Systematic Reviews最新文献

{"title":"Effectiveness of interventions to improve vaccine efficacy: a systematic review and meta-analysis.","authors":"Aviraj K S, Apoorva Wasnik, Lalima Gupta, Ayushi Ranjan, Harshini Suresh","doi":"10.1186/s13643-025-02856-6","DOIUrl":"10.1186/s13643-025-02856-6","url":null,"abstract":"<p><strong>Background: </strong>Vaccination is a crucial public health intervention that has significantly reduced the incidence of infectious diseases. Vaccine-related interventions refer to strategies implemented to enhance vaccination uptake, coverage, and effectiveness, like modes of delivery, types or dosages. Despite extensive research on vaccine efficacy, a comprehensive analysis of the variability in vaccine effectiveness across different interventions, settings, and populations is limited. This study aims to systematically review and meta-analyze the impact of various Vaccine-Related Interventions (VRIs).</p><p><strong>Methods: </strong>This review included 139 randomized controlled trials, cohort, and case-control studies evaluating VRIs from January 2015 to December 2023. The risk of bias was assessed using the ROB-2 and ROBINS-E tools. Statistical analyses were conducted to evaluate overall effect sizes, infection rates, and heterogeneity and subgroup analysis.</p><p><strong>Results: </strong>Of the 139 studies reviewed, 97 were included in the meta-analysis, comprising approximately 1.4 million participants. Populations across various settings were analyzed, with median vaccinated population sizes for the 1st dose (4598, IQR = 15,749), 2nd dose (6214, IQR = 13,817), and 3rd dose (3508, IQR = 5546). The overall total vaccinated population had a median of 4370 and an IQR of 16,475. The interventions showed a significant positive effect on vaccine efficacy, with an estimated effect size of 0.6432 (95% CI 0.4049 to 0.8815). Heterogeneity was negligible, with Tau² = 0, I² = 0.00%, and H² = 1.00. The Galbraith plot suggested minimal variability. The study utilized ROB-2 and ROBINS-E tools to evaluate bias, with Egger's test (t = - 0.9941, p = 0.3227) confirming no significant publication bias. The funnel plot indicated minimal bias in the included studies.</p><p><strong>Conclusion: </strong>The study supports the effectiveness of vaccine-related interventions in enhancing vaccine efficacy. The negligible heterogeneity and consistent effect sizes across diverse populations and settings provide a robust basis for implementing public health strategies aimed at improving vaccination outcomes.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024543608.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"105"},"PeriodicalIF":6.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy and acceptability of novel biologics in the treatment of myasthenia gravis: systematic review and network meta-analysis of randomized trials.","authors":"Chang Guan, Peixi Zhao, Meijin Song, Jing Lu, Huijing Cui, Dongxu Li, Tianying Chang, Yingzi Cui, Xikang Ding, Jian Wang, Peng Xu","doi":"10.1186/s13643-025-02859-3","DOIUrl":"10.1186/s13643-025-02859-3","url":null,"abstract":"<p><strong>Background: </strong>Myasthenia gravis (MG) is a chronic autoimmune disorder affecting the neuromuscular junction. The emergence of molecular therapies, such as monoclonal antibodies, B-cell-depleting agents, and chimeric antigen receptor T-cell-based therapies, has the potential to transform the treatment landscape for myasthenia gravis. The clinical efficacy of novel biologics in the treatment of individuals with myasthenia gravis is still a subject of debate. The objective was to compare and rank the efficacy and acceptability of novel biologics in the treatment of individuals with MG through a network meta-analysis.</p><p><strong>Methods: </strong>This systematic review and network meta-analysis (NMA) involved a comprehensive search for published randomized controlled trials (RCTs) across several databases, including PubMed, Web of Science, Embase, Cochrane Library, SinoMed, CNKI, Wanfang, and VIP, covering articles published from inception until July 3, 2024. We included randomized controlled trials involving patients with myasthenia gravis. The main outcome was the overall symptomatology. Random-effects pairwise meta-analyses and network meta-analyses (NMAs) were conducted to compute standardized mean differences (SMDs) or risk ratios with 95% confidence intervals (CIs). The research process did not include individuals with lived experience. The studies' quality was evaluated utilizing the risk-of-bias assessment tool created by the Cochrane Collaboration. Network meta-analysis was performed utilizing Stata 16 and R4.2.3.</p><p><strong>Results: </strong>Eleven RCTs including 840 participants with myasthenia gravis were eligible. Belimumab improvement of the MG-ADL score is compared to placebo (MD = - 3.29, 95% CI (- 5.78, - 0.80), P < 0.05). Compared to placebo, batoclimab enhanced the QMG score (MD = - 4.46, 95% CI (- 7.57, - 1.35), P < 0.05) and the MGC score (MD = - 3.58, 95% CI (- 6.68, - 0.47), P < 0.05). Eculizumab improvement of the MG-QoL 15r score is compared to placebo (MD = - 7.10, 95% CI (- 12.20, - 2.00), P < 0.05). Regarding adverse reactions, we found no difference in the network comparison of novel biologics compared to placebo, but this conclusion requires further validation through rigorous research.</p><p><strong>Conclusions: </strong>This study provides an updated, relative rank-order efficacy of novel biologics therapies for myasthenia gravis. These data may help inform the design and sample size calculation of future clinical trials and assist selection of combination therapy.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024559757.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"106"},"PeriodicalIF":6.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventions to improve referrals from primary care to outpatient specialist services for chronic conditions: a systematic review and framework synthesis update.","authors":"Layla Bolton Saghdaoui, Smaragda Lampridou, Sara Tavares, Rachael Lear, Alun Huw Davies, Mary Wells, Sarah Onida","doi":"10.1186/s13643-025-02841-z","DOIUrl":"https://doi.org/10.1186/s13643-025-02841-z","url":null,"abstract":"<p><strong>Background: </strong>Prior systematic reviews highlight that accessing specialist healthcare to treat chronic conditions can be obstructed by variations in referral rates, inappropriate referrals, and poor communication. Structured referral proformas, peer feedback, and educational interventions involving specialists have been identified as successful strategies for improving referral rates and appropriateness. However, the success of such interventions is often dependent on specific clinical contexts, and little is known about the practicalities of implementation. Additionally, with advancements in healthcare delivery, such as e-referral systems, there is a need to explore new interventions and how they address barriers to referral.</p><p><strong>Methods: </strong>This systematic review evaluated the updated evidence exploring interventions aiming to improve rates and/or appropriateness of referral from primary care to specialist services in patients with chronic conditions.Five academic databases were searched (CINAHL, MEDLINE, Embase, British Nursing Index, and Public Health Database), and studies published in English between 2013 and 2023 were included. The Joanna Briggs Institute's appraisal tool was used to assess the quality of studies, and a narrative synthesis was conducted using the TiDiER framework (template for intervention description and replication).</p><p><strong>Results: </strong>Eighteen full-text publications and five abstracts were included. A behavioral theory or framework for intervention development was used in seven studies. All interventions were based on primary care, and thirteen studies evaluated a multi-component intervention. Process and system changes were most commonly used to improve referral, including electronic health systems, referral algorithms, collaborative working, and patient direct access. Interventions targeted at patients were the least common. Staff education was often used in addition to process and system changes. When used alone, referral algorithms and staff education were less effective at improving referral rates or appropriateness. Implementation barriers included time constraints, logistical issues, and patients/staff preconceived perceptions of referral necessity.</p><p><strong>Conclusion: </strong>Unsurprisingly, the success of interventions aimed at improving referral practices is based on contextual circumstances, and as with previous reviews, there is no one-size-fits-all approach.Given the challenges highlighted in this review, multi-component interventions addressing referral barriers in both primary and secondary care appear to be a successful way to improve referral practices.</p><p><strong>Review registration: </strong>PROSPERO CRD42023480493.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"103"},"PeriodicalIF":6.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meaning-centred intervention for managing loneliness among community-dwelling older adults: a mixed-methods systematic review protocol.","authors":"Ken Hok Man Ho, Jackie Hoi Man Chan, Daphne Sze Ki Cheung, Wallace Chi Ho Chan, Paul McQuillan, Mei Tim Yu, Malik Gulzar, Cho Lee Wong, Chaojie Liu","doi":"10.1186/s13643-025-02843-x","DOIUrl":"10.1186/s13643-025-02843-x","url":null,"abstract":"<p><strong>Background: </strong>Loneliness can pose serious health and psychological concerns among community-dwelling older adults. Meaning-centred interventions, which aim to help individuals find meaning in their lives, appeared to alleviate loneliness among older adults. Yet, systematic evidence on the effectiveness of meaning-centred intervention and the experience among older adults towards this intervention is lacking. This review will systematically synthesise the evidence to examine the effect of meaning-centred intervention on loneliness among community-dwelling older adults.</p><p><strong>Methods: </strong>A mixed-methods systematic review (MMSR) with a convergent segregated approach will be employed according to the Joanna Briggs Institute framework for MMSRs. Relevant studies will be searched from inception to 31 December 2024 from nine databases: MEDLINE (PubMed), PsycINFO, CINAHL, Scopus, Embase, Cochrane Library, ProQuest Social Science, Wangfang, and Google Scholar. Quantitative, qualitative, and mixed-methods study designs will be included. Two authors will independently perform data extraction and complete risk of bias and quality assessment using recommended tools. The evidence quality will be assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach and the Confidence in the Evidence from Reviews of Qualitative Research (CERQual) guidelines approach for quantitative and qualitative studies, respectively. The phenomena of interest will be the experience of meaning-centred intervention among older adults living in the community and long-term care facilities. The primary outcome will be loneliness. Other related outcomes include meanings in life, social connections, social participation, social isolation, suicide ideation, anxiety, and depressive symptoms.</p><p><strong>Discussion: </strong>The review will contribute to a comprehensive understanding of meaning-centred intervention on loneliness among community-dwelling older adults by integrating the quantitative and qualitative evidence. The findings will provide practitioners, researchers, and policy workers with insights on developing and/or adopting meaning-centred interventions for alleviating the loneliness of older adults in the community and eventually promoting healthy ageing.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD 42024614173.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"102"},"PeriodicalIF":6.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the health benefits of outdoor exercise for cancer survivors: a systematic review of more than 700 individuals.","authors":"Sonia Ortega-Gómez, Luca Di Bartolo, Joanna Velissari, Beatriz Gomes, Susanna Pusa, Joshua Thaller, Sofia Papakonstantinou, Musa Kirkar, Ennio Iannitto, Nádia Moura, Carmen Nogueira, Jesús Gustavo Ponce-González, Rebecca Baxter, Paula Tavares, Apostolos Vantarakis, Antonino Bianco, Ana Carbonell-Baeza, David Jiménez-Pavón","doi":"10.1186/s13643-025-02834-y","DOIUrl":"10.1186/s13643-025-02834-y","url":null,"abstract":"<p><strong>Background: </strong>Cancer's rising incidence and growing survivor population underscore the need for strategies to enhance health and quality of life. Outdoor physical activity (PA) settings may provide unique benefits, yet evidence in this context is scarce. This systematic review aims to evaluate the impact of outdoor PA and exercise interventions on the health and well-being of cancer survivors.</p><p><strong>Methods: </strong>A systematic search was conducted in PubMed, Web of Science, and PsycINFO databases from their inception until April 23, 2024. Studies included randomized controlled trials (RCTs) and non-RCTs involving outdoor PA or exercise interventions for cancer survivors. The search strategy adhered to PRISMA guidelines, and the quality of studies was assessed using the PEDro scale.</p><p><strong>Results: </strong>Twelve studies involving 712 cancer survivors were included, comprising 7 RCTs and 5 non-RCTs. Four studies compared outdoor exercise to indoor exercise instead of a usual care control group, and one used a crossover design. The interventions varied in frequency, intensity, time, and type, with Nordic walking and walking being the most common. Key findings indicated significant improvements in mental health, PA levels, muscular fitness, body composition, and exercise motivation. However, the impact on vital signs and sleep quality was inconclusive due to the limited number of studies and variability in interventions.</p><p><strong>Conclusions: </strong>Outdoor PA, including structured exercise interventions, substantially benefits cancer survivors, particularly in enhancing mental health and physical fitness. Despite the promising findings, further research is needed to explore long-term effects, the benefits for different cancer types and age groups, and the underlying mechanisms of these interventions. Health practitioners should consider incorporating outdoor activities into cancer rehabilitation programs.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024545392.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"101"},"PeriodicalIF":6.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: screening for breast cancer: a systematic review update to inform the canadian task force on preventive health care guideline, by A Bennett and colleagues, published on December 19, 2024.","authors":"Philippe Autier","doi":"10.1186/s13643-025-02844-w","DOIUrl":"https://doi.org/10.1186/s13643-025-02844-w","url":null,"abstract":"","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"100"},"PeriodicalIF":6.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers and facilitators of acceptability and uptake of long-acting reversible contraceptives in Ethiopia: a systematic review using the COM-B model.","authors":"Tariku Shimels, Zewdneh Shewamene, Getachew Teshome","doi":"10.1186/s13643-025-02827-x","DOIUrl":"10.1186/s13643-025-02827-x","url":null,"abstract":"<p><strong>Background: </strong>Long-acting reversible contraceptives (LARCs), including implants and intrauterine contraceptive devices (IUCDs), are essential in preventing unintended pregnancies and empowering women by providing long-term, reliable contraception that supports informed decision-making about family planning and reproductive health. However, their uptake and acceptability remain low in Ethiopia due to various individual, social, and systemic barriers. This study systematically reviews the factors influencing LARC acceptability and utilization among Ethiopian women, adolescents, and healthcare providers, using the Capability, Opportunity, Motivation, and Behaviour (COM-B) framework.</p><p><strong>Methods: </strong>A systematic search of PubMed, Embase, Scopus, African Journals OnLine, and EBSCOhost (CINAHL) was conducted, along with gray literature sources, to identify studies published between January 2021 and June 2024. Inclusion criteria encompassed studies conducted in Ethiopia that examined the acceptability and utilization of LARCs, focusing on implants and IUCDs. The types of studies considered included quantitative, qualitative, and mixed-method designs, focusing on postpartum, post-abortion, and nonpostpartum women, adolescents, and healthcare providers. Data on barriers, facilitators, and associated factors of acceptability and utilization were extracted, and the findings were mapped to the COM-B framework. Atlas.ti v.9 software was used in the analysis process.</p><p><strong>Results: </strong>A total of 58 cross-sectional, qualitative, and mixed-method studies were included, encompassing diverse Ethiopian populations and geographies. Among immediate and extended postpartum women, barriers included limited awareness and fear of insertion pain for IUCDs, low awareness, and limited access to LARCs, while postpartum counselling emerged as a facilitator. For adolescents, social stigma, male partner disapproval, and misconceptions about LARC side effects were prominent barriers; school-based education and youth-friendly services supported acceptability. Healthcare providers noted inadequate training on family planning methods as a barrier, while targeted training improved their confidence in recommending LARCs. Nonpostpartum women frequently cited partner opposition and cultural beliefs as barriers, but family planning programs with partner engagement facilitated greater acceptance.</p><p><strong>Conclusions: </strong>The findings highlight an urgent need to expand community-based education programs to dispel myths and misconceptions about LARCs, particularly in rural and pastoral regions. Prioritizing provider training to improve counselling and service delivery, alongside engaging male partners in family planning discussions, is essential for enhancing LARC utilization and meeting reproductive health needs in Ethiopia.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024594288.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"99"},"PeriodicalIF":6.3,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of spinal manipulative therapy in the management of acute neck pain: a systematic review and meta-analysis.","authors":"Yingxiu Diao, Yifang Liu, Jiaxin Pan, Junming Chen, Jiahui Pan, Manxia Liao, Hao Liu, Linrong Liao","doi":"10.1186/s13643-025-02855-7","DOIUrl":"10.1186/s13643-025-02855-7","url":null,"abstract":"<p><strong>Background: </strong>Spinal manipulative therapy (SMT) is frequently used to manage neck pain; however, its efficacy and safety in treating acute neck pain (ANP) remain uncertain and require further investigation.</p><p><strong>Objectives: </strong>This study aims to comprehensively evaluate the efficacy and safety of SMT in the treatment of ANP.</p><p><strong>Databases and data treatment: </strong>A thorough search was conducted in PubMed, Embase, Web of Science, PEDro, and Cochrane Library databases, covering all studies from inception to March 20, 2023. Mean differences (MD) with 95% confidence intervals (CIs) were calculated to assess outcomes such as pain intensity, cervical range of motion (CROM), and disability. The PEDro Scale and the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach were utilized to evaluate the methodological quality and strength of evidence.</p><p><strong>Results: </strong>Eight randomized controlled trials (RCTs) with 965 patients were included. Their PEDro scores ranged from 4-9 (mean: 6.38, SD: 1.25). Forest plot analysis showed SMT was better than the control in reducing pain (MD = -1.53, 95% CI [-2.22, -0.83]) and improving CROM in all measured aspects. It also significantly reduced disability scores (MD = -6.20, 95% CI [-9.81, -2.59]). No serious adverse events were reported.</p><p><strong>Conclusions: </strong>The evidence supports the use of SMT as an effective and safe intervention for reducing pain, improving CROM, and decreasing disability in patients with ANP. These findings provide valuable insights for clinical practitioners and highlight the potential of SMT as a viable therapeutic option in managing ANP.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42021264411.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"97"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors for loneliness among individuals with diabetes: a systematic review and meta-analysis.","authors":"Anggi Lukman Wicaksana, Renny Wulan Apriliyasari, Pei-Shan Tsai","doi":"10.1186/s13643-025-02850-y","DOIUrl":"10.1186/s13643-025-02850-y","url":null,"abstract":"<p><strong>Background: </strong>Loneliness is more pronounced in individuals with diabetes; however, limited studies have investigated loneliness and its risk factors. This study estimated the pooled prevalence of loneliness and identified its risk factors in individuals with diabetes.</p><p><strong>Methods: </strong>A systematic review and meta-analysis of observational studies was conducted. CINAHL, Cochrane, Embase, PubMed, Scopus, and Web of Science databases were searched from their inception to September 22, 2023. We systematically searched and analyzed 10 studies involving 6036 individuals with diabetes to determine the pooled prevalence of loneliness. Five studies provided information on risk factors. Using a random-effects model, we calculated prevalence rates and odds ratios with 95% confidence intervals.</p><p><strong>Results: </strong>The overall prevalence of loneliness was 31.1% and severe loneliness was 4.6%. White race, lower education level, middle income, low income, longer diabetes duration, lower cognitive function, living alone, previous loneliness experience, and depression were identified as significant risk factors for loneliness in individuals with diabetes.</p><p><strong>Conclusion: </strong>Over 30% of individuals with diabetes experience loneliness. Several sociodemographic factors, low cognitive function, and depression are risk factors for loneliness.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"96"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predictive value of endocan as a novel biomarker: an umbrella study on meta-analyses.","authors":"Sandeep Samethadka Nayak, Daniyal Ameen, Sara Nobakht, Ranjan Nayak, Shrinidhi Vilas Prabhu, Mohammad-Hossein Keivanlou, Soheil Hassanipour, Ehsan Amini-Salehi, Nisarg Thakker","doi":"10.1186/s13643-025-02858-4","DOIUrl":"10.1186/s13643-025-02858-4","url":null,"abstract":"<p><strong>Background and aim: </strong>In recent years, endocan has emerged as a potential biomarker in various medical conditions. This multifaceted molecule, involved in key processes such as inflammation and endothelial dysfunction, has shown promise in predicting disease progression and therapeutic response across a spectrum of pathologies. However, the heterogeneity of studies and the complexity of endocan's role in different diseases necessitate a comprehensive review. This umbrella review aimed to systematically synthesize and evaluate the evidence from multiple meta-analyses, offering a view of endocan's effectiveness as a predictive biomarker in medical diseases.</p><p><strong>Methods: </strong>An extensive search was carried out on March 12, 2024, using the following four databases: PubMed, Scopus, Web of Science, and Cochrane Library. The goal was to identify meta-analyses that assess endocan's predictive efficacy. The pooled effect size and its 95% confidence interval were taken out of each discovered meta-analysis. Furthermore, power analyses were performed to assess the robustness and dependability of the results. An additional GRADE assessment was carried out to gauge the epidemiological reliability of the findings.</p><p><strong>Results: </strong>In the final analysis, 12 meta-analyses were included in the current umbrella review. The results showed that there is a significant correlation between a higher endocan level and COVID-19 (SMD: 1.40, 95% CI 0.21-2.58, P = 0.02), followed by chronic kidney disease (SMD: 1.34, 95% CI 0.20 to 2.48, P < 0.01), obstructive sleep apnea (SMD: 1.30, 95% CI 1.06-1.54, P < 0.01), diabetes mellitus (SMD: 1.00, 95% CI 0.81 to 1.19, P < 0.01), coronary artery disease (SMD: 0.99, 95% CI 0.58-1.39, P < 0.01), hypertension (SMD: 0.91, 95% CI 0.44-1.38, P < 0.01), and preeclampsia (SMD: 0.37, 95% CI 0.13-0.62, P < 0.01).</p><p><strong>Conclusion: </strong>Endocan has emerged as a highly promising biomarker with considerable potential across various medical conditions. Its relevance spans critical areas such as COVID-19, chronic kidney disease, obstructive sleep apnea, diabetes mellitus, coronary artery disease, and preeclampsia. The broad applicability of endocan highlights its value in improving diagnostic accuracy and enhancing our understanding of these diseases. Clinically, incorporating endocan testing could aid in early detection, monitoring disease progression, and refining patient management, particularly for high-risk populations. However, additional research is needed to fully assess its specificity, sensitivity, and overall clinical utility, paving the way for its integration into routine healthcare practices and enabling more precise, individualized treatment strategies.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"98"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}