Small Methods最新文献_第4页

Vanadium-Doped Molybdenum Diselenide Accelerates Sulfur Redox Kinetics in Lithium-Sulfur Batteries. 掺钒二硒化钼加速锂硫电池硫氧化还原动力学

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-04-01 DOI: 10.1002/smtd.202500255

Pengfei Zhang, Rui Wang, Huiting Cheng, Jiatong Li, Chan Wang, Xuening Zhao, Fushuai Yu, Kaichen Zhao, Junfeng Hui, Huigang Zhang, Xiaoyan Zheng

{"title":"Vanadium-Doped Molybdenum Diselenide Accelerates Sulfur Redox Kinetics in Lithium-Sulfur Batteries.","authors":"Pengfei Zhang, Rui Wang, Huiting Cheng, Jiatong Li, Chan Wang, Xuening Zhao, Fushuai Yu, Kaichen Zhao, Junfeng Hui, Huigang Zhang, Xiaoyan Zheng","doi":"10.1002/smtd.202500255","DOIUrl":"https://doi.org/10.1002/smtd.202500255","url":null,"abstract":"The persistent shuttle effect of polysulfides and slow liquid-solid redox kinetics remain major obstacles to the practical application of Lithium-Sulfur (Li─S) batteries. In this study, a vanadium-doped molybdenum diselenide catalyst designed to address these challenges are presented. Experimental analysis and theoretical calculations reveal that V doping slightly disrupts the 2D growth of MoSe2, creating structural defects and abundant edge-active sites. These active sites enhance polysulfide adsorption, facilitate efficient catalytic conversion, and promote the utilization of S species. Additionally, electron redistribution induced by V dopants improves electronic conductivity and accelerates redox kinetics. As a result, Li─S batteries using V0.1Mo0.9Se2 as a catalyst deliver a high discharge capacity of 1467.3 mA h g-1 at 0.1 C and maintain a capacity of 651.9 mA h g-1 after 1000 cycles at 1 C, with an ultralow decay rate of 0.036% per cycle. Under high sulfur loading (5.5 mg cm-2), the batteries exhibit a specific capacity of 803.9 mA h g-1 after 100 cycles and a decay rate of only 0.11% per cycle. This study demonstrates that V doping effectively activates inert MoSe2, providing a promising strategy for designing high-performance sulfur cathode catalysts and advancing the development of next-generation Li─S batteries.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500255"},"PeriodicalIF":10.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Luminescence-Based Implied Voltage Imaging of Tandem Solar Cells Using Bandpass Filters 利用带通滤波器对串联太阳能电池进行基于发光的隐含电压成像。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-04-01 DOI: 10.1002/smtd.202401003

Soma Zandi, Shuai Nie, Yan Zhu, Thomas G. Allen, Erkan Aydin, Esma Ugur, Jianghui Zheng, Guoliang Wang, Xu Liu, Xiaojing Hao, Anita Ho-Baillie, Stefaan De Wolf, Thorsten Trupke, Ziv Hameiri

{"title":"Luminescence-Based Implied Voltage Imaging of Tandem Solar Cells Using Bandpass Filters","authors":"Soma Zandi, Shuai Nie, Yan Zhu, Thomas G. Allen, Erkan Aydin, Esma Ugur, Jianghui Zheng, Guoliang Wang, Xu Liu, Xiaojing Hao, Anita Ho-Baillie, Stefaan De Wolf, Thorsten Trupke, Ziv Hameiri","doi":"10.1002/smtd.202401003","DOIUrl":"10.1002/smtd.202401003","url":null,"abstract":"A luminescence-based technique is demonstrated for selectively imaging the implied voltages of tandem solar cells. The luminescence emission is captured using a narrow bandpass filter so that the detected luminescence signal is insensitive to the optical properties of the device, thus, revealing the variations in the implied voltages. The proposed method is validated through simulation and experiments conducted on two-terminal perovskite/silicon tandem solar cells with different structures, optical properties, and compositions (e.g., different bandgaps for the perovskite cells). Implied voltage images of each sub-cell can be determined with a maximum relative error of 1%. The proposed technique can also be used to obtain local current–voltage curves. The method is expected to be a valuable tool for optimizing the performance of tandem solar cells, scaling up tandem devices, investigating local defects, and predicting the ultimate device performance.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":"9 4","pages":""},"PeriodicalIF":10.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smtd.202401003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hierarchical Porous Aerogel-Hydrogel Interlocking Bioelectronic Interface for Arrhythmia Management. 分层多孔气凝胶-水凝胶联锁生物电子界面用于心律失常管理。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-31 DOI: 10.1002/smtd.202401844

Lei Zhao, Yuhan Lu, Xinxin Lu, Bihan Guo, Zhiqiang Chang, Qinjuan Ren, Xiang Li, Bingfang Wang, Ailin Lv, Jing Wei, Jianfang Nie, Yingying Lv, Menahem Y Rotenberg, Ya Zhang, Daizong Ji, Yin Fang

{"title":"Hierarchical Porous Aerogel-Hydrogel Interlocking Bioelectronic Interface for Arrhythmia Management.","authors":"Lei Zhao, Yuhan Lu, Xinxin Lu, Bihan Guo, Zhiqiang Chang, Qinjuan Ren, Xiang Li, Bingfang Wang, Ailin Lv, Jing Wei, Jianfang Nie, Yingying Lv, Menahem Y Rotenberg, Ya Zhang, Daizong Ji, Yin Fang","doi":"10.1002/smtd.202401844","DOIUrl":"https://doi.org/10.1002/smtd.202401844","url":null,"abstract":"Carbon aerogels with exceptional electrical properties are considered promising materials for bioelectronics in signal detection and electrical stimulation. To address the mechanical incompatibilities of carbon aerogels with bio-interfaces, particularly for dynamic tissues and organs, the incorporation of hydrogels is an effective strategy. However, achieving excellent electrical performance in carbon aerogel-hydrogel hybrids remains a significant challenge. Two key factors contribute to this difficulty: 1) unrestricted hydrogel infiltration during preparation can lead to complete encapsulation of the conductive aerogel, and 2) the high swelling behavior of hydrogels can cause disconnection of the aerogel. Herein, a stretchable, highly conductive bioelectronic interface is achieved by forming an interlocking network between hierarchical porous carbon aerogel (PA) with polyvinyl alcohol (PVA) hydrogel. Partial exposure of the PA due to confined infiltration of PVA into the porous structure maintains the electrical performance, while the non-swellable PVA ensures mechanical stretchability and stability. The hybrid demonstrates excellent conductivity (370 S·m-1), high charge storage capacity (1.66 mC cm-2), remarkable stretchability (250%), and long-term stability over three months, enabling effective signal recording and electrical stimulation. For the first time, carbon aerogel-hydrogel hybrids enable cardiac pacing both ex vivo and in vivo in rat heart models. Compared to conventional platinum electrodes, the PA-PVA electrodes require lower pacing voltages, suggesting potential advantages in power efficiency and reduced tissue damage. The electrodes can be integrated with a wireless implantable device for in vivo synchronous electrocardiogram monitoring and cardiac pacing, underscoring their potential for arrhythmia management.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2401844"},"PeriodicalIF":10.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the Effect of Regioselective Fluorination in Tuning Miscibility and Crystallinity of Polymer Donors for Efficient Organic Solar Cells. 了解区域选择性氟化对高效有机太阳能电池聚合物供体混溶性和结晶度调节的影响。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-30 DOI: 10.1002/smtd.202500239

Yuchang Zhao, Chuanlong Cui, Jialiang Hao, Tan Wang, Fuzhen Bi, Hao Lu, Chunming Yang, Junhao Chu, Xichang Bao

{"title":"Understanding the Effect of Regioselective Fluorination in Tuning Miscibility and Crystallinity of Polymer Donors for Efficient Organic Solar Cells.","authors":"Yuchang Zhao, Chuanlong Cui, Jialiang Hao, Tan Wang, Fuzhen Bi, Hao Lu, Chunming Yang, Junhao Chu, Xichang Bao","doi":"10.1002/smtd.202500239","DOIUrl":"https://doi.org/10.1002/smtd.202500239","url":null,"abstract":"Fluorination is a widely adopted strategy for modifying polymer donors (PDs) in organic solar cells (OSCs). The incorporation of fluorine atoms is known to enhance crystallinity and facilitate charge transport of PDs, thereby boosting the short-circuit current density of related OSCs. However, improperly executed fluorination can impair miscibility with acceptors, leading to excessive self-aggregation, unfavorable phase separation, serious charge reorganization, and increased energy loss. It is crucial to balance the crystallinity and miscibility of PDs for efficient OSCs. In this study, four PDs, SL1 to SL4, are designed with varying degrees of fluorination by precisely controlling the fluorination sites within D-A conjugate polymers. Notably, SL2, fluorinated on the A unit, exhibits optimal aggregation behavior and crystallinity while maintaining good miscibility with acceptors. Consequently, SL2 achieved reduced energy loss and delivered an impressive power conversion efficiency of 15.35% in binary devices. Furthermore, D18:Y6:SL2 based ternary device achieved a remarkable PCE of over 19%. This work offers new insights into the fluorination of PDs and a strategy for synergistic enhancement in crystallinity and miscibility for OSCs.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500239"},"PeriodicalIF":10.7,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ag on NiCo Layered Double Hydroxide as Oxygen Evolution Electrocatalyst for Anion Exchange Membrane Water Electrolyzer Under Large Current Densities. Ag / NiCo层状双氢氧化物作为大电流密度阴离子交换膜水电解槽析氧电催化剂。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-30 DOI: 10.1002/smtd.202500103

Yan Sun, Gongjin Chen, Fatima El Bachraoui, Yingdan Cui, Guimei Liu, Fei Xiao, Xitang Qian, Zhiwen Xu, Minhua Shao

{"title":"Ag on NiCo Layered Double Hydroxide as Oxygen Evolution Electrocatalyst for Anion Exchange Membrane Water Electrolyzer Under Large Current Densities.","authors":"Yan Sun, Gongjin Chen, Fatima El Bachraoui, Yingdan Cui, Guimei Liu, Fei Xiao, Xitang Qian, Zhiwen Xu, Minhua Shao","doi":"10.1002/smtd.202500103","DOIUrl":"https://doi.org/10.1002/smtd.202500103","url":null,"abstract":"A facile and universal strategy is employed to synthesize Ag decorated NiCo layered double hydroxide (LDH) heterogeneous structure for the oxygen evolution reaction (OER). The Ag nanoparticles are deposited on NiCo LDH nanosheets via a spontaneous redox reaction. The synthesized Ag/NiCo LDH achieves an overpotential of 460 mV at a current density of 1 A cm-2 geo, surpassing that of NiCo LDH (722 mV). In an anion exchange membrane water electrolyzer (AEMWE) with Ag/NiCo LDH as the anode and Pt/C as the cathode, the cell can deliver an ultrahigh current density of 5 A cm-2 at a low voltage of 2.10 V. This superior current density is nearly four times larger than that of AEMWEs with other non-precious anode electrocatalysts reported in literature under the same effective area. Furthermore, it exhibits desired durability with no performance decay for over 300 h at 1 A cm-2, which is almost six times longer than that of electrolyzer with an IrO2 anode. Operando electrochemical impedance spectroscopy results reveal that Ag decoration facilitates active site formation and reduces the OER onset potential compared to NiCo LDH. This study showcases a practical approach to designing highly effective and durable OER electrocatalysts in industrial hydrogen production.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500103"},"PeriodicalIF":10.7,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2D In-Plane Mesoporous N-Doped Carbon for Co-Planar Integrated Microsystem of Micro-Supercapacitor and Pressure Sensor. 二维平面内介孔氮掺杂碳用于微超级电容器和压力传感器共面集成微系统。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-30 DOI: 10.1002/smtd.202402205

Jieqiong Qin, Wenbei Bo, Pratteek Das, Zhuoya Dong, Yuanhang Feng, Jiaxin Ma, Xiao Wang, Lixia Xie, Yunlai Ren, Zhong-Shuai Wu

{"title":"2D In-Plane Mesoporous N-Doped Carbon for Co-Planar Integrated Microsystem of Micro-Supercapacitor and Pressure Sensor.","authors":"Jieqiong Qin, Wenbei Bo, Pratteek Das, Zhuoya Dong, Yuanhang Feng, Jiaxin Ma, Xiao Wang, Lixia Xie, Yunlai Ren, Zhong-Shuai Wu","doi":"10.1002/smtd.202402205","DOIUrl":"https://doi.org/10.1002/smtd.202402205","url":null,"abstract":"The rapid evolution of next-generation portable, wearable and implantable electronics has increased the demand for multi-functional materials and flexible miniaturized integrated microsystems of micro-supercapacitors (MSCs) and sensors. To address this urgent need, a dual-template interfacial assembly strategy is proposed to fabricate 2D in-plane mesoporous N-doped carbon (imNC) as dual-functional materials in both MSCs and pressure sensors, achieving a co-planar integrated microsystem. The as-prepared imNC nanosheets feature adjustable in-plane mesopore size (7.3 - 23.2 nm), specific surface area (222 - 413 m2 g-1) and nitrogen content (3.8% - 5.9%). The relationship between mesopore size/nitrogen composition and electrochemical performance of the imNC are established. Subsequently, the imNC-based MSCs employing ionogel electrolyte delivere a wide operating voltage of 3.8 V, high areal energy density of 41.9 µWh cm-2 and excellent flexibility with negligible capacitance loss over 2000 bending cycles, along with tunable voltage and current output through multi-device integration. More importantly, one imNC-based MSC can readily power an imNC-based pressure sensor on the same flexible substrate for monitoring various pressures and vibrations, verifying the dual-functionality and high performance of imNC in the integrated microsystem. This work provides a broad platform for creating multi-functional 2D mesoporous materials towards flexible and miniaturized integrated microsystem.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2402205"},"PeriodicalIF":10.7,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intelligent Nanomaterials Design for Osteoarthritis Managements. 智能纳米材料设计用于骨关节炎治疗。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-30 DOI: 10.1002/smtd.202402263

Zhihao Chen, Xuan Zheng, Zhengzhi Mu, Weijie Lu, Haiyuan Zhang, Jiao Yan

{"title":"Intelligent Nanomaterials Design for Osteoarthritis Managements.","authors":"Zhihao Chen, Xuan Zheng, Zhengzhi Mu, Weijie Lu, Haiyuan Zhang, Jiao Yan","doi":"10.1002/smtd.202402263","DOIUrl":"https://doi.org/10.1002/smtd.202402263","url":null,"abstract":"Osteoarthritis (OA) is the most prevalent degenerative joint disorder, characterized by progressive joint degradation, pain, and diminished mobility, all of which collectively impair patients' quality of life and escalate healthcare expenditures. Current treatment options are often inadequate due to limited efficacy, adverse side effects, and temporary symptom relief, underscoring the urgent need for more effective therapeutic strategies. Recent advancements in nanomaterials and nanomedicines offer promising solutions by improving drug bioavailability, reducing side effects and providing targeted therapeutic benefits. This review critically examines the pathogenesis of OA, highlights the limitations of existing treatments, and explores the latest innovations in intelligent nanomaterials design for OA therapy, with an emphasis on their engineered properties, therapeutic mechanisms, and translational potential in clinical application. By compiling recent findings, this work aims to inspire further exploration and innovation in nanomedicine, ultimately advancing the development of more effective and personalized OA therapies.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2402263"},"PeriodicalIF":10.7,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid Universal Detection of High-Risk and Low-Abundance Microbial Contaminations in CAR-T Cell Therapy. CAR-T细胞治疗中高风险和低丰度微生物污染的快速普遍检测。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-30 DOI: 10.1002/smtd.202500253

Xiaolin Wu, Joshua Jebaraj Raymond, Yaoping Liu, Alexander Jeremias Odermatt, Wei-Xiang Sin, Denise Bei Lin Teo, Meenubharathi Natarajan, Inn Chuan Ng, Michael E Birnbaum, Timothy K Lu, Jongyoon Han, Stacy L Springs, Hanry Yu

{"title":"Rapid Universal Detection of High-Risk and Low-Abundance Microbial Contaminations in CAR-T Cell Therapy.","authors":"Xiaolin Wu, Joshua Jebaraj Raymond, Yaoping Liu, Alexander Jeremias Odermatt, Wei-Xiang Sin, Denise Bei Lin Teo, Meenubharathi Natarajan, Inn Chuan Ng, Michael E Birnbaum, Timothy K Lu, Jongyoon Han, Stacy L Springs, Hanry Yu","doi":"10.1002/smtd.202500253","DOIUrl":"https://doi.org/10.1002/smtd.202500253","url":null,"abstract":"Live microbial contamination poses high risks to cell and gene therapies, threatening manufacturing processes and patient safety. Rapid, sensitive detection of live microbes in complex environments, such as CAR-T cell cultures, remains an urgent need. Here, an innovative sample-to-result workflow is introduced using digital loop-mediated isothermal amplification (dLAMP), enhanced by Electrostatic Microfiltration (EM)-based enrichment, for rapid sterility testing. By rationally designing primers targeting 16S and 18S rRNA, dLAMP assay enables both universal detection (covering >80% of known species) and strain-specific identification of bacterial and fungal contaminants in CAR-T cell spent medium and final products, directly from microorganism lysates. Enhanced by EM-based enrichment of low-abundance live microbes, the workflow achieves unparalleled sensitivity and speed, detecting contamination levels as low as 1 CFU/mL in complex CAR-T cell cultures within 6 h. Compared to qPCR and 14-day compendial methods, the approach demonstrates superior accuracy and significantly faster turnaround times. This workflow holds transformative potential for real-time monitoring in cell therapy manufacturing and rapid safety assessments of CAR-T cell products prior to patient infusion. Beyond cell therapy, the method is broadly applicable to infectious disease diagnostics, biomanufacturing monitoring, food safety, and environmental surveillance.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500253"},"PeriodicalIF":10.7,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Manipulation of Wnt/β-Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo. 合成卷曲激动剂和LRP拮抗剂在类器官培养和体内对Wnt/β-Catenin信号的调控

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-28 DOI: 10.1002/smtd.202500425

Quanhui Dai, Jiawen Wang, Zihuan Lin, Danni Yu, Hui Yang, Jinsong Wei, Xiaoyu Li, Hao Hu, Chao Ni, Bing Zhao

{"title":"Manipulation of Wnt/β-Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo.","authors":"Quanhui Dai, Jiawen Wang, Zihuan Lin, Danni Yu, Hui Yang, Jinsong Wei, Xiaoyu Li, Hao Hu, Chao Ni, Bing Zhao","doi":"10.1002/smtd.202500425","DOIUrl":"https://doi.org/10.1002/smtd.202500425","url":null,"abstract":"Wnt/β-catenin signaling and its dysregulation play critical roles in stem cell fate determination and the pathology of various diseases. However, the application of translated Wnt ligand in regenerative medicine is hampered by its hydrophobicity and cross-reactivity with Frizzled (FZD) receptors. Here, a synthetic key receptor modulator, the FZD agonist RRP-pbFn is generated, for high-efficiency Wnt/β-catenin signaling activation in the absence of direct binding to LRP5/6. RRP-pbFn demonstrates superior potency compared to surrogate Wnt, supporting the growth of diverse mouse and human organoids and inducing the expansion of liver and intestine progenitors in vivo. Complementing this, a synthetic LRP antagonist, RRP-Dkk1c is developed, which exhibits heightened effectiveness in attenuating Wnt/β-catenin signaling activity compared to Dkk1, thereby abolishing the formation of CT26-derived colon cancer xenograft in vivo. Together, these two paired key receptor modulators targeting individual type of cell-surface receptors hold great promise for biomedical research and potential therapeutics.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500425"},"PeriodicalIF":10.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rational Design and Characterization of 2D Metal-Semiconductor Junctions for Optoelectronics by Combining Quantum Transport and Excited State Carrier Dynamics Simulations: Case of 2H-WTe₂ Based Junctions. 结合量子输运和激发态载流子动力学模拟的光电子学二维金属半导体结的合理设计和表征：以2H-WTe2为基础的结为例。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-03-27 DOI: 10.1002/smtd.202402037

Chengfeng Pan, Dazhong Sun, Wang Gong, Leran Xu, Xiuyun Zhang, Anqi Shi, Yongtao Li, Xianghong Niu

{"title":"Rational Design and Characterization of 2D Metal-Semiconductor Junctions for Optoelectronics by Combining Quantum Transport and Excited State Carrier Dynamics Simulations: Case of 2H-WTe2 Based Junctions.","authors":"Chengfeng Pan, Dazhong Sun, Wang Gong, Leran Xu, Xiuyun Zhang, Anqi Shi, Yongtao Li, Xianghong Niu","doi":"10.1002/smtd.202402037","DOIUrl":"https://doi.org/10.1002/smtd.202402037","url":null,"abstract":"Rising 2D metal-semiconductor junctions (MSJs) greatly advance nanoelectronics. Currently, evaluating the performance of MSJs mainly relies on determining the formation of Ohmic or Schottky contacts through static electronic structures. However, when MSJs are integrated into optoelectronic devices, dynamic transport and excited state carrier dynamics become crucial, yet the impact of the interface remains unclear. Herein, taking 2H-WTe2 based vertical and lateral MSJs as examples, their performances are evaluated in the perspective of ground and excited states. Faced with the significant band hybridization induced by strong interfacial coupling, identifying Ohmic contact only by analyzing electronic structures possibly becomes defunct. Through quantum transport simulation, the junction with the largest on-state current can be further filtered. Meanwhile, non-adiabatic molecular dynamics simulation uncovers the carrier lifetime can be shortened or extended as the interfaces are formed, which depends on the competitive relationship between electron-phonon coupling and trap states. In these MSJs studied, the photoexcited carriers with the nanosecond lifetime can be rapidly conducted away by electrodes, indicating a high-effect utilization rate. The work advances the all-around routine for rational designing and characterizing 2D MSJs.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2402037"},"PeriodicalIF":10.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0