Impact of alcohol consumption, substance use, and smoking on treatment outcomes in tuberculosis: a systematic review and meta-analysis.

IF 6.3 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Systematic Reviews Pub Date : 2025-07-05 DOI:10.1186/s13643-025-02888-y

Bahram Heshmati, Sanaz Omidi, Younes Mohammadi

{"title":"Impact of alcohol consumption, substance use, and smoking on treatment outcomes in tuberculosis: a systematic review and meta-analysis.","authors":"Bahram Heshmati, Sanaz Omidi, Younes Mohammadi","doi":"10.1186/s13643-025-02888-y","DOIUrl":null,"url":null,"abstract":"Background: This study aimed to elucidate the influence of alcohol, smoking, and substance use on tuberculosis (TB) treatment failure using a meta-analysis approach.Method: A comprehensive search strategy was developed and applied to three major databases: MEDLINE, Web of Science, and Scopus. Additionally, Google Scholar, and Google were used to locate grey literature. Studies were identified through title and abstract screening, followed by a full-text review for eligibility. The Newcastle-Ottawa Scale checklist was employed to assess the quality of included studies. Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated for each factor.Results: The initial database search and other sources yielded 10,518 articles. After applying inclusion criteria, 19 studies with a total of 180,119 participants were selected for the meta-analysis. The results revealed significant associations between all three factors and treatment failure. Pooled ORs indicated that alcohol consumption (OR 2.05; 95% CI 1.65 to 2.55), smoking (OR = 1.85; 95% CI 1.44 to 2.37), and substance use (OR 2.04; 95% CI 1.63 to 2.55) were each associated with an increased risk of TB treatment failure. Additionally, the majority of included studies demonstrated high methodological quality.Conclusion: Our findings suggest that alcohol, smoking, and substance use are significant risk factors for unsuccessful TB treatment. To enhance TB treatment efficacy, preventive interventions aimed at reducing these behaviors before treatment initiation are recommended.","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"139"},"PeriodicalIF":6.3000,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229002/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Systematic Reviews","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13643-025-02888-y","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background: This study aimed to elucidate the influence of alcohol, smoking, and substance use on tuberculosis (TB) treatment failure using a meta-analysis approach.

Method: A comprehensive search strategy was developed and applied to three major databases: MEDLINE, Web of Science, and Scopus. Additionally, Google Scholar, and Google were used to locate grey literature. Studies were identified through title and abstract screening, followed by a full-text review for eligibility. The Newcastle-Ottawa Scale checklist was employed to assess the quality of included studies. Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated for each factor.

Results: The initial database search and other sources yielded 10,518 articles. After applying inclusion criteria, 19 studies with a total of 180,119 participants were selected for the meta-analysis. The results revealed significant associations between all three factors and treatment failure. Pooled ORs indicated that alcohol consumption (OR 2.05; 95% CI 1.65 to 2.55), smoking (OR = 1.85; 95% CI 1.44 to 2.37), and substance use (OR 2.04; 95% CI 1.63 to 2.55) were each associated with an increased risk of TB treatment failure. Additionally, the majority of included studies demonstrated high methodological quality.

Conclusion: Our findings suggest that alcohol, smoking, and substance use are significant risk factors for unsuccessful TB treatment. To enhance TB treatment efficacy, preventive interventions aimed at reducing these behaviors before treatment initiation are recommended.

查看原文本刊更多论文

饮酒、药物使用和吸烟对结核病治疗结果的影响：系统回顾和荟萃分析

背景：本研究旨在通过荟萃分析方法阐明酒精、吸烟和药物使用对结核病治疗失败的影响。方法：在MEDLINE、Web of Science和Scopus三个主要数据库中开发并应用综合检索策略。此外，谷歌Scholar和谷歌用于定位灰色文献。通过标题和摘要筛选来确定研究，然后进行全文审查以确定是否合格。采用纽卡斯尔-渥太华量表检查表评估纳入研究的质量。计算每个因素的合并优势比（OR）和95%置信区间（CI）。结果：最初的数据库搜索和其他来源产生了10,518篇文章。在应用纳入标准后，19项研究共180119名受试者被选中进行meta分析。结果显示，这三个因素与治疗失败之间存在显著关联。合并的OR值表明饮酒(OR 2.05；95% CI 1.65 ~ 2.55)，吸烟(OR = 1.85；95% CI 1.44 - 2.37)和物质使用(OR 2.04；95% CI 1.63 - 2.55)均与结核病治疗失败风险增加相关。此外，大多数纳入的研究显示出较高的方法学质量。结论：我们的研究结果表明，酒精、吸烟和药物使用是结核病治疗失败的重要危险因素。为提高结核病治疗效果，建议在开始治疗前采取旨在减少这些行为的预防性干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Systematic Reviews Medicine-Medicine (miscellaneous)

CiteScore

8.30

自引率

0.00%

发文量

241

审稿时长

11 weeks

期刊介绍： Systematic Reviews encompasses all aspects of the design, conduct and reporting of systematic reviews. The journal publishes high quality systematic review products including systematic review protocols, systematic reviews related to a very broad definition of health, rapid reviews, updates of already completed systematic reviews, and methods research related to the science of systematic reviews, such as decision modelling. At this time Systematic Reviews does not accept reviews of in vitro studies. The journal also aims to ensure that the results of all well-conducted systematic reviews are published, regardless of their outcome.