Systematic Reviews最新文献

{"title":"Efficacy and safety of spinal manipulative therapy in the management of acute neck pain: a systematic review and meta-analysis.","authors":"Yingxiu Diao, Yifang Liu, Jiaxin Pan, Junming Chen, Jiahui Pan, Manxia Liao, Hao Liu, Linrong Liao","doi":"10.1186/s13643-025-02855-7","DOIUrl":"10.1186/s13643-025-02855-7","url":null,"abstract":"<p><strong>Background: </strong>Spinal manipulative therapy (SMT) is frequently used to manage neck pain; however, its efficacy and safety in treating acute neck pain (ANP) remain uncertain and require further investigation.</p><p><strong>Objectives: </strong>This study aims to comprehensively evaluate the efficacy and safety of SMT in the treatment of ANP.</p><p><strong>Databases and data treatment: </strong>A thorough search was conducted in PubMed, Embase, Web of Science, PEDro, and Cochrane Library databases, covering all studies from inception to March 20, 2023. Mean differences (MD) with 95% confidence intervals (CIs) were calculated to assess outcomes such as pain intensity, cervical range of motion (CROM), and disability. The PEDro Scale and the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach were utilized to evaluate the methodological quality and strength of evidence.</p><p><strong>Results: </strong>Eight randomized controlled trials (RCTs) with 965 patients were included. Their PEDro scores ranged from 4-9 (mean: 6.38, SD: 1.25). Forest plot analysis showed SMT was better than the control in reducing pain (MD = -1.53, 95% CI [-2.22, -0.83]) and improving CROM in all measured aspects. It also significantly reduced disability scores (MD = -6.20, 95% CI [-9.81, -2.59]). No serious adverse events were reported.</p><p><strong>Conclusions: </strong>The evidence supports the use of SMT as an effective and safe intervention for reducing pain, improving CROM, and decreasing disability in patients with ANP. These findings provide valuable insights for clinical practitioners and highlight the potential of SMT as a viable therapeutic option in managing ANP.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42021264411.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"97"},"PeriodicalIF":6.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors for loneliness among individuals with diabetes: a systematic review and meta-analysis.","authors":"Anggi Lukman Wicaksana, Renny Wulan Apriliyasari, Pei-Shan Tsai","doi":"10.1186/s13643-025-02850-y","DOIUrl":"10.1186/s13643-025-02850-y","url":null,"abstract":"<p><strong>Background: </strong>Loneliness is more pronounced in individuals with diabetes; however, limited studies have investigated loneliness and its risk factors. This study estimated the pooled prevalence of loneliness and identified its risk factors in individuals with diabetes.</p><p><strong>Methods: </strong>A systematic review and meta-analysis of observational studies was conducted. CINAHL, Cochrane, Embase, PubMed, Scopus, and Web of Science databases were searched from their inception to September 22, 2023. We systematically searched and analyzed 10 studies involving 6036 individuals with diabetes to determine the pooled prevalence of loneliness. Five studies provided information on risk factors. Using a random-effects model, we calculated prevalence rates and odds ratios with 95% confidence intervals.</p><p><strong>Results: </strong>The overall prevalence of loneliness was 31.1% and severe loneliness was 4.6%. White race, lower education level, middle income, low income, longer diabetes duration, lower cognitive function, living alone, previous loneliness experience, and depression were identified as significant risk factors for loneliness in individuals with diabetes.</p><p><strong>Conclusion: </strong>Over 30% of individuals with diabetes experience loneliness. Several sociodemographic factors, low cognitive function, and depression are risk factors for loneliness.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"96"},"PeriodicalIF":6.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predictive value of endocan as a novel biomarker: an umbrella study on meta-analyses.","authors":"Sandeep Samethadka Nayak, Daniyal Ameen, Sara Nobakht, Ranjan Nayak, Shrinidhi Vilas Prabhu, Mohammad-Hossein Keivanlou, Soheil Hassanipour, Ehsan Amini-Salehi, Nisarg Thakker","doi":"10.1186/s13643-025-02858-4","DOIUrl":"10.1186/s13643-025-02858-4","url":null,"abstract":"<p><strong>Background and aim: </strong>In recent years, endocan has emerged as a potential biomarker in various medical conditions. This multifaceted molecule, involved in key processes such as inflammation and endothelial dysfunction, has shown promise in predicting disease progression and therapeutic response across a spectrum of pathologies. However, the heterogeneity of studies and the complexity of endocan's role in different diseases necessitate a comprehensive review. This umbrella review aimed to systematically synthesize and evaluate the evidence from multiple meta-analyses, offering a view of endocan's effectiveness as a predictive biomarker in medical diseases.</p><p><strong>Methods: </strong>An extensive search was carried out on March 12, 2024, using the following four databases: PubMed, Scopus, Web of Science, and Cochrane Library. The goal was to identify meta-analyses that assess endocan's predictive efficacy. The pooled effect size and its 95% confidence interval were taken out of each discovered meta-analysis. Furthermore, power analyses were performed to assess the robustness and dependability of the results. An additional GRADE assessment was carried out to gauge the epidemiological reliability of the findings.</p><p><strong>Results: </strong>In the final analysis, 12 meta-analyses were included in the current umbrella review. The results showed that there is a significant correlation between a higher endocan level and COVID-19 (SMD: 1.40, 95% CI 0.21-2.58, P = 0.02), followed by chronic kidney disease (SMD: 1.34, 95% CI 0.20 to 2.48, P < 0.01), obstructive sleep apnea (SMD: 1.30, 95% CI 1.06-1.54, P < 0.01), diabetes mellitus (SMD: 1.00, 95% CI 0.81 to 1.19, P < 0.01), coronary artery disease (SMD: 0.99, 95% CI 0.58-1.39, P < 0.01), hypertension (SMD: 0.91, 95% CI 0.44-1.38, P < 0.01), and preeclampsia (SMD: 0.37, 95% CI 0.13-0.62, P < 0.01).</p><p><strong>Conclusion: </strong>Endocan has emerged as a highly promising biomarker with considerable potential across various medical conditions. Its relevance spans critical areas such as COVID-19, chronic kidney disease, obstructive sleep apnea, diabetes mellitus, coronary artery disease, and preeclampsia. The broad applicability of endocan highlights its value in improving diagnostic accuracy and enhancing our understanding of these diseases. Clinically, incorporating endocan testing could aid in early detection, monitoring disease progression, and refining patient management, particularly for high-risk populations. However, additional research is needed to fully assess its specificity, sensitivity, and overall clinical utility, paving the way for its integration into routine healthcare practices and enabling more precise, individualized treatment strategies.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"98"},"PeriodicalIF":6.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review and meta-analysis of Jueyin disease theory in the treatment of gangrene with traditional Chinese medicine formulations.","authors":"Youzhi Zhang, Bochuan Lv, Yue Teng, Jintao Xu","doi":"10.1186/s13643-025-02854-8","DOIUrl":"10.1186/s13643-025-02854-8","url":null,"abstract":"<p><strong>Objective: </strong>This review aims to systematically evaluate the application of Jueyin disease theory in the diagnosis and treatment of gangrene within the framework of traditional Chinese medicine (TCM). Through systematic review and meta-analysis, the efficacy of commonly used TCM formulations, including Wumei pill, Pulsatilla decoction, and Dang-Gui-Si-Ni decoction, is explored.</p><p><strong>Methods: </strong>A systematic search of PubMed, Web of Science, and CNKI was conducted, integrating meta-analysis and systematic review. Clinical trials and case reports based on Jueyin disease theory for gangrene treatment were included. Data extraction, quality assessment, and statistical analyses were performed.</p><p><strong>Results: </strong>A total of nine studies met the inclusion criteria. The meta-analysis indicated that TCM formulations significantly improved clinical outcomes, particularly in enhancing the ankle-brachial index (ABI) and maximum walking distance, with mean differences of 0.17 (95% CI, 0.11, 0.24; p < 0.01) and 293.22 (95% CI, 174.85, 411.60; p < 0.01), respectively. Sensitivity analysis and tests for publication bias confirmed the robustness and consistency of the findings. Sensitivity analysis and publication bias assessment confirmed the robustness and reliability of the results.</p><p><strong>Conclusion: </strong>Jueyin disease theory and its related formulas (Wumei pill, Pulsatilla decoction, and Dang-Gui-Si-Ni decoction) demonstrate significant clinical value in traditional Chinese medicine (TCM) treatment of gangrene, effectively improving clinical symptoms and blood circulation. The findings provide scientific evidence for the modern application of Jueyin disease theory in TCM while acknowledging limitations such as small sample sizes and study heterogeneity, offering valuable insights for future research and clinical practice.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"95"},"PeriodicalIF":6.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of clinical research units on clinical research - a systematic review of empirical studies.","authors":"Fan Wang, Xu Wang, Enmei Liu, Fujian Song, Yaolong Chen","doi":"10.1186/s13643-025-02813-3","DOIUrl":"10.1186/s13643-025-02813-3","url":null,"abstract":"<p><strong>Background: </strong>Clinical research is essential for evidence-based decision-making in healthcare practice, but its conduct is hindered by various barriers. While previous studies suggest that clinical research units (CRUs) provide critical support and expertise for complex clinical research, their necessity for ensuring high-quality clinical research remains uncertain. The primary objective of this systematic review is to identify, assess, and summarize results of studies that empirically evaluated the impacts of CRUs on clinical research.</p><p><strong>Methods: </strong>We conducted a comprehensive search of PubMed, Embase, Web of Science, and ProQuest Dissertations and Theses Global from inception to July 2024 to identify relevant studies. Study selection, quality evaluation, and data extraction were performed independently by two reviewers, with any disagreements resolved through discussion. Data extracted from the included studies were summarized in tables, and the synthesis were guided by a realist review approach.</p><p><strong>Results: </strong>A total of 11 publications corresponding to 10 studies were included in the review. These studies involved 8 independent CRUs and 2 groups of CRUs. The settings in the CRUs operated were diverse, including general hospitals or medical centres, paediatric hospitals, professional sarcoma group, and others. The CRUs featured varied structures and staff compositions, with services tailored to the specific needs of local research teams, study types, and the availability of other research resources. The reported impacts of CRUs were consistently positive in terms of efficiency, quantity, and quality of clinical research. Following the establishment of the CRUs, the number of clinical research has increased by 5 to 23 annually.</p><p><strong>Conclusions: </strong>The implementation of CRU enhances the efficiency, quantity, and quality of clinical research through process refinement, methodological support, resource pooling, reduced researcher workload, and adherence to good clinical practice (GCP), thereby ensuring patient safety and data integrity. Future research should include rigorous comparative studies, such as randomized controlled trials (RCTs) comparing outcomes with and without CRUs, to further validate these findings.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024575392.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"94"},"PeriodicalIF":6.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double versus single blastocyst biopsy and vitrification in preimplantation genetic testing (PGT) cycles: protocol for a systematic review and meta-analysis of clinical and neonatal outcomes.","authors":"Alessandra A Vireque, Vasileios Stolakis, Thalita S Berteli, Maria C Bertero, Jason Kofinas","doi":"10.1186/s13643-025-02846-8","DOIUrl":"10.1186/s13643-025-02846-8","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The number of re-biopsied blastocysts is widely increasing in IVF cycles and concerns regarding retesting, which involves double biopsy and vitrification-warming, have been raised. The re-biopsy intervention seems to significantly reduce the pregnancy potential of a blastocyst but the evidence is still restricted to retrospective observational studies reporting a low number of cycles with re-biopsied embryos. Additionally, the neonatal outcomes after the transfer of re-biopsied and re-vitrified embryos are poorly documented to date.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A systematic review will be conducted, using PubMed/Medline, EMBASE, Cochrane Central Register of Controlled Trials, Scopus, Web of Science, and Google Scholar to identify all relevant randomized control trials (RCTs), cohort and case-control studies published until December 2024. The participants will include women undergoing preimplantation genetic testing and single euploid frozen embryo transfer (FET) cycles. The primary outcomes are live birth rate (LBR) and singleton birthweight, whereas secondary outcomes are post-warming embryo survival rate, clinical pregnancy (fetal heart pregnancies at 4.5 weeks), miscarriage rate (loss of pregnancy before the 20th week, and stillbirth), preterm birth (PB) rate, small-for-gestational age (SGA, &lt; - 1.28 SDS (standard deviation score)), large-for-gestational age (LGA, &gt; + 1.28 SDS), low birthweight (LBW; birthweight &lt; 2500 g), preterm birth (gestation &lt; 37 weeks), macrosomia (birthweight &gt; 4000 g), pre-eclampsia, eclampsia, perinatal death, and major congenital malformations. Eligible studies will be selected according to pre-specified inclusion and exclusion criteria. Additionally, manual search will target other unpublished reports and supplementary data. At least two independent reviewers will be responsible for article screening, data extraction and bias assessment of eligible studies. A third reviewer will resolve any disagreements. The Newcastle-Ottawa scale (NOS) will be used to assess the quality of the included studies. Studies that receive a score of 7 or higher on the NOS will be considered to have high methodological quality. The extracted data will be pooled and a meta-analysis will be performed. To carry out the data synthesis, a random effects meta-analysis will be conducted using the RevMan software. Heterogeneity will be evaluated by Cochran's Q test and the I&lt;sup&gt;2&lt;/sup&gt; statistics and the strength of evidence will be rated with reference to GRADE. The review and meta-analysis will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;The findings of this systematic review will be important to clinicians, embryologists, patients, and assisted reproductive service providers regarding the decision-making on retesting embryos for PGT in FET cycles.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Systematic review registration: &lt;/strong","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"93"},"PeriodicalIF":6.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Google to search for evidence: how much is enough? One center's experience.","authors":"Isomi M Miake-Lye, Selene Mak, Meron M Begashaw, Paul G Shekelle","doi":"10.1186/s13643-025-02836-w","DOIUrl":"10.1186/s13643-025-02836-w","url":null,"abstract":"<p><p>The rise of powerful search engines (e.g., Google) make the searching for gray literature more feasible within the time and resources of a typical systematic review. However, there are no hypothesis-testing studies to guide us on how to conduct such a search. It is our belief that the \"best practices\" for incorporating Google searches might come from the collection of experiential evidence that users have had, from which can be drawn some tentative conclusions. It is our intention with this communication to relay our experience with Google searches for five projects and the lessons we think we have learned. We invite our systematic review colleagues to contribute their own experiences and thus to build up the experiential evidence about when and how to use Google as a search engine to supplement traditional computerized database searches.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"92"},"PeriodicalIF":6.3,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial work determinants of older adults' participation in the job market: protocol for a scoping review of quantitative longitudinal studies.","authors":"Ruth Ndjaboue, Stella Ruddy, Fadila Bulver, Joel Diendere, Mélanie Levasseur, Micaelle Nguefack, Heidi Noël, Abigail Djossou","doi":"10.1186/s13643-025-02809-z","DOIUrl":"10.1186/s13643-025-02809-z","url":null,"abstract":"<p><strong>Background: </strong>More than one-third of the population in developed countries is aged 50 and older (hereafter older adults), and this proportion has been increasing every year. Aging is associated with labor shortages which places a large socioeconomic stress on individuals, organizations, and governments. Evidence on the influences of psychosocial factors in older workers mostly focuses on adverse health outcomes and early retirement, with little or no evidence of their influences on other aspects or assessments of older adults' participation in the job market. In this work, we aim to describe existing quantitative longitudinal studies on the relationship between psychosocial work factors and older adult's participation in the job market, and to explore how the outcome is operationalized in existing studies on this topic.</p><p><strong>Methods: </strong>The scoping review frameworks developed by the Joanna Briggs Institute (JBI) and Levac and colleagues will guide this study. We will perform a comprehensive search for eligible publications in the followingdatabases: MEDLINE, AgeLine, CINAHL, PsycInfo, SCOPUS, ProQuest One Business, SOCindex, Abstracts in Social Gerontology, and Social Works Abstract. This work will focus on the job-demand-control-support, the effort-reward imbalance, the organizational justice, three renowned theretical models, while paying attention to other work risk factors measured in selected studies. Studies involving older adults of 50 years old or more and published in English or French will be considered, regardless of publication date. Abstracts, full-text screening, and data extraction will be performed independently by two trained reviewers using standard methodology. While sorting studies, we will complete a narrative synthesis of findings considering, when possible, sex and gender.</p><p><strong>Discussion: </strong>While rigorous reviews are increasingly being recommended for decision-making in organizational and political guidelines, providing an overview of psychosocial work factors associated with older adult's participation in the job market is a crucial start point. This scoping review will contribute to the understanding of how to define and assess participation in the job market and its work-related determinants in older adults. Our findings may also help to prioritize if and what future systematic reviews on this topic should focus on.</p><p><strong>Systematic review registration: </strong>Submitted in Open Science Framework on 07-10-2023.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"91"},"PeriodicalIF":6.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral health effects of non-combustible nicotine products: protocol for a systematic review and network meta-analysis.","authors":"Giusy Rita Maria La Rosa, Cinzia Del Giovane, Eugenio Pedullà, Jan Kowalski, Iain Chapple, Silvia Minozzi, Amaliya Amaliya, Riccardo Polosa","doi":"10.1186/s13643-025-02839-7","DOIUrl":"10.1186/s13643-025-02839-7","url":null,"abstract":"<p><strong>Background: </strong>Tobacco use is a global issue, and non-combustible nicotine products (NCNPs) like electronic nicotine delivery systems, nicotine pouches, snus, and nicotine replacement therapies offer potential risk/harm reduction for smokers unable or unwilling to quit. Although NCNPs are less harmful than tobacco smoking, their impact on oral health remains unclear. A systematic review and network meta-analysis will be conducted to answer the research question: What are the oral signs and symptoms associated with NCNPs as both monotherapies and combination therapies compared to each other, placebo, standard care, no drug treatment, and combustible cigarette smoking?</p><p><strong>Methods: </strong>We will search PubMed and Scopus databases, and the Cochrane Central Register of Controlled Trials (CENTRAL) from inception to August 2024. This review will focus on randomized controlled trials (RCTs) with a minimum follow-up period of 1 month, comparing any NCNPs versus placebo, standard care, no drug treatment, combustible cigarette smoking or to each other in adult smokers. Our primary outcomes will be the number of participants reporting any oral side effect, aphthous ulcers, dry mouth and mouth irritation. Studies will be excluded if they involve: non-smokers, pregnant women, individuals with mental health or neurological disorders, participants consuming alcohol or other substances. Data will be analyzed using a network meta-analysis framework, estimating odds ratios with 95% confidence intervals. Risk of bias will be determined using the Cochrane risk of bias tool-version 2.0 for included RCTs and the Confidence In Network Meta-Analysis tool will be employed to assess the confidence of evidence contributing to each network estimate.</p><p><strong>Discussion: </strong>Our findings will provide critical insights into the oral health implications of NCNPs, informing clinical and public health decisions. Results are expected by May 2025 and will be disseminated through publications and presentations to guide tobacco harm reduction strategies.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024565118.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"90"},"PeriodicalIF":6.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of technology use for care by informal female caregivers on their well-being: a scoping review.","authors":"Andrés Aparicio, María Alejandra Inostroza-Correa, Paula Miranda, Carolina Salinas, Valeria Herskovic, Camila Chackiel, Catalina Alarcón","doi":"10.1186/s13643-025-02817-z","DOIUrl":"10.1186/s13643-025-02817-z","url":null,"abstract":"<p><strong>Introduction: </strong>Informal caregiving roles are predominantly assumed by women, who often experience unique challenges related to physical, emotional, and social stress due to entrenched gender disparities. Within this context, the use of technologies to assist in caregiving tasks has become popular, and some evidence about their impact on caregiver well-being is available. However, significant research gaps persist. This scoping review was intended to assess the extent of literature examining the impact of technology use by informal female caregivers on their quality of life, to characterize existing research gaps, and to identify available evidence regarding gender-specific challenges.</p><p><strong>Methods: </strong>We searched for studies in English, Spanish, and Portuguese published in peer-reviewed journals since 2018. We included studies exploring how informal female caregivers use technology and how such use impacts their well-being. The studies included in the review analyze the impact of technology use on the physical, emotional, or material well-being of informal female caregivers. Sources were screened in stages by two independent reviewers; data were extracted from selected full texts, and results were integrated into a narrative summary.</p><p><strong>Results: </strong>A total of 14 studies were included in the review, highlighting a range of technologies such as health monitoring devices, communication platforms, and assistive aids. The review identified improvements in caregiver well-being related to reduced physical burden, enhanced emotional support, and increased social connectivity. However, significant research gaps were noted, particularly regarding the long-term effects of technology use, differences based on socio-economic contexts, and the limited inclusion of gender-specific analyses.</p><p><strong>Conclusions: </strong>This review supports the notion that technology use can positively impact the well-being of informal female caregivers, especially in terms of emotional and social support. Nevertheless, the review also found that in certain situations, technology can fail to improve or even worsen the quality of life of caregivers. However, the limited availability of studies with standardized quantitative measures, gender-specific data, and comprehensive assessments of long-term effects highlights areas for future research. Further exploration into diverse sociocultural contexts and empirical model development will be essential to better understand the nuanced ways in which technology use influences caregiver quality of life. These findings underscore the potential for targeted technology solutions to support informal caregivers, with implications for healthcare professionals and policymakers designing caregiver support initiatives.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"89"},"PeriodicalIF":6.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}