Impact of cycling exercise in patients with chronic kidney disease: protocol for a systematic review and trial sequential meta-analysis.

IF 3.9 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Systematic Reviews Pub Date : 2025-08-29 DOI:10.1186/s13643-025-02932-x

Chen Chen, Shao-Hua Chen, Yan Cao, Ji-Ming Tao

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引用次数: 0

Abstract

Background: Chronic kidney disease is a global public health problem affecting approximately 10% of the adult population. Conventional management combines pharmacotherapy and dialysis, yet long-term complications persist. Cycling, a low joint load exercise, may improve cardiopulmonary function and renal outcomes, but conflicting evidence exists regarding its efficacy in advanced CKD.

Methods and analysis: Randomized controlled trials (RCTs) that compare cycling exercise and usual care in patients with chronic kidney disease will be included. Literature searches will be conducted in PubMed, Web of Science, Embase, and Cochrane Library. Two reviewers will independently perform the processes of literature retrieval, screening, data extraction, and assessment of risk of bias. Risk of bias in included studies will be evaluated using Revised Cochrane risk-of-bias tool (ROB 2) for RCTs. Review Manager (RevMan) will be used for data pooling. Subgroup analysis, trial sequential analysis (TSA), and sensitivity analysis will be conducted.

Ethics and dissemination: Ethical approval is not required because this study is a secondary analysis of existing data. We will disseminate the findings through peer-reviewed publications.

Systematic review registration: PROSPERO CRD420251048364.

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骑车运动对慢性肾病患者的影响：系统评价和试验序贯荟萃分析方案

背景：慢性肾脏疾病是影响大约10%成人人口的全球性公共卫生问题。常规治疗结合药物治疗和透析，但长期并发症持续存在。骑自行车是一种低关节负荷的运动，可以改善心肺功能和肾脏预后，但关于其对晚期CKD的疗效存在矛盾的证据。方法和分析：随机对照试验（rct）比较骑车运动和常规护理对慢性肾病患者的影响。文献检索将在PubMed、Web of Science、Embase和Cochrane Library进行。两名审稿人将独立完成文献检索、筛选、数据提取和偏倚风险评估的过程。纳入研究的偏倚风险将使用rct的修订Cochrane风险偏倚工具（ROB 2）进行评估。Review Manager （RevMan）将用于数据池。进行亚组分析、试验序贯分析（TSA）和敏感性分析。伦理和传播：由于本研究是对现有数据的二次分析，因此不需要伦理批准。我们将通过同行评审的出版物传播研究结果。系统评价注册：PROSPERO CRD420251048364。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Systematic Reviews Medicine-Medicine (miscellaneous)

CiteScore

8.30

自引率

0.00%

发文量

241

审稿时长

11 weeks

期刊介绍： Systematic Reviews encompasses all aspects of the design, conduct and reporting of systematic reviews. The journal publishes high quality systematic review products including systematic review protocols, systematic reviews related to a very broad definition of health, rapid reviews, updates of already completed systematic reviews, and methods research related to the science of systematic reviews, such as decision modelling. At this time Systematic Reviews does not accept reviews of in vitro studies. The journal also aims to ensure that the results of all well-conducted systematic reviews are published, regardless of their outcome.