Small Methods最新文献_第3页

Ultrahigh-Selectivity Photocatalytic Upgrading of Bio-Aldehydes/Diols to Monoalcohols Via In Situ Circumventing Coupling Co-Products Over Janus Single-Atom Pd/TiO₂. 生物醛/二醇在Janus单原子Pd/TiO2上通过原位环偶联副产物的超高选择性光催化升级为单醇。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-01-15 DOI: 10.1002/smtd.202401510

Ye Meng, Jie Li, Huan Liu, Tengyu Liu, Jinguang Hu, Hu Li

{"title":"Ultrahigh-Selectivity Photocatalytic Upgrading of Bio-Aldehydes/Diols to Monoalcohols Via In Situ Circumventing Coupling Co-Products Over Janus Single-Atom Pd/TiO2.","authors":"Ye Meng, Jie Li, Huan Liu, Tengyu Liu, Jinguang Hu, Hu Li","doi":"10.1002/smtd.202401510","DOIUrl":"https://doi.org/10.1002/smtd.202401510","url":null,"abstract":"Photocatalytic transfer hydrogenation of biomass-derived aldehydes to alcohols often results in unwanted coupling co-products. Herein, an ultraselective hydrogen transfer system enabled by in situ oxidative C─C bond cleavage over a Janus single-atom palladium on titanium dioxide (0.5Pd/TiO2) photocatalyst is presented. The TiO2 carrier promotes hydrogen-donor activation, while Pd single atoms function as both electron and hydrogen transfer centers, enabling photocatalytic conversion of bio-based furfural to furfuryl alcohol in >99% yield using ethanol as solvent/H-donor at 25 °C. The control/in situ experiments and calculations reveal that ethanol on 0.5Pd/TiO2 preferentially activates a co-formed coupling by-product to undergo C─C bond cleavage followed by proton-coupled electron transfer, exclusively producing furfuryl alcohol. 0.5Pd/TiO2 with good reusability is applicable to hydrogenative upgrading of various aldehydes/diols into corresponding monoalcohols with 81‒99% yields. This in situ Janus photocatalytic conversion strategy offers a new approach to eliminate side reactions in reductive upgrading of unsaturated organics/biomass with high selectivity.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2401510"},"PeriodicalIF":10.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bifunctional NiCo-CuO Nanostructures: A Promising Catalyst for Energy Conversion and Storage. 双功能NiCo-CuO纳米结构：一种有前途的能量转换和储存催化剂。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-01-15 DOI: 10.1002/smtd.202401463

Thanigai Arul Kumaravelu, Ta Thi Thuy Nga, Ramana Ramya J, Gajendiran J, Karthikeyan M, Wu-Ching Chou, Jeng-Lung Chen, Chi-Liang Chen, Bi-Hsuan Lin, Chao-Hung Du, Ping-Hung Yeh, Asokan Kandasami, Ju-Hung Hsu, Chun-Chieh Wang, Chung-Li Dong

{"title":"Bifunctional NiCo-CuO Nanostructures: A Promising Catalyst for Energy Conversion and Storage.","authors":"Thanigai Arul Kumaravelu, Ta Thi Thuy Nga, Ramana Ramya J, Gajendiran J, Karthikeyan M, Wu-Ching Chou, Jeng-Lung Chen, Chi-Liang Chen, Bi-Hsuan Lin, Chao-Hung Du, Ping-Hung Yeh, Asokan Kandasami, Ju-Hung Hsu, Chun-Chieh Wang, Chung-Li Dong","doi":"10.1002/smtd.202401463","DOIUrl":"https://doi.org/10.1002/smtd.202401463","url":null,"abstract":"This investigation explores the potential of co-incorporating nickel (Ni) and cobalt (Co) into copper oxide (CuO) nanostructures for bifunctional electrochemical charge storage and oxygen evolution reactions (OER). A facile wet chemical synthesis method is employed to co-incorporate Ni and Co into CuO, yielding diverse nanostructured morphologies, including rods, spheres, and flake. The X-ray diffraction (XRD) and Raman analyses confirmed the formation of NiCo-CuO nanostructure, with minor phases of nickel oxide (NiO) and cobalt tetraoxide (Co3O4). High-resolution Transmission Electron Microscope (HRTEM) also confirms the diverse morphologies and the minor phases of oxides. Synchrotron X-ray absorption spectroscopy revealed higher charge states of Cu, Ni, and Co in the NiCo-CuO nanostructure, enhancing its charge storage and OER. Site-selective X-ray absorption near edge structure analysis elucidated the spatial distribution of Cu, Ni, and Co in the nanostructure. Furthermore, extended X-ray absorption fine structure spectroscopy provided insights into the local atomic structures, revealing increased coordination numbers and interatomic distances in the NiCo-CuO nanostructure. In situ Raman analysis discloses the transformation of Co3O4 into cobalt hydroxide (Co(OH)2) and cobalt oxide (CoO) into cobalt oxyhydroxide (CoOOH) The NiCo-CuO nanostructures exhibited superior specific capacitance, favorable Tafel behavior, and low overpotential positioning as promising bifunctional materials for energy storage and conversion applications. This work contributes to the development of efficient CuO nanocatalysts.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2401463"},"PeriodicalIF":10.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress Release of Zincophilic N-Doped Carbon@Sn Composite on High-Curvature Surface of Zinc Foam for Dendrite-Free 3D Zinc Anode. 亲锌n掺杂Carbon@Sn复合材料在无枝晶三维锌阳极泡沫锌高曲率表面的应力释放

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-01-15 DOI: 10.1002/smtd.202401817

Yunhui Lin, Fang Lin, Ming Zhang, Xingxing Jiao, Panpan Dong, Weiqing Yang

{"title":"Stress Release of Zincophilic N-Doped Carbon@Sn Composite on High-Curvature Surface of Zinc Foam for Dendrite-Free 3D Zinc Anode.","authors":"Yunhui Lin, Fang Lin, Ming Zhang, Xingxing Jiao, Panpan Dong, Weiqing Yang","doi":"10.1002/smtd.202401817","DOIUrl":"https://doi.org/10.1002/smtd.202401817","url":null,"abstract":"Commercial 3D zinc foam anodes with high deposition space and ion permeation have shown great potential in aqueous ion batteries. However, the local accumulated stress from its high-curvature surface exacerbates the Zn dendrite issue, leading to poor reversibility. Herein, we have employed zincophilic N-doped carbon@Sn composites (N-C@Sn) as nano-fillings to effectively release the local stress of high curvature surface of 3D Zn foams toward dendrite-free anode in aqueous zinc ion battery (AZIB). These electronegative and conductive N-C@Sn nano-fillings as supporters can provide a highly zincophilic channel for initial Zn nucleation and reduce local current density for regulating Zn deposition. Uniform Zn deposition further assists homogenous stress distribution on the platting surface, which gives a positive feedback loop to improve anode reversibility. As a result, zinc foam with N-C@Sn composite (ZCSn Foam) symmetric cell achieves a long cycle lifespan of 1100h at 0.5 mA cm-2, much more than that of Zn Foam (∼80 h lifespan). The full cell ZCSn Foam||MnO2 exhibits remarkable reversibility with 67% retention after 1000 cycles at 0.8 A g-1 and 76% after 1600 cycles at 2 Ag-1. This 3D-constructing strategy may offer a promising and practical pathway for metal anode application.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2401817"},"PeriodicalIF":10.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Flexible Perovskite Photovoltaic Cells and Modules Through Light-Trapping and Light-Shifting Strategies. 通过捕光和光移策略增强柔性钙钛矿光伏电池和组件。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-01-15 DOI: 10.1002/smtd.202401954

Mingzhu He, Yin Gao, Huilin Tan, Haoyang Zhang, Zexing Zhuang, Shaohang Wu, Yanyan Gao, Cuiling Zhang, Liang Liu, Qinrong Luo, Li Qin, Peng Jia, Chong Liu, Ruud E I Schropp, Yaohua Mai

{"title":"Enhancing Flexible Perovskite Photovoltaic Cells and Modules Through Light-Trapping and Light-Shifting Strategies.","authors":"Mingzhu He, Yin Gao, Huilin Tan, Haoyang Zhang, Zexing Zhuang, Shaohang Wu, Yanyan Gao, Cuiling Zhang, Liang Liu, Qinrong Luo, Li Qin, Peng Jia, Chong Liu, Ruud E I Schropp, Yaohua Mai","doi":"10.1002/smtd.202401954","DOIUrl":"https://doi.org/10.1002/smtd.202401954","url":null,"abstract":"Flexible perovskite photovoltaic devices are typically constructed on flexible polyethylene naphthalate (PEN) substrates, which exhibit near-ultraviolet absorption and high visible-light reflection, leading to significant optical losses. To address this issue, a reusable optical-management sticker tailored for flexible substrates has been proposed in this work. The sticker incorporates a light-shifting material that converts near-ultraviolet light into visible light, enabling photoelectric conversion of near-ultraviolet light. Additionally, the sticker features a light-trapping microstructure that creates a refractive index gradient from PEN to air, thereby achieving a significant anti-reflection effect. As a result, the efficiency of a flexible perovskite solar cell reached 23.05% (certified 22.46%) under 1 sun AM1.5G illumination and 36.65% (certified 34.03%) under 1000 lux artificial light illumination. Furthermore, scaling this solution to large-area modules has yielded remarkable improvements, achieving a breakthrough certified efficiency of 20.48% (aperture area 21 cm2) in flexible perovskite photovoltaic modules.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2401954"},"PeriodicalIF":10.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrafast Synthesis of Hard Carbon Anodes for Sodium-ion Batteries: An Intense-Pulsed-Light-Assisted Approach to Photothermal Carbonization of Polymer/Carbon Nanotube Composite Films. 钠离子电池硬碳阳极的超快合成：一种强脉冲光辅助的聚合物/碳纳米管复合膜光热碳化方法。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-01-15 DOI: 10.1002/smtd.202401801

Gyeongbeom Ryoo, Mi-Jeong Kim, Min Su Kim, Sunghyeon Shin, Jae-Won Lee, Byeong Guk Kim, Do Geun Lee, Yujin Kim, Hyunjeong Seo, Joon Young Cho, Joong Tark Han, Seung Yol Jeong, Jungmo Kim, Dong Yun Lee, Hee Jin Jeong, Jong Hwan Park

{"title":"Ultrafast Synthesis of Hard Carbon Anodes for Sodium-ion Batteries: An Intense-Pulsed-Light-Assisted Approach to Photothermal Carbonization of Polymer/Carbon Nanotube Composite Films.","authors":"Gyeongbeom Ryoo, Mi-Jeong Kim, Min Su Kim, Sunghyeon Shin, Jae-Won Lee, Byeong Guk Kim, Do Geun Lee, Yujin Kim, Hyunjeong Seo, Joon Young Cho, Joong Tark Han, Seung Yol Jeong, Jungmo Kim, Dong Yun Lee, Hee Jin Jeong, Jong Hwan Park","doi":"10.1002/smtd.202401801","DOIUrl":"https://doi.org/10.1002/smtd.202401801","url":null,"abstract":"The conventional carbonization process for synthesizing hard carbons (HCs) requires high-temperature furnace operations exceeding 1000 °C, leading to excessive energy consumption and lengthy processing times, which necessitates the exploration of more efficient synthesis methods. This study demonstrates the rapid preparation of HC anodes using intense pulsed light (IPL)-assisted photothermal carbonization without the prolonged and complex operations typical of traditional carbonization methods. A composite film of microcrystalline cellulose (MCC) and single-walled carbon nanotubes (SWCNTs) is carbonized at high temperatures in less than 1 min. The SWCNTs efficiently absorbed light energy, enabling ultrafast heating and eliminating the need for prolonged, high-energy furnace-based processes. The IPL-assisted HC anodes exhibited excellent electrochemical performance, with an initial desodiation capacity of 260.4 mAh g⁻¹anode and 97.5% capacity retention after 200 cycles. These results are comparable to those achieved using traditional furnace-based carbonization processes, such as carbonizing HC anodes at 1200 °C, validating the effectiveness of IPL-assisted processes. Additionally, surface and structural analyses revealed the development of pseudo-graphitic domains, crucial for enhanced sodium-ion storage. This research highlights IPL-assisted photothermal carbonization as a viable, time-efficient, and energy-saving alternative to conventional methods, offering a sustainable pathway for the large-scale production of HC anodes for future sodium-ion battery technologies.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2401801"},"PeriodicalIF":10.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copper Tantalate by a Sodium-Driven Flux-Mediated Synthesis for Photoelectrochemical CO₂ Reduction. 钠驱动通量介导合成钽酸铜用于光电化学CO2还原。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-01-15 DOI: 10.1002/smtd.202401432

Ariadne Köche, Kootak Hong, Sehun Seo, Finn Babbe, Hyeongyu Gim, Keon-Han Kim, Hojoong Choi, Yoonsung Jung, Inhyeok Oh, Gnanavel Vaidhyanathan Krishnamurthy, Michael Störmer, Sanghan Lee, Tae-Hoon Kim, Alexis T Bell, Sherdil Khan, Carolin M Sutter-Fella, Francesca M Toma

{"title":"Copper Tantalate by a Sodium-Driven Flux-Mediated Synthesis for Photoelectrochemical CO2 Reduction.","authors":"Ariadne Köche, Kootak Hong, Sehun Seo, Finn Babbe, Hyeongyu Gim, Keon-Han Kim, Hojoong Choi, Yoonsung Jung, Inhyeok Oh, Gnanavel Vaidhyanathan Krishnamurthy, Michael Störmer, Sanghan Lee, Tae-Hoon Kim, Alexis T Bell, Sherdil Khan, Carolin M Sutter-Fella, Francesca M Toma","doi":"10.1002/smtd.202401432","DOIUrl":"https://doi.org/10.1002/smtd.202401432","url":null,"abstract":"Copper-tantalate, Cu2Ta4O11 (CTO), shows significant promise as an efficient photocathode for multi-carbon compounds (C2+) production through photoelectrochemical (PEC) CO2 reduction, owing to its suitable energy bands and catalytic surface. However, synthesizing CTO poses a significant challenge due to its metastable nature and thermal instability. In this study, this challenge is addressed by employing a flux-mediated synthesis technique using a sodium-based flux to create sodium-doped CTO (Na-CTO) thin films, providing enhanced nucleation and stabilization for the CTO phase. To evaluate the PEC performance and catalytic properties of the films, copper(II) oxide (CuO) at the Na-CTO surface is selectively etched. The etched Na-CTO shows a lower dark current, with decreased contribution from photocorrosion, unlike the non-etched Na-CTO which has remaining CuO on the surface. Furthermore, Na-CTO exhibits 7.3-fold ethylene selectivity over hydrogen, thus highlighting its promising potential as a photocathode for C2+ production through PEC CO2 reduction.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2401432"},"PeriodicalIF":10.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Evolution of Nucleic Acid Nanotechnology: From DNA Assembly to DNA-Encoded Library. 核酸纳米技术的进化：从DNA组装到DNA编码文库。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-01-13 DOI: 10.1002/smtd.202401631

Qigui Nie, Xianfu Fang, Jiale Huang, Tingting Xu, Yangfeng Li, Gong Zhang, Yizhou Li

{"title":"The Evolution of Nucleic Acid Nanotechnology: From DNA Assembly to DNA-Encoded Library.","authors":"Qigui Nie, Xianfu Fang, Jiale Huang, Tingting Xu, Yangfeng Li, Gong Zhang, Yizhou Li","doi":"10.1002/smtd.202401631","DOIUrl":"https://doi.org/10.1002/smtd.202401631","url":null,"abstract":"Deoxyribonucleic acid (DNA), a fundamental biomacromolecule in living organisms, serves as the carrier of genetic information. Beyond its role in encoding biological functions, DNA's inherent ability to hybridize through base pairing has opened new avenues for its application in biological sciences. This review introduces DNA nanotechnology and DNA-encoded library (DEL), and highlights their shared design principles related to DNA assembly. First, a foundational overview of structural DNA nanotechnology, including its design strategies and historical development is provided. Subsequently, various approaches are examined to dynamic DNA nanotechnology, from strand displacement reactions to DNA-templated polymer synthesis. Second, how the principle of DNA assembly has facilitated the development of diverse formats of self-assembly-based DEL synthesis, DNA-template reactions (DTS), and DNA template-mediated proximity induction effects are examined. These advancements are all underpinned by the unique property of DNA assembly. Finally, this review summarizes the common principles shared by DNA nanotechnology and DEL in terms of methodology and design. Additionally, the potential synergies are explored between these two technologies, envisioning future applications where they can be combined to create more versatile and exquisite functionalities.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2401631"},"PeriodicalIF":10.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances on Characterization Techniques for the Composition-Structure-Property Relationships of Solid Electrolyte Interphase. 固体电解质界面相组成-结构-性能关系表征技术研究进展。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-01-13 DOI: 10.1002/smtd.202401786

Hongyi Lu, Mangayarkarasi Nagarathinam, Yue Chen, Weijian Zhang, Xi Chen, Jing Chen, Jianming Tao, Jiaxin Li, Yingbin Lin, Oleg Kolosov, Zhigao Huang

{"title":"Recent Advances on Characterization Techniques for the Composition-Structure-Property Relationships of Solid Electrolyte Interphase.","authors":"Hongyi Lu, Mangayarkarasi Nagarathinam, Yue Chen, Weijian Zhang, Xi Chen, Jing Chen, Jianming Tao, Jiaxin Li, Yingbin Lin, Oleg Kolosov, Zhigao Huang","doi":"10.1002/smtd.202401786","DOIUrl":"https://doi.org/10.1002/smtd.202401786","url":null,"abstract":"The Solid Electrolyte Interphase (SEI) is a nanoscale thickness passivation layer that forms as a product of electrolyte decomposition through a combination of chemical and electrochemical reactions in the cell and evolves over time with charge/discharge cycling. The formation and stability of SEI directly determine the fundamental properties of the battery such as first coulombic efficiency (FCE), energy/power density, storage life, cycle life, and safety. The dynamic nature of SEI along with the presence of spatially inhomogeneous organic and inorganic components in SEI encompassing crystalline, amorphous, and polymeric nature distributed across the electrolyte to the electrolyte-electrode interface, highlights the need for advanced in situ/operando techniques to understand the formation and structure of these materials in creating a stable interface in real-world operating conditions. This perspective discusses the recent developments in interface-sensitive in situ/operando techniques, providing valuable insights and addressing the challenges of understanding the composition/structure/property of SEI and their correlations during the formation processes at spatio-temporal resolution across various length scales.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2401786"},"PeriodicalIF":10.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nucleophilic Reactions of Phosphorothioate Oligonucleotides. 硫代寡核苷酸的亲核反应。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-01-12 DOI: 10.1002/smtd.202401476

Jin Jin, Cheng Tian, Chunfa Chen, Cheng Zhi Huang, Hua Zuo

{"title":"Nucleophilic Reactions of Phosphorothioate Oligonucleotides.","authors":"Jin Jin, Cheng Tian, Chunfa Chen, Cheng Zhi Huang, Hua Zuo","doi":"10.1002/smtd.202401476","DOIUrl":"https://doi.org/10.1002/smtd.202401476","url":null,"abstract":"The nucleophilic reaction between phosphorothioate oligonucleotides and electrophilic reagents has become a cost-effective and efficient approach for oligonucleotide functionalization. This method allows for the precise incorporation of desired chemical structures at specific sites on the phosphorothioate backbone through conjugation with electrophilic groups. The reaction is characterized by its high reactivity and yield, as well as its ability to enhance the hydrophilicity of otherwise hydrophobic compounds. Importantly, this modification preserves the structural and functional integrity of the oligonucleotides, making it a topic of significant interest in nucleic acid research. This article reviews recent advancements in the covalent conjugation of phosphorothioate oligonucleotides with various electrophilic compounds. The article starts with an overview of the mechanisms and general reaction conditions involved in nucleophilic reactions. It then proceeds to examine the distinctive properties and benefits of various electrophilic reagents, offering insights that can inform the rational design of phosphorothioate oligonucleotide functionalization. Finally, the article addresses both the challenges and opportunities in this field, providing perspectives on future theoretical and practical developments to enhance the application of phosphorothioate oligonucleotides in areas like structural analysis, drug develop, drug delivery, fluorescent labeling, and nucleic acid nanotechnology.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2401476"},"PeriodicalIF":10.7,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Giant-Shell CdSe/CdS Quantum Dots via Analytical Ultracentrifugation Combined with Spectrally Resolved Photoluminescence. 通过分析超速离心结合光谱分辨光致发光分析巨壳镉/镉Se/镉S量子点

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-01-12 DOI: 10.1002/smtd.202401700

Lisa M S Stiegler, K David Wegner, Florian Weigert, Wolfgang Peukert, Ute Resch-Genger, Johannes Walter

{"title":"Analysis of Giant-Shell CdSe/CdS Quantum Dots via Analytical Ultracentrifugation Combined with Spectrally Resolved Photoluminescence.","authors":"Lisa M S Stiegler, K David Wegner, Florian Weigert, Wolfgang Peukert, Ute Resch-Genger, Johannes Walter","doi":"10.1002/smtd.202401700","DOIUrl":"https://doi.org/10.1002/smtd.202401700","url":null,"abstract":"Knowledge of the structure-property relationships of functional nanomaterials, including, for example, their size- and composition-dependent photoluminescence (PL) and particle-to-particle variations, is crucial for their design and reproducibility. Herein, the Angstrom-resolution capability of an analytical ultracentrifuge combined with an in-line multiwavelength emission detection system (MWE-AUC) for measuring the sedimentation coefficient-resolved spectrally corrected PL spectra of dispersed nanoparticles is demonstrated. The capabilities of this technique are shown for giant-shell CdSe/CdS quantum dots (g-QDs) with a PL quantum yield (PL QY) close to unity capped with oleic acid and oleylamine ligands. The MWE-AUC PL measurements are calibrated and validated with certified fluorescence standards. The spectrally corrected and size-dependent PL spectra of the g-QDs derived from a single MWE-AUC experiment are then analyzed and compared with the results of single-particle spectroscopic studies, yielding the PL spectra, decay kinetics, and blinking behavior of individual g-QDs. This study underlines the vast potential of MWE-AUC with in-line optical detection for the characterization of advanced nanomaterials with a complex structure.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2401700"},"PeriodicalIF":10.7,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0