Small Methods最新文献_第4页

Challenges and Opportunities of Uranium Extraction From Seawater: a Systematic Roadmap From Laboratory to Industry (Small Methods 3/2025)

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-20 DOI: 10.1002/smtd.202570020

Tao Wang, Binbin Tao, Bin Zuo, Guoze Yan, Shaoqing Liu, Ruoyu Wang, Zhongzhou Zhao, Feifei Chu, Zhengtong Li, Yusuke Yamauchi, Xingtao Xu

引用次数: 0

Strain-Engineered 2D Materials: Challenges, Opportunities, and Future Perspectives (Small Methods 3/2025)

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-20 DOI: 10.1002/smtd.202570018

Ajit Kumar Katiyar, Jong-Hyun Ahn

引用次数: 0

Integrating Metabolic RNA Labeling-Based Time-Resolved Single-Cell RNA Sequencing with Spatial Transcriptomics for Spatiotemporal Transcriptomic Analysis (Small Methods 3/2025)

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-20 DOI: 10.1002/smtd.202570019

Xiaoyong Chen, Shichao Lin, Honghai You, Jinyuan Chen, Qiaoyi Wu, Kun Yin, Fanghe Lin, Yingkun Zhang, Jia Song, Chenyu Ding, Dezhi Kang, Chaoyong Yang

引用次数: 0

Self-Powered Hydrogen Production via Laser-Coordinated NiCoPt Alloy Catalysts in an Integrated Zn-Hydrazine Battery with Hydrazine Splitting (Small Methods 3/2025)

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-20 DOI: 10.1002/smtd.202570016

Akash Prabhu Sundar Rajan, Raja Arumugam Senthil, Cheol Joo Moon, Anuj Kumar, Ahreum Min, Mohd Ubaidullah, Myong Yong Choi

引用次数: 0

Revealing the Impact of CZTSe/CdS Interface Fluctuations on PV Device Performance through Big Data Analysis Assisted by Machine Learning Methods

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-20 DOI: 10.1002/smtd.202400661

Jon Garí-Galíndez, Fabien Atlan, Jacob Andrade-Arvizu, Robert Fonoll-Rubio, David Payno, Enric Grau-Luque, Alejandro Pérez-Rodríguez, Ignacio Becerril-Romero, Maxim Guc, Victor Izquierdo-Roca, Pedro Vidal-Fuentes

{"title":"Revealing the Impact of CZTSe/CdS Interface Fluctuations on PV Device Performance through Big Data Analysis Assisted by Machine Learning Methods","authors":"Jon Garí-Galíndez, Fabien Atlan, Jacob Andrade-Arvizu, Robert Fonoll-Rubio, David Payno, Enric Grau-Luque, Alejandro Pérez-Rodríguez, Ignacio Becerril-Romero, Maxim Guc, Victor Izquierdo-Roca, Pedro Vidal-Fuentes","doi":"10.1002/smtd.202400661","DOIUrl":"10.1002/smtd.202400661","url":null,"abstract":"This work showcases the importance of developing suitable inspection and analysis methodologies with high statistical relevance data coupled with machine learning algorithms, for the detection, control, and understanding of small fluctuations in the scale-up of thin film photovoltaics to industrial sizes. To exhibit this methodology, this work investigates the effect of subtle inhomogeneities on the efficiency of thin film solar cells based on the Cu2ZnSnSe4/CdS interface using two large area samples subdivided in ≈400 individual solar cells. A large dataset obtained from Raman and photoluminescence spectroscopic techniques together with J–V optoelectronic data is generated to elucidate the impact of these inhomogeneities on the efficiency of the devices. Using a combination of statistical (spectral difference) and over 440 000 multivariate polynomial regressions through machine learning algorithms, it is revealed how the main limiting factor for device performance are subtle fluctuations in the nanostructure and surface defects of the CdS layer, rather than compositional fluctuations or defects in the kesterite absorber. It is estimated that the avoidance of these issues could result in an absolute increase in device efficiency of 2%. This could provide a potential avenue for further technology advancement within the kesterite community.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":"9 3","pages":""},"PeriodicalIF":10.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophil Hitchhiking-Mediated Delivery of ROS-Scavenging Biomimetic Nanoparticles for Enhanced Treatment of Atherosclerosis.

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-20 DOI: 10.1002/smtd.202402019

Ming Wu, Mengjuan Chen, Yuzhen Zhao, Xijun Zhang, Xiao Ding, Jianjun Yuan, Jinjin Shi, Wenyan Yu, Haohui Zhu

{"title":"Neutrophil Hitchhiking-Mediated Delivery of ROS-Scavenging Biomimetic Nanoparticles for Enhanced Treatment of Atherosclerosis.","authors":"Ming Wu, Mengjuan Chen, Yuzhen Zhao, Xijun Zhang, Xiao Ding, Jianjun Yuan, Jinjin Shi, Wenyan Yu, Haohui Zhu","doi":"10.1002/smtd.202402019","DOIUrl":"https://doi.org/10.1002/smtd.202402019","url":null,"abstract":"Atherosclerosis (AS), a chronic inflammatory disease and a leading cause of cardiovascular morbidity and mortality worldwide, is a significant contributor to disability. Neutrophil extracellular traps (NETs) have been closely associated with the progression of AS and plaque vulnerability. However, developing a treatment strategy that specifically targets neutrophils and effectively reduces NET release at the lesion site remains a major challenge. In this study, a biomimetic nanosystem with neutrophil-targeting properties is engineered. Coating Prussian blue nanoparticles with bacterial biomimetic membranes (MPB NPs) enables specific recognition and internalization by neutrophils. By hitching onto neutrophils, the MPB NPs scavenge intracellular reactive oxygen species (ROS) and suppress NET formation at the lesion site. Importantly, MPB NPs reduce the size of atherosclerotic plaques by 3.29-fold, from 22.53% to 6.85%, stabilize the plaques, and halt their progression in atherosclerotic mouse models. These findings suggest that MPB NPs offer a promising therapeutic strategy for atherosclerosis, and provide a versatile platform for the treatment of NET-associated diseases.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2402019"},"PeriodicalIF":10.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical Liquid Phase TEM in Aqueous Electrolytes for Energy Applications: the Role of Liquid Flow Configuration (Small Methods 3/2025)

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-20 DOI: 10.1002/smtd.202570015

Katarzyna Bejtka, Marco Fontana, Cecilia Irene Gho, Stefan Merkens, Andrey Chuvilin, Candido Fabrizio Pirri, Angelica Chiodoni

引用次数: 0

Engineered Intelligent Microenvironment Responsive Prodrug Conjugates Navigated by Bioinspired Lipoproteins for Reversing Liver Fibrosis.

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-19 DOI: 10.1002/smtd.202402247

Mingzhu Fang, Boyu Su, Shilin Zhang, Fangxin Li, Yun Guo, Qinjun Chen, Yuxing Wu, Huiyi Liu, Chen Jiang, Tao Sun

{"title":"Engineered Intelligent Microenvironment Responsive Prodrug Conjugates Navigated by Bioinspired Lipoproteins for Reversing Liver Fibrosis.","authors":"Mingzhu Fang, Boyu Su, Shilin Zhang, Fangxin Li, Yun Guo, Qinjun Chen, Yuxing Wu, Huiyi Liu, Chen Jiang, Tao Sun","doi":"10.1002/smtd.202402247","DOIUrl":"https://doi.org/10.1002/smtd.202402247","url":null,"abstract":"Liver fibrosis (LF) is characterized by excessive production of reactive oxygen species (ROS), abnormal activation of hepatic stellate cells (HSCs), and subsequent extracellular matrix (ECM) deposition. The complexity of multiple interrelated pathways involved in this process makes it challenging for monotherapy to achieve the desired therapeutic effects. To address this issue, this study designs a ROS-activated heterodimer conjugate (VTO) to collaboratively alleviate LF. Additionally, a biomimetic high-density lipoprotein is utilized for encapsulation, resulting in the formation of PL-VTO, which enables natural liver targeting. Once PL-VTO is delivered to the fibrotic liver, it can respond and release both parent drugs upon encountering the high ROS microenvironment, effectively scavenge ROS, induce quiescence of activated HSCs, and reduce collagen deposition, ultimately reversing LF. Overall, this study presents a feasible and versatile nanotherapeutic approach to enhance the prodrug-driven treatment of LF.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2402247"},"PeriodicalIF":10.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical Sensor Based on Black Phosphorus for Antimony Detection Using Dip-Pen Nanolithography: The Role of Dwell Time.

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-19 DOI: 10.1002/smtd.202402157

Krishna K Yadav, Dror Shamir, Haya Kornweitz, Lonia Friedlander, Moshe Zohar, Ariela Burg

{"title":"Electrochemical Sensor Based on Black Phosphorus for Antimony Detection Using Dip-Pen Nanolithography: The Role of Dwell Time.","authors":"Krishna K Yadav, Dror Shamir, Haya Kornweitz, Lonia Friedlander, Moshe Zohar, Ariela Burg","doi":"10.1002/smtd.202402157","DOIUrl":"https://doi.org/10.1002/smtd.202402157","url":null,"abstract":"Heavy metals, including Sb, are major pollutants with limits on their allowed concentration in drinking water. Therefore, there is a need for sensitive, simple, and portable detection methods for which electrochemical sensors are ideally suited. In this current study, Meta-chemical surfaces are developed for electrochemical sensing by patterning gold electrode surfaces with a mixture of black phosphorus (BP) and polymethyl methacrylate (PMMA) as nanoclusters using dip-pen nanolithography. It is found that the surface-to-volume ratio (S/V), fill factor, and ink composition affect the sensitivity of the sensor for Sb detection. The S/V ratio and fill factor can be altered by the dwell time, which has a complex effect on the limit of detection (varying from 14 to 24 ppb with the changes in the dwell time). Density functional theory calculations show that the binding between Sb(III) and BP is more exergonic in the presence of PMMA. These results are significant because they allow for the development of more sensitive Sb sensors, which can affect the wider field of the detection of heavy metals in drinking water sources and achieve higher efficiency than the commonly used instruments.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2402157"},"PeriodicalIF":10.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atomic Layer Thickness Modulated the Catalytic Activity of Platinum for Oxygen Reduction and Hydrogen Oxidation Reaction.

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-19 DOI: 10.1002/smtd.202401978

Shengyao Lv, Jin Liu, Zhuoyang Xie, Li Li, Zidong Wei

{"title":"Atomic Layer Thickness Modulated the Catalytic Activity of Platinum for Oxygen Reduction and Hydrogen Oxidation Reaction.","authors":"Shengyao Lv, Jin Liu, Zhuoyang Xie, Li Li, Zidong Wei","doi":"10.1002/smtd.202401978","DOIUrl":"https://doi.org/10.1002/smtd.202401978","url":null,"abstract":"Reducing platinum (Pt) usage and enhancing its catalytic performance in the hydrogen oxidation reaction (HOR) and the oxygen reduction reaction (ORR) are vital for advancing fuel cell technology. This study presents the design and investigation of monolayer and few-layer Pt structures with high platinum utilization, developed through theoretical calculations. By minimizing the metal thickness from 1 to 3 atomic layers, an atomic utilization rate ranging from 66.66% to 100% is achieved, in contrast to conventional multilayer Pt structures. This reduction resulted in a unique surface coordination environment. These thinner structures exhibited nonlinear fluctuations in key electronic characteristics-such as the d-band center, surface charge, and work function-as the atomic layer thickness decreased. These variations significantly impacted species adsorption and the Pt-H2O interfacial structure, which in turn affected the catalytic activity. Notably, 1-layer Pt exhibited the best performance for HOR, while 3-layer Pt showed high activity for both HOR and ORR. The findings establish a clear relationship between atomic layer thickness, surface characteristics, adsorption behavior, electric double-layer structure, and catalytic performance in Pt systems. This research contributes to a deeper understanding of precision atomic-structured electrocatalyst design and paves the way for the development of highly effective, low-loading Pt-based catalytic materials.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2401978"},"PeriodicalIF":10.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0