Systematic Reviews最新文献

{"title":"Efficacy and safety of Chinese classical prescriptions for dilated cardiomyopathy: a systematic review and Bayesian network meta-analysis.","authors":"Shiyi Tao, Lintong Yu, Jun Li, Ji Wu, Xiao Xia, Yonghao Li, Deshuang Yang, Wenjie Zhang","doi":"10.1186/s13643-025-02802-6","DOIUrl":"10.1186/s13643-025-02802-6","url":null,"abstract":"<p><strong>Background: </strong>Chinese classical prescriptions (CCPs) are commonly utilized in China as an adjuvant treatment for dilated cardiomyopathy (DCM). Nevertheless, there was insufficient systematic evidence data to show the advantages of CCPs plus current conventional therapy (CT) against DCM. This network meta-analysis (NMA) sought to evaluate and prioritize the six different CCP types' respective efficacies for DCM.</p><p><strong>Methods: </strong>A comprehensive search was conducted from the databases' inception to November 30, 2024, to extract RCTs that addressed the use of CCPs in conjunction with CT for DCM. The databases included PubMed, Embase, Web of Science Core Collection, Cochrane Library, ProQuest, China National Knowledge Infrastructure (CNKI), China Science Periodical Database (CSPD), Chinese Citation Database (CCD), Chinese Biomedical Literature Database (CBM), and ClinicalTrials.gov. The Cochrane Risk of Bias assessment tool was used to evaluate the quality of the included RCTs. Surface under the cumulative ranking curve (SUCRA) probability values was employed to rank the relative efficacy. Bayesian network meta-analysis was applied to evaluate the efficacy of various CCPs. This review was registered with PROSPERO (CRD42024586365).</p><p><strong>Results: </strong>Following the application of inclusion and exclusion criteria, 27 eligible RCTs involving 2019 patients were included. The evaluated outcomes included clinical effectiveness rate (CER), left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD), left ventricular end-systolic dimension (LVESD), brain natriuretic peptide (BNP), cardiac output (CO), hypersensitive C-reactive protein (hs-CRP), and six-min walk test (6MWT). According to the NMA, Zhigancao decoction (ZGCD), Zhenwu decoction (ZWD), Shenfu decoction (SFD), Shengmai powder (SMP), Yangxin decoction (YXD), and Buyang Huanwu decoction (BYHW) in addition to CT considerably enhanced DCM treatment outcomes when compared to CT alone. SMP + CT (MD = 12.75, 95%CI 8.28-17.22) showed the highest probability of being the best treatment on account of the enhancement of LVEF. SFD + CT was most likely to be the optimal intervention for LVEDD decrease (MD = -4.68, 95%CI -8.73 to -0.62). YXD + CT (MD = -4.47, 95%CI -4.47 to -4.47) had the highest likelihood of being the optimal therapy for reducing LVESD. ZGCD + CT seemed to be the most promising intervention on the improvement in hs-CRP (MD = -2.82, 95%CI -3.60 to -2.04) and 6MWT (MD = 141.00, 95%CI 136.57 to 145.43). However, the optimal CCP for improving BNP and CO could not be identified based on the present studies. No significant adverse events emerged in the included studies.</p><p><strong>Conclusion: </strong>This NMA indicated that adding CCPs to current CT treatment had a favorable effect on DCM. In light of the clinical efficacy and other outcomes, SMP + CT, SFD + CT, YXD + CT, and ZGCD + CT demonstrated a preferred improveme","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"59"},"PeriodicalIF":6.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double gloving for self-protection in high-risk surgeries: a systematic review and meta-analysis.","authors":"Kumari Vandana Singh, Kamini Walia, Kamran Farooque, Purva Mathur","doi":"10.1186/s13643-025-02760-z","DOIUrl":"10.1186/s13643-025-02760-z","url":null,"abstract":"<p><strong>Background: </strong>Double gloving is recommended for protecting surgical personnel from infections, but it is not a universal practice, especially in low- and middle-income countries where risk is very high. Evidence for double gloving is still only moderate, and for indicator double gloves, it is even rare. This systematic review and meta-analysis includes recent trials to analyse outcomes like glove perforations (inner/outer/matched/intraoperatively detected) and hand contamination rates for single versus double including indicator double-gloved conditions and identify factors to be considered for deciding double gloving.</p><p><strong>Method: </strong>Six databases PubMed, EBESCO, Embase, CINAHL, Scopus, Web of Science, and CENTRAL were searched up to May 2024. The quality of included trials was assessed using Cochrane risk-of-bias tool (version 5.1.0). Heterogeneity among trials was estimated using the chi-squared (I²) test. RevMan 5.3 was used for meta-analysis and subgroup analysis. Odds ratio at 95% confidence interval was used as statistical measure to compare outcomes and calculate effect size. Publication bias was assessed through a funnel plot.</p><p><strong>Result: </strong>A review of these total of 18 randomized controlled trials showed that deep/major/emergent surgeries, primary surgeons, and longer surgical duration are prone to have higher glove perforations. Impaired dexterity is not a constraint for double gloving and has no impact on glove perforations. Meta-analysis of outcomes suggests that double gloving (standard or indicator) provides significant protection against infections compared to single gloves in terms of reduced inner (OR = 0.2, 95% CI 0.14-0.31) and matched glove perforations (OR = 0.1, 95% Cl 0.07-0.13) and lower incidences of hand contamination (OR = 0.28, 95% Cl 0.14-0.54). Standard double gloves were more effective in reducing matched glove perforations than indicator double gloves. But for detecting glove perforations intraoperatively, only the indicator double glove (OR = 8.64, 95% Cl 4.78-15.61) was effective.</p><p><strong>Conclusion: </strong>Double gloving is recommended over single gloving for better safety of surgical personnel and indicator gloves for better detection of perforations during surgery so that it can be changed timely, but it does not provide any additional protection. In the future, there should be high-quality trials for specific surgeries, surgical personnel, and different surgical durations taking into consideration the cost-effectiveness of indicator gloving over standard double gloving so that specific recommendations can be made.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"57"},"PeriodicalIF":6.3,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and determinants of maternal near miss in Ethiopia: a systematic review and meta-analysis, 2023.","authors":"Befkad Derese Tilahun, Mulat Ayele, Gebremeskel Kibret Abebe, Addis Wondmagegn Alamaw, Biruk Beletew Abate, Alemu Birara Zemariam, Gizachew Yilak","doi":"10.1186/s13643-025-02770-x","DOIUrl":"10.1186/s13643-025-02770-x","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Ethiopia's progress in maternal health is commendable, but the persistence of life-threatening complications during pregnancy and childbirth highlights the need for further research and action. While individual studies on maternal near-misses (MNM) exist, a comprehensive understanding of their prevalence and underlying factors remains elusive. This systematic review and meta-analysis aimed to bridge that gap by consolidating available evidence, paving the way for targeted interventions to improve maternal health outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A search for relevant studies was performed using the databases of PubMed, Scopus, the Cochrane Library, and Google Scholar, from years November 26 to 30, 2023, encompassed studies conducted in Ethiopia and published in English that reported the prevalence of maternal near miss and/or identified at least one determinant. Duplicate studies were removed using Endnote X8, resulting in a total of 13 studies included for analysis. The methodological quality of the included studies was assessed using the Joanna Briggs Institute's (JBI) quality appraisal checklist. The data synthesis and statistical analysis were performed using STATA Version 17 software. The pooled prevalence was presented using forest plots based on the random effects model.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Result: &lt;/strong&gt;The nationwide combined prevalence of maternal near misses (MNM) in Ethiopia was an adjusted odds ratio (AOR) of 12.9 and a 95% confidence interval (CI) of 6.30 to 19.49. Several factors were identified as determinants of maternal near-misses based on the pooled estimate. These factors included the absence of formal education (AOR = 2.48, 95% CI: 1.59-3.36), pre-existing chronic conditions (AOR = 4.70, 95% CI: 2.97-6.42), lack of antenatal care (AOR = 3.09, 95% CI: 2.12, 4.05), previous cesarean section (AOR = 4.40, 95% CI: 3.51, 5.28), and a history of referral (AOR = 2.67, 95% CI: 1.36-3.98); thus, factors were found to contribute significantly.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Maternal near-misses are prevalent in Ethiopia, with determinates including chronic conditions, lack of education, referral history, inadequate antenatal care, and previous cesarean sections. Addressing this requires improving women's education access, enhancing antenatal care services for early complication management, and proactive chronic condition care during pregnancy. Promoting safe delivery practices, reducing unnecessary cesarean sections, and enhancing referral systems are crucial steps. Effective implementation necessitates collaboration among healthcare providers, policymakers, the Ethiopian Ministry of Health, and hospitals to reduce maternal near-misses in Ethiopia. The cross-sectional design hinders drawing causal conclusions, and the relevance of the findings may be limited to countries with specific socio-economic and cultural contexts, considering that the research was conducted exclusively in Ethiopia.&lt;/p&gt;&lt;p","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"56"},"PeriodicalIF":6.3,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the clinical spectrum of herpes simplex virus CNS infections in adults: a systematic review.","authors":"Pascale Grzonka, Tamina Mosimann, Sebastian Berger, Simon A Amacher, Sira M Baumann, Caroline E Gebhard, Gian Marco De Marchis, Tolga D Dittrich, Raoul Sutter","doi":"10.1186/s13643-025-02797-0","DOIUrl":"10.1186/s13643-025-02797-0","url":null,"abstract":"<p><strong>Background: </strong>Herpes simplex virus (HSV) infections of the central nervous system (CNS) are associated with high morbidity and mortality. Prompt recognition and antiviral treatment are critical to improve patient outcomes. This systematic review of the literature aimed to aggregate the symptoms described with HSV infections of the CNS which may provide a framework to aid in early diagnosis.</p><p><strong>Methods: </strong>This review was registered (PROSPERO; CRD42022366036) and adheres to PRISMA guidelines. MEDLINE, Embase, and Cochrane databases were systematically screened for studies including adult patients with HSV infections confirmed by histopathology or polymerase chain reaction. Demographics, clinical characteristics, diagnostics, and outcomes were assessed.</p><p><strong>Results: </strong>Of 21 studies from 18 countries describing 1605 patients, the most frequently reported symptoms were fever (75%), headache (65%), neck stiffness (55%), and language/speech abnormalities (41%). Other common symptoms included seizures (36%) and gastrointestinal issues (35%). Information regarding a combination of symptoms was not provided. Diagnostics often included lumbar puncture and magnetic resonance imaging, revealing temporal lobe abnormalities in 88%. While mortality was 13%, 72% of survivors had good neurological outcomes. The risk of bias was high in most studies.</p><p><strong>Conclusions: </strong>Fever, headache, neck stiffness, and language/speech abnormalities were frequently reported clinical findings in patients with proven HSV infection of the CNS. Despite limited evidence, these symptoms warrant a high index of suspicion, prompting early empiric antiviral therapy, especially when alternative diagnoses lack strong support. The predictive value of these symptoms and their combination for diagnosing HSV infection of the CNS should be further investigated, as they could accelerate diagnostics and treatment.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"55"},"PeriodicalIF":6.3,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of corticosteroids for stroke and traumatic brain injury: a systematic review and meta-analysis.","authors":"Yanan Wang, Linrui Huang, Jingjing Li, Jiangang Duan, Xiaohua Pan, Bijoy K Menon, Craig S Anderson, Ming Liu, Simiao Wu","doi":"10.1186/s13643-025-02803-5","DOIUrl":"10.1186/s13643-025-02803-5","url":null,"abstract":"<p><strong>Background: </strong>Corticosteroids are frequently used in practice to treat patients with neurological disorders. However, its effect for stroke and traumatic brain injury (TBI) remains controversial. This study aimed to systematically review and evaluate efficacy and safety of corticosteroids for the treatment of stroke and TBI.</p><p><strong>Methods: </strong>We searched Ovid-Medline and Ovid-Embase databases for randomised controlled trials (RCTs) and cohort studies evaluating the efficacy and safety of corticosteroids in patients with ischaemic stroke, intracerebral haemorrhage (ICH), subarachnoid haemorrhage (SAH) or TBI. The treatment intervention was corticosteroid, and the control was placebo or routine care. Outcome measures were death, functional outcomes and adverse events. We calculated odds ratio (OR) and 95% confidence interval (CI) for the effect size, pooled the results using random-effects modelling, and assessed heterogeneity by I² statistic.</p><p><strong>Results: </strong>We identified 47 studies (41 RCTs and 6 cohort studies). Nine studies enrolled patients with ischaemic stroke (n = 2806), 6 studies for ICH (n = 1229), 1 study recruited both ischaemic stroke (n = 13) and ICH (n = 27), 10 studies for SAH (n = 1318) and 21 studies for TBI (n = 12,414). Dexamethasone was the most used corticosteroid (28 studies). Corticosteroids reduced risk of death at 3 months after ischaemic stroke (n = 1791; 31% vs. 26%, OR 0.77, 95% CI 0.62-0.95; df = 1, I² = 0%) and after ICH (1 study; n = 850; 44% vs. 27%, OR 0.48, 95% CI 0.35-0.64), had no effect on death at 1 month after SAH (1 study; n = 140; 22% vs. 32%, OR 1.73, 95% CI 0.81-3.68), and increased risk of death at 6 months after TBI (n = 10,755; 23% vs. 27%, OR 1.20, 95% CI 1.10-1.32; df = 6, I² = 0%). The pooled analyses found no significant effect of corticosteroids on functional outcome after ischaemic stroke, ICH, SAH or TBI, respectively.</p><p><strong>Conclusion: </strong>Corticosteroids reduced the risk of death and in selected patients with stroke, such as those with large artery occlusion after thrombectomy, but increased the risk of death after TBI, had no effect on functional outcomes. Further trials are needed to identify individual stroke patients who may benefit from corticosteroids.</p><p><strong>Systematic review registration: </strong>International Prospective Register of Systematic Reviews (CRD42023474473).</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"54"},"PeriodicalIF":6.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-processed foods and risk of all-cause mortality: an updated systematic review and dose-response meta-analysis of prospective cohort studies.","authors":"Shuming Liang, Yesheng Zhou, Qian Zhang, Shuang Yu, Shanshan Wu","doi":"10.1186/s13643-025-02800-8","DOIUrl":"10.1186/s13643-025-02800-8","url":null,"abstract":"<p><strong>Background: </strong>Ultra-processed food (UPF) consumption has been steadily increasing globally, yet the associated risk of all-cause mortality remains unclear. We aimed to assess the risk of all-cause mortality of UPFs via an updated systematic review and dose-response meta-analysis.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in PubMed, Embase, and Cochrane Library for studies published until July 2, 2024, in addition to referred studies included in the previous systematic review. Prospective cohort studies assessing the association between NOVA classification-defined UPF consumption and all-cause mortality were included. Dose-response meta-analysis via a random-effect model was used to combine the results with hazard ratio (HR) as an effect measure.</p><p><strong>Results: </strong>Overall, 18 studies with 1,148,387 participants (173,107 deaths) were identified. Compared to the lowest, participants with the highest UPF consumption had a 15% increased risk of all-cause mortality (HR = 1.15, 95% CI 1.09-1.22; I² = 83.0%). Furthermore, a 10% higher risk of all-cause mortality was detected with each 10% increment in UPF consumption (HR = 1.10, 95% CI 1.04-1.16; I² = 91.0%). Dose-response analysis showed a positive linear association (P_{dose-response} < 0.001). Moreover, subgroups and sensitivity analyses indicated consistent findings, while meta-regression analyses suggested sex distributions partially explained heterogeneity, with a higher risk of all-cause mortality in males.</p><p><strong>Conclusions: </strong>Our updated meta-analysis, incorporating a greater number of newly published cohort studies using NOVA classification with the largest sample size to date, strengthens the evidence linking higher UPF consumption to increased all-cause mortality risk. Strategies such as dietary guidelines and policies for limiting UPF consumption worldwide should be encouraged.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42023467226.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"53"},"PeriodicalIF":6.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using virtual patients to enhance empathy in medical students: a scoping review protocol.","authors":"Rie Yamada, Kaori Futakawa, Kuangzhe Xu, Satoshi Kondo","doi":"10.1186/s13643-025-02793-4","DOIUrl":"10.1186/s13643-025-02793-4","url":null,"abstract":"<p><strong>Introduction: </strong>Empathy is a crucial skill that enhances the quality of patient care, reduces burnout among healthcare professionals, and fosters professionalism in medical students. Clinical practice and standardized patient-based education provide opportunities to enhance empathy, but a lack of consistency and reproducibility as well as significant dependency on resources are impediments. The COVID-19 pandemic has further restricted these opportunities, highlighting the need for alternative approaches. Virtual patients through standardized scenarios ensure consistency and reproducibility while offering safe, flexible, and repetitive learning opportunities unconstrained by time or location. Empathy education using virtual patients could serve as a temporary alternative during the COVID-19 pandemic and address the limitations of traditional face-to-face learning methods. This review aims to comprehensively map existing literature on the use of virtual patients in empathy education and identify research gaps.</p><p><strong>Methods: </strong>This scoping review will follow the Joanna Briggs Institute's guidelines and be reported according to PRISMA-P. The search strategy includes a comprehensive search across databases such as PubMed (MEDLINE), CINAHL, Web of Science, Scopus, ERIC, Google, Google Scholar, and Semantic Scholar, covering both published and gray literature without language restrictions. Both quantitative and qualitative studies will be included. Two independent researchers will screen all titles/abstracts and full texts for eligibility. Data will be extracted to summarize definitions of empathy, characteristics of virtual patient scenarios, and methods for measuring their impact on empathy development. Results will be presented in narrative and tabular formats to highlight key findings and research gaps.</p><p><strong>Discussion: </strong>As this review analyzes existing literature, ethical approval is not required. Findings will be actively disseminated through academic conferences and peer-reviewed publications, providing educators and researchers with valuable insights into the potential of virtual patients to enhance empathy in medical education. This study goes beyond the mere synthesis of academic knowledge by contributing to the advancement of medical education and clinical practice by clarifying virtual patient scenario design and evaluation methods in empathy education. The findings provide a critical foundation for our ongoing development of a medical education platform aimed at enhancing empathy through the use of virtual patients.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"52"},"PeriodicalIF":6.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research priority setting for implementation science and practice: a living systematic review protocol.","authors":"Junqiang Zhao, Wenjun Chen, Wenhui Bai, Xiaoyan Zhang, Ruixue Hui, Sihan Chen, Guillaume Fontaine, Xiaolin Wei, Ning Zhang, Ian D Graham","doi":"10.1186/s13643-025-02786-3","DOIUrl":"10.1186/s13643-025-02786-3","url":null,"abstract":"<p><strong>Background: </strong>Research priority setting has the potential to bridge knowledge gaps, optimize resource allocation, foster collaborations, and inform funding directions for implementation science and practice when these priorities are properly acted upon. This systematic review aims to determine the extent of research in priority setting for implementation science and practice, examine the methodologies employed, synthesize these research priorities, and identify strategies for evaluating and implementing these priorities.</p><p><strong>Methods: </strong>We will conduct a living systematic review following the Cochrane guidance. We will search literature from six databases, the website of James Lind Alliance, five implementation science-focused journals and several related journals, Google Scholar, and the reference lists of included studies. Two reviewers will independently screen studies based on the eligibility criteria. The characteristics of the included documents, their prioritization methods, and outcomes, as well as the evaluation and implementation strategies, will be extracted. We will critically appraise these documents using the nine common themes of good practice for research priority setting, and synthesize data using a narrative approach. We will re-run the search 12 months after the original search date to monitor the development of new literature and determine the time to update the review.</p><p><strong>Discussions: </strong>By conducting this living systematic review, we will gain a comprehensive and dynamic understanding of the potential research gaps and hotspots in implementation science as perceived by researchers and practitioners. The findings of this review will inform the future research directions of implementation science and practice.</p><p><strong>Systematic review registration: </strong>This review has been registered with the Open Science Framework ( https://osf.io/sr69k ).</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"51"},"PeriodicalIF":6.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-care interventions among women with gestational diabetes mellitus in low and middle-income countries: a scoping review.","authors":"Ngoc-Anh Thi Dang, Hieu Minh Le, Ai Nguyen, Per C Glöde, Christina A Vinter, Jannie Nielsen, Kien Dang Nguyen, Tine M Gammeltoft, Ditte S Linde","doi":"10.1186/s13643-025-02790-7","DOIUrl":"10.1186/s13643-025-02790-7","url":null,"abstract":"<p><strong>Background: </strong>Gestational diabetes mellitus (GDM) is a transitory form of diabetes occurring in pregnancy with maternal and neonatal health consequences if left untreated. GDM can, in most instances, be managed non-medically through self-care practices, such as eating healthy or engaging in physical activity. This is especially relevant in a global health context with scarce resources. There is no official definition of \"GDM self-care\"; hence, the content and delivery modes of such interventions may vary greatly. Therefore, this study aimed to landscape GDM self-care interventions in low- and middle-income countries according to the WHO's three dimensions of health.</p><p><strong>Methods: </strong>PubMed, Embase, Global Health Library, and Web of Science were searched for published intervention studies that compared the effect of a self-care intervention to standard care or had no comparator. Studies that targeted women with GDM that reported maternal health and/or neonatal health outcomes (physical, mental, and social health outcomes) and were conducted in low- and middle-income countries were included in the review.</p><p><strong>Results: </strong>Twenty-nine studies (randomised controlled trials and non-randomised studies) were included in the review. No studies were conducted in low-income countries, and studies were primarily conducted in Asia. Most interventions were complex and contained several interacting elements in relation to content, delivery mode, duration, and modality. Most interventions aimed to improve the physical health dimension (n = 28; 96.6%), whilst the mental health (n = 11; 37.9%) and social health dimensions (n = 9; 31.0%) were addressed to a lesser extent.</p><p><strong>Conclusions: </strong>Current GDM self-care interventions in LMICs are complex, and the content of self-care interventions overlaps with lifestyle and non-pharmaceutical interventions. It is recommended that the scientific community use a standardised terminology for such interventions and that future GDM intervention studies, as a minimum, use the core outcome set for GDM when developing future studies.</p><p><strong>Systematic review registration: </strong>OSF Registries (2 December 2022) [ https://doi.org/10.17605/OSF.IO/PJZQ3 ].</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"50"},"PeriodicalIF":6.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caregiver experiences and needs in pediatric rheumatic disease: a mixed-methods systematic review protocol.","authors":"Yuxuan Xiang, Ru Ding, Yuan Bixia, Jing Wu, Yongmei Lu, Xiangwei Yang","doi":"10.1186/s13643-025-02788-1","DOIUrl":"10.1186/s13643-025-02788-1","url":null,"abstract":"<p><strong>Introduction: </strong>Understanding the genuine experiences and requirements of caregivers and implementing targeted interventions can have a positive impact on the physical and mental well-being of caregivers with children diagnosed with rheumatic diseases, ultimately reducing their burden and enhancing their quality of life. While there has been a gradual increase in research in this area in recent years, there remains a gap in the evidence that comprehensively and systematically reflects the actual experiences and needs of caregivers. We will employ a mixed-methods approach to evaluate the real-life experiences and requirements of caregivers for children diagnosed with rheumatic diseases to provide insights for both research and clinical interventions. METHODS AND ANALYSIS: All types of studies (quantitative, qualitative, and mixed-methods) involving caregivers of children aged 0 to 18 with rheumatic diseases will be included. We will conduct a comprehensive search across multiple databases, including MEDLINE (PubMed), Embase (Ovid), PsycINFO (Ovid), CINAHL (EBSCO), Cochrane Central Register of Controlled Trials (CENTRAL), CNKI, WanFang, and VIP, as well as the grey literature, to identify primary studies published in either English or Chinese since 2000. Two independent reviewers will conduct the selection process and cross-check the data extraction. The focus of interest will be on understanding the experiences and needs of caregivers for pediatric rheumatic disease patients. In our systematic review, we will employ the 2018 version of the Mixed Methods Assessment Tool (MMAT) to evaluate study quality, and we will apply a convergent integration approach to synthesize the data.</p><p><strong>Ethics and dissemination: </strong>Ethical approval is not needed, as no primary data will be collected. The results will be made available through a peer-reviewed publication.</p><p><strong>Systematic review registration: </strong>PROSPERO 42023465302.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"48"},"PeriodicalIF":6.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}