Systematic Reviews最新文献

{"title":"Barriers and facilitators impacting the implementation of digital interventions targeted at mental health and musculoskeletal disorders in the workplace: a scoping review protocol.","authors":"Mallorie Leduc, Andrea Sinesi, Margaret Kenneally, Margaret Maxwell, Birgit Greiner, Birgit Aust, Carolina Piña, Andreas Czaplicki, Evelien Coppens, Alex Burdorf, Ricardo Gusmão, Daniel Guinart, Johanna Cresswell-Smith, Gentiana Qirjako, Naim Fanaj, Eleftherios Giovanis, Ainslie O'Connor, Eva Zsak, Pedro Lobo, Arlinda Cerga Pashoja, Victoria Ross, Ella Arensman, Eve Griffin","doi":"10.1186/s13643-025-02881-5","DOIUrl":"https://doi.org/10.1186/s13643-025-02881-5","url":null,"abstract":"<p><strong>Background: </strong>The digital transition in the workplace has increased trends such as permanent connectivity, an increased sedentary lifestyle, and reduced social interaction, leading to additional psychosocial and ergonomic risks for workers. Musculoskeletal disorders (MSDs) and mental health problems are particularly prevalent, posing a significant burden. To address these challenges, organisations can implement digital or blended interventions targeting MSDs and mental health problems. However, there is still limited evidence on combined workplace interventions targeting both MSDs and mental health problems and respective facilitators and barriers for their successful implementation and sustainability. The objective of this scoping review is to identify barriers and facilitators to the implementation of blended and digital interventions targeted at combined mental health and MSDs in the workplace.</p><p><strong>Methods: </strong>Bibliographic databases will be searched for studies published since 2014 and reported on the implementation of interventions with a digital component targeted at mental health and MSDs in the workplace. Studies will be included if the intervention was delivered within, or access provided through, the workplace. The title and abstract screen and the full-text screening will be completed independently by two reviewers, with a third reviewer resolving any arising conflicts in the process.</p><p><strong>Results: </strong>Descriptive characteristics of the study design, workplace sector, mode of working, intervention details, mode of intervention delivery, outcomes, and barriers and facilitators will be extracted. Results will be reported in accordance with the PRISMA for Scoping Reviews checklist and a narrative synthesis used to summarise characteristics of included studies, as well as barriers and facilitators to the implementation of interventions.</p><p><strong>Discussion: </strong>The findings from this review will provide practical recommendations relevant to researchers and practitioners developing or implementing digital interventions in the workplace targeting mental health conditions and MSDs.</p><p><strong>Systematic review registration: </strong>Research Registry, reviewregistry1847, https://www.researchregistry.com/browse-the-registry#registryofsystematicreviewsmeta-analyses/registryofsystematicreviewsmeta-analysesdetails/66671b683a0f410028a230bd/ .</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"148"},"PeriodicalIF":6.3,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144620644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual networks, sexual practices, and sexual health among youths in WHO-South East Asia Region: a scoping review protocol.","authors":"Amrita Rao, Rashmi Shinde, Sheikh Mohammed Shahabuddin","doi":"10.1186/s13643-025-02905-0","DOIUrl":"https://doi.org/10.1186/s13643-025-02905-0","url":null,"abstract":"<p><strong>Background: </strong>South-East Asia Region has one of the largest youth populations in the world. All countries are striving to achieve the sustainable development goal by 2030; hence, it is important to prioritize healthcare services for youths. Youths in the age bracket of 18 to 24 years often engage in high-risk behaviors such as unsafe injecting practices/substance abuse. These high-risk practices lead to increased transmission of sexually transmitted infections including HIV among them. It is imperative to understand the dynamics around sexual transmission of diseases among youth. This review will map the available evidence and identify the gaps in sexual health interventions related to the sexual networks, sexual practices, and sexual health among youths across the World Health Organization (WHO)-South East Asia Region (SEAR).</p><p><strong>Methods: </strong>The scoping review is guided by the Arksey and Malley framework. Peer-reviewed articles focusing on youths in the age groups of 18 to 24 years, from the 11 countries of SEAR, will be accessed from three databases, namely PubMed, Scopus, and Journals@Ovid. Additionally, grey literature from 2015 to date will also be accessed. Two reviewers will independently screen the articles based on pre-defined eligibility criteria in Rayyan software. Data extraction will be carried out based on pre-specified variables aligned with the objectives. We will synthesize the evidence from the relevant qualitative, quantitative, and mixed method studies. The reporting will follow Preferred Reporting Items for Systematic reviews and Meta-Analysis extension for Scoping Reviews (PRISMA-ScR).</p><p><strong>Discussion: </strong>This review will help to generate evidence focusing on the current sexual networks, sexual practices, and sexual health among youths in WHO SEAR with a focus on India, highlighting the gaps in sexual health interventions that need to be bridged. The insights from this review will assist in designing larger evidence-based intervention studies for improving the sexual networks, sexual practices, and sexual health among youths in this region. The findings from this review will be disseminated through peer-reviewed journals and conferences.</p><p><strong>Systematic review registration: </strong>Open Science Framework. The link is https://doi.org/10.17605/OSF.IO/2JSMC .</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"147"},"PeriodicalIF":6.3,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144620646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do occupational health and safety tools that utilize artificial intelligence have a measurable impact on worker injury or illness? Findings from a systematic review.","authors":"Arif Jetha, Hela Bakhtari, Emma Irvin, Aviroop Biswas, Maxwell J Smith, Cameron Mustard, Victoria H Arrandale, Jack T Dennerlein, Peter M Smith","doi":"10.1186/s13643-025-02869-1","DOIUrl":"10.1186/s13643-025-02869-1","url":null,"abstract":"<p><strong>Background: </strong>Artificial intelligence (AI) holds promise as a tool that can be used by practitioners in the field of occupational health and safety (OHS). This study aimed to identify AI applications specifically used for OHS and examine their impact on worker morbidity or mortality outcomes.</p><p><strong>Methods: </strong>We conducted a comprehensive systematic review. We searched six databases to identify published quantitative studies of OHS AI applications across the hierarchy of controls that were published between years 2018 to 2024. Title/abstract and full-text screening was conducted to identify eligible studies which were then assessed for quality and risk of bias and synthesized.</p><p><strong>Results: </strong>Of the 1255 articles identified by our search, only two met eligibility criteria; one of which was appraised as medium quality and the other as low quality. The one medium quality study identified by our review was an AI-based chatbot health promotion tool which was shown to improve musculoskeletal symptoms. Our systematic review shows that we are at the early stages of understanding the role AI can play in OHS and it may be premature to recommend the wide-spread use of AI for health and safety practice within workplaces.</p><p><strong>Conclusion: </strong>There is a critical need for future research to unpack how considerations taken in the development and adoption of workplace AI tools for OHS can determine their effectiveness in addressing worker injury or illness.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42023414422.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"146"},"PeriodicalIF":6.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144620645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the ability to diagnose gestational diabetes mellitus between glycated albumin or fructosamine and hemoglobin A1c-a meta-analysis of diagnostic studies.","authors":"Satoru Kodama, Takaho Yamada, Noriko Yagyuda, Nanako Tanaka, Sijia Wu, Efrem D'Avila Ferreira, Khin Laymon, Kazuya Fujihara, Chika Horikawa, Yoko Yachi, Hirohito Sone","doi":"10.1186/s13643-025-02894-0","DOIUrl":"10.1186/s13643-025-02894-0","url":null,"abstract":"<p><strong>Background: </strong>While the oral glucose tolerance test (OGTT) is the gold standard for diagnosing gestational diabetes mellitus (GDM), hemoglobin A1c (A1C), glycated albumin (GA), and fructosamine (Fruc) have the potential to conveniently classify pregnant women as having or not having GDM because two or more measurements are not necessary, unlike with OGTT. Compared with A1C, GA or Fruc, which reflects more recent glycemic indices, may more accurately detect GDM. This meta-analysis compared the diagnostic ability of GDM between GA or Fruc and A1C.</p><p><strong>Method: </strong>Comprehensive literature searches were performed for studies published up to Sep.11, 2023. Selected studies were limited to those that attempted to identify GDM using both GA and/or Fruc and A1C to compare these indicators. Two authors extracted the data. Disagreements were resolved by a third author. Study quality was assessed by a revised tool for quality assessment of diagnostic accuracy in studies (QUADUS-2). The dataset consisting of true-positives, false-positives, false-negatives, and true-negatives was pooled with a bivariate between-study model and hierarchical summary receiver operating characteristic model. Pooled relative sensitivity and specificity based on a random-effects model were calculated to compare the diagnostic ability of A1C and GA and/or Fruc for GDM.</p><p><strong>Result: </strong>There were 20 eligible studies. Pooled positive and negative likelihood ratios with 95% confidence intervals (CI) were 5.11 (2.30-11.37) and 0.53 (0.40-0.71), respectively, if GA or Fruc was used and 3.75 (2.61-11.39) and 0.53 (0.42-0.66), respectively, if A1C was used. Relative sensitivity and specificity (95% CI) for GA or Fruc compared with A1C was 1.00 (0.94-1.07) and 0.99 (0.97-1.01), respectively.</p><p><strong>Conclusion: </strong>The insufficiently low value of the negative likelihood ratio did not support the single use of GA/Fruc or A1C in screening for GDM suggesting the necessity of combining other risk factors with glycemic indicators. Although there was no statistically significant difference in diagnostic ability between GA or Fruc and A1C, the value of the positive likelihood ratio indicated that GA or Fruc was somewhat more useful than A1C as a rule-in test for the diagnosis of GDM.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42023461975.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"144"},"PeriodicalIF":6.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bayesian inference in racial health inequity analyses for noncommunicable diseases: a systematic review.","authors":"Oscar Espinosa, Valeria Bejarano, Andrea Mejía, Héctor Castro, Angel Paternina-Caicedo","doi":"10.1186/s13643-025-02898-w","DOIUrl":"10.1186/s13643-025-02898-w","url":null,"abstract":"<p><strong>Background: </strong>Health inequalities are differences in health status or in the distribution of resources and opportunities between different population groups. Bayesian models are well-suited to address the special features and uncertainties in inequality analyses, making them useful for informing policymaking. This research reviewed the use of Bayesian models in racial health equity studies focused on non-communicable diseases.</p><p><strong>Methodology: </strong>A systematic review was conducted to assess the applications and utility of Bayesian inference in racial health equity studies for non-communicable diseases (PROSPERO Registry No. CRD42024568708). A total of 2274 articles were identified through electronic databases, and 46 studies met inclusion criteria. All but three articles were from high-income countries, and all were published between 2008 and 2024. We summarized the information qualitatively, and each document included was assessed using the Bennett-Manuel checklist tool.</p><p><strong>Findings: </strong>Studies on cancer and cardiovascular diseases were the most frequent. The most frequently used models were Poisson, spatial, and logistic regressions, with Markov-chain Monte Carlo and Integrated nested Laplace approximations being the dominant sampling strategies. The studies found that Black individuals, followed by those of Hispanic ethnicity, are the racial/ethnic groups most affected by health inequities. Data on other racial groups (e.g., Indigenous populations, people of Asian heritage) was insufficient for drawing definitive conclusions. The main factor contributing to these disparities lies within the health system, particularly in terms of access and quality, which can be understood in the context of each disease.</p><p><strong>Interpretation: </strong>The integration of Bayesian modeling into health equity studies holds promise for developing methodologies that lead to insights and foster meaningful change.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"145"},"PeriodicalIF":6.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological and nonpharmacological approaches to hypertension treatment among veterans: a systematic review protocol.","authors":"Oleksandr Svyntozelskyi, Olesia Nasonenko","doi":"10.1186/s13643-025-02900-5","DOIUrl":"10.1186/s13643-025-02900-5","url":null,"abstract":"<p><strong>Background: </strong>Hypertension (HTN) is the leading cause of mortality worldwide, contributing to significant healthcare spending in both developed and developing countries. Veterans are disproportionately affected by HTN, potentially owing to exposure to active combat, a risk factor specific to this population. However, the most recent review of existing treatment approaches for HTN in this population was conducted in 2014 and addressed only behavioral interventions. We aim to examine existing pharmacological and nonpharmacological interventions to improve HTN control or blood pressure measures among veterans.</p><p><strong>Methods: </strong>This is the protocol for a systematic review that will examine existing pharmacological and nonpharmacological interventions (i.e., lifestyle modifications and psychological and psychosocial interventions) to improve HTN control or blood pressure measures among veterans. Our systematic review will follow the Joanna Briggs Institute Manual for Evidence Synthesis, searching four databases (Embase, MEDLINE, Cochrane, and PsycINFO) for eligible studies. The risk of bias will be assessed using the Mixed Methods Appraisal Tool (MMAT) version 2018, followed by content analysis with narrative synthesis to classify and describe the associated interventions and outcomes.</p><p><strong>Discussion: </strong>Although we expect to identify gaps in the literature, the findings from this review may guide further research on veteran health and help establish treatment guidelines for this population. This review is one of the few focusing on the veteran population and encompassing both pharmacological and nonpharmacological approaches to treating HTN. It is also the first review on the topic conducted in the last 10 years.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024579112.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"143"},"PeriodicalIF":6.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local recurrence of phyllodes tumors after surgery with wide compared to narrow margins: study protocol for a systematic review and meta-analysis.","authors":"Carl Sars, Jan Frisell, Paul W Dickman, Helena Sackey, Ebba K Lindqvist","doi":"10.1186/s13643-025-02904-1","DOIUrl":"10.1186/s13643-025-02904-1","url":null,"abstract":"<p><strong>Background: </strong>Phyllodes tumors are rare fibroepithelial breast lesions graded as benign, borderline, or malignant. Surgical resection with clear margins is the primary method of treatment. Consensus on margin width could prevent unnecessary large primary resections or reoperations, yet the optimal margins for different tumor grades remain unclear. This systematic review and meta-analysis will evaluate the effect of wide versus narrow margins on local recurrence rates after surgery for phyllodes tumors of the breast. In addition, the re-excision rates, adjuvant treatment and adverse events will be assessed.</p><p><strong>Methods: </strong>An information specialist will assist in searching MEDLINE, EMBASE, Web of Science, Google Scholar, and Cochrane Library databases, as well as gray literature to identify randomized controlled trials, observational studies, and case series. Relevant abstracts from professional society meetings and web-based registries of clinical trials will also be included via hand-search and by forward-tracking papers and by searching the reference lists of the obtained articles. Studies included will compare patients, without age limitation, who were surgically treated for a histopathologically confirmed phyllodes tumor of the breast. Studies reporting both local recurrence rate and surgical excision margins will be included. No language restriction will be applied. Two reviewers will independently screen the titles and abstracts of the studies identified during the search using pre-defined inclusion criteria and data extraction from the full texts of selected studies will be performed. The quality of included studies will be assessed by two independent reviewers using the Cochrane Risk of Bias 2.0 tool for randomized trials, the Newcastle-Ottawa Scale for observational studies and the Joanna Briggs Institute Checklist for case series. A meta-analysis on pooled local recurrence rates will be conducted, stratified by different phyllodes tumor grades and surgical margins.</p><p><strong>Discussion: </strong>This systematic review will provide a synthesis of current evidence on the optimal surgical margins of phyllodes tumors and its effect on local recurrence rates. These findings aim to provide clinicians with guidelines and to establish a strong research base for future studies in this field.</p><p><strong>Trial registration: </strong>PROSPERO CRD420250640098.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"142"},"PeriodicalIF":6.3,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of physical activity on visual outcomes among type 2 diabetes patients: protocol for a scoping review of randomized controlled trials.","authors":"Ebenezer Oduro Antiri, Thomas Hormenu, Stephen Ocansey, Edward Wilson Ansah","doi":"10.1186/s13643-025-02887-z","DOIUrl":"10.1186/s13643-025-02887-z","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus remains a major global health concern, affecting millions of patients worldwide resulting in complications, including diabetic retinopathy, one of the leading causes of blindness. Despite the existence and popularity of lifestyle interventions like physical activity in managing diabetes, there is limited evidence exploring higher evidence like randomized controlled trials (RCTs) that have investigated these interventions and their relation with visual outcomes in people with type 2 diabetes mellitus. This protocol outlines a scoping review method that aims to explore literature that used RCTs to study the effects of physical activity interventions on visual outcomes in persons with T2DM.</p><p><strong>Methods: </strong>This scoping review protocol will be guided by the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) and the JBI framework for conducting scoping reviews. Thorough search strategies will be designed across databases, including MEDLINE, Cochrane CENTRAL, and JSTOR. Searches will be conducted in clinical registries to supplement the search in the above databases. The studies will be included in this review if they are RCTs conducted among individuals with T2DM and measured the effects of physical activity on visual outcomes. Because this is a scoping review, all relevant studies will be included without a risk-of-bias assessment. The data will be extracted, charted, and analyzed to give an overview of the interrelations of the variables in the literature. The review is expected to be completed by end of June 2025.</p><p><strong>Discussion: </strong>Despite the debilitating effects of diabetes, including its telling effects on the eye and vision, the thoroughness of the evidence concerning physical activity clinical trials, and how they affect visual outcomes in people with T2DM, is yet to be assessed. While acknowledging potential limitations like language limits and publication bias, this review seeks to provide valuable insight regarding the contribution of physical activity in enhancing visual health among T2DM patients. This review aims to synthesize evidence from RCTs to contribute to broader discussions on clinical care and policy-making and to encourage future research efforts.</p><p><strong>Systematic review registration: </strong>The scoping review protocol has been registered on the Open Science Framework ( https://osf.io/856yb ).</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"141"},"PeriodicalIF":6.3,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPV-16 lineages among women in Africa: a systematic review with meta-analysis.","authors":"Ivy Akinyi, Matthew Thomas Ferreira, Rosana Veronica Mendoza Lopez, Frank Onyango, Dollen Osundwa, Shehu Shagari Awandu, Johannes Bogers","doi":"10.1186/s13643-025-02891-3","DOIUrl":"10.1186/s13643-025-02891-3","url":null,"abstract":"<p><strong>Background: </strong>Infection with high-risk human papillomavirus type 16 (HPV-16) is associated with cervical oncogenesis. The prevalence of HPV-16 lineages has not been well investigated in Africa. There is a lack of comprehensive epidemiological data on the distribution and oncogenic potential of the different HPV-16 lineages and sub-lineages in these populations. Through systematic review and meta-analysis, we aimed to determine the prevalence of HPV-16 lineages among women in Africa between 1997 and 2023.</p><p><strong>Method: </strong>Eight databases were searched, and studies that identified HPV-16 positive women with distinct HPV-16 lineages, and those that clearly defined an African population, were included. The eight databases include PubMed, PubMed Central, BVS, Embase, Cochrane Library, Scopus, Web of Science, and EBSCOhost. This protocol is registered in PROSPERO (CRD42023437748) and followed the PRISMA guidelines.</p><p><strong>Results: </strong>Out of the 2698 studies that were screened, 12 studies met the inclusion criteria and were included in the systematic review and meta-analysis. Analysis of these 12 studies identified yielded 1209 HPV-16-positive samples based on distinct diagnostic tests. These samples were classified as lineage A (n = 556), lineage C (n = 278), lineage B (n = 235), and lineage D (n = 140). Overall, lineage A variants were found in 11 studies (556 samples), establishing an overall prevalence of 58% (95% CI: 0.31-0.80; I² = 96.0%; τ² = 2.924; p < 0.0001). Lineage C variants were identified in 8 studies (278 samples), with an overall prevalence of 39% (95% CI: 0.21-0.60; I² = 84.1%; τ² = 1.362; p < 0.0001). Lineage B variants were identified across 7 studies (235 samples), with a prevalence of 20% (95% CI: 0.09-0.37; I² = 90.4%; τ² = 1.109; p < 0.0001). Lineage D variants were identified across 5 studies (140 samples), and its overall prevalence was 10% (95% CI: 0.05-0.19; I² = 89.1%; τ² = 0.672; p < 0.0001).</p><p><strong>Conclusion: </strong>Women in Africa exhibit a varied distribution of the four HPV-16 lineages. The high prevalence of HPV-16 lineage A in the entire population calls for developing targeted interventions to maximize impact and effectiveness. Future studies that are standardized and include defined geographic region, cytological details, and individual patient data should be conducted to enhance robust findings.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"140"},"PeriodicalIF":6.3,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facilitators and barriers in Academic-Practice Partnerships (APPs) between Approved Educational Institutions (AEIs) and Residential Aged Care Facilities (RACFs) during pre-registration nursing students' placements: a systematic review protocol.","authors":"Ashley Chivaura, Iseult Wilson, Deborah Rainey, Wai Yee Amy Wong","doi":"10.1186/s13643-025-02877-1","DOIUrl":"10.1186/s13643-025-02877-1","url":null,"abstract":"<p><strong>Background: </strong>Effective Academic-Practice Partnerships (APPs) between Approved Educational Institutions (AEIs) and practice learning partners are essential for enhancing the integration of the theoretical and practical aspects of nursing education. Recent literature regarding nursing student placements in Residential Aged Care Facilities (RACFs) highlights the significance of these partnerships and a need to explore the dynamic partnerships between AEIs and RACFs to better understand their role in improving student experiences and learning outcomes. Despite the recognition of the significance of understanding these APPs, this remains a significant gap in the existing literature.</p><p><strong>Methods: </strong>We will conduct a systematic review to identify facilitators and barriers to maintaining productive APPs between AEI and RACFs during pre-registration nursing student placements. Our research will involve an electronic literature search within MEDLINE, CINAHL, Web of Science, PsycINFO, and ERIC. Two independent reviewers will screen eligible papers, and a third reviewer will resolve any conflicts based on predefined inclusion and exclusion criteria. Eligible studies must have been published in English after 1990, and they should specifically address collaborative efforts between AEIs and RACFs in the context of pre-registration nursing student placements. All studies will be appraised using Caldwell's Framework. Findings will be extracted using a standardised extraction table, and an in-depth synthesis will be conducted using thematic analysis.</p><p><strong>Discussion: </strong>This systematic review addresses a gap in the literature by identifying key factors that influence APPs in the context of RACF placements. The findings from this review have the potential to guide improvements in pre-registration nursing education by informing, nurturing, and supporting collaborative relationships between AEIs and RACFs, which promote enriched experiences for nursing students during their RACF placements. The review will also provide both clinical and academic educators with a deeper understanding of what facilitates and hinders collaboration, which will empower them to facilitate effective collaboration and develop their shared capacity in supporting students. Strengthening the partnerships between AEIs and RACFs fosters a shared vision and enhances the quality of pre-registration nursing education, which improves the standard of care for RACF residents.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"137"},"PeriodicalIF":6.3,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}