Prognostic value of the pretreatment Naples prognostic score in gastrointestinal cancer patients: an updated meta-analysis with 28 studies.

IF 3.9 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Systematic Reviews Pub Date : 2025-10-10 DOI:10.1186/s13643-025-02944-7

Huayang Pang, Fengsheng Dai, Lihui Chen, Menghua Yan, Zhou Zhao, Hao Sun

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引用次数: 0

Abstract

Background: The Naples prognostic score (NPS) has been extensively documented as a promising prognostic biomarker in various malignancies. The objective of this study is to systematically investigate the correlation between the pretreatment NPS and survival outcomes in patients with gastrointestinal (GI) cancer.

Methods: This meta-analysis was prospectively registered with PROSPERO (CRD42024567576). We conducted a systematic literature search using electronic databases, including Web of Science, PubMed, and Embase, from inception until July 1st, 2024. The primary endpoints assessed were long-term survival outcomes. Pooled hazard ratios (HR) with corresponding 95% confidence intervals (CI) were calculated using a random-effects model during the pooled analysis. Additionally, prediction intervals (PI) were generated to capture the variability of the pooled effect across different study settings.

Results: A total of 28 studies, including 10,874 patients with GI cancer, were included in this meta-analysis. The results unequivocally demonstrated a significant association between elevated NPS and worse OS, bolstered by the robust PIs. Moreover, the elevated NPS was found to be significantly related to poor DFS, while the evidence remained uncertain due to heterogeneous PIs. Additionally, findings from a single study suggested that a high NPS may be associated with poor CSS.

Conclusion: Our evidence suggests that the pretreatment NPS could be a valuable prognostic biomarker in GI cancer patients, particularly for OS. This information can be utilized by clinicians to stratify patients and develop personalized treatment plans.

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预处理那不勒斯预后评分在胃肠道肿瘤患者中的预后价值：一项包含28项研究的最新荟萃分析。

背景：那不勒斯预后评分（NPS）已被广泛记录为各种恶性肿瘤的预后生物标志物。本研究的目的是系统地探讨预处理NPS与胃肠道（GI）癌患者生存结局的相关性。方法：本荟萃分析在PROSPERO （CRD42024567576）进行前瞻性注册。我们利用Web of Science、PubMed和Embase等电子数据库，从建校到2024年7月1日进行了系统的文献检索。评估的主要终点是长期生存结局。在合并分析过程中，使用随机效应模型计算合并风险比（HR）和相应的95%置信区间（CI）。此外，生成预测区间（PI）以捕获不同研究设置中合并效应的可变性。结果：本荟萃分析共纳入28项研究，包括10,874例胃肠道癌患者。结果明确表明，NPS升高和OS恶化之间存在显著关联，这得到了强劲的pi的支持。此外，NPS升高被发现与不良的DFS显著相关，但由于pi的异质性，证据仍不确定。此外，一项研究结果表明，高NPS可能与较差的CSS有关。结论：我们的证据表明预处理NPS可能是一种有价值的胃肠道肿瘤患者预后生物标志物，特别是对于OS。临床医生可以利用这些信息对患者进行分层并制定个性化的治疗计划。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Systematic Reviews Medicine-Medicine (miscellaneous)

CiteScore

8.30

自引率

0.00%

发文量

241

审稿时长

11 weeks

期刊介绍： Systematic Reviews encompasses all aspects of the design, conduct and reporting of systematic reviews. The journal publishes high quality systematic review products including systematic review protocols, systematic reviews related to a very broad definition of health, rapid reviews, updates of already completed systematic reviews, and methods research related to the science of systematic reviews, such as decision modelling. At this time Systematic Reviews does not accept reviews of in vitro studies. The journal also aims to ensure that the results of all well-conducted systematic reviews are published, regardless of their outcome.