Systematic Reviews最新文献

{"title":"Effectiveness of acceptance and commitment therapy for weight stigma and related psychological outcomes: a systematic review protocol.","authors":"Fanfan Cao, Huan Wen, Xiangmin Tan, Nan Hua, QingYi Wu, Mei Sun","doi":"10.1186/s13643-026-03205-x","DOIUrl":"10.1186/s13643-026-03205-x","url":null,"abstract":"<p><strong>Background: </strong>Weight stigma, a pervasive public health concern, is characterized by negative attitudes, prejudices, and stereotypes directed towards individuals with larger body sizes. Empirical evidence indicates a significant association between experiencing weight stigma and adverse psychological health outcomes, including body image dissatisfaction, eating disorders, and increased risk of depression, anxiety, self-harm, and suicidal ideation. Acceptance and Commitment Therapy (ACT), a third-wave behavioral approach, shows potential in reducing weight stigma by targeting psychological flexibility and values-based action. However, current evidence remains limited and fragmented, often neglecting the complex, multidimensional nature of weight stigma. Therefore, this review aims to synthesize and evaluate existing evidence on the effectiveness of ACT in reducing weight stigma and improving related psychological outcomes. Additionally, we will identify the specific content and delivery features of effective ACT interventions targeting weight stigma.</p><p><strong>Methods: </strong>We will conduct a comprehensive search of electronic databases, including PubMed, Embase, Web of Science, Scopus, CINAHL, and the Cochrane Library. The Association for Contextual Behavioral Science (ACBS) website will be searched to identify summaries of randomized controlled trials and Google Scholar will be utilized to identify relevant grey literature. Only original research articles published in English from 1994 to 2025 will be included, and the database searches will be updated prior to final manuscript submission to capture the most recent evidence. Screening, data extraction and quality assessment will be conducted independently by the primary reviewer and the second reviewer. Any inconsistencies will be addressed through discussion with a third reviewer. If substantial heterogeneity (I² > 75%) or insufficient comparable data precludes meta-analysis, findings will be synthesized narratively.</p><p><strong>Discussion: </strong>This systematic review will synthesize the extant literature on the effectiveness of ACT, encompassing its contents and delivery features in reducing weight stigma and improving related psychological outcomes among individuals experiencing weight-related stigmatization. The evidence generated from this review has the potential to inform public health initiatives, shape future intervention research, and contribute to broader efforts to mitigate the harmful impact of weight stigma on individual and societal levels.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD420251121507.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13430913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148102112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Treatment effects of psychological interventions on self‑harm in individuals with PTSD: a systematic review and meta‑analysis protocol.","authors":"Anthony Tsang, Caroline Clements, Catherine Robinson, Peter J Taylor","doi":"10.1186/s13643-026-03211-z","DOIUrl":"10.1186/s13643-026-03211-z","url":null,"abstract":"","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"15 1","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13200300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of late presentation of HIV among older adults in Asia: a systematic review and meta-analysis protocol.","authors":"Xiaoyu Du, Jiajia Liu, Xiaochen Yan, Ruixue Hui, Wendi Guo, Xincen Liu, Yucheng Gao, Wenjiao Li, Jia Chen, Nina Wang, Wenjun Chen","doi":"10.1186/s13643-026-03208-8","DOIUrl":"10.1186/s13643-026-03208-8","url":null,"abstract":"<p><strong>Background: </strong>Late presentation of HIV among older adults challenges the \"End AIDS by 2030\" target, posing devastating consequences of individual health outcomes and increasing the burden on social health systems. While Asia faces the double burden of HIV aging and population aging, evidence on late presentation remains fragmented and lacks contextual relevance.</p><p><strong>Aims: </strong>We aim to summarize the prevalence of late presentation of HIV and its associated factors in older people living with HIV in Asia.</p><p><strong>Method: </strong>The protocol will follow the 2015 Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols. We will search six international databases and three Chinese language databases. Observational studies reporting the prevalence of late presentation of HIV in older adults in Asia will be included. Study quality will be assessed using the Joanna Briggs Institute Critical Appraisal tools. Data will be analyzed using Stata 18, with meta-analysis, meta-regression and subgroup analyses conducted as appropriate.</p><p><strong>Discussion: </strong>This study will synthesize evidence on the prevalence of late presentation among older people living with HIV in Asia. Our findings will clarify the status and risk factors of late presentation in older people living with HIV in Asia, offering insights to guide targeted strategies and policy response.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024618152.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13378257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148006848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of antimicrobial stewardship interventions on prescribing rates for urinary tract infections in residential aged care facilities: a systematic review and meta-analysis.","authors":"Antonina Maria Lin, Nadine Hillock, John Turnidge, Jaklin Eliott, Nicola Spurrier","doi":"10.1186/s13643-026-03177-y","DOIUrl":"10.1186/s13643-026-03177-y","url":null,"abstract":"<p><strong>Background and rationale: </strong>Current research identifies a large proportion of urinary antimicrobial prescribing in aged care as being non-concordant, however, the efficacy of interventions targeted at reducing these prescriptions in aged care remains unclear. This review summarises effective interventions targeting non-concordant urinary antimicrobial prescriptions in aged care.</p><p><strong>Methods: </strong>This review follows PRISMA reporting guidelines and includes studies published up to June 2024. The search aimed to capture interventional studies and included studies that examined urinary tract infections in the aged care setting. All hospital-based studies and non-interventional studies were excluded. The search was conducted in 6 databases: PubMed, Scopus, Embase, PsychInfo, CINAHL Ultimate, and AgeLine. All studies were assessed against the ROBINS-I risk of bias tool. Meta-analyses for effects on urinary prescribing and hospitalisations were conducted on eligible studies and pooled risk ratios were calculated using DerSimonian and Laird random effects modelling.</p><p><strong>Results: </strong>Twenty studies were included and interventions from four eligible randomised controlled trials were selected for the meta-analysis. The meta-analyses indicate that educational interventions coupled with routine audits were effective at reducing urinary prescribing (RR = 0.64, 95% CI = 0.49 - 0.83) and does not increase the risk of hospitalisations (RR = 1.02, 95% CI = 0.70 - 1.49). The review found that while effective interventions were heterogeneous in design, the majority included a combination of educational material(s) with routine audits and feedback for clinicians.</p><p><strong>Discussion: </strong>Educational interventions coupled with routine audits and feedback are effective at reducing inappropriate urinary prescribing in aged care and do not increase risk of hospitalisation. The synthesis of evidence in this review is limited by the heterogeneity of these tailored interventions and the lack of consistent reporting of changes in prescribing. However, the studies pooled in the meta-analysis can give some confidence in the efficacy and safety of some of these interventions.</p><p><strong>Systematic review registration: </strong>This review is registered with the International Prospective Register for Systematic Reviews (PROSPERO) (CRD42024569226).</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13374228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148006802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reviewing ecosystems of evidence: synthesising the evidence on the commercial determinants of health from a complex systems perspective.","authors":"Alice Tompson, James Thomas, Harry Rutter, Laurence Blanchard, Éadaoin Cott, Rebecca E Glover, Cecile Knai, Nason Maani, May C I van Schalkwyk, Vivian Welch, Mark Petticrew","doi":"10.1186/s13643-026-03187-w","DOIUrl":"10.1186/s13643-026-03187-w","url":null,"abstract":"<p><p>The Commercial Determinants of Health (CDoH) are the systems, practices, and pathways through which commercial actors drive health and equity. This includes their influence on systems of evidence production and dissemination (evidence ecosystems) in order to protect and promote commercial interests. In the Commercial Determinants of Health and Evidence Synthesis (CODES) methodological guidance, we provided advice for conducing CDoH relevant evidence syntheses, from developing a protocol to reporting the review and planning an update. This follow-up paper considers reasons and practical implications for integrating a complex systems perspective in such reviews. This commentary describes how a complex systems perspective can benefit research, including evidence synthesis related to the CDoH, by embracing the complexity of the real world, understanding interventions in context, rendering visible the corporate playbook, and exposing the power dynamics that drive inequity. We then reflect on the practical implications of adopting a complex systems approach in CDoH evidence synthesis, including drawing on a systems lens and/or incorporating specific systems methods in the review. This commentary complements existing CODES guidance in highlighting considerations for conducting CDoH relevant evidence synthesis from a complex systems perspective. It can help interpreting such reviews and raise awareness of how commercial actors can shape evidence ecosystems, particularly evidence synthesis. Having a robust evidence base that considers systems elements and dynamics will support effective action to address the CDoH, improve public health and reduce inequity at scale.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"15 1","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13195904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147989158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the COVID-19 pandemic on diagnosis, and healthcare utilization, among patients with cancer (lung, breast, and pancreas) and cardiovascular diseases (HF, AF, hypertensive, and chronic ischemic heart disease) in Germany: two systematic reviews.","authors":"Janine Ropeter, Nina Overhageböck, Maren Dreier, Dörthe Meyerdierks, Adil Imran, Torben Heinsohn, Maren Steinmann, Alexander Kuhlmann, Beate Jahn, Berit Lange, Carolina J Klett-Tammen, Manuela Harries","doi":"10.1186/s13643-026-03192-z","DOIUrl":"10.1186/s13643-026-03192-z","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic and related non-pharmaceutical interventions (NPIs) (e.g., lockdowns and contact restrictions) disrupted routine healthcare delivery. In Germany, these measures affected diagnostic and treatment services for people with cancer and cardiovascular diseases, potentially delaying diagnosis and adversely influencing outcomes. We assessed whether and to what extent diagnosis, health utilization and health outcome among patients with selected cancer and cardiovascular conditions changed in Germany during the pandemic.</p><p><strong>Methods: </strong>We conducted two systematic reviews of studies from Germany on selected cancers (breast, lung and pancreatic) and cardiovascular conditions (atrial fibrillation/flutter, heart failure, hypertensive and chronic ischemic heart disease). Protocols were registered in PROSPERO and the reviews were reported in accordance with PRISMA. We searched PubMed, Web of Science, Cochrane Library, Scopus, and Embase and screened grey literature. Outcomes included changes in new diagnoses, healthcare utilization, treatment, and disease-specific mortality during the pandemic (2020-2023) compared with the pre-pandemic period (2018-2019). Two reviewers independently screened records, extracted data, and assessed risk of bias using an adapted ROBINS-E tool. Owing to heterogeneity, we synthesized findings narratively.</p><p><strong>Results: </strong>We screened 1991 records for cancer and 4,981 records for cardiovascular diseases, and included 9 cancer studies and 10 cardiovascular studies. For cancer, several studies reported a relative reduction in new breast and lung cancer diagnoses of up to 25% during lockdown periods; hospital admissions decreased by up to 9%. For cardiovascular conditions, hospital admissions for atrial fibrillation/flutter and heart failure decreased by up to 20%, particularly during pandemic peaks. Evidence on treatment delays, changes in treatment, and mortality was limited, and outcomes for other included diagnoses were often not reported.</p><p><strong>Discussion: </strong>The available evidence indicates substantial reductions in hospital admissions and new diagnoses among patients with cancer and cardiovascular disease in Germany during the pandemic, suggesting major disruptions to care delivery. However, heterogeneity and gaps in the evidence base limit a comprehensive assessment of downstream outcomes. More comprehensive, linked data and further research are needed to quantify the full pandemic's impact and to strengthen health-system resilience for future crises.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"15 1","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13196194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147989155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methods of skeletal age assessment using hand and wrist radiographs in children and their applicability across different ethnicities: systematic review and meta-analysis protocol.","authors":"Sameera Wijayawardhana, Deepan Jayapala, Cree Gaskin, Jerrard Fernando, Yasith Mathagasinghe, Pujitha Wickramasinghe","doi":"10.1186/s13643-025-03030-8","DOIUrl":"10.1186/s13643-025-03030-8","url":null,"abstract":"<p><strong>Background: </strong>Skeletal age assessment using hand and wrist X-rays is commonly used to determine the biological maturity of children. It is invaluable when the chronological age is not known or in diagnosing and treating various endocrine, genetic, and developmental disorders as well as in a forensic context. Skeletal age is affected by both internal and external factors, leading to differences in skeletal maturity between children of different ethnicities. Regional studies have even questioned the applicability of current international skeletal age references across ethnicities.</p><p><strong>Methods: </strong>A comprehensive literature search will be conducted utilising the PubMed, Scopus, Web of Science, EMBASE, and Ovid online databases to identify existing publications. A combination of Medical Subject Headings (MeSH) terms and keywords, including \"Skeletal age\", \"bone age\", \"radiograph\", and \"hand\", will be used. Data screening and extraction will be done with Covidence software. Two independent reviewers will screen literature against predefined inclusion and exclusion criteria in abstract and full-text forms. A third reviewer will be consulted if consensus cannot be reached. The process will be reported in whole and presented in a PRISMA flow diagram. Study quality will be assessed by using the JBI critical appraisal tool. A meta-analysis will be conducted.</p><p><strong>Discussion: </strong>This review will present a comprehensive analysis of existing literature on the applicability of skeletal age assessment methods using hand and wrist radiographs across different ethnicities. Further, this will be highlighting both strengths and gaps in existing knowledge. The inclusion of high-quality data will facilitate a quantitative meta-analysis for the exploration of ethnic differences in skeletal age assessments, ultimately laying the foundation for the development of population-specific reference standards.</p><p><strong>Systematic review registration: </strong>PROSPERO registration ID CRD42025646662.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13371705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147989122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of magnesium levels in pregnancy on adverse birth outcomes: a protocol for a systematic review and meta-analysis.","authors":"Naeera Abdul, Vinogrin Dorsamy, Chauntelle Bagwandeen","doi":"10.1186/s13643-026-03204-y","DOIUrl":"10.1186/s13643-026-03204-y","url":null,"abstract":"<p><strong>Background: </strong>Magnesium plays a critical role in maternal and fetal physiology, influencing vascular tone, inflammation, and cellular metabolism. Despite its established biological importance, evidence linking maternal magnesium status to adverse pregnancy outcomes remains inconsistent, partly due to heterogeneity in measurement methods, reference ranges, and study populations. These uncertainties are of significant public health importance globally but are of particular relevance in low- and middle-income countries (LMICs), where comorbidities such as HIV infection, anaemia, and obesity are prevalent. This review will therefore include studies from all settings while prespecifying subgroup analyses relevant to LMIC contexts.</p><p><strong>Objectives: </strong>This systematic review and meta-analysis aims to synthesise global evidence on the association between maternal magnesium levels and adverse pregnancy outcomes. Secondary objectives are to explore trimester-specific patterns of maternal magnesium status, assess whether common comorbidities modify these associations, including HIV infection, anaemia, and obesity, and examine evidence from magnesium supplementation trials in a separate interventional evidence stream.</p><p><strong>Eligibility criteria: </strong>We will include observational studies (cross-sectional, case-control, and cohort) and randomised controlled trials reporting quantitative maternal magnesium measurements and at least one adverse maternal or neonatal outcome. Peer-reviewed journal articles and postgraduate theses will be eligible, with no restrictions on language, setting, or publication year.</p><p><strong>Information sources: </strong>Electronic searches will be conducted in PubMed, Embase, Scopus, Cochrane Library, DOAJ, LILACS, and African Index Medicus, alongside grey literature sources including OpenGrey and ProQuest Dissertations and Theses.</p><p><strong>Risk of bias: </strong>Risk of bias will be assessed independently by two reviewers using design-specific tools: Hoy's Risk of Bias Tool for prevalence studies, ROBINS-I for non-randomised observational studies, and the Cochrane Risk of Bias 2 tool for randomised controlled trials.</p><p><strong>Synthesis of results: </strong>Observational and interventional studies will be analysed in separate prespecified analytic streams. Meta-analyses will be conducted where sufficient clinical and methodological homogeneity exists, using random-effects or quality-effects models. Where quantitative synthesis is not appropriate, findings will be synthesised narratively. Subgroup analyses will explore trimester of pregnancy, geographic region, laboratory measurement method, and comorbidity status. Certainty of evidence will be assessed using the GRADE framework.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024518427.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13366814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147983310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statins for the prevention of exacerbations in COPD: a systematic review and meta-analysis of randomized controlled trials.","authors":"Guizuo Wang, Wenli Shang, Dong Han","doi":"10.1186/s13643-026-03203-z","DOIUrl":"10.1186/s13643-026-03203-z","url":null,"abstract":"<p><strong>Background: </strong>The role of statins in reduction of acute exacerbations in chronic obstructive pulmonary disease (COPD) remains unclear. This systematic review and meta-analysis aimed to determine the preventive effect of statins on exacerbations in COPD patients.</p><p><strong>Methods: </strong>A systematic search was conducted in PubMed, Embase, Cochrane Library, and clinicaltrials.gov, without language restrictions. Randomized controlled trials (RCTs) on treatment of COPD with statins, compared with placebo, were reviewed. Estimated effects of included studies were pooled as risk ratios (RRs) and weighted mean differences (WMDs), with 95% confidence intervals (CIs). The certainty of evidence was assessed using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) framework.</p><p><strong>Results: </strong>Three RCTs (enrolling 1190 patients) met the inclusion criteria. Compared with placebo, the exacerbation related hospitalization rate (RR 0.87, 95% CI 0.77 to 0.97; GRADE = low) and severe exacerbation rate (RR 0.88, 95% CI 0.78 to 0.99; low) were significantly lower in statins groups. There was no statistically significant difference in moderate exacerbation rate (RR 0.71, 95% CI 0.48 to 1.04; very low), annualized exacerbation rate (WMD -0.21 per person-year, 95% CI -0.61 to 0.20; very low), and annualized moderate-to-severe exacerbation rate (WMD -0.21 per person-year, 95% CI -0.57 to 0.15; very low) between the two groups.</p><p><strong>Conclusions: </strong>In the absence of single-inhaler triple therapy (SITT), statins were associated with a reduction in severe exacerbations and hospitalization rates of COPD. Given the limitations of the evidence we found, further large-scale, high-quality studies are needed to clarify the impact of statins on prognosis and the beneficiary population.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42025644971.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13362045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147975609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating test-retest reliability of patient-reported outcome measures in cancer patients: a protocol for a methodological systematic review.","authors":"Xiaoyu Fan, Kejiemu Sunzi, Wen Zhou, Tingting Zhu, Xin Zhou, Wei You, Yao Chen, Cheng Lei","doi":"10.1186/s13643-026-03195-w","DOIUrl":"10.1186/s13643-026-03195-w","url":null,"abstract":"<p><strong>Background: </strong>Patient-Reported Outcomes (PROs) are increasingly important in oncology, providing a unique patient perspective for evaluating treatment efficacy, symptom burden, and quality of life. The psychometric properties of Patient-Reported Outcome Measures (PROMs), particularly test-retest reliability, form the cornerstone of ensuring the stability and credibility of their measurement results. However, the clinical status of cancer patients often fluctuates rapidly due to disease progression or treatment side effects, posing unique methodological challenges for assessing test-retest reliability, especially in determining appropriate retest intervals and evaluating patient stability. Currently, there is a lack of systematic reviews on methodological elements of test-retest reliability studies for PROMs in cancer populations.</p><p><strong>Objective: </strong>This study aims to systematically search, summarize, and critically appraise published studies on test-retest reliability of PROMs in cancer patients, focusing on their methodological quality and key design elements, including retest intervals, sample size, patient stability assessment, and statistical analysis methods.</p><p><strong>Methods: </strong>This protocol adheres to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guidelines. A comprehensive literature search will be conducted across five electronic databases (PubMed, EMBASE, CINAHL, PsycINFO, Web of Science) and two supplementary sources (ClinicalTrials.gov and PROQOLID) from their inception to December 2025. All original studies reporting test-retest reliability assessments of PROMs for adult cancer patients will be included. Two reviewers will independently conduct literature screening, data extraction, and methodological quality assessment. Extracted data will include basic study information, PROMs characteristics, patient characteristics, and detailed information on test-retest reliability design. Methodological quality will be appraised using the COSMIN Risk of Bias checklist, while reporting completeness will be evaluated against the COSMIN reporting guideline (version 2.0). Due to study heterogeneity, we will perform a narrative synthesis, summarizing results in tables and figures.</p><p><strong>Discussion and significance: </strong>This study will be the first to comprehensively depict the current status of test-retest reliability assessment of PROMs in oncology, identifying strengths and weaknesses in current practices. The findings will provide evidence-based methodological recommendations for designing and reporting PROMs validation studies in cancer populations. By enhancing the rigor of PROMs validation studies, this research ultimately aims to improve the quality of patient-centered evidence in cancer clinical research and practice.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD420251070381.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13343898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147933735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}