Small Methods最新文献_第6页

Improve the Internal and Interface Stability of Sulfide-Based Composite Electrolytes Through High Concentration Electrolyte and Continuous Li⁺ Conductive Frameworks. 通过高浓度电解液和连续的Li+导电框架提高硫化物基复合电解质的内部和界面稳定性。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-23 DOI: 10.1002/smtd.202500179

Jie Zhang, Chengshuai Bao, Jun Jin, Jiajie Wen, Zhaoyin Wen

{"title":"Improve the Internal and Interface Stability of Sulfide-Based Composite Electrolytes Through High Concentration Electrolyte and Continuous Li+ Conductive Frameworks.","authors":"Jie Zhang, Chengshuai Bao, Jun Jin, Jiajie Wen, Zhaoyin Wen","doi":"10.1002/smtd.202500179","DOIUrl":"https://doi.org/10.1002/smtd.202500179","url":null,"abstract":"Composite electrolytes have received widespread attention due to their potential to simultaneously integrate the advantages of different types of electrolytes. However, composite electrolytes based on sulfides and polymers electrolyte still face issues such as instability toward lithium metal, low ion transference number, and instability between polymers and sulfides. Based on this, a composite electrolyte based on a continuous conductive Li5.4PS4.4Cl1.6(LPSC) framework with polytetrafluoroethylene (PTFE) is prepared as a binder (LPSC@PTFE) and gel electrolyte containing high concentration lithium salt. The gel electrolyte fills the pores in the LPSC@PTFE membrane and protects the interface between the sulfide electrolyte and lithium metal. In addition, high-concentration electrolytes exhibit better stability compared to low-concentration electrolytes, whether for lithium metal or sulfides. The improvement has been demonstrated in stability through analysis of in-situ electrochemical impedance spectroscopy (EIS) combined with relaxation time distribution (DRT), as well as characterization by X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy. The mechanism behind the performance enhancement through theoretical calculations and simulations has also been speculated on. The optimized composite electrolyte membrane has an electrochemical window of 4.98 V, an increased ion transference number of 0.74, a critical current density of 1.8 mA cm-2@0.1 mAh cm-2, and can cycle for more than 4000 h at a current density of 0.1 mA cm-2@0.1 mAh cm-2. After matching with LiFePO4 (LFP) cathode, the capacity retention rate is 94.1% after 150 cycles at a rate of 1C and 89.7% after 150 cycles at a rate of 2C.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500179"},"PeriodicalIF":10.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Microcavity Chemiluminescent Immunoimaging Protocol for Fast in Situ Detection of Antibody Secreted from Single Hybridoma Cells. 一种快速原位检测杂交瘤细胞分泌抗体的微腔化学发光免疫成像方法。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-23 DOI: 10.1002/smtd.202500656

Hang Ao, Wencheng Xiao, Weiwei Chen, Wenrui Hu, Jie Wu, Huangxian Ju

{"title":"A Microcavity Chemiluminescent Immunoimaging Protocol for Fast in Situ Detection of Antibody Secreted from Single Hybridoma Cells.","authors":"Hang Ao, Wencheng Xiao, Weiwei Chen, Wenrui Hu, Jie Wu, Huangxian Ju","doi":"10.1002/smtd.202500656","DOIUrl":"https://doi.org/10.1002/smtd.202500656","url":null,"abstract":"Chemiluminescent immunoassay is the most widely used protein detection technique in clinical diagnosis but still faces substantial challenges in antibody-related single-cell analysis due to the lack of a homogeneous immunoassay with strong and stable chemiluminescence signal. Herein, a single-cell microfluidic platform for efficient in situ detection of antibody secreted from single hybridoma cells through a microcavity chemiluminescent immunoimaging (MCCLII) protocol is reported, which consist of an imidazole-enhanced chemiluminescence system, a proximity-triggered DNA nanomachine and a hybrid-regulated hemin-DNA switch. In MCCLII, antibody secreted from single hybridoma cells can be visualized through a homogeneous proximity CL assay, which converses the target antibody to DNA for triggering the DNA nanomachine and then activates the catalytic activity of hemin-DNA switch to produce strong and persistent chemiluminescence for micro-imaging. The MCCLII realizes immunoimaging detection down to 66 antibody molecules in 0.79-nL microchamber and demonstrates the possibility of specific hybridoma cell screening within 30 min, which provides a simple and fast antibody screening platform to promote antibody-drug production.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500656"},"PeriodicalIF":10.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on Dry Etching of iCVD-Grown pV3D3 Dielectric Polymer Film. icvd生长pV3D3介电聚合物膜的干法刻蚀研究。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-23 DOI: 10.1002/smtd.202500744

Jueun Baek, Yukyung Kim, Jeonghoon Oh, Junghyun Park, Kwang Hyeon Baik, Soohwan Jang, Junhwan Choi

{"title":"Study on Dry Etching of iCVD-Grown pV3D3 Dielectric Polymer Film.","authors":"Jueun Baek, Yukyung Kim, Jeonghoon Oh, Junghyun Park, Kwang Hyeon Baik, Soohwan Jang, Junhwan Choi","doi":"10.1002/smtd.202500744","DOIUrl":"https://doi.org/10.1002/smtd.202500744","url":null,"abstract":"Polymer dielectric materials are promising candidates for next-generation electronics due to their cost-effectiveness, molecular-level structural tunability, and mechanical deformability. Among various fabrication techniques, initiated chemical vapor deposition (iCVD) enables high-purity polymer dielectric films with robust insulating properties. However, the lack of high-resolution patterning techniques has hindered their integration into high-density electronics. Here, the dry etching process of an organosilicon polymer dielectric layer fabricated via iCVD process is systematically investigated by using reactive ion etching (RIE) with CF4 plasma. Direct mode RIE enabled a higher etch rate owing to the combined physical and chemical etching mechanisms, whereas remote mode RIE provided uniform etching with minimal perturbation on the surface morphology. Furthermore, introducing O2 gas in CF4 RIE significantly enhanced the etch rate in both modes, reaching ≈1 000 Å min-1, despite localized pattern distortions caused by SiOx formation. To validate its applicability, an ultrathin (≈33 nm), RIE-patterned polymer dielectric layer was implemented in an AlGaN/GaN-based metal-insulator-semiconductor high electron mobility transistor (MISHEMT), where the effective gate modulationwas achieved, along with a decent transconductance (≈1.5 mS) and a high current on/off ratio (>108). This study establishes a systematic, high-resolution dry etching method for the vapor-phase deposited, crosslinked polymer dielectric layer, paving the way toward high-density electronics.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500744"},"PeriodicalIF":10.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atomic Force Microscopy for Cross-Disciplinary Materials Research. 用于跨学科材料研究的原子力显微镜。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-23 DOI: 10.1002/smtd.202500514

Soyun Joo, Seongmun Eom, Youngwoo Choi, Uichang Jeong, Yoonhan Cho, WonJeong Yu, Kunwoo Park, Seungbum Hong

{"title":"Atomic Force Microscopy for Cross-Disciplinary Materials Research.","authors":"Soyun Joo, Seongmun Eom, Youngwoo Choi, Uichang Jeong, Yoonhan Cho, WonJeong Yu, Kunwoo Park, Seungbum Hong","doi":"10.1002/smtd.202500514","DOIUrl":"10.1002/smtd.202500514","url":null,"abstract":"While microscopy remains the primary method for verifying material structures, recent technological advancements have both enabled and necessitated the analysis of ever-finer details. Unlike scanning electron microscopy (SEM) and transmission electron microscopy (TEM), atomic force microscopy (AFM) provides unique capabilities beyond visualization, mapping surface properties through precisely controlled physical interactions between the probe and sample. In materials research specifically, AFM has become indispensable for characterizing mechanical, electrical, chemical, and magnetic properties at the nanoscale with exceptional spatial resolution. With ongoing technological progress and the expansion of specialized imaging modes, AFM enables cross-disciplinary collaboration across various materials science domains, from electronic materials to energy storage systems. However, its effective implementation is often challenged by the technical complexity and varied domain expertise among collaborators. This review examines critical considerations in AFM-based research, from experimental protocols to quantitative data analysis. Validated approaches for measurement optimization are presented to ensure reproducibility and support successful cross-disciplinary AFM implementation. The review includes detailed implementation guidance for advanced AFM methodologies and comprehensive case studies spanning diverse material systems. By providing theoretical foundations and practical guidance, this review aims to facilitate more effective collaboration across disciplines, ultimately advancing the use of AFM in complex, multi-faceted research.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500514"},"PeriodicalIF":10.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing the Full Potential of Zr Dopant for LiNiO₂ by Tailoring Spatial Distribution. 通过调整空间分布来充分利用Zr掺杂对LiNiO2的潜力。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-23 DOI: 10.1002/smtd.202500606

Eun Hee Lee, JinHa Shim, Jin Ho Bang

{"title":"Harnessing the Full Potential of Zr Dopant for LiNiO2 by Tailoring Spatial Distribution.","authors":"Eun Hee Lee, JinHa Shim, Jin Ho Bang","doi":"10.1002/smtd.202500606","DOIUrl":"https://doi.org/10.1002/smtd.202500606","url":null,"abstract":"High-nickel layered oxide materials are crucial for high-energy lithium-ion batteries; however, their stability remains a significant challenge. While doping has emerged as a promising strategy for stabilization, the inconsistent doping effects reported in the literature necessitate a more profound mechanistic understanding. To address this, a Zr-doped LiNiO2 model system is employed to investigate the influence of dopant distribution. These findings reveal that the spatial distribution of the dopant, primarily dictated by the slow solid-state diffusion kinetics during sintering, critically influences its functional role. By utilizing different doping methodologies, varying Zr distributions are achieved within the LiNiO2 matrix. Solid-state doping resulted in the formation of a monoclinic Li2ZrO3 surface layer, attributed to diffusion limitations, which led to an enhanced initial capacity. Conversely, co-precipitation facilitated a more uniform Zr distribution and induced surface cation mixing, thereby improving structural stability. Given these insights, a novel hybrid doping strategy that synergistically combines the benefits of both distribution profiles, ultimately achieving superior electrochemical performance, is proposed. This work highlights the critical importance of precisely controlling dopant spatial distribution, suggesting that this challenge, exemplified by Zr in this study, represents a general consideration for various dopants in the rational design of advanced materials for energy applications.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500606"},"PeriodicalIF":10.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Resolution Heterogeneous Hydrogel Printing Using a Home Projector. 使用家用投影仪的高分辨率非均质水凝胶打印。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-23 DOI: 10.1002/smtd.202500631

Zhangkang Li, Jaemyung Shin, Kartikeya Dixit, Daichen Liu, Hongguang Zhang, Qingye Lu, Hitendra Kumar, Keekyoung Kim, Jinguang Hu

{"title":"High-Resolution Heterogeneous Hydrogel Printing Using a Home Projector.","authors":"Zhangkang Li, Jaemyung Shin, Kartikeya Dixit, Daichen Liu, Hongguang Zhang, Qingye Lu, Hitendra Kumar, Keekyoung Kim, Jinguang Hu","doi":"10.1002/smtd.202500631","DOIUrl":"https://doi.org/10.1002/smtd.202500631","url":null,"abstract":"Soft hydrogels are being increasingly recognized for their versatility and unique properties, making them attractive for a range of applications in tissue engineering, biomedical devices, and beyond. Among fabrication methods, 3D printing stands out for its precise control over material distribution, enabling the creation of complex structures. Traditional printing methods, however, struggle to produce heterogeneous hydrogels with diverse properties. Here, a novel approach is introduced utilizing polyvinyl alcohol bearing styrylpyridinium groups (PVA-SbQ) for high-resolution heterogeneous hydrogel printing. By leveraging the photoreactive nature of PVA-SbQ, precise control over crosslinking time at different positions within a PVA-SbQ hydrogel is demonstrated using a simple home projector. This enables the creation of intricate patterns with tailored properties within a heterogeneous hydrogel, showcasing synergistic combinations of soft and tough domains, as well as high and low swelling regions. The method not only advances the field of hydrogel printing but also holds promise for applications in pattern encryption, 4D printing, cell organization, and cell alignment. By overcoming the limitations of traditional printing techniques, the approach opens new avenues for the fabrication of complex and heterogeneous hydrogel structures with diverse applications in biomedical engineering and beyond.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500631"},"PeriodicalIF":10.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Sandwich-Structured Na₂Ti₆O₁₃/Reduced Graphene Oxide Composite for Improved Energy Storage in Sodium-Ion Batteries. 用于改善钠离子电池储能性能的三明治结构Na2Ti6O13/还原氧化石墨烯复合材料。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-23 DOI: 10.1002/smtd.202500671

Jungwook Song, Jungmin Han, Hwi Cheol Ju, Hyun A Seo, Boram Yun, Dohyun Moon, Dukhyun Choi, Jongsik Kim

{"title":"A Sandwich-Structured Na2Ti6O13/Reduced Graphene Oxide Composite for Improved Energy Storage in Sodium-Ion Batteries.","authors":"Jungwook Song, Jungmin Han, Hwi Cheol Ju, Hyun A Seo, Boram Yun, Dohyun Moon, Dukhyun Choi, Jongsik Kim","doi":"10.1002/smtd.202500671","DOIUrl":"https://doi.org/10.1002/smtd.202500671","url":null,"abstract":"Sodium-ion batteries (SIBs) have the potential to be a cost-effective and sustainable solution for large-scale energy storage systems (ESSs) due to the abundance of sodium reserves. Na2Ti6O13 has been considered as a suitable candidate for use as an anode material in SIBs owing to its environmental friendliness, low cost, and excellent cycling stability. Despite its advantages, Na2Ti6O13 has intrinsic limitations such as electrical conductivity. To overcome these obstacles, a sandwich-structured Na2Ti6O13/reduced graphene oxide (rGO) composite is synthesized through a liquid-phase exfoliation and restacking method using electrostatic interactions. The Na2Ti6O13/rGO composite showed remarkable improvement in both reversible discharge capacity and cycle stability. In comparison to bare Na2Ti6O13 with a discharge capacity of 20.1 mAh g-1 after 500 cycles, the Na2Ti6O13/rGO1 composite displayed a discharge capacity of 196.5 mAh g-1 at a current density of 0.1 A g-1 and a voltage range of 0.01-2.5 V. Furthermore, the Na2Ti6O13/rGO1||Na3V2(PO4)3 full cell are assembled, discharging an energy density of 251.3 Wh kg-1 anode with a power density of 228.1 W kg-1 anode after 100 cycles in a voltage range of 1.0-4.0 V.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500671"},"PeriodicalIF":10.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laser Synthesis in Liquid Induced Lattice Distortion in PtFeSn/Activated Carbon for Enhanced Methylcyclohexane Dehydrogenation. 液体诱导晶格畸变的激光合成PtFeSn/活性炭增强甲基环己烷脱氢。

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-23 DOI: 10.1002/smtd.202500474

Zheng Wang, Hossein Akhoundzadeh, Mudi Wu, Mingwu Tan, Yizhong Huang, Rong Xu

{"title":"Laser Synthesis in Liquid Induced Lattice Distortion in PtFeSn/Activated Carbon for Enhanced Methylcyclohexane Dehydrogenation.","authors":"Zheng Wang, Hossein Akhoundzadeh, Mudi Wu, Mingwu Tan, Yizhong Huang, Rong Xu","doi":"10.1002/smtd.202500474","DOIUrl":"https://doi.org/10.1002/smtd.202500474","url":null,"abstract":"Methylcyclohexane (MCH) has emerged as one of the most promising liquid organic hydrogen carriers (LOHCs) for H2 storage and long-distance transportation. Developing efficient, selective, and stable catalysts for MCH dehydrogenation is essential to make the process viable for practical applications. In this study, a platinum-iron-tin alloy supported on activated carbon (PtFeSn/AC) is reported, prepared via laser synthesis in liquid (LSL), exhibiting excellent dehydrogenation performance. The rapid crystallization and quenching inherent to the LSL process kinetically trap lattice distortions in the PtFeSn/AC catalyst due to atomic radius mismatches among Pt, Fe, and Sn. These distortions generate strain effects that create a local unsaturated coordination environment and downshift the d-band center of the catalyst, thereby enhancing the exposure of active sites and facilitating the desorption of toluene (TOL). As a result, the PtFeSn/AC catalyst demonstrates exceptional dehydrogenation performance, achieving a hydrogen evolution rate of 2625 mmol gPt -1 min-1 under a weight hourly space velocity (WHSV) of 27.7 h-1. Notably, the catalyst exhibits remarkable stability, with only a 3.2% drop in conversion after 193 h of continuous reaction. Additionally, TOL selectivity remains extraordinarily high at 99.96%. This work provides critical insights into the design of high-performance catalysts via non-conventional synthesis methods for practical applications.","PeriodicalId":229,"journal":{"name":"Small Methods","volume":" ","pages":"e2500474"},"PeriodicalIF":10.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing Topoisomerase Research Using DNA Nanotechnology (Small Methods 6/2025) 利用DNA纳米技术推进拓扑异构酶的研究（Small Methods） 6/2025

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-22 DOI: 10.1002/smtd.202570040

Doron Yesodi, Adi Katz, Yossi Weizmann

引用次数: 0

Advancements in Engineering Tetrahedral Framework Nucleic Acids for Biomedical Innovations (Small Methods 6/2025) 生物医学创新工程四面体框架核酸研究进展（小方法6/2025）

IF 10.7 2区材料科学

Small Methods Pub Date : 2025-06-22 DOI: 10.1002/smtd.202570039

Qin Fan, Bicheng Sun, Jie Chao

引用次数: 0