Systematic Reviews最新文献

{"title":"Exploring the factors that influence engagement with and experiences of integrated care for adults at risk of cardiovascular disease and mild-to-moderate mental health concerns in the UK (OptICS): a systematic review protocol.","authors":"Alison R McKinlay, Neil Howlett, Vivi Antonopoulou, Fabiana Lorencatto, Laura J McGowan, David Osborn, Amy O'Donnell, Emily J Oliver, Ivo Vlaev, Falko F Sniehotta, Michael P Kelly, Susan Michie, Caroline Kemp, Yannis Pappas, Gurch Randhawa, Nasreen Ali, Emily Munro, Angel M Chater","doi":"10.1186/s13643-025-02903-2","DOIUrl":"https://doi.org/10.1186/s13643-025-02903-2","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease (CVD) is one of the leading causes of premature death globally. CVD is expensive to treat and therefore carries a significant cost for public healthcare systems and the people in them. Those most likely to develop CVD often report co-occurring mental health concerns such as depression and anxiety, in addition to behavioural factors (e.g. physical inactivity) and physical health conditions (e.g. hypertension, high cholesterol, obesity and diabetes). Due to these inter-connecting issues, healthcare provision for CVD patients necessitates a joined-up care pathway providing holistic, person-centred support. Despite the rapid emergence and growth in attempts to deliver such care, evidence concerning how it is experienced and how to promote engagement is fragmented. This review aims to capture the experiences and factors that influence integrated care engagement, reported by adults with CVD risk factors and mild-to-moderate mental health concerns.</p><p><strong>Methods: </strong>This systematic review protocol will be reported according to the updated Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA-P) guidelines. Proposed database searches will include Emcare, MEDLINE, PsycINFO (via OVID), CINAHL and preprint databases for grey literature. Articles of interest will include adults' experiences of and factors that influence engagement with integrated care in the UK, specifically for support with CVD risk and mild-to-moderate mental health concerns. Any study design reporting qualitative primary data will be included (excluding conference abstracts). Data on study population (actors/targets), what they do (behaviours) care setting (context), care format (time) and participant experiences and perspectives will be extracted. Where appropriate, thematic synthesis of extracted data will be coded to the Theoretical Domains Framework (TDF), updated Consolidated Framework for Implementation Research (CFIR) and Action, Actor, Context, Target and Time (AACTT) framework.</p><p><strong>Discussion: </strong>Findings from this review will provide foundation evidence for a behavioural systems map and recommendations for policymakers, commissioners and those involved or interested in integrated care for people at risk of CVD with mental health concerns. Such evidence can be used to develop future intervention strategies to assist the optimisation of integrated care.</p><p><strong>Systematic review registration: </strong>PROSPERO (CRD42024554282.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"168"},"PeriodicalIF":3.9,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ReviewGenie: a novel automated system for systematic reviews-an exploratory study in speech and language disorders.","authors":"Abeer Z Al-Marridi, Ahmed Bensaid, Samawiyah M Ulde, Tariq Khwaileh","doi":"10.1186/s13643-025-02895-z","DOIUrl":"10.1186/s13643-025-02895-z","url":null,"abstract":"<p><strong>Background: </strong>Systematic reviews (SRs) are a cornerstone in providing high-quality evidence that guides policy and practice across various disciplines. Despite their critical role, SRs require substantial financial investment and are constrained by time-consuming manual processes. Existing solutions primarily focus on semi-automating the title and abstract screening stages, yet these approaches still face limitations in terms of efficiency and practicality. The SR process comprises several stages beyond abstract screening, each of which is resource-intensive. To overcome these challenges, this paper introduces ReviewGenie, a novel system that automates SR stages up to and including abstract screening, utilizing artificial intelligence.</p><p><strong>Method: </strong>The SR process involves eight key stages, beginning with the definition of search keywords and the selection of target databases, and culminating in full screening. While the initial and final stages require human expertise, the intermediate stages can be automated. ReviewGenie automates all intermediary stages, including database searching, data retrieval, cleaning, deduplication, filtering, and abstract screening. The system is domain-agnostic, as evidenced by a case study focused on databases related to speech and language disorders.</p><p><strong>Results: </strong>ReviewGenie significantly reduces the workload across various stages of the SR process, delivering notable time and cost savings while enhancing efficiency and accuracy. In the case study, where the article-fetching stage involved tens of thousands of publications, ReviewGenie achieved a 2.62% improvement in duplicate detection in less than a second, compared to the 1 to 3 h typically required for manual deduplication of 100 records. This process included cleaning abstracts before removing duplicates. Additionally, ReviewGenie reduced the number of articles from 28,674 to 3520 using an automatic filtering approach executed in seconds. This substantial reduction underscores the effectiveness of our automated method in preparing datasets for the abstract screening stage. Moreover, the artificial intelligence-driven abstract screening method resulted in cost savings exceeding $6230 compared to manual methods.</p><p><strong>Conclusions: </strong>ReviewGenie represents a significant advancement in reducing the burden on researchers conducting comprehensive systematic reviews. By automating intermediate stages, ReviewGenie enhances efficiency, accuracy, and cost-effectiveness, establishing itself as an indispensable tool for SRs across various disciplines.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"167"},"PeriodicalIF":3.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12359888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the challenges of medicine optimisation among older people (aged 60 years and above) from ethnic minority communities with polypharmacy in primary care: a realist review protocol.","authors":"Nesrein Hamed, Clare Bates, Muhammed Umair Khan, Ian Maidment","doi":"10.1186/s13643-025-02920-1","DOIUrl":"10.1186/s13643-025-02920-1","url":null,"abstract":"<p><strong>Background: </strong>Across many countries, the number of older people from ethnic minority communities is growing due to ageing populations and migration trends. In England and Wales, the population of older people from ethnic minority communities, particularly those aged 60 and above, is also increasing. This demographic change, often accompanied by the prevalence of polypharmacy in these communities, presents unique challenges in the context of medicine optimisation. Failure in this context can lead to exacerbated health disparities, non-adherence, and inappropriate prescribing (whether over or under). Building on the MEMORABLE study exploring medication management in older people, this review aims to understand the complexities of medicine optimisation, exploring what works and does not work, when and under what circumstances for older people from ethnic minority communities. Key possible areas include cultural backgrounds, traditional beliefs, and systemic barriers that may influence medicine optimisation.</p><p><strong>Methods: </strong>The review will follow the five-step realist approach that firstly establishes initial programme theories to highlight the expected context, mechanisms, and outcomes. Then a formal search for evidence will be conducted. The third step involves the selection and appraisal of studies screened by title, abstract/keywords and full text based on exclusion/inclusion criteria. Then data from these studies will be extracted, recorded, and coded. The final step will synthesise this information, to test, refine, and expand our initial programme theories and generate context-mechanism-outcome configurations to better understand medicine optimisation in these communities.</p><p><strong>Discussion: </strong>This review will be conducted in line with the RAMESES reporting standards. By explaining what works, for whom, and in what contexts, the review will generate theory-informed insights into MO for older people from ethnic minority communities with polypharmacy in primary care. These findings can support the development of culturally responsive, person-centred interventions. Results will be shared through peer-reviewed publications and presentations at relevant national and international conferences. TRIAL REGISTRATION: Systematic review registration: PROSPERO CRD42023432204.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"166"},"PeriodicalIF":3.9,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of biofilm-targeted therapy in managing and preventing dental caries: protocol for a systematic review and meta-analysis.","authors":"Venkata Suresh Venkataiah, Mohmed Isaqali Karobari","doi":"10.1186/s13643-025-02921-0","DOIUrl":"10.1186/s13643-025-02921-0","url":null,"abstract":"<p><strong>Background: </strong>Dental caries is a biofilm-dependent disease that continues to challenge conventional preventive strategies, such as fluoride application and mechanical plaque removal. Biofilm-targeted therapies (BTT), including probiotics, photodynamic therapy, enzymatic treatments, and natural compounds, represent promising alternatives to disrupt pathogenic biofilms effectively. However, the available evidence remains fragmented, with inconsistent methodologies and limited clinical data hindering comprehensive conclusions.</p><p><strong>Methods: </strong>This systematic review and meta-analysis will synthesize evidence on the effectiveness of BTT in preventing and managing dental caries. A comprehensive search of PubMed (MEDLINE), Embase, and the Cochrane Library will identify randomized controlled trials (RCTs) and observational studies evaluating BTT interventions. To ensure methodological robustness, quantitative synthesis of intervention effectiveness will be restricted to RCTs, while observational studies will contribute to a structured narrative synthesis. Two independent reviewers will conduct study selection, data extraction, and risk of bias assessment using the RoB 2 tool for RCTs and ROBINS-I for observational studies. Where feasible, pairwise meta-analyses will be performed using random-effects models. If sufficient data are available, a network meta-analysis (NMA) will be considered. Subgroup and sensitivity analyses will explore the impact of age, caries risk level, and intervention type on treatment outcomes.</p><p><strong>Discussion: </strong>This review anticipates providing evidence on the efficacy of BTT in reducing bacterial load, altering biofilm composition, and preventing caries progression. Variability in study design and outcome measures is expected, underscoring the need for standardized methodologies and more robust clinical trials. The findings aim to deliver evidence-based insights into the clinical applicability of BTT, addressing current knowledge gaps and guiding future research toward more effective caries prevention and management strategies.</p><p><strong>Trial registration: </strong>Systematic review registration: PROSPERO CRD42024615568.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"165"},"PeriodicalIF":3.9,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12337361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventions for promoting physical activity in people with newly diagnosed Parkinson's disease: scoping review.","authors":"Jonathan Gilby, Bridie Kent, Rachel Knight Lozano, Jonathan Marsden","doi":"10.1186/s13643-025-02892-2","DOIUrl":"10.1186/s13643-025-02892-2","url":null,"abstract":"<p><strong>Background: </strong>There is increasing evidence to suggest that physical activity can slow Parkinson's progression. There is also increasing interest in non-pharmacological interventions to alleviate Parkinson's symptoms. This scoping review aimed to map and describe the evidence for interventions that promote physical activity in people with newly diagnosed Parkinson's.</p><p><strong>Methods: </strong>Studies conducted since 2011, on adults with Parkinson's (≥ 18 years), investigating the effects of non-pharmacological interventions to promote physical activity and/or exercise were considered. Interventions needed to be conducted in healthcare or healthcare-related settings for people within 5 years of Parkinson's diagnosis. Published or unpublished full-text articles since 2011 were searched in November 2023, using online focused, broad, and grey literature databases. JBI scoping review methodology was used and results presented in table format accompanied by a narrative review.</p><p><strong>Results: </strong>A total of 22 articles with a variety of research designs were included with 14 randomized trials, one single-site, prospective, single-arm study, two retrospective cohort studies, one case series, two case reports, and two qualitative reports. Many studies (n = 7) were conducted in outpatient clinics with the majority of interventions (n = 17) involving physiotherapists. Interventions varied widely, including aerobic exercise, balance exercise, dance, and yoga. The duration of intervention varied from 4 weeks to 8 years. Dosage of interventions varied widely from 30 to 90 min, and from twice weekly to seven times weekly. Several different outcome measures related to physical activity levels and/or physical fitness were used. The most frequent clinician/researcher reported outcome measure was the 6-min walk test (in nine studies) and the most frequently used participant/patient reported outcome measure was the 39-item Parkinson's Disease Questionnaire (PDQ-39) (also in nine studies). The review showed limited research in identifiable cohorts with newly diagnosed Parkinson's. Sample sizes were predominantly small. In all but one study, authors interpreted their results as favoring interventions to promote physical activity for people with newly diagnosed Parkinson's. All authors recommended further studies.</p><p><strong>Conclusions: </strong>There is a need for more research with larger sample sizes and standardized reporting to inform the evidence base for interventions that promote physical activity in people with newly diagnosed Parkinson's.</p><p><strong>Systematic review registration: </strong>https://pearl.plymouth.ac.uk/ ( http://hdl.handle.net/10026.1/20098 ).</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"164"},"PeriodicalIF":3.9,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence for various interventions to reduce depressive symptoms for children and adolescents: protocol of a global evidence and gap map.","authors":"Pengpeng Cao, Yuhao Li, Luyao Yang, Liping Guo, Jiyixi Hua, Shuo Zhang, Chuying Li, Bingxia Dang, Yanzhuang Sun, Ming Liu, Zheng Xu, Kehu Yang, Bei An","doi":"10.1186/s13643-025-02909-w","DOIUrl":"10.1186/s13643-025-02909-w","url":null,"abstract":"<p><strong>Background: </strong>Children and adolescent depression conditions are responsible for high levels of disability burden and negatively influence academic participation and life-long outcomes while their interventions and outcomes remain controversial.</p><p><strong>Methods: </strong>We conducted a comprehensive search in multiple databases of primary studies. The EPPI-Mapper mapping tool was applied to present identified studies as framework-described results.</p><p><strong>Discussion: </strong>This is the protocol for an evidence and gap map (EGM). The objectives of this EGM are to identify and map all randomized controlled studies (RCTs) on universal, school-based social and emotional learning programs for children and adolescents with depressive symptoms or diagnoses of depression, and to identify existing gaps in the evidence for creating an interactive, searchable, and publicly accessible EGM. The map will provide insights for researchers and decision-makers, build on the evidence bases in this field, and identify key areas for future research.</p><p><strong>Systematic review registration: </strong>Campbell Systematic Reviews cl2.20240091.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"162"},"PeriodicalIF":3.9,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A critical evaluation of available explicit deprescribing tools for their applicability to Indian elderly patients: a scoping review protocol.","authors":"Ajay Kumar Shukla, Ratinder Jhaj, Shubham Atal, Anindo Majumdar, Mahadev Meena, Sandeep Tiwari, Bushra Siddiqui, Jerin Jose Cherian, Atiya R Faruqui, Sowparnika Treasa Sabu","doi":"10.1186/s13643-025-02884-2","DOIUrl":"10.1186/s13643-025-02884-2","url":null,"abstract":"<p><strong>Background: </strong>Among the elderly, who are often exposed to polypharmacy, explicit deprescribing tools offer clear, validated guidelines for safely reducing medications. However, the effectiveness of these tools varies across healthcare settings and populations. In India, unique sociocultural and healthcare challenges demand a tailored approach to deprescribing for elderly patients, and the need to adapt existing tools to local contexts. The primary objective of this scoping review is mapping of the contextual relevance and applicability of the existing explicit deprescribing tools for elderly population in Indian healthcare settings.</p><p><strong>Methodology: </strong>The scoping review will be carried out in six stages: (1) Identifying the review question. (2) Identifying relevant studies through electronic databases (i.e., PubMed, Web of Science, and Embase). (3) Selection of studies to be included based on inclusion and exclusion criteria. Inclusion criteria for this scoping review are studies implementing explicit deprescribing tools involving Indian elderly patients, reporting on outcomes, validation methods, or contextual relevance of deprescribing tools, published in English or non-English language with English translation available. Exclusion criteria for this scoping review are studies focused on implicit deprescribing tools, review articles, case reports, commentaries, and editorials. Two independent reviewers will conduct the search and initial screening of studies. Discrepancies will then be solved through discussion with the third reviewer. (4) Charting, categorizing, and thematic analysis of the extracted data. (5) Collating, summarizing, and reporting the results. (6) Dissemination of findings.</p><p><strong>Discussion: </strong>By reviewing the patient population and study setting of studies of explicit tools in India, vis a vis the healthcare setting and patient population for which the tool was designed, our scoping review highlighted the strengths and weaknesses in the existing literature. These findings could be used to direct future research and assess the need for a deprescribing tool adapted for the Indian elderly patients.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"163"},"PeriodicalIF":3.9,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of photobiomodulation on multiple health outcomes: an umbrella review of randomized clinical trials.","authors":"Yejun Son, Hyeri Lee, Seungyeong Yu, Hyeon Jin Kim, Jaeyu Park, Selin Woo, Hayeon Lee, Guillaume Fond, Laurent Boyer, Masoud Rahmati, Lee Smith, Guillermo F López Sánchez, Elena Dragioti, Jiseung Kang, Tae Kim, Dong Keon Yon","doi":"10.1186/s13643-025-02902-3","DOIUrl":"10.1186/s13643-025-02902-3","url":null,"abstract":"<p><strong>Background: </strong>Photobiomodulation (PBM) is a non-invasive therapy increasingly used for pain, inflammation, and tissue repair, yet a comprehensive synthesis of its effectiveness across multiple health outcomes remains lacking. Herein, we aimed to systematically assess the clinical effects and strength of evidence for PBM across a wide range of health outcomes using data from existing meta-analyses of randomized controlled trials (RCTs).</p><p><strong>Methods: </strong>We conducted an umbrella review of meta-analyses of RCTs, searching five databases up to December 8, 2023. Two reviewers independently assessed methodological quality using AMSTAR 2 and evaluated certainty of evidence using a modified GRADE framework. Pooled effect sizes were recalculated as equivalent standardized mean differences (eSMD) with 95% confidence intervals (CI). The study was registered with PROSPERO (CRD42023495502).</p><p><strong>Results: </strong>A total of 15 meta-analyses encompassing 204 RCTs and over 9000 participants were included, covering 35 health endpoints across 15 disease conditions. PBM showed significant effects for 12 outcomes, with moderate certainty of evidence supporting improvements in burning mouth syndrome (pain reduction, eSMD - 0.92 [95% CI - 1.38 to - 0.46]), knee osteoarthritis (disability, 0.65 [0.14 to 1.15]), fibromyalgia (fatigue, 1.25 [0.63 to 1.87]), androgenetic alopecia (hair density, 1.32 [1.00 to 1.63]), and cognitive function (0.49 [0.14 to 0.84]). Most other outcomes exhibited low or very low certainty due to heterogeneity or small-study effects. P-curve and funnel plot analyses indicated evidential value for several outcomes, though potential publication bias was identified in some.</p><p><strong>Conclusions: </strong>PBM appeared beneficial for some health conditions, such as the strongest support for fibromyalgia, osteoarthritis-related disability, and cognitive impairment. However, given the overall low-to-moderate certainty of evidence for most endpoints, further high-quality trials and standardization of PBM protocols are warranted before widespread clinical adoption.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"160"},"PeriodicalIF":3.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural barriers and facilitators to accessing postsurgical rehabilitation in adults who were treated with surgery for low back pain: protocol for a scoping review.","authors":"Jessica J Wong, Jen Rinaldi, Paulo Pereira, Silvano Mior, Lauren Ead, Alanna Veitch, Kent Murnaghan, Pierre Côté","doi":"10.1186/s13643-025-02919-8","DOIUrl":"10.1186/s13643-025-02919-8","url":null,"abstract":"<p><strong>Background: </strong>Low back pain (LBP) is a major contributor to disability and rehabilitation needs globally. A proportion of patients with LBP undergo surgery and require postsurgical rehabilitation to optimize functioning. However, many encounter barriers to accessing rehabilitation due to structurally generated inequities linked to socioeconomic position. Structural barriers to accessing rehabilitation intersect with diversity-related factors (e.g., gender, ethnicity) to perpetuate stigma and marginalization, leading to tremendous consequences. This literature needs to be reviewed to identify key themes and knowledge gaps focused on structural factors to accessing post-surgical rehabilitation. Our objectives are to conduct a scoping review of the literature to (1) systematically map the literature on the experiences with structural barriers and facilitators to accessing post-surgical rehabilitation of adults who were treated with surgery for LBP (including with or without radiculopathy, symptomatic spinal stenosis); (2) investigate whether these experiences differ when grouped by diversity-related factors (e.g., gender, ethnicity, geographic region).</p><p><strong>Methods: </strong>We will conduct a scoping review of the literature based on Joanna Briggs Institute (JBI) scoping review guidance and report it according to PRISMA-Scoping Reviews. We will search multiple databases from inception to 2025 for qualitative research exploring experiences with structural barriers or facilitators to rehabilitation access after surgery among adults with LBP. Drawing upon the World Health Organization (WHO) Action on Social Determinants of Health framework, structural factors to accessing rehabilitation will include socioeconomic and political contexts; governance; macroeconomic, social and public policies; and cultural and societal values/norms. Paired reviewers will independently screen articles and extract data. Results will be summarized and grouped by type of LBP and rehabilitation, and by intersections with diversity-related factors (e.g., gender, age, ethnicity, disabilities, geographic region). Our interdisciplinary team will engage with an Advisory Committee of knowledge users with lived experience throughout.</p><p><strong>Discussion: </strong>Aligned with WHO and EUROSPINE priorities, our scoping review will elucidate the structural barriers and facilitators influencing access to post-surgical rehabilitation for LBP more inclusively. Findings will advance knowledge of structural challenges experienced by adults needing post-surgical rehabilitation, informing rehabilitation and other healthcare strategies to remove barriers and improve functioning globally.</p><p><strong>Systematic review registration: </strong>Open Science Framework (OSF) https://osf.io/26h9w.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"161"},"PeriodicalIF":3.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related quality-of-life evaluation in epidermolysis bullosa: a scoping review protocol.","authors":"Greta Arias-Merino, Juan Benito-Lozano, Renata Linertová, Verónica Alonso-Ferreira","doi":"10.1186/s13643-025-02918-9","DOIUrl":"10.1186/s13643-025-02918-9","url":null,"abstract":"<p><strong>Background: </strong>Epidermolysis bullosa (EB) is a group of rare congenital inherited skin diseases. Evaluation of health-related quality of life (HRQoL) is key to understanding the psychosocial and emotional impact on patients and their relatives or carers. The BUR-EB project aims at ascertaining the socio-economic burden of the disease, including its impact on costs and HRQoL. The aim of this scoping review is to identify which instruments or questionnaires are being used to evaluate the HRQoL of patients with EB and their relatives and carers.</p><p><strong>Methods: </strong>A scoping review will be conducted to ascertain the HRQoL of EB patients, their family circle and caregivers over the past 12 years. The wide-ranging review question is as follows: \"Which measurement tools are available for evaluation of HRQoL in EB?\" A search will be made in the MEDLINE, WOS and Scopus databases, and the Joanna Briggs Institute methodology will be applied. The data and findings will be shown in tables and in narrative form, in line with the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR).</p><p><strong>Discussion: </strong>This scoping review will provide an overview of evidence on the use of HRQoL instruments, both in patients with EB and in relatives and carers. The results of this scoping review will offer a guidance to the researchers to measure the health and well-being of EB patients.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"159"},"PeriodicalIF":3.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}