Advancing Topoisomerase Research Using DNA Nanotechnology (Small Methods 6/2025)

IF 10.7 2区材料科学 Q1 CHEMISTRY, PHYSICAL

Small Methods Pub Date : 2025-06-22 DOI:10.1002/smtd.202570040

Doron Yesodi, Adi Katz, Yossi Weizmann

引用次数: 0

Abstract

Back Cover

This cover image illustrates the evolving landscape of topoisomerase research powered by DNA nanotechnology. Depicted as a molecular staircase, the journey begins with classical plasmid-based assays and ascends through synthetic DNA nanoprobes and amplification-based strategies, ultimately guiding the discovery of new therapeutic drug candidates. Each step represents an innovative method for probing topoisomerase activity with greater sensitivity, programmability, and throughput—advancing both our mechanistic understanding and translational potential. More in article number 2401113, Weizmann and co-workers.

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利用DNA纳米技术推进拓扑异构酶的研究（Small Methods） 6/2025

这张封面图片说明了由DNA纳米技术驱动的拓扑异构酶研究的发展前景。描述为分子阶梯，旅程从经典的基于质粒的分析开始，通过合成DNA纳米探针和基于扩增的策略上升，最终指导新的治疗候选药物的发现。每一步都代表了一种探测拓扑异构酶活性的创新方法，具有更高的灵敏度、可编程性和吞吐量——推进了我们对机制的理解和转化潜力。文章编号2401113，Weizmann和他的同事。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Small Methods Materials Science-General Materials Science

CiteScore

17.40

自引率

1.60%

发文量

347

期刊介绍： Small Methods is a multidisciplinary journal that publishes groundbreaking research on methods relevant to nano- and microscale research. It welcomes contributions from the fields of materials science, biomedical science, chemistry, and physics, showcasing the latest advancements in experimental techniques. With a notable 2022 Impact Factor of 12.4 (Journal Citation Reports, Clarivate Analytics, 2023), Small Methods is recognized for its significant impact on the scientific community. The online ISSN for Small Methods is 2366-9608.