Systematic Reviews最新文献

{"title":"Revolutionizing cancer diagnosis and dose biodistribution: a meta-analysis of [68ga] FAPI- 46 vs. [18f] FDG imaging.","authors":"Samaneh Abbasi, Mohsen Dehghani, Sara Khademi, Rasoul Irajirad, Zahra Pakdin Parizi, Mahdieh Sahebi, Masoumeh Sadeghi, Alireza Montazerabadi, Meysam Tavakoli","doi":"10.1186/s13643-025-02835-x","DOIUrl":"https://doi.org/10.1186/s13643-025-02835-x","url":null,"abstract":"<p><strong>Background: </strong>Advancements in novel peptides significantly affect cancer diagnosis by targeting cancer-specific markers, thereby improving imaging modalities, such as positron emission tomography combined with computed tomography (PET/CT) for more accurate tumor detection. This systematic review and meta-analysis aimed to assess the diagnostic accuracy of [18F] Fluorodeoxyglucose (FDG) and <sup>68</sup>Ga-fibroblast activation protein inhibitor (FAPI- 46) PET/CT for early cancer detection.</p><p><strong>Methods: </strong>A comprehensive search was conducted in Scopus, MEDLINE, Web of Science, and Embase databases up to March 28, 2024, using MeSH keywords. Titles and abstracts were screened to identify studies on hybrid [68Ga] FAPI- 46 and [18F] FDG, followed by a detailed full-text evaluation. Only cohort or cross-sectional studies published in English, focusing on the clinical diagnosis of cancer patients, were included, while reviews, case reports, conference proceedings, and abstracts were excluded. Random-effects meta-analysis was used for the estimation of pooled specificity and sensitivity with 95% confidence intervals (CIs). In addition, the heterogeneity was assessed across studies and subgroup meta-analyses for the detection rate via Stata.</p><p><strong>Results: </strong>Among the 615 retrieved studies, nine articles were incorporated in the present systematic review, with five (n = 144 patients) eligible for meta-analysis. For [68Ga] FAPI- 46, the pooled sensitivity and specificity compared with immunohistopathology were 0.96 (95% CI 0.84, 0.99) and 0.92 (95% CI 0.53, 0.99), respectively, with a positive likelihood ratio (LR +) of 4.41 (95% CI 1.64, 11.79) and a negative likelihood ratio (LR -) of 3.07 (95% CI 1.01, 9.37). For [18F] FDG, pooled sensitivity and specificity compared with immunohistopathology were 0.73 (95% CI 0.34, 0.93) and 0.83 (95% CI 0.57, 0.95), with an LR + of 12.73 (95% CI 1.43, 113.45) and an LR - of 0.32 (95% CI 0.11, 0.17). The pooled odds ratio for the detection rate on a per-lesion basis was 1.73 (95% CI 0.99, 3.02) for [68Ga] FAPI- 46 compared with [18F] FDG. The pooled weighted mean differences in the standardized uptake value (SUV<sub>max</sub>) for primary tumor uptake and the tumor-to-background ratio (TBR) in [68Ga] FAPI- 46 vs. 18F-FDG were 4.40 (95% CI - 0.7, 9.5) and 6.18 (95% CI 1.74, 10.61), respectively. Moderate to high heterogeneity was noted because of the variations in patient selection, interpretation criteria, and scanning procedures.</p><p><strong>Conclusions: </strong>This study revealed that [68Ga] FAPI- 46 outperforms [18F] FDG in cancer diagnosis, with higher sensitivity (0.96 vs. 0.73) and specificity (0.92 vs. 0.83). [Ga] FAPI- 46 improved tumor detection with higher SUVmax and TBR. While FDG had a higher LR +, its lower LR - highlighted more false negatives. Accordingly, [68Ga] FAPI- 46 exhibited superior accuracy and reliability than FDG in cancer diagnosis.</p><p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"109"},"PeriodicalIF":6.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of scalp acupuncture and comparison with traditional acupuncture for stroke: an overview of systematic reviews and updated evidence.","authors":"Sun-Young Park, In Heo, Man-Suk Hwang, Eui-Hyoung Hwang, Byung-Cheul Shin","doi":"10.1186/s13643-025-02819-x","DOIUrl":"10.1186/s13643-025-02819-x","url":null,"abstract":"<p><strong>Background: </strong>Stroke recovery is a critical global-health priority; there is growing interest alternative therapies in scalp acupuncture (SA) to overcome the limitations of conventional treatments and improve outcomes. This study provides an overview of systematic reviews to evaluate the evidence on the effectiveness and safety of SA and to compare its therapeutic potential with traditional acupuncture (TA).</p><p><strong>Methods: </strong>A systematic search of 12 databases was conducted to identify systematic reviews and meta-analyses, completed on September 30, 2023, was performed without language restrictions. Selection criteria included adult stroke patients treated with SA, focusing on comparisons of effectiveness and safety in neurological deficits, motor function, disability, and total efficacy rate. Two reviewers independently screened studies and assessed methodological quality using AMSTAR-2, ROBIS, PRISMA-A, and GRADE frameworks. Data were synthesized to compare SA and TA for stroke outcomes, using total searched SA studies and TA data from the Cochrane review, followed by an analysis of high-quality studies to enhance evidence reliability.</p><p><strong>Results: </strong>After overviewing seven systematic reviews, the certainty of evidence supporting the standalone effectiveness and safety of SA remains low owing to methodological shortcomings. However, SA showed a greater effect size in the neurological deficits (-0.96 vs -0.53) in total studies and high-quality studies (-0.92 vs -0.48). Regarding motor function, SA had a higher effect size in total studies (0.94 vs 0.70), but TA outperformed it in high-quality studies (0.39 vs 0.82). Regarding disability outcomes, TA had a slightly larger effect size in total studies (1.27 vs 1.06), whereas SA surpassed it in high-quality studies (1.65 vs. 1.16).</p><p><strong>Conclusions: </strong>This overview highlights the potential of SA as an effective alternative therapy for stroke recovery, with high-quality studies demonstrating its effectiveness in improving neurological deficits and disability outcomes. This work guides clinicians on integrating SA for stroke recovery and offers insights for improving public health rehabilitation strategies. Despite limitations in the overall evidence owing to methodological shortcomings, the positive results from high-quality studies support SA as a possible approach for stroke recovery, underscoring the need for further rigorous research to strengthen its clinical application.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"108"},"PeriodicalIF":6.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scoping review of worldwide guidelines for diagnosis and treatment of Helicobacter pylori infection.","authors":"Mingyao Sun, Enyu Liu, Liwen Yang, Huijuan Cao, Mei Han","doi":"10.1186/s13643-025-02816-0","DOIUrl":"10.1186/s13643-025-02816-0","url":null,"abstract":"<p><strong>Background: </strong>This study comprehensively analyzes the diagnostic criteria, eradication indications, treatment, and other information in the latest guidelines published by various countries around the world, so that researchers can have a systematic understanding of Helicobacter pylori and further provide a basis for clinical H. pylori diagnosis and treatment.</p><p><strong>Methods: </strong>Nine online databases were searched to find the latest version of guidelines for H. pylori worldwide. Two researchers read the included guidelines independently and extracted the eradication indications, diagnostic criteria, and treatment in the guidelines, conducting a summary of them.</p><p><strong>Results: </strong>A total of 25 guidelines or consensus were included. Among all diagnostic methods for H. pylori infection, the urea breath test is widely recommended as the first choice. A total of 20 guidelines mentioned indications for H. pylori eradication. Among them, the indications with a higher proportion of recommendations were long-term use of non-steroidal anti-inflammatory drugs (including low-dose aspirin) in 90% of patients with peptic ulcer history or active peptic ulcer disease 80%; gastric mucosa-associated lymphoid tissue (MALT) lymphoma 75%. It is worth mentioning that 40% of the guidelines pointed out that, as long as H. pylori infection is confirmed, it should be eradicated. A total of 24 guidelines mentioned treatment for H. pylori. Among them, bismuth quadruple therapy (a combination of a bismuth, two antibiotics, and a proton pump inhibitor (PPI)) was the most recommended first-line therapy. Levofloxacin triple therapy (a combining of a bismuth, an antibiotic, and a PPI) was the most recommended second-line therapy.</p><p><strong>Conclusion: </strong>Current global Helicobacter pylori management guidelines share foundational consensus, yet exhibit regional variations in diagnostic criteria, eradication indications, and therapeutic regimens due to context-specific epidemiological, socioeconomic, and antimicrobial resistance profiles. Clinical practice should prioritize regionally tailored approaches, integrating local guidelines while maintaining awareness of international recommendations to optimize decision-making. Moreover, health authorities responsible for guideline development must ensure timely updates based on dynamic surveillance of local resistance patterns and socioeconomic realities.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"107"},"PeriodicalIF":6.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic and clinicopathological impact of systemic inflammation response index (SIRI) on patients with esophageal cancer: a meta-analysis.","authors":"Zhong Wu, Zongxin Zhang, Chao Gu","doi":"10.1186/s13643-025-02847-7","DOIUrl":"https://doi.org/10.1186/s13643-025-02847-7","url":null,"abstract":"<p><strong>Background: </strong>Although the systemic inflammation response index (SIRI) is often associated with prognostic significance in esophageal cancer (EC) patients, the results continue to be conflicting. We focused on identifying SIRI's precise role in forecasting EC prognosis through performing this meta-analysis.</p><p><strong>Methods: </strong>This work searched PubMed, Web of Science, Embase, Cochrane Library, and CNKI till November 16, 2024, and determined pooled hazard ratios (HRs) and 95% confidence intervals (CIs) for evaluating EC prognosis forecasting efficiency of SIRI. The inclusion criteria: (1) pathologic confirmation of EC; (2) those reporting associations of SIRI with EC survival outcomes; (3) those reporting HRs and 95% CIs; (4) those with an available cut-off value of SIRI; and (5) no restriction in language. The exclusion criteria: (1) case reports, reviews, meeting abstracts, comments and letters; (2) those enrolling duplicate cases; and (3) animal studies.</p><p><strong>Results: </strong>We enrolled six studies comprising 2176 cases into the present work. Based on our combined findings, elevated SIRI showed significant relation to dismal overall survival (OS) (HR = 1.43, 95%CI = 1.20-1.71, p < 0.001; I² = 48.8%, p = 0.098) and shortened progression-free survival (PFS) (HR = 2.00, 95%CI = 1.35-2.98, p = 0.001; I² = 0, p = 0.409) in EC. Moreover, high SIRI exhibited obvious relation to male gender (OR = 1.86, 95%CI = 1.07-3.22, p = 0.027; I² = 69.4%, p = 0.020), TNM stage of III-IV (OR = 1.52, 95%CI = 1.18-1.94, p = 0.001; I² = 24.3%, p = 0.265), T3-T4 stage (OR = 1.73, 95%CI = 1.12-2.69, p = 0.014; I² = 61.0%, p = 0.053), and lymph node metastasis (OR = 1.29, 95%CI = 1.02-1.64, p = 0.036; I² = 42.7%, p = 0.155). However, SIRI was not markedly related to age, tumor location, tumor differentiation, or smoking history.</p><p><strong>Conclusion: </strong>In summary, high SIRI is significantly related to dismal OS and shortened PFS of EC cases, together with advanced tumor stage, T3-T4 stage, and lymph node metastasis of EC. Due to some limitations, large prospective studies that utilize standardized threshold SIRI should be conducted to validate our results in the future.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"104"},"PeriodicalIF":6.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of interventions to improve vaccine efficacy: a systematic review and meta-analysis.","authors":"Aviraj K S, Apoorva Wasnik, Lalima Gupta, Ayushi Ranjan, Harshini Suresh","doi":"10.1186/s13643-025-02856-6","DOIUrl":"10.1186/s13643-025-02856-6","url":null,"abstract":"<p><strong>Background: </strong>Vaccination is a crucial public health intervention that has significantly reduced the incidence of infectious diseases. Vaccine-related interventions refer to strategies implemented to enhance vaccination uptake, coverage, and effectiveness, like modes of delivery, types or dosages. Despite extensive research on vaccine efficacy, a comprehensive analysis of the variability in vaccine effectiveness across different interventions, settings, and populations is limited. This study aims to systematically review and meta-analyze the impact of various Vaccine-Related Interventions (VRIs).</p><p><strong>Methods: </strong>This review included 139 randomized controlled trials, cohort, and case-control studies evaluating VRIs from January 2015 to December 2023. The risk of bias was assessed using the ROB-2 and ROBINS-E tools. Statistical analyses were conducted to evaluate overall effect sizes, infection rates, and heterogeneity and subgroup analysis.</p><p><strong>Results: </strong>Of the 139 studies reviewed, 97 were included in the meta-analysis, comprising approximately 1.4 million participants. Populations across various settings were analyzed, with median vaccinated population sizes for the 1st dose (4598, IQR = 15,749), 2nd dose (6214, IQR = 13,817), and 3rd dose (3508, IQR = 5546). The overall total vaccinated population had a median of 4370 and an IQR of 16,475. The interventions showed a significant positive effect on vaccine efficacy, with an estimated effect size of 0.6432 (95% CI 0.4049 to 0.8815). Heterogeneity was negligible, with Tau² = 0, I² = 0.00%, and H² = 1.00. The Galbraith plot suggested minimal variability. The study utilized ROB-2 and ROBINS-E tools to evaluate bias, with Egger's test (t = - 0.9941, p = 0.3227) confirming no significant publication bias. The funnel plot indicated minimal bias in the included studies.</p><p><strong>Conclusion: </strong>The study supports the effectiveness of vaccine-related interventions in enhancing vaccine efficacy. The negligible heterogeneity and consistent effect sizes across diverse populations and settings provide a robust basis for implementing public health strategies aimed at improving vaccination outcomes.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024543608.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"105"},"PeriodicalIF":6.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy and acceptability of novel biologics in the treatment of myasthenia gravis: systematic review and network meta-analysis of randomized trials.","authors":"Chang Guan, Peixi Zhao, Meijin Song, Jing Lu, Huijing Cui, Dongxu Li, Tianying Chang, Yingzi Cui, Xikang Ding, Jian Wang, Peng Xu","doi":"10.1186/s13643-025-02859-3","DOIUrl":"10.1186/s13643-025-02859-3","url":null,"abstract":"<p><strong>Background: </strong>Myasthenia gravis (MG) is a chronic autoimmune disorder affecting the neuromuscular junction. The emergence of molecular therapies, such as monoclonal antibodies, B-cell-depleting agents, and chimeric antigen receptor T-cell-based therapies, has the potential to transform the treatment landscape for myasthenia gravis. The clinical efficacy of novel biologics in the treatment of individuals with myasthenia gravis is still a subject of debate. The objective was to compare and rank the efficacy and acceptability of novel biologics in the treatment of individuals with MG through a network meta-analysis.</p><p><strong>Methods: </strong>This systematic review and network meta-analysis (NMA) involved a comprehensive search for published randomized controlled trials (RCTs) across several databases, including PubMed, Web of Science, Embase, Cochrane Library, SinoMed, CNKI, Wanfang, and VIP, covering articles published from inception until July 3, 2024. We included randomized controlled trials involving patients with myasthenia gravis. The main outcome was the overall symptomatology. Random-effects pairwise meta-analyses and network meta-analyses (NMAs) were conducted to compute standardized mean differences (SMDs) or risk ratios with 95% confidence intervals (CIs). The research process did not include individuals with lived experience. The studies' quality was evaluated utilizing the risk-of-bias assessment tool created by the Cochrane Collaboration. Network meta-analysis was performed utilizing Stata 16 and R4.2.3.</p><p><strong>Results: </strong>Eleven RCTs including 840 participants with myasthenia gravis were eligible. Belimumab improvement of the MG-ADL score is compared to placebo (MD = - 3.29, 95% CI (- 5.78, - 0.80), P < 0.05). Compared to placebo, batoclimab enhanced the QMG score (MD = - 4.46, 95% CI (- 7.57, - 1.35), P < 0.05) and the MGC score (MD = - 3.58, 95% CI (- 6.68, - 0.47), P < 0.05). Eculizumab improvement of the MG-QoL 15r score is compared to placebo (MD = - 7.10, 95% CI (- 12.20, - 2.00), P < 0.05). Regarding adverse reactions, we found no difference in the network comparison of novel biologics compared to placebo, but this conclusion requires further validation through rigorous research.</p><p><strong>Conclusions: </strong>This study provides an updated, relative rank-order efficacy of novel biologics therapies for myasthenia gravis. These data may help inform the design and sample size calculation of future clinical trials and assist selection of combination therapy.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024559757.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"106"},"PeriodicalIF":6.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventions to improve referrals from primary care to outpatient specialist services for chronic conditions: a systematic review and framework synthesis update.","authors":"Layla Bolton Saghdaoui, Smaragda Lampridou, Sara Tavares, Rachael Lear, Alun Huw Davies, Mary Wells, Sarah Onida","doi":"10.1186/s13643-025-02841-z","DOIUrl":"https://doi.org/10.1186/s13643-025-02841-z","url":null,"abstract":"<p><strong>Background: </strong>Prior systematic reviews highlight that accessing specialist healthcare to treat chronic conditions can be obstructed by variations in referral rates, inappropriate referrals, and poor communication. Structured referral proformas, peer feedback, and educational interventions involving specialists have been identified as successful strategies for improving referral rates and appropriateness. However, the success of such interventions is often dependent on specific clinical contexts, and little is known about the practicalities of implementation. Additionally, with advancements in healthcare delivery, such as e-referral systems, there is a need to explore new interventions and how they address barriers to referral.</p><p><strong>Methods: </strong>This systematic review evaluated the updated evidence exploring interventions aiming to improve rates and/or appropriateness of referral from primary care to specialist services in patients with chronic conditions.Five academic databases were searched (CINAHL, MEDLINE, Embase, British Nursing Index, and Public Health Database), and studies published in English between 2013 and 2023 were included. The Joanna Briggs Institute's appraisal tool was used to assess the quality of studies, and a narrative synthesis was conducted using the TiDiER framework (template for intervention description and replication).</p><p><strong>Results: </strong>Eighteen full-text publications and five abstracts were included. A behavioral theory or framework for intervention development was used in seven studies. All interventions were based on primary care, and thirteen studies evaluated a multi-component intervention. Process and system changes were most commonly used to improve referral, including electronic health systems, referral algorithms, collaborative working, and patient direct access. Interventions targeted at patients were the least common. Staff education was often used in addition to process and system changes. When used alone, referral algorithms and staff education were less effective at improving referral rates or appropriateness. Implementation barriers included time constraints, logistical issues, and patients/staff preconceived perceptions of referral necessity.</p><p><strong>Conclusion: </strong>Unsurprisingly, the success of interventions aimed at improving referral practices is based on contextual circumstances, and as with previous reviews, there is no one-size-fits-all approach.Given the challenges highlighted in this review, multi-component interventions addressing referral barriers in both primary and secondary care appear to be a successful way to improve referral practices.</p><p><strong>Review registration: </strong>PROSPERO CRD42023480493.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"103"},"PeriodicalIF":6.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meaning-centred intervention for managing loneliness among community-dwelling older adults: a mixed-methods systematic review protocol.","authors":"Ken Hok Man Ho, Jackie Hoi Man Chan, Daphne Sze Ki Cheung, Wallace Chi Ho Chan, Paul McQuillan, Mei Tim Yu, Malik Gulzar, Cho Lee Wong, Chaojie Liu","doi":"10.1186/s13643-025-02843-x","DOIUrl":"10.1186/s13643-025-02843-x","url":null,"abstract":"<p><strong>Background: </strong>Loneliness can pose serious health and psychological concerns among community-dwelling older adults. Meaning-centred interventions, which aim to help individuals find meaning in their lives, appeared to alleviate loneliness among older adults. Yet, systematic evidence on the effectiveness of meaning-centred intervention and the experience among older adults towards this intervention is lacking. This review will systematically synthesise the evidence to examine the effect of meaning-centred intervention on loneliness among community-dwelling older adults.</p><p><strong>Methods: </strong>A mixed-methods systematic review (MMSR) with a convergent segregated approach will be employed according to the Joanna Briggs Institute framework for MMSRs. Relevant studies will be searched from inception to 31 December 2024 from nine databases: MEDLINE (PubMed), PsycINFO, CINAHL, Scopus, Embase, Cochrane Library, ProQuest Social Science, Wangfang, and Google Scholar. Quantitative, qualitative, and mixed-methods study designs will be included. Two authors will independently perform data extraction and complete risk of bias and quality assessment using recommended tools. The evidence quality will be assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach and the Confidence in the Evidence from Reviews of Qualitative Research (CERQual) guidelines approach for quantitative and qualitative studies, respectively. The phenomena of interest will be the experience of meaning-centred intervention among older adults living in the community and long-term care facilities. The primary outcome will be loneliness. Other related outcomes include meanings in life, social connections, social participation, social isolation, suicide ideation, anxiety, and depressive symptoms.</p><p><strong>Discussion: </strong>The review will contribute to a comprehensive understanding of meaning-centred intervention on loneliness among community-dwelling older adults by integrating the quantitative and qualitative evidence. The findings will provide practitioners, researchers, and policy workers with insights on developing and/or adopting meaning-centred interventions for alleviating the loneliness of older adults in the community and eventually promoting healthy ageing.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD 42024614173.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"102"},"PeriodicalIF":6.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the health benefits of outdoor exercise for cancer survivors: a systematic review of more than 700 individuals.","authors":"Sonia Ortega-Gómez, Luca Di Bartolo, Joanna Velissari, Beatriz Gomes, Susanna Pusa, Joshua Thaller, Sofia Papakonstantinou, Musa Kirkar, Ennio Iannitto, Nádia Moura, Carmen Nogueira, Jesús Gustavo Ponce-González, Rebecca Baxter, Paula Tavares, Apostolos Vantarakis, Antonino Bianco, Ana Carbonell-Baeza, David Jiménez-Pavón","doi":"10.1186/s13643-025-02834-y","DOIUrl":"https://doi.org/10.1186/s13643-025-02834-y","url":null,"abstract":"<p><strong>Background: </strong>Cancer's rising incidence and growing survivor population underscore the need for strategies to enhance health and quality of life. Outdoor physical activity (PA) settings may provide unique benefits, yet evidence in this context is scarce. This systematic review aims to evaluate the impact of outdoor PA and exercise interventions on the health and well-being of cancer survivors.</p><p><strong>Methods: </strong>A systematic search was conducted in PubMed, Web of Science, and PsycINFO databases from their inception until April 23, 2024. Studies included randomized controlled trials (RCTs) and non-RCTs involving outdoor PA or exercise interventions for cancer survivors. The search strategy adhered to PRISMA guidelines, and the quality of studies was assessed using the PEDro scale.</p><p><strong>Results: </strong>Twelve studies involving 712 cancer survivors were included, comprising 7 RCTs and 5 non-RCTs. Four studies compared outdoor exercise to indoor exercise instead of a usual care control group, and one used a crossover design. The interventions varied in frequency, intensity, time, and type, with Nordic walking and walking being the most common. Key findings indicated significant improvements in mental health, PA levels, muscular fitness, body composition, and exercise motivation. However, the impact on vital signs and sleep quality was inconclusive due to the limited number of studies and variability in interventions.</p><p><strong>Conclusions: </strong>Outdoor PA, including structured exercise interventions, substantially benefits cancer survivors, particularly in enhancing mental health and physical fitness. Despite the promising findings, further research is needed to explore long-term effects, the benefits for different cancer types and age groups, and the underlying mechanisms of these interventions. Health practitioners should consider incorporating outdoor activities into cancer rehabilitation programs.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024545392.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"101"},"PeriodicalIF":6.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: screening for breast cancer: a systematic review update to inform the canadian task force on preventive health care guideline, by A Bennett and colleagues, published on December 19, 2024.","authors":"Philippe Autier","doi":"10.1186/s13643-025-02844-w","DOIUrl":"https://doi.org/10.1186/s13643-025-02844-w","url":null,"abstract":"","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"100"},"PeriodicalIF":6.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}