability. Researchers have since turned to nanoparticles as promising delivery vehicles that offer tunable properties to protect therapeutic payloads and enhance transport across these barriers. In addition to material optimization and delivery strategies, biomimetic designs-particularly those inspired by viruses-have significantly advanced the field, leveraging natural mechanisms to penetrate mucosal layers through size, charge, and enzymatic functions. This review examines the key physiological challenges limiting oral drug absorption, including the harsh gastric environment, the mucosal layer, and the polarized epithelial barrier. Recent preclinical advancements are then highlighted in nanoparticle engineering aimed at overcoming these barriers and improving bioavailability. Continued innovation in oral nanomedicine holds immense potential to revolutionize treatment paradigms, enhancing both therapeutic efficacy and patient outcomes worldwide.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500624"},"PeriodicalIF":10.7,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0