Systematic Reviews最新文献

{"title":"Protocol for a systematic review and meta-analysis of risky sexual behaviors among adolescents and young adults in West Africa.","authors":"Kouamé Mathias N'dri, Yao Eugène Konan, Bayaki Saka, Djedjro Franck Renaud Meless, Aboubakari Nambiema, Simplice N 'cho Dagnan, Issifou Yaya","doi":"10.1186/s13643-025-02878-0","DOIUrl":"10.1186/s13643-025-02878-0","url":null,"abstract":"<p><strong>Background: </strong>Sexually transmitted infections (STIs) are a major public health concern, particularly among adolescents and young adults (AYA) in West Africa who reported higher prevalence of risky sexual behaviors. We therefore proposed a protocol for systematic review and meta-analysis to assess the prevalence of risky sexual behaviors for STIs among adolescents and young adults living in West Africa. METHODS AND ANALYSIS: Systematic searches of electronic databases (PubMed/MEDLINE, Embase, African Index Medicus) will be conducted. Studies published between January 1, 2013, and June 30, 2023, on the prevalence of sexual behaviors associated with STIs risk in AYA living in West Africa will be included. Two reviewers will independently conduct studies selection, data extraction, and risk of bias assessment. The selection of eligible studies will be based on titles and abstracts, followed by full-text review. The risk of bias assessment for eligible studies will be performed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool. If possible, a meta-analysis of data on the prevalence of each sexual risk behavior will be performed. The heterogeneity will be statistically assessed using a I² statistic. This protocol is developed following the guideline of Preferred Reporting Items for Systematic Reviews and Meta-analyses Protocols 2015. STATA or R software will be used for the meta-analysis.</p><p><strong>Discussion: </strong>This review will estimate the prevalence of risky sexual behaviors among AYA aged 15-24 years in West Africa to inform appropriate interventions.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"174"},"PeriodicalIF":3.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of transcranial direct current stimulation on mental fatigue reduction and physical performance improvement in healthy adults: a systematic review protocol.","authors":"Gabriel Rodrigues Aguiar, Alberto Souza de Sá Filho, Marcelo Couto Jorge Rodrigues, Eduardo Macedo Penna, Vicente Aprigliano, Claudio Andre Barbosa de Lira, Augusto Cezar Rodrigues Rocha, Gabriela Souza de Vasconcelos, Else Saliés Fonseca, José Carlos Pontes Corrêa, Matias Noll, Gustavo De Conti Teixeira Costa","doi":"10.1186/s13643-025-02916-x","DOIUrl":"10.1186/s13643-025-02916-x","url":null,"abstract":"<p><strong>Background: </strong>Mental fatigue (MF) is a psychobiological state that impairs physical and cognitive performance, particularly in endurance and resistance tasks. Transcranial direct current stimulation (tDCS) has emerged as a promising noninvasive neuromodulation technique to mitigate MF and increase exercise capacity. However, evidence remains inconsistent due to methodological heterogeneity in stimulation parameters, fatigue induction protocols, and outcome assessments. This research aims to systematically review randomized controlled trials (RCTs) investigating the effects of active versus sham tDCS on reducing MF and improving physical performance, such as time to exhaustion and muscular endurance, in healthy, physically active adults, including athletes.</p><p><strong>Methods: </strong>This protocol follows the PRISMA-P guidelines and is registered with PROSPERO (CRD4202541050229). Eligible studies will include RCTs (parallel or crossover) comparing active tDCS (any validated protocol) with sham stimulation in adults ≥ 18 years of age without neurological, psychiatric, or cardiovascular conditions. Searches will be conducted in PubMed, Embase, Scopus, Web of Science, SPORTDiscus, PsycINFO, and ClinicalTrials.gov. Primary outcomes are time to exhaustion and number of repetitions to failure; secondary outcomes include MF scores. Two independent reviewers will select studies, extract data, and assess risk of bias using Cochrane RoB 2.0. Metaanalyses will be performed where possible, with subgroup, sensitivity, and metaregression analyses as appropriate.</p><p><strong>Discussion: </strong>This review will synthesize the available evidence on the efficacy of tDCS on MF and physical performance in healthy adults. The results aim to inform the design of future research and support the standardization of tDCS protocols in sport and exercise science.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD420251050229.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"175"},"PeriodicalIF":3.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Realist review protocol for understanding young people's experiences of engaging with police-mental health practitioner collaboration in emergency responses to mental health crises.","authors":"Sarah Parry, Lucy Oakes, Zarah Eve, Stephen Edwards, Fiona Lobban, Prathiba Chitsabesan, Geoff Wong","doi":"10.1186/s13643-025-02882-4","DOIUrl":"10.1186/s13643-025-02882-4","url":null,"abstract":"<p><strong>Background: </strong>Children and young people are facing increasing mental health challenges. Access to emergency mental health care for young people is under-researched and poorly understood. Police data indicates a rise in youth mental health emergency calls, but officers often feel unprepared to support young people in crisis. Mental health practitioners have the experience and training to provide helpful support to young people in crisis, although the availability of mental health services for young people can be limited during evenings and weekends, especially in rural areas. We know that children and young people can benefit when police and mental health services work together. However, we need to better understand the full range of impacts of joint responses for young people and their families and how these impacts are generated. Joint emergency response is a complex intervention, and a realist synthesis was chosen as it can make sense of such interventions. Therefore, this realist synthesis aims to develop a programme theory of the underlying generative mechanisms by which, and contexts within which, emergency responders collaborate and co-respond to support young people experiencing a mental health crisis.</p><p><strong>Methods and analysis: </strong>We will follow five steps to undertake the realist review: (1) Define the review scope, (2) develop initial programme theories, (3) conduct an evidence search, (4) select and appraise evidence, and (5) extract and synthesise data. Embase, CINAHL, Social Policy and Practice, MEDLINE, PsycINFO, and AMED databases will be searched up to June 2024, supplementing searches with citation tracking, grey literature, relevant NHS England guidance, and practitioner interpretation workshops. Data selection will be based on relevance and richness. Data will be extracted and synthesised iteratively, and causal links between contexts, mechanisms, and outcomes will be illuminated in the process. The results will be conducted and reported according to the Realist and Meta-narrative Evidence Syntheses: Evolving Standards (RAMESES) quality and publication standards.</p><p><strong>Collaboration and dissemination: </strong>Findings will be disseminated to the research community through conference presentations and a peer-reviewed journal article. We will work with healthcare and police organisations, as well as professional and expert-by-experience stakeholder groups, including commissioners, to develop a strategy for far-reaching dissemination with impact to share findings across a range of audiences.</p><p><strong>Discussion: </strong>This study will develop a programme theory regarding how emergency responders collaborate to support young people experiencing mental health crises. Findings will inform future practices, aiming to improve collaborative responses and outcomes across youth contexts.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024542081.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"173"},"PeriodicalIF":3.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of vitamin D supplements on bone metabolism in kidney transplant recipients: a systematic review and meta-analysis.","authors":"Peishan Cai, Zhou Shu, Taotao Zhou, Jie Li, Wei Chen, Xianpeng Zeng, Fang Zeng","doi":"10.1186/s13643-025-02828-w","DOIUrl":"10.1186/s13643-025-02828-w","url":null,"abstract":"<p><strong>Background: </strong>Vitamin D has been reported to decrease parathyroid hormone (PTH), reduce bone loss, and promote calcium absorption. However, its effects on bone metabolism in kidney transplant recipients (KTRs) remain controversial. This review aimed to analyze the effects of vitamin D supplements on bone metabolism in KTRs.</p><p><strong>Methods: </strong>We searched PubMed, EMBASE, Web of Science, and the Cochrane Library from inception through September 30, 2023, for randomized controlled trials (RCTs) on the effect of vitamin D on bone metabolism after kidney transplantation. We also searched the reference lists of systematic reviews and included studies. The outcomes were expressed using relative risk (RR) or standardized mean difference (SMD) with the corresponding 95% confidence interval (CI).</p><p><strong>Results: </strong>Fourteen studies involving a total of 985 KTRs were included in this analysis. The treatments consisted vitamin D supplementation at various doses and types. The duration of follow-up ranged from 3 to 12 months. More than half of the 14 studies (n = 8) had an overall high risk of bias, as they had at least one high-risk domain. Compared to placebo or no treatment, vitamin D supplementation significantly improved bone mineral density (BMD) at the femoral neck (SMD 0.54; 95% CI 0.10 to 0.98; P = 0.02), reduced serum PTH level (SMD -0.49; 95% CI -0.76 to -0.22; P = 0.0003), decreased bone alkaline phosphatase (BAP) level (SMD -0.31; 95% CI -0.52 to -0.09; P = 0.006), increased serum calcium level (SMD 0.35; 95% CI 0.12 to 0.58; P = 0.003) and increased the risk of hypercalcemia (RR 1.92; 95% CI 1.23 to 3.01; P = 0.004). After treatment, there were no significant differences in the changes in lumbar spine BMD, 25-hydroxyvitamin D (25[OH]D) level, serum phosphate level, serum alkaline phosphatase (ALP) level, calciuria level, proteinuria level and estimated glomerular filtration rate (eGFR). No significant differences were observed in the incidence of fracture and acute graft rejection.</p><p><strong>Conclusions: </strong>Vitamin D supplementation does not improve overall BMD or prevent fracture in KTRs. Vitamin D supplementation may effectively reduce serum PTH and BAP level. However, it may also increase the risk of hypercalcemia, necessitating the monitoring of serum calcium level.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"172"},"PeriodicalIF":3.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of efficacy and safety profiles of perioperative sufentanil and remifentanil: a systematic review and meta-analysis with trial sequential analysis.","authors":"Hyo Jin Kim, Geun Joo Choi, Hyun Kang","doi":"10.1186/s13643-025-02933-w","DOIUrl":"10.1186/s13643-025-02933-w","url":null,"abstract":"<p><strong>Background: </strong>Sufentanil and remifentanil are commonly used during general anesthesia. This systematic review and meta-analysis with trial sequential analysis of randomized controlled trials (RCTs) aims to comprehensively evaluate and compare the efficacy and safety profiles of perioperative sufentanil and remifentanil administration in patients undergoing surgery under general anesthesia.</p><p><strong>Methods: </strong>This study was registered in INPLASY (INPLASY202270070). A comprehensive search was performed using MEDLINE, EMBASE, CENTRAL, Web of Science, and Google Scholar to identify all RCTs comparing the efficacy of the intraoperative use of sufentanil to that of remifentanil. The primary outcome were the postoperative pain scores measured using visual analogue scale (VAS) or numerical rating scales (NRS). The secondary outcomes were the postoperative analgesic use, time to first analgesic need, intraoperative hemodynamic profiles, postoperative nausea and vomiting (PONV), incidence of respiratory depression, and recovery characteristics.</p><p><strong>Results: </strong>A total of 31 studies were included in the final analysis. Postoperative pain score was significantly higher in remifentanil group than that in sufentanil group, with a small effect size (standardized mean difference [SMD] =  - 0.47; 95% confidence interval [CI] = 0.24 to 0.70). Postoperative analgesic amount used was lower in sufentanil group than that in remifentanil group, with a medium effect size (SMD = 0.55; 95% CI = 0.12 to 0.99). In terms of hemodynamic profiles, intraoperative systolic blood pressure (mean difference [MD] =  - 6.30; 95% CI =  - 10.76 to - 1.85), mean arterial pressure (MD =  - 6.38; 95% CI =  - 10.25 to - 2.51), and heart rate (MD =  - 4.16; 95% CI =  - 6.65 to - 1.68) were lower in remifentanil group than in sufentanil group. Incidence of postoperative nausea (relative risk = 1.39; 95% CI = 1.13 to 1.71) was higher in remifentanil group than in sufentanil group. The remifentanil group showed a faster recovery profile than the sufentanil group.</p><p><strong>Conclusions: </strong>Compared with remifentanil, sufentanil demonstrated superior efficacy in postoperative pain management and superior safety profiles with respect to postoperative nausea and hemodynamic stability; however, remifentanil showed a faster recovery profile.</p><p><strong>Systematic review registration: </strong>International Prospective Register of Systematic Reviews (INPLASY), NPLASY202270070.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"171"},"PeriodicalIF":3.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of cycling exercise in patients with chronic kidney disease: protocol for a systematic review and trial sequential meta-analysis.","authors":"Chen Chen, Shao-Hua Chen, Yan Cao, Ji-Ming Tao","doi":"10.1186/s13643-025-02932-x","DOIUrl":"https://doi.org/10.1186/s13643-025-02932-x","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease is a global public health problem affecting approximately 10% of the adult population. Conventional management combines pharmacotherapy and dialysis, yet long-term complications persist. Cycling, a low joint load exercise, may improve cardiopulmonary function and renal outcomes, but conflicting evidence exists regarding its efficacy in advanced CKD.</p><p><strong>Methods and analysis: </strong>Randomized controlled trials (RCTs) that compare cycling exercise and usual care in patients with chronic kidney disease will be included. Literature searches will be conducted in PubMed, Web of Science, Embase, and Cochrane Library. Two reviewers will independently perform the processes of literature retrieval, screening, data extraction, and assessment of risk of bias. Risk of bias in included studies will be evaluated using Revised Cochrane risk-of-bias tool (ROB 2) for RCTs. Review Manager (RevMan) will be used for data pooling. Subgroup analysis, trial sequential analysis (TSA), and sensitivity analysis will be conducted.</p><p><strong>Ethics and dissemination: </strong>Ethical approval is not required because this study is a secondary analysis of existing data. We will disseminate the findings through peer-reviewed publications.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD420251048364.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"170"},"PeriodicalIF":3.9,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144969999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis B reactivation with TNF-α inhibitors: assessing antiviral prophylaxis efficacy - protocol for systematic review and meta-analysis.","authors":"Alhalabi Marouf, Sawan Sedra","doi":"10.1186/s13643-025-02923-y","DOIUrl":"10.1186/s13643-025-02923-y","url":null,"abstract":"<p><strong>Background: </strong>The widespread use of TNF-α inhibitors (infliximab, adalimumab, golimumab, certolizumab pegol, and etanercept) in gastrointestinal, rheumatologic, and dermatologic disorders raises concerns about hepatitis B reactivation (HBVr). The exact risk remains unclear due to the variability in previous meta-analyses. This study aims to assess the effectiveness of antiviral prophylaxis in preventing HBV reactivation in patients on TNF-α therapy and to investigate the associated reactivation risk.</p><p><strong>Method: </strong>A systematic review adhering to PRISMA guidelines will be conducted. Comprehensive searches of electronic databases (MEDLINE via PubMed, Google Scholar, CENTRAL, and ClinicalTrials.gov) will identify relevant studies. Eligible studies will include patients with a hepatitis B infection treated with anti-TNF-α therapy. The efficacy of antiviral prophylaxis will be assessed using risk ratios (RR) with 95% confidence intervals (CI) in a random-effects model that controls for variation among trials. Heterogeneity will be evaluated using the I² statistic and Cochran's Q test, with I² > 50% or p < 0.10 indicating significant heterogeneity. Subgroup analyses will explore sources of heterogeneity, such as the type of antiviral medication, HBV serostatus, and the type of anti-TNF agent. Publication bias will be assessed using funnel plots and Egger's test. The incidence of HBV reactivation will be estimated using pooled estimates and 95% CIs in a random-effects model, excluding patients receiving antiviral prophylaxis.</p><p><strong>Discussion: </strong>The rate of hepatitis B virus (HBV) reactivation varies greatly between chronic and occult carrier states. Despite established practice standards, high-risk individuals still get insufficient preventative antiviral treatment. Current recommendations propose prophylactic nucleoside/nucleotide analogue (NA) prophylaxis for immunosuppressive treatment that has a high risk of reactivating HBV. For low-risk treatments, on-demand NA treatment is recommended. For intermediate-risk drugs, either strategy might be suitable. However, there is an urgent need for agreement on standardized criteria and reporting protocols for HBV reactivation in the setting of immunosuppressive treatments. TRIAL REGISTRATION: Systematic review registration: PROSPERO CRD42024548106.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"169"},"PeriodicalIF":3.9,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12376473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144969947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the factors that influence engagement with and experiences of integrated care for adults at risk of cardiovascular disease and mild-to-moderate mental health concerns in the UK (OptICS): a systematic review protocol.","authors":"Alison R McKinlay, Neil Howlett, Vivi Antonopoulou, Fabiana Lorencatto, Laura J McGowan, David Osborn, Amy O'Donnell, Emily J Oliver, Ivo Vlaev, Falko F Sniehotta, Michael P Kelly, Susan Michie, Caroline Kemp, Yannis Pappas, Gurch Randhawa, Nasreen Ali, Emily Munro, Angel M Chater","doi":"10.1186/s13643-025-02903-2","DOIUrl":"https://doi.org/10.1186/s13643-025-02903-2","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease (CVD) is one of the leading causes of premature death globally. CVD is expensive to treat and therefore carries a significant cost for public healthcare systems and the people in them. Those most likely to develop CVD often report co-occurring mental health concerns such as depression and anxiety, in addition to behavioural factors (e.g. physical inactivity) and physical health conditions (e.g. hypertension, high cholesterol, obesity and diabetes). Due to these inter-connecting issues, healthcare provision for CVD patients necessitates a joined-up care pathway providing holistic, person-centred support. Despite the rapid emergence and growth in attempts to deliver such care, evidence concerning how it is experienced and how to promote engagement is fragmented. This review aims to capture the experiences and factors that influence integrated care engagement, reported by adults with CVD risk factors and mild-to-moderate mental health concerns.</p><p><strong>Methods: </strong>This systematic review protocol will be reported according to the updated Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA-P) guidelines. Proposed database searches will include Emcare, MEDLINE, PsycINFO (via OVID), CINAHL and preprint databases for grey literature. Articles of interest will include adults' experiences of and factors that influence engagement with integrated care in the UK, specifically for support with CVD risk and mild-to-moderate mental health concerns. Any study design reporting qualitative primary data will be included (excluding conference abstracts). Data on study population (actors/targets), what they do (behaviours) care setting (context), care format (time) and participant experiences and perspectives will be extracted. Where appropriate, thematic synthesis of extracted data will be coded to the Theoretical Domains Framework (TDF), updated Consolidated Framework for Implementation Research (CFIR) and Action, Actor, Context, Target and Time (AACTT) framework.</p><p><strong>Discussion: </strong>Findings from this review will provide foundation evidence for a behavioural systems map and recommendations for policymakers, commissioners and those involved or interested in integrated care for people at risk of CVD with mental health concerns. Such evidence can be used to develop future intervention strategies to assist the optimisation of integrated care.</p><p><strong>Systematic review registration: </strong>PROSPERO (CRD42024554282.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"168"},"PeriodicalIF":3.9,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ReviewGenie: a novel automated system for systematic reviews-an exploratory study in speech and language disorders.","authors":"Abeer Z Al-Marridi, Ahmed Bensaid, Samawiyah M Ulde, Tariq Khwaileh","doi":"10.1186/s13643-025-02895-z","DOIUrl":"10.1186/s13643-025-02895-z","url":null,"abstract":"<p><strong>Background: </strong>Systematic reviews (SRs) are a cornerstone in providing high-quality evidence that guides policy and practice across various disciplines. Despite their critical role, SRs require substantial financial investment and are constrained by time-consuming manual processes. Existing solutions primarily focus on semi-automating the title and abstract screening stages, yet these approaches still face limitations in terms of efficiency and practicality. The SR process comprises several stages beyond abstract screening, each of which is resource-intensive. To overcome these challenges, this paper introduces ReviewGenie, a novel system that automates SR stages up to and including abstract screening, utilizing artificial intelligence.</p><p><strong>Method: </strong>The SR process involves eight key stages, beginning with the definition of search keywords and the selection of target databases, and culminating in full screening. While the initial and final stages require human expertise, the intermediate stages can be automated. ReviewGenie automates all intermediary stages, including database searching, data retrieval, cleaning, deduplication, filtering, and abstract screening. The system is domain-agnostic, as evidenced by a case study focused on databases related to speech and language disorders.</p><p><strong>Results: </strong>ReviewGenie significantly reduces the workload across various stages of the SR process, delivering notable time and cost savings while enhancing efficiency and accuracy. In the case study, where the article-fetching stage involved tens of thousands of publications, ReviewGenie achieved a 2.62% improvement in duplicate detection in less than a second, compared to the 1 to 3 h typically required for manual deduplication of 100 records. This process included cleaning abstracts before removing duplicates. Additionally, ReviewGenie reduced the number of articles from 28,674 to 3520 using an automatic filtering approach executed in seconds. This substantial reduction underscores the effectiveness of our automated method in preparing datasets for the abstract screening stage. Moreover, the artificial intelligence-driven abstract screening method resulted in cost savings exceeding $6230 compared to manual methods.</p><p><strong>Conclusions: </strong>ReviewGenie represents a significant advancement in reducing the burden on researchers conducting comprehensive systematic reviews. By automating intermediate stages, ReviewGenie enhances efficiency, accuracy, and cost-effectiveness, establishing itself as an indispensable tool for SRs across various disciplines.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"167"},"PeriodicalIF":3.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12359888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the challenges of medicine optimisation among older people (aged 60 years and above) from ethnic minority communities with polypharmacy in primary care: a realist review protocol.","authors":"Nesrein Hamed, Clare Bates, Muhammed Umair Khan, Ian Maidment","doi":"10.1186/s13643-025-02920-1","DOIUrl":"10.1186/s13643-025-02920-1","url":null,"abstract":"<p><strong>Background: </strong>Across many countries, the number of older people from ethnic minority communities is growing due to ageing populations and migration trends. In England and Wales, the population of older people from ethnic minority communities, particularly those aged 60 and above, is also increasing. This demographic change, often accompanied by the prevalence of polypharmacy in these communities, presents unique challenges in the context of medicine optimisation. Failure in this context can lead to exacerbated health disparities, non-adherence, and inappropriate prescribing (whether over or under). Building on the MEMORABLE study exploring medication management in older people, this review aims to understand the complexities of medicine optimisation, exploring what works and does not work, when and under what circumstances for older people from ethnic minority communities. Key possible areas include cultural backgrounds, traditional beliefs, and systemic barriers that may influence medicine optimisation.</p><p><strong>Methods: </strong>The review will follow the five-step realist approach that firstly establishes initial programme theories to highlight the expected context, mechanisms, and outcomes. Then a formal search for evidence will be conducted. The third step involves the selection and appraisal of studies screened by title, abstract/keywords and full text based on exclusion/inclusion criteria. Then data from these studies will be extracted, recorded, and coded. The final step will synthesise this information, to test, refine, and expand our initial programme theories and generate context-mechanism-outcome configurations to better understand medicine optimisation in these communities.</p><p><strong>Discussion: </strong>This review will be conducted in line with the RAMESES reporting standards. By explaining what works, for whom, and in what contexts, the review will generate theory-informed insights into MO for older people from ethnic minority communities with polypharmacy in primary care. These findings can support the development of culturally responsive, person-centred interventions. Results will be shared through peer-reviewed publications and presentations at relevant national and international conferences. TRIAL REGISTRATION: Systematic review registration: PROSPERO CRD42023432204.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"166"},"PeriodicalIF":3.9,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}