一种电负性调制的压电金属-有机框架用于肿瘤压电催化铁下垂。

IF 10.7 2区 材料科学 Q1 CHEMISTRY, PHYSICAL
Zheng Chen, Qiyue Wang, Sirui Cui, Xi Hu, Peihua Lin, Bo Zhang, Daishun Ling, Fangyuan Li
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引用次数: 0

摘要

压电材料已成为超声触发癌症治疗的多功能工具,但其临床应用受到低效电荷分离和肿瘤微环境中催化底物可用性有限的限制。本文报道了一种电负性调制的压电金属有机框架(CapMOF@HA),通过在pMOFs上控制CaO2的异质外延生长,然后用透明质酸(HA)进行表面功能化,以增强肿瘤靶向能力,从而增强压电催化治疗。值得注意的是,CaO2和pMOF之间的电负性调制的非均相界面促进了电子-空穴对的分离,同时通过电负性效应抑制了重组,在超声刺激下显著增加了压催化活性氧(•OH, 1O2和•O2)的生成。此外,过氧化钙的受控分解提供了H2O2和O2作为催化底物的持续供应,同时释放Ca2+诱导钙超载,引发线粒体功能障碍和谷胱甘肽过氧化物酶4抑制,诱导铁下垂。该策略整合了增强的压电催化与铁凋亡诱导,克服了压电催化系统长期存在的局限性,以实现精确和稳健的肿瘤消融。通过将基质自给自足与多功能治疗机制相结合,本研究建立了肿瘤压电催化铁凋亡作为下一代压电癌症治疗的变革平台。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An Electronegativity-Modulated Piezoelectric Metal-Organic Framework for Tumor Piezocatalytic Ferroptosis.

Piezoelectric materials have emerged as versatile tools for ultrasound-triggered cancer therapy, yet their clinical application is constrained by inefficient charge separation and the limited availability of catalytic substrates in the tumor microenvironment. Here, an electronegativity-modulated piezoelectric metal-organic framework (CapMOF@HA) is reported through controlled heteroepitaxial growth of CaO2 on pMOFs, followed by surface functionalization with hyaluronic acid (HA) for tumor-targeting capability for enhanced piezocatalytic therapy. Of note, the electronegativity-modulated heterogeneous interfaces between CaO2 and pMOF promote the separation of electron-hole pairs while suppressing recombination through the electronegativity effect, significantly amplifying piezocatalytic reactive oxygen species (ROS) generation (•OH, 1O2, and •O2⁻) under ultrasound stimulation. Furthermore, the controlled decomposition of calcium peroxide provides a continuous supply of H2O2 and O2 as catalytic substrates, while releasing Ca2+ to induce calcium overload, triggering mitochondrial dysfunction and glutathione peroxidase 4 inhibition for ferroptosis induction. This strategy integrates enhanced piezoelectric catalysis with ferroptosis induction, overcoming long-standing limitations in piezocatalytic systems to achieve precise and robust tumor ablation. By combining substrate self-sufficiency with multifunctional therapeutic mechanisms, this work establishes tumor piezocatalytic ferroptosis as a transformative platform for next-generation piezoelectric cancer therapy.

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来源期刊
Small Methods
Small Methods Materials Science-General Materials Science
CiteScore
17.40
自引率
1.60%
发文量
347
期刊介绍: Small Methods is a multidisciplinary journal that publishes groundbreaking research on methods relevant to nano- and microscale research. It welcomes contributions from the fields of materials science, biomedical science, chemistry, and physics, showcasing the latest advancements in experimental techniques. With a notable 2022 Impact Factor of 12.4 (Journal Citation Reports, Clarivate Analytics, 2023), Small Methods is recognized for its significant impact on the scientific community. The online ISSN for Small Methods is 2366-9608.
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