Systematic Reviews最新文献

{"title":"Risk factors for colonisation and infection with multidrug-resistant Pseudomonas aeruginosa in intensive care unit: a systematic review and meta-analysis.","authors":"Serge Eyebe, Guy Sadeu Wafeu, Emilia Lyonga Mbamyah, Chritine Danielle Evina, Pierre Ongolo-Zogo, Alain Bertrand Dongmo, Arthur Mbida","doi":"10.1186/s13643-025-02975-0","DOIUrl":"https://doi.org/10.1186/s13643-025-02975-0","url":null,"abstract":"<p><strong>Background: </strong>There are currently two opposing hypotheses regarding the risk factors for acquisition, colonisation and infection with multidrug-resistant Pseudomonas aeruginosa (MDR-PA) in the intensive care unit (ICU). Acquisition could be either endogenous or exogenous or both. It is of great interest to estimate pooled prevalence and describe individual and environmental factors associated with the colonisation and infection with MDR Pseudomonas aeruginosa in intensive care units.</p><p><strong>Methods: </strong>This systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The protocol of this review has been registered under CRD42021233832 in the International Prospective Register of Systematic Reviews (PROSPERO) and has been published on Systematic review on November 2022All types of studies carried out in intensive care units (ICUs) were included. MEDLINE (Pubmed), EMBASE (OVID), the Cochrane Library (Wiley), Web of Science, CINAHL (EBSCOHost), LILACS (BIREME), Google Scholar and Open Grey were searched from 1983 to 2023 and the results of electronic searches were uploaded to Rayyan software. The methodological quality of the studies was assessed using the National Heart, Lung, and Blood Institute Critical Appraisal Tools. The I<sup>2</sup> test was performed to assess the statistical heterogeneity among the included studies. The publication bias was assessed by using the funnel plot and Egger's test. Descriptive analysis and meta-analysis were performed. Fixed effect model were used to calculate the surveyed prevalence and odds ratio (OR) with their respective 95% confidence intervals (95% CI).</p><p><strong>Results: </strong>A total of 10,791 articles were identified, of which 13 were retained for descriptive analysis and 8 for meta-analysis. The majority of these 13 studies were conducted in Western countries. Methods were heterogeneous and few studies addressed environmental factors. The pooled prevalence of MDR-PA in the ICU was 4% (95% CI: 0%-11%). Identified risk factors were: length of stay in ICU (> 8 days), mechanical ventilation with OR: 3.19; 95% CI: 2.25-4.53, use of invasive devices with OR: 2.97; 95% CI: 2.40-3.68 (use of central venous catheter with OR: 3.16 95% CI: 1.87-5.33, the use of urinary catheters with OR: 2.65; 95% CI: 2.05-3.44, the use of parenteral nutrition with OR: 2.43; 95% CI: 1.15-5.16 and the use of arterial catheters with OR: 7.00; 95% CI: 2.77-17.68) and the use of antibiotics with OR: 3.69; 95% CI: 3.16-4.27 (carbapenem with OR: 4.12; 95% CI: 3.29-5.16, quinolones with OR: 3.31; 95% CI: 2.45-4.47, bectalactam with OR: 3.58; 95% CI: 2.4-5.24, and aminoglycosides with OR: 3.32; 95% CI: 2.33-4.73) and environmental factors.</p><p><strong>Conclusion: </strong>All this suggest that acquisition or infection by MDR-PA in ICU could be due to endogenous and exogenous transmission. Due to the few numbers of studies analy","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147864398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perishable food supply chain management and food access in remote Indigenous communities of high-income countries: a systematic scoping review protocol.","authors":"Behnaz Gharakhani Dehsorkhi, Karima Afif, Maurice Doyon","doi":"10.1186/s13643-026-03156-3","DOIUrl":"https://doi.org/10.1186/s13643-026-03156-3","url":null,"abstract":"<p><strong>Background: </strong>Indigenous populations in high-income countries (HICs) experience disproportionately high rates of food insecurity, particularly in remote regions where high costs, poor quality, and limited variety limit access to perishable foods. Fragile perishable food supply chains (PFSCs) further compound these vulnerabilities. Although existing reviews have examined nutrition policies, socioeconomic interventions, and retail food environments, they have largely overlooked the operational and logistical challenges associated with perishable food supply chain management (PFSCM). Moreover, no review has systematically mapped the reported practices in the literature to address these challenges across interconnected supply chain levels, including procurement, transportation, distribution, and retail. To address these gaps, this systematic scoping literature review (SSLR) will employ a food access framework to synthesize the challenges and practices of PFSCM in remote Indigenous communities across 17 HICs.</p><p><strong>Methods: </strong>This SSLR will follow the Joanna Briggs Institute (JBI) methodology for scoping reviews and will be reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Protocols (PRISMA-P). A three-step JBI search strategy will be used to identify relevant published and unpublished evidence, including grey literature. Databases will include IEEE, MEDLINE (Ovid), ABI/Inform Global (ProQuest), CAB Abstracts, and Web of Science (Core Collection). Grey literature will be sourced from the Grey Source Index, Web of Conferences, government publications, OpenDOAR, OpenAIRE, and SSRN. Sources will be included if published in English between 1996 and 2024 and if they address PFSCM (phenomenon), perishable food access (concept), and remote Indigenous communities in HICs (context). Data will be extracted using a structured framework. Descriptive statistics will summarize study characteristics, and thematic analysis will be conducted to identify patterns in PFSCM challenges and reported practices. NVivo will support data management, and results will be reported in accordance with PRISMA-ScR guidelines.</p><p><strong>Discussion: </strong>This review will provide the first systematic scoping synthesis of PFSCM challenges and reported practices in remote Indigenous communities across HICs. By integrating a food access framework with a systems-oriented supply chain perspective, the review will extend prior work that has primarily focused on retail or policy interventions and limited geographic settings. The resulting evidence map and conceptual framework will support future research, policy dialogue, and context-sensitive planning to strengthen perishable food systems and food access in remote Indigenous settings.</p><p><strong>Systematic review registration: </strong>Open science framework registration: https://osf.io/kqpvn.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nursing research on physical, relational and psychosocial care for older people in Germany: protocol for a mapping review guided by the Fundamentals of Care Framework.","authors":"Ozlem Koseoglu Ornek, Franziska Jagoda, Claudia Dinand, Dominique Autschbach, Manuela Malek, Margareta Halek","doi":"10.1186/s13643-026-03191-0","DOIUrl":"10.1186/s13643-026-03191-0","url":null,"abstract":"<p><strong>Background: </strong>The number of older people in Germany has risen steadily in recent decades. One in four people is now aged 65 or over. As people age, their health problems tend to increase, as do their fundamental care needs. Nurses play a key role in addressing these needs through a holistic approach. To fulfil this responsibility effectively, it is necessary to examine existing nursing research on the fundamentals of care for older people and to identify gaps in the current evidence base. Therefore, we plan to conduct a mapping review with the aim of mapping the extent, range and nature of nursing research activities on the fundamentals of care, as defined in the physical, psychosocial and relational components of the Integration of Care dimension of the Fundamentals of Care Framework for older people in Germany.</p><p><strong>Methods: </strong>We will search the electronic databases PubMed/MEDLINE, CINAHL, CareLit and GeroLit, the catalogue of the German Federal Ministry of Research, Technology and Space and the German National Library for publications on nursing research based on the Integration of Care dimension of the Fundamentals of Care Framework among older people (≥ 65 years). There will be no time limit. We will include studies published in English and German. Initial screening of the first ten per cent of titles and abstracts and other stages will be carried out by two independent researchers. This process will be repeated until full agreement between the researchers. Any discrepancies will be resolved with consultation of a third reviewer. Results will be reported in a narrative synthesis and complemented by tabular and numerical presentations.</p><p><strong>Discussion: </strong>To the best of our knowledge, this mapping review will be the first to provide an overview of current nursing research on the fundamentals of care for older people in Germany. The inclusion of German-language texts and the absence of time limits in this review are intended to complement previous reviews. The planned mapping review will also identify the evidence gap in research in this area and contribute to the determination of future scientific research in Germany. Consequently, the findings of the mapping review could be of great interest to nurses and other health professionals for evidence-based practice, research and educational programmes. In addition, the data can be used to develop a programme for the provision of age-friendly and caring living conditions for older people in the future.</p><p><strong>Systematic review registration: </strong>The protocol was registered with Open Science Framework (osf.io/9e3uv).</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"15 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13154650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrolides usage as anti-inflammatory agents in the treatment of community-acquired pneumonia and ventilator-associated pneumonia: a systematic review and meta-analysis.","authors":"Ramona Nasr, Abir Abdel Rahman, Nisrine ElHadi, Pascale Salameh, Hanine Mansour","doi":"10.1186/s13643-026-03190-1","DOIUrl":"https://doi.org/10.1186/s13643-026-03190-1","url":null,"abstract":"<p><strong>Background: </strong>Community-acquired pneumonia (CAP) and ventilator-associated pneumonia (VAP) require effective treatment strategies. In addition to their antimicrobial role, macrolides may have a potential anti-inflammatory role in CAP and VAP. The purpose of this systematic review is to explore the use of macrolides as anti-inflammatory drugs in CAP and VAP and to assess their impact on mortality and hospital length of stay while adhering to treatment guidelines.</p><p><strong>Methods: </strong>A comprehensive search was conducted. Inclusion criteria were determined based on the PICOS (Population, Intervention, Comparison, Outcome, and Study Design) framework. The PICOS framework was used to define study eligibility and was not applied as a weighting or scoring system. Only observational studies, non-randomized studies, and randomized controlled trials (RCTs) meeting these criteria were included. A standardized eligibility screening form was employed by three independent reviewers, adhering to the established Cochrane guidelines and utilizing specialized software for analysis.</p><p><strong>Results: </strong>Among 11,960 identified records, 13 studies met the inclusion criteria and underwent qualitative synthesis. Nine studies underwent meta-analysis. Of these, 25% exhibited a low risk of bias, and approximately 50% presented a moderate risk of bias. Meta-analysis showed that macrolide's use was associated with a significant reduction in in-hospital mortality (OR 0.42, 95% CI 0.25-0.71) and post-discharge mortality (OR 0.52, 95% CI 0.31-0.87). A non-significant reduction in length of hospital stay was also observed (MD - 0.68, 95% CI - 1.67 to 0.32). However, the limited number of RCTs reduces the overall quality of the available evidence.</p><p><strong>Conclusions: </strong>Macrolides demonstrate potential anti-inflammatory benefits in CAP and VAP, leading to improved clinical outcomes. However, further well-designed RCTs are needed to strengthen the evidence and confirm these findings.</p><p><strong>Systematic review registration: </strong>This review was registered in PROSPERO (registration number: CRD42018088203).</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical exercise therapy for autism spectrum disorder: protocol for a scoping review of systematic reviews.","authors":"Fei Fan, Ji Li, Xuan Zhang, Zilin Chen, Yuchen Hu, Fei Han","doi":"10.1186/s13643-026-03193-y","DOIUrl":"https://doi.org/10.1186/s13643-026-03193-y","url":null,"abstract":"<p><strong>Background: </strong>Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by core symptoms of impaired social communication and restricted repetitive patterns of behavior. Physical exercise therapy (PET), as a non-pharmacological intervention, has seen increasing application and research in the ASD field. Although multiple systematic reviews have examined the efficacy of PET interventions for ASD and associated factors, a scoping review is still needed to systematically analyze existing systematic reviews and meta-analyses, thereby identifying current research gaps.</p><p><strong>Methods: </strong>This study will be based on the scoping-review methodological framework proposed by Arksey and O'Malley in 2005 and the PRISMA-ScR reporting guidelines. The search will cover four databases: MEDLINE (PubMed), EMBASE, Web of Science, and Cochrane Library (Wiley), screening systematic reviews published in English from database inception through December 2025. The study will include systematic reviews of randomized controlled trials and observational studies (with or without meta-analysis). Two reviewers will independently perform literature screening and data extraction. All eligible articles will be evaluated using the AMSTAR-2 tool. Tabulated data will be summarized through quantitative analysis, with qualitative synthesis conducted using narrative methods.</p><p><strong>Discussion: </strong>This scoping review will highlight the evidence needed to guide decision-making for PET interventions in individuals with ASD.</p><p><strong>Systematic review registration: </strong>Open Science Framework (https://doi.org/10.17605/OSF.IO/JVM4H).</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interprofessional teams and capacity in collaborative primary care: a rapid scoping review.","authors":"Hina Ansari, Dipika Neupane, Noah Ivers, Tara Kiran, Sai Surabi Thirugnanasampanthar, Jasmeen Dourka, Lyn M Sibley, Paul A Khan, Vera Nincic, Rachel Thelen, Sydney Pearce, Kanya Rajendra, Cris Carter, Danielle Martin, Jane Zhao, Marianna Kong, Andrea C Tricco","doi":"10.1186/s13643-026-03189-8","DOIUrl":"https://doi.org/10.1186/s13643-026-03189-8","url":null,"abstract":"<p><strong>Purpose: </strong>Interprofessional team-based primary care models are pursued often as a means to improve access to primary care services and increase capacity within the health system for more patients to be served. However, this relationship has not been previously synthesized in the available literature. Our objective was to investigate what is and is not known about the impact of interprofessional primary care teams on the most responsible clinician's capacity to serve more patients.</p><p><strong>Methods: </strong>We conducted a rapid scoping review of literature published between 2000 and 2023 using MEDLINE. Eligibility criteria included studies of team-based care defined as at least one most-responsible clinician and one regulated health professional working together on an ongoing basis with shared patients. The primary outcome was a quantitative assessment of the capacity of the most responsible clinician(s) on the team.</p><p><strong>Results: </strong>After screening 14,639 citations and 853 full-text articles, 35 studies were included. There was substantial variation in: patient populations served; team size and composition; comparator groups; team governance and culture of teamwork; types of health professionals and their roles and ratios; and the basket of services provided.</p><p><strong>Conclusions: </strong>Findings document a range of ways that capacity is pursued and achieved through interprofessional primary care teams. The heterogeneity in this review highlights the need to identify the mechanisms through which interprofessional teams facilitate or optimize primary care capacity, and the patient populations who may be best served by various team configurations. The gaps highlighted in this review and the paucity of studies warrant further in-depth evaluations of interprofessional team-based primary care.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of using local anesthesia with general anesthesia in pediatric dental rehabilitation: a systematic review and meta-analysis.","authors":"Shimaa T Ibrahim, Doaa Y Jamal, Ahmed Y Alzahrani, Deem A AlBlaihed, Narmin M Helal, Heba Jafar Sabbagh","doi":"10.1186/s13643-026-03181-2","DOIUrl":"https://doi.org/10.1186/s13643-026-03181-2","url":null,"abstract":"<p><strong>Background: </strong>There are no established evidence-based guidelines for the administration of intraoperative local anesthesia (LA) during dental rehabilitation under general anesthesia (GA). This systematic review aims to evaluate the effects of intraoperative LA on physiological parameters and pain control in children undergoing GA for comprehensive dental treatment.</p><p><strong>Methods: </strong>Comprehensive search was conducted across four electronic databases: PubMed, Cochrane Central Register of Controlled Trials, EBSCO, and Scopus. Search strategy was structured, yielding 14 articles that follow the study inclusion criteria. Risk of bias was performed using Cochrane Collaboration's tool for randomized trials and confidence of recommendation according to Grading of Recommendations, Assessment, Development, and Evaluations (GRADE). Whenever there were sufficient studies with comparable data, meta-analysis was performed.</p><p><strong>Results: </strong>Pain levels were significantly lower in the LA group compared to controls (OR = 0.32, 95% CI 0.14-0.70, P = 0.005). Lip and/or cheek biting occurred more frequently in the LA group, though this difference was not statistically significant. Although reductions were observed in physiological parameters, only the decrease in end-tidal CO₂ volume reached statistical significance (P = 0.02). The included studies were rated as having low confidence and quality based on the GRADE assessment.</p><p><strong>Conclusion: </strong>While the intraoperative use of LA under GA reduced postoperative pain and end-tidal CO₂ volume, other effects were negligible, making its routine use optional. Evidence suggests targeting LA for high-pain procedures, such as multiple extractions, while exercising caution or withholding it during deep sedation to mitigate potential drops in tidal volume.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42022340846.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Segmentation for pelvic malignancies in radiation oncology practice: a systematic review and meta-analysis protocol.","authors":"Sidharth Satish Menon, Umesh Velu, Lavanya Gurram, Ganesh Paramasivam, Manjunath Kn, Divya Susanna Patil, Vijay Shree Dhyani, Roshan David Jathanna, Shirley Lewis","doi":"10.1186/s13643-026-03173-2","DOIUrl":"https://doi.org/10.1186/s13643-026-03173-2","url":null,"abstract":"<p><strong>Background: </strong>Deep learning (DL)-based artificial intelligence (AI) models, the fourth generation in autosegmentation, have been adopted both for commercial and research applications worldwide and have shown great promise as reliable and comprehensive resource strategies for radiotherapy workflows.</p><p><strong>Methods: </strong>A comprehensive search will be conducted on Medline (PubMed), Scopus, the Cochrane Library, EMBASE, and Web of Science between January 2004 and December 2025. We will conduct a title, abstract, and full-text screening of all studies as per the eligibility criteria. Two reviewers will be involved in screening studies, quality appraisal, and data extraction, and a third reviewer will be consulted to resolve conflicts. Based on data availability, the data will be synthesised via meta-analysis and narrative synthesis. The reporting will be performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, ensuring the reliability and validity of the results.</p><p><strong>Discussion: </strong>The model's performance will be assessed using various quantitative indices, qualitative tools, timesavings, and dosimetry. This review will enable us to determine the accuracy of autosegmentation for targets and various pelvic organs, boosting clinicians' confidence in facilitating the clinical implementation of such tools in routine clinical practice.</p><p><strong>Systematic review registration: </strong>The protocol is prospectively registered on PROSPERO. The registration ID is CRD42024491066.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A methodologic survey on use of the GRADE approach in evidence syntheses published in high-impact factor neurology journals.","authors":"Anna Balsamão Vaz, Julia Mafra Vasconcelos, Pollyana Helena Vieira Costa, Aline Alvim Scianni, Christina D C M Faria, Janaine Cunha Polese","doi":"10.1186/s13643-025-02928-7","DOIUrl":"https://doi.org/10.1186/s13643-025-02928-7","url":null,"abstract":"<p><strong>Background: </strong>The GRADE system is a transparent approach to assess the quality of evidence and strength of recommendations in health. It aids in converting evidence into guidelines, enhancing clarity and application in clinical practice. This study aims to identify scoping and systematic reviews using GRADE in top rehabilitation and neurology journals from 2020 to 2022.</p><p><strong>Methods: </strong>The top 13 journals of rehabilitation and/or neurology area were selected by Scopus Sources. All systematic reviews and scoping reviews published between 2020 and 2022 were included. Studies that did not use the original GRADE system or failed to describe the GRADE details were excluded. The data of interest were extracted and analyzed by three researchers for an Excel table.</p><p><strong>Results: </strong>There is no relation between the journals' quality and the number of systematic reviews that used the GRADE system. The Neurorehabilitation and Neural Repair and Journal of Stroke and Cerebrovascular Diseases had the highest number of systematic reviews that used the GRADE system (16.7% and 4.8%, respectively). The most used downgrading criteria are both risk of bias and imprecision (100%).</p><p><strong>Conclusions: </strong>The GRADE system is not widely used in the top 13 journals in the rehabilitation and neurology journals.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of the effectiveness, safety and acceptance of nicotine replacement therapy use for vaping cessation in youth aged 17 years or younger.","authors":"Ben Wamamili, Louise McDermott, Tony Walls, Philip Pattemore, Rebecca Phibbs, Rachel Isba","doi":"10.1186/s13643-026-03163-4","DOIUrl":"https://doi.org/10.1186/s13643-026-03163-4","url":null,"abstract":"<p><strong>Background: </strong>Youth vaping is a major global public health issue with significant physical, psychological and behavioural risks. This systematic review aims to review published studies and guidelines on the effectiveness, safety and acceptability of nicotine replacement therapy (NRT) use to promote vaping cessation in youth aged 17-years or younger.</p><p><strong>Methods: </strong>We searched MEDLINE, Embase, CINAHL, Scopus, PsychINFO, Cochrane Library, Web of Science, NIH Clinical Trials, EU Clinical Trials, WHO International Clinical Trials Registry Platform, Google Scholar and reference lists of relevant publications for studies on NRT and vaping cessation published in English since 2010. One reviewer screened titles and abstracts, and two reviewers independently performed title-abstract and full text screening according to the pre-determined inclusion criteria. There were no disagreements. Data on study and intervention characteristics, vaping cessation, safety concerns and acceptance of NRT were extracted by one reviewer and checked by another. Risk of bias assessment was performed by one reviewer and verified by another using the \"NOS-xs tool\" adapted from the Newcastle-Ottawa Scale (NOS) for cross-sectional studies and a novel tool was developed for case series.</p><p><strong>Results: </strong>Two records and eight guidelines were identified. One case series (n = 6; only one aged ≤ 17) assessed the effectiveness and acceptance of NRT and 4 participants including 1 aged 17 were vape-free at 8-months; all participants 'felt comfortable' using NRT. A cross-sectional study (n = 2229) found 58.9% of participants were interested in using NRT as a vaping cessation aid if it was offered for free. Most of the 8 guidelines supported NRT use in youth aged ≥ 12 years for smoking cessation: none mentioned vaping cessation.</p><p><strong>Conclusions: </strong>This review underscores the critical gaps in the evidence for NRT use as a vaping cessation tool for youth aged 17 or younger and calls for urgent research to address these gaps. Vaping is a global public health issue and the detrimental effects of nicotine on youth are well established.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024561969.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147781819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}