Small Methods最新文献_第5页

In-Situ Heating X-Ray Diffraction of LiNi_0.6Mn_0.3Co_0.1O₂ and LiNi_0.7Mn_0.3O₂ Made Using the All-Dry Synthesis Process. 全干法合成LiNi0.6Mn0.3Co0.1O2和LiNi0.7Mn0.3O2的原位加热x射线衍射

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-25 DOI: 10.1002/smtd.202500632

Svena Yu, Toby Bond, Al Rahemtulla, Adam F G Leontowich, Daphne Thompson, J R Dahn

{"title":"In-Situ Heating X-Ray Diffraction of LiNi0.6Mn0.3Co0.1O2 and LiNi0.7Mn0.3O2 Made Using the All-Dry Synthesis Process.","authors":"Svena Yu, Toby Bond, Al Rahemtulla, Adam F G Leontowich, Daphne Thompson, J R Dahn","doi":"10.1002/smtd.202500632","DOIUrl":"https://doi.org/10.1002/smtd.202500632","url":null,"abstract":"In-situ synthesis X-ray diffraction is conducted at the Canadian Light Source to probe phase changes during the all-dry synthesis of LiNi0.6Mn0.3Co0.1O2 (NMC631) and LiNi0.7Mn0.3O2 (NM73) made using either LiOH·H2O or Li2CO3. All materials are heated up to 950 °C and held for one hour at 950 °C under flowing oxygen. The pathway to a layered phase is similar for all samples. First, a lithiated manganese oxide phase is formed at low temperature, then cations are incorporated into a rock salt phase from ≈420 °C. A spinel intermediary phase is formed before cation ordering occurs between Li and transition metal ions above 800 °C, giving rise to the intended layered hexagonal structure. Amongst the three materials tested, the layered phase of NMC631 (made using LiOH·H2O) evolves at the lowest temperature of ≈820 °C and refines rapidly during the high temperature hold. The melting of LiOH coincides nicely with the oxidation of Ni, which forms the basis for the rock salt structure. It is postulated that the molten LiOH facilitates cation diffusion into the rock salt phase, allowing for an earlier formation of the layered phase in comparison to using Li2CO3, which has a higher decomposition temperature.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500632"},"PeriodicalIF":10.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Electronegativity-Modulated Piezoelectric Metal-Organic Framework for Tumor Piezocatalytic Ferroptosis. 一种电负性调制的压电金属-有机框架用于肿瘤压电催化铁下垂。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-25 DOI: 10.1002/smtd.202501016

Zheng Chen, Qiyue Wang, Sirui Cui, Xi Hu, Peihua Lin, Bo Zhang, Daishun Ling, Fangyuan Li

{"title":"An Electronegativity-Modulated Piezoelectric Metal-Organic Framework for Tumor Piezocatalytic Ferroptosis.","authors":"Zheng Chen, Qiyue Wang, Sirui Cui, Xi Hu, Peihua Lin, Bo Zhang, Daishun Ling, Fangyuan Li","doi":"10.1002/smtd.202501016","DOIUrl":"https://doi.org/10.1002/smtd.202501016","url":null,"abstract":"Piezoelectric materials have emerged as versatile tools for ultrasound-triggered cancer therapy, yet their clinical application is constrained by inefficient charge separation and the limited availability of catalytic substrates in the tumor microenvironment. Here, an electronegativity-modulated piezoelectric metal-organic framework (CapMOF@HA) is reported through controlled heteroepitaxial growth of CaO2 on pMOFs, followed by surface functionalization with hyaluronic acid (HA) for tumor-targeting capability for enhanced piezocatalytic therapy. Of note, the electronegativity-modulated heterogeneous interfaces between CaO2 and pMOF promote the separation of electron-hole pairs while suppressing recombination through the electronegativity effect, significantly amplifying piezocatalytic reactive oxygen species (ROS) generation (•OH, 1O2, and •O2⁻) under ultrasound stimulation. Furthermore, the controlled decomposition of calcium peroxide provides a continuous supply of H2O2 and O2 as catalytic substrates, while releasing Ca2+ to induce calcium overload, triggering mitochondrial dysfunction and glutathione peroxidase 4 inhibition for ferroptosis induction. This strategy integrates enhanced piezoelectric catalysis with ferroptosis induction, overcoming long-standing limitations in piezocatalytic systems to achieve precise and robust tumor ablation. By combining substrate self-sufficiency with multifunctional therapeutic mechanisms, this work establishes tumor piezocatalytic ferroptosis as a transformative platform for next-generation piezoelectric cancer therapy.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2501016"},"PeriodicalIF":10.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of Automated Workflow Pipelines for Computational Chemists. 计算化学家自动化工作流程研究进展。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-24 DOI: 10.1002/smtd.202500308

Tong Wu, Mingzi Sun, Bolong Huang

引用次数: 0

Modulus-Engineered Silicates-Buffering Matrix for Enhanced Lithium Storage of Micro-Sized SiO_x Anodes. 微尺寸SiOx阳极增强锂存储的模量工程硅酸盐缓冲矩阵。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-24 DOI: 10.1002/smtd.202500556

Tuan Lv, Feng Zhou, Yang He, Yingxi Zhang, Haoqin Feng, Yu Liu, Xianwei Yu, Biao Gao, Paul K Chu, Kaifu Huo

{"title":"Modulus-Engineered Silicates-Buffering Matrix for Enhanced Lithium Storage of Micro-Sized SiOx Anodes.","authors":"Tuan Lv, Feng Zhou, Yang He, Yingxi Zhang, Haoqin Feng, Yu Liu, Xianwei Yu, Biao Gao, Paul K Chu, Kaifu Huo","doi":"10.1002/smtd.202500556","DOIUrl":"https://doi.org/10.1002/smtd.202500556","url":null,"abstract":"Microscale Silicon suboxide (SiOx) is a promising anode material and elemental doping is an effective strategy to enhance the initial coulombic efficiency (ICE) and cycle stability of SiOx by converting SiO2 into the electrochemically inert silicates-buffering matrix. However, the impact of the silicates-buffering modulus on the electrochemical properties is not well understood. Herein, the modulus of the silicate-buffering matrix is found to be crucial to restraining internal cracks and improving the electrochemical properties of microscale SiOx during cycling. Compared with the Li2SiO3 and MgSiO3 buffering matrixes, Mg2SiO4 has a higher modulus and yield stress resulting in better resistance to Si expansion-induced cracks during cycling. Moreover, Mg2SiO4 has a smaller Li+ diffusion energy barrier than Li2SiO3 and MgSiO3. Consequently, the microscale Mg-doped SiOx with the Mg2SiO4 buffering matrix has a high ICE, excellent structural integrity, and small electrode expansion during cycling. The results provide insights into the design of microscale SiOx anode materials by optimizing the silicates-buffering matrix for high-energy Li-ion batteries.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500556"},"PeriodicalIF":10.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PruEV-AI: a Simple Approach Combines Urinary Extracellular Vesicle Isolation with AI-Assisted Analysis for Prostate Cancer Diagnosis. PruEV-AI：一种结合尿细胞外囊泡分离和ai辅助分析的前列腺癌诊断的简单方法

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-23 DOI: 10.1002/smtd.202500659

Minju Lee, Bonhan Koo, Myoung Gyu Kim, Hyo Joo Lee, Eun Yeong Lee, Yeonjeong Roh, Chae Eun Bae, Seungil Park, Zhen Qiao, Il-Hwan Kim, Myung Kyun Woo, Choung-Soo Kim, Yong Shin

{"title":"PruEV-AI: a Simple Approach Combines Urinary Extracellular Vesicle Isolation with AI-Assisted Analysis for Prostate Cancer Diagnosis.","authors":"Minju Lee, Bonhan Koo, Myoung Gyu Kim, Hyo Joo Lee, Eun Yeong Lee, Yeonjeong Roh, Chae Eun Bae, Seungil Park, Zhen Qiao, Il-Hwan Kim, Myung Kyun Woo, Choung-Soo Kim, Yong Shin","doi":"10.1002/smtd.202500659","DOIUrl":"https://doi.org/10.1002/smtd.202500659","url":null,"abstract":"Urinary extracellular vesicles (uEVs) are a promising source of prostate-derived biomarkers for non-invasive prostate cancer (PCa) diagnosis. However, conventional uEV isolation methods and single-marker assays often lack efficiency and diagnostic accuracy. Here, PruEV-AI is introduced, an integrated diagnostic system that combines rapid uEV isolation with AI-based biomarker analysis. The PruEV platform employs amine-modified zeolites (AZ) and carbohydrazide (CDH) to isolate uEVs and extract miRNAs in less than 30 min through electrostatic and covalent interactions. This one-step syringe-filter process enables high-throughput, reproducible, and user-friendly isolation of uEVs suitable for clinical diagnostics. Among 12 candidate miRNAs, 6 are validated using RT-qPCR in urine samples from 48 PCa patients and 49 controls. Individually, these miRNAs and PSA show modest diagnostic performance, with area under the curve (AUC) values ranging from 0.6 to 0.8. To overcome the limitations of single biomarkers, a deep learning (DL) model evaluates all 127 possible combinations of the 6 miRNAs and PSA. The optimal biomarker combination identified by the DL model achieves an AUC of 0.9556, with 93.33% sensitivity, specificity, and accuracy. Consequently, the PruEV-AI system provides a robust, non-invasive, and clinically relevant diagnostic approach for accurately identifying PCa, thereby supporting improved screening protocols and more effective therapeutic strategies.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500659"},"PeriodicalIF":10.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Demonstrating Faster Multi-Label Grey-Level Analysis for Crack Detection in Ex Situ and Operando Micro-CT Images of NMC Electrode. 在NMC电极非原位和操作微ct图像中更快的多标签灰度分析检测裂纹。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-23 DOI: 10.1002/smtd.202500082

Matthew P Jones, Huw C W Parks, Alice V Llewellyn, Hamish T Reid, Chun Tan, Aaron Wade, Thomas M M Heenan, Francesco Iacoviello, Shashidhara Marathe, Paul R Shearing, Rhodri Jervis

{"title":"Demonstrating Faster Multi-Label Grey-Level Analysis for Crack Detection in Ex Situ and Operando Micro-CT Images of NMC Electrode.","authors":"Matthew P Jones, Huw C W Parks, Alice V Llewellyn, Hamish T Reid, Chun Tan, Aaron Wade, Thomas M M Heenan, Francesco Iacoviello, Shashidhara Marathe, Paul R Shearing, Rhodri Jervis","doi":"10.1002/smtd.202500082","DOIUrl":"https://doi.org/10.1002/smtd.202500082","url":null,"abstract":"During battery operation, cracking occurs in Nickel Manganese Cobalt (NMC) oxide secondary particles. Cracked particles appear darker in micro-computed tomography (micro-CT) images due to the partial volume effect, where voxels containing both void and solid yield intermediate grey-levels. This work presents an automated method for tracking grey-level changes caused by this effect in large, statistically meaningful micro-CT datasets containing over 10 000 individual particles. It extends earlier work using the GREAT algorithm to analyze NMC particles in tomography images. The new GREAT2 algorithm increases processing speed, from around 1,400 particles per day with GREAT to over 10 000 particles in under a minute. Furthermore, this work introduces methods for automated tracking of grey-level intensity changes in individual particles through different states of charge in an operando experiment. This capability enables temporal analysis of particle degradation mechanisms. Additional data processing methods are presented that extract useful insights. Through this work we show that the large sample sizes, enabled by this method and GREAT2, allow for statistically robust analysis of particle populations. These advances significantly accelerate the tomographic study of cracking in battery electrodes. The GREAT2 algorithm and associated workflows have been made available as the GRAPES Python toolkit.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500082"},"PeriodicalIF":10.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improve the Internal and Interface Stability of Sulfide-Based Composite Electrolytes Through High Concentration Electrolyte and Continuous Li⁺ Conductive Frameworks. 通过高浓度电解液和连续的Li+导电框架提高硫化物基复合电解质的内部和界面稳定性。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-23 DOI: 10.1002/smtd.202500179

Jie Zhang, Chengshuai Bao, Jun Jin, Jiajie Wen, Zhaoyin Wen

{"title":"Improve the Internal and Interface Stability of Sulfide-Based Composite Electrolytes Through High Concentration Electrolyte and Continuous Li+ Conductive Frameworks.","authors":"Jie Zhang, Chengshuai Bao, Jun Jin, Jiajie Wen, Zhaoyin Wen","doi":"10.1002/smtd.202500179","DOIUrl":"https://doi.org/10.1002/smtd.202500179","url":null,"abstract":"Composite electrolytes have received widespread attention due to their potential to simultaneously integrate the advantages of different types of electrolytes. However, composite electrolytes based on sulfides and polymers electrolyte still face issues such as instability toward lithium metal, low ion transference number, and instability between polymers and sulfides. Based on this, a composite electrolyte based on a continuous conductive Li5.4PS4.4Cl1.6(LPSC) framework with polytetrafluoroethylene (PTFE) is prepared as a binder (LPSC@PTFE) and gel electrolyte containing high concentration lithium salt. The gel electrolyte fills the pores in the LPSC@PTFE membrane and protects the interface between the sulfide electrolyte and lithium metal. In addition, high-concentration electrolytes exhibit better stability compared to low-concentration electrolytes, whether for lithium metal or sulfides. The improvement has been demonstrated in stability through analysis of in-situ electrochemical impedance spectroscopy (EIS) combined with relaxation time distribution (DRT), as well as characterization by X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy. The mechanism behind the performance enhancement through theoretical calculations and simulations has also been speculated on. The optimized composite electrolyte membrane has an electrochemical window of 4.98 V, an increased ion transference number of 0.74, a critical current density of 1.8 mA cm-2@0.1 mAh cm-2, and can cycle for more than 4000 h at a current density of 0.1 mA cm-2@0.1 mAh cm-2. After matching with LiFePO4 (LFP) cathode, the capacity retention rate is 94.1% after 150 cycles at a rate of 1C and 89.7% after 150 cycles at a rate of 2C.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500179"},"PeriodicalIF":10.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Microcavity Chemiluminescent Immunoimaging Protocol for Fast in Situ Detection of Antibody Secreted from Single Hybridoma Cells. 一种快速原位检测杂交瘤细胞分泌抗体的微腔化学发光免疫成像方法。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-23 DOI: 10.1002/smtd.202500656

Hang Ao, Wencheng Xiao, Weiwei Chen, Wenrui Hu, Jie Wu, Huangxian Ju

{"title":"A Microcavity Chemiluminescent Immunoimaging Protocol for Fast in Situ Detection of Antibody Secreted from Single Hybridoma Cells.","authors":"Hang Ao, Wencheng Xiao, Weiwei Chen, Wenrui Hu, Jie Wu, Huangxian Ju","doi":"10.1002/smtd.202500656","DOIUrl":"https://doi.org/10.1002/smtd.202500656","url":null,"abstract":"Chemiluminescent immunoassay is the most widely used protein detection technique in clinical diagnosis but still faces substantial challenges in antibody-related single-cell analysis due to the lack of a homogeneous immunoassay with strong and stable chemiluminescence signal. Herein, a single-cell microfluidic platform for efficient in situ detection of antibody secreted from single hybridoma cells through a microcavity chemiluminescent immunoimaging (MCCLII) protocol is reported, which consist of an imidazole-enhanced chemiluminescence system, a proximity-triggered DNA nanomachine and a hybrid-regulated hemin-DNA switch. In MCCLII, antibody secreted from single hybridoma cells can be visualized through a homogeneous proximity CL assay, which converses the target antibody to DNA for triggering the DNA nanomachine and then activates the catalytic activity of hemin-DNA switch to produce strong and persistent chemiluminescence for micro-imaging. The MCCLII realizes immunoimaging detection down to 66 antibody molecules in 0.79-nL microchamber and demonstrates the possibility of specific hybridoma cell screening within 30 min, which provides a simple and fast antibody screening platform to promote antibody-drug production.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500656"},"PeriodicalIF":10.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on Dry Etching of iCVD-Grown pV3D3 Dielectric Polymer Film. icvd生长pV3D3介电聚合物膜的干法刻蚀研究。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-23 DOI: 10.1002/smtd.202500744

Jueun Baek, Yukyung Kim, Jeonghoon Oh, Junghyun Park, Kwang Hyeon Baik, Soohwan Jang, Junhwan Choi

{"title":"Study on Dry Etching of iCVD-Grown pV3D3 Dielectric Polymer Film.","authors":"Jueun Baek, Yukyung Kim, Jeonghoon Oh, Junghyun Park, Kwang Hyeon Baik, Soohwan Jang, Junhwan Choi","doi":"10.1002/smtd.202500744","DOIUrl":"https://doi.org/10.1002/smtd.202500744","url":null,"abstract":"Polymer dielectric materials are promising candidates for next-generation electronics due to their cost-effectiveness, molecular-level structural tunability, and mechanical deformability. Among various fabrication techniques, initiated chemical vapor deposition (iCVD) enables high-purity polymer dielectric films with robust insulating properties. However, the lack of high-resolution patterning techniques has hindered their integration into high-density electronics. Here, the dry etching process of an organosilicon polymer dielectric layer fabricated via iCVD process is systematically investigated by using reactive ion etching (RIE) with CF4 plasma. Direct mode RIE enabled a higher etch rate owing to the combined physical and chemical etching mechanisms, whereas remote mode RIE provided uniform etching with minimal perturbation on the surface morphology. Furthermore, introducing O2 gas in CF4 RIE significantly enhanced the etch rate in both modes, reaching ≈1 000 Å min-1, despite localized pattern distortions caused by SiOx formation. To validate its applicability, an ultrathin (≈33 nm), RIE-patterned polymer dielectric layer was implemented in an AlGaN/GaN-based metal-insulator-semiconductor high electron mobility transistor (MISHEMT), where the effective gate modulationwas achieved, along with a decent transconductance (≈1.5 mS) and a high current on/off ratio (>108). This study establishes a systematic, high-resolution dry etching method for the vapor-phase deposited, crosslinked polymer dielectric layer, paving the way toward high-density electronics.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500744"},"PeriodicalIF":10.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atomic Force Microscopy for Cross-Disciplinary Materials Research. 用于跨学科材料研究的原子力显微镜。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-23 DOI: 10.1002/smtd.202500514

Soyun Joo, Seongmun Eom, Youngwoo Choi, Uichang Jeong, Yoonhan Cho, WonJeong Yu, Kunwoo Park, Seungbum Hong

{"title":"Atomic Force Microscopy for Cross-Disciplinary Materials Research.","authors":"Soyun Joo, Seongmun Eom, Youngwoo Choi, Uichang Jeong, Yoonhan Cho, WonJeong Yu, Kunwoo Park, Seungbum Hong","doi":"10.1002/smtd.202500514","DOIUrl":"10.1002/smtd.202500514","url":null,"abstract":"While microscopy remains the primary method for verifying material structures, recent technological advancements have both enabled and necessitated the analysis of ever-finer details. Unlike scanning electron microscopy (SEM) and transmission electron microscopy (TEM), atomic force microscopy (AFM) provides unique capabilities beyond visualization, mapping surface properties through precisely controlled physical interactions between the probe and sample. In materials research specifically, AFM has become indispensable for characterizing mechanical, electrical, chemical, and magnetic properties at the nanoscale with exceptional spatial resolution. With ongoing technological progress and the expansion of specialized imaging modes, AFM enables cross-disciplinary collaboration across various materials science domains, from electronic materials to energy storage systems. However, its effective implementation is often challenged by the technical complexity and varied domain expertise among collaborators. This review examines critical considerations in AFM-based research, from experimental protocols to quantitative data analysis. Validated approaches for measurement optimization are presented to ensure reproducibility and support successful cross-disciplinary AFM implementation. The review includes detailed implementation guidance for advanced AFM methodologies and comprehensive case studies spanning diverse material systems. By providing theoretical foundations and practical guidance, this review aims to facilitate more effective collaboration across disciplines, ultimately advancing the use of AFM in complex, multi-faceted research.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500514"},"PeriodicalIF":10.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0